Abstract:
:Chronic myelogenous leukemia (CML) has a typical progressive course with transition from a chronic phase to a terminal blast crisis phase. However, the mechanisms that lead to disease progression remain unclear. Bone marrow mesenchymal stem cells (BMMSCs) play important roles in maintaining the bone marrow microenvironment. In the present study, the biological characteristics of BMMSCs were determined including proliferation, apoptosis and secretion of cytokines during blastic phase CML (CML-Bp). The effect of BMMSCs in CML-Bp on K562 human CML cells and the CML-Bp original generation leukemia cells were also explored. Our results showed that CML-Bp BMMSCs protect tumor cells and increase their anti-apoptotic ability through regulating the expression of apoptosis-related proteins and activating the Wnt pathway.
journal_name
Oncol Repjournal_title
Oncology reportsauthors
Han Y,Wang Y,Xu Z,Li J,Yang J,Li Y,Shang Y,Luo Jdoi
10.3892/or.2013.2518subject
Has Abstractpub_date
2013-08-01 00:00:00pages
1007-13issue
2eissn
1021-335Xissn
1791-2431journal_volume
30pub_type
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