Abstract:
:An arsenical compound, As2O3 has been reported to be effective for treating acute leukemia and induce apoptosis in many different tumor cell types. In this study we designed a novel arsenical compound, As4O6, and compared its ability to induce cell growth inhibition as well as gene expression profiles along with As2O3 in HPV16 infected SiHa cervical cancer cells. Both As2O3 and As4O6 induced apoptosis in SiHa cells, as determined by a DNA ladder formation. As4O6 was more effective in suppressing the growth of SiHa cells in vitro, as compared to As2O3. To further compare gene expression profiles between these two drugs, we used a 384 cDNA microarray system. The gene expression profiles were also classified into the Gene Ontology (GO) to investigate apoptosis-related cellular processes. In the case of As2O3, 41 genes were up- or down-regulated at least 2-fold, as compared to non-treatment, whereas, 65 genes were up- or down-regulated by As4O6 treatment. In particular, 27 genes were commonly regulated by both arsenic compounds. The GO analysis also indicated that down-regulation of cell-regulatory functions, such as cell cycle, protein kinase activity and DNA repair, induces an anti-tumor effect. Taken together, these data support that As4O6 could be more effective than As2O3 in inhibiting the growth of HPV16 infected cervical cancer cells. This appears to be mediated through a unique but overlapping regulatory mechanism(s), suggesting that the regulated genes and cellular processes could be used for a new potential drug approach for treating cervical cancer in clinical settings.
journal_name
Oncol Repjournal_title
Oncology reportsauthors
Ahn WS,Bae SM,Lee KH,Kim YW,Lee JM,Namkoong SE,Lee IP,Kim CK,Seo JS,Sin JI,Kim YWkeywords:
subject
Has Abstractpub_date
2004-09-01 00:00:00pages
573-80issue
3eissn
1021-335Xissn
1791-2431journal_volume
12pub_type
杂志文章相关文献
ONCOLOGY REPORTS文献大全abstract::Although the impact of vascular endothelial growth factor (VEGF) is clearly established in advanced prostate cancer (PCa), its role in localized PCa remains to be determined. The aim of our study was to analyse the plasma levels of VEGF-A and the expression of VEGF-A in prostatic tissue in a population of patients wit...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2007-07-01 00:00:00
abstract::Neuropilin-1 (NRP-1), a co-receptor for VEGF165, is overexpressed in various prostate cancer cell lines and in advanced prostate tumors. However, distribution of the NRP-1 in prostate tumors has not yet been evaluated. Using immunohistochemical analysis, we evaluated 21 archival prostate tumors and 5 benign glands for...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2003-09-01 00:00:00
abstract::Studies of tumor-infiltrating immune cells have revealed that immune escape plays an important role in tumor growth. The aim of the present study was to investigate the impact of metastasis affecting CD4+ T cell subsets in human clinical samples. Single-cell suspensions derived from tumor-draining lymph node (TDLN) an...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2015.4064
更新日期:2015-08-01 00:00:00
abstract::Many prostate cancer (PCa) patients die of recurrent disease due to the emergence of hormone-independent cancer cells of which the mechanism is not fully understood. Our previous studies demonstrated that most castration- resistant prostate cancers (CRPC) overexpress the HOXB13 transcription factor to confer positive ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2016.4563
更新日期:2016-04-01 00:00:00
abstract::Retinoblastoma, a well-vascularized tumor that is dependent on a very robust angiogenic response, is the most common intraocular malignancy in children. Tissue factor (TF) is known to regulate tumor progression and in the present study we demonstrated that TF regulates tumor angioge...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2012.2048
更新日期:2012-12-01 00:00:00
abstract::Arginine is a critical amino acid in specific cancer types including hepatocellular carcinoma (HCC) and melanoma. Novel molecular mechanisms and therapeutic targets in arginine metabolism-mediated cancer formation await further identification. Our laboratory has previously demonstrated that arginine metabolic enzyme a...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2016.5334
更新日期:2017-02-01 00:00:00
abstract::Iodine-125 (125I) seed irradiation can be used as an important supplementary treatment for unresectable advanced gastric cancer. However, the radiobiological mechanism underlying brachytherapy remains unclear. Therefore, we investigated the influence of continuous and low-energy 125I irradiation on the cell cycle dist...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2014.3255
更新日期:2014-08-01 00:00:00
abstract::Bone morphogenetic protein 9 (BMP9) is a member of the BMP family, which is involved in the regulation of tumor biogenesis, development and metastasis. The present study aimed to investigate whether BMP9 inhibits the growth of MDA‑MB‑231 breast cancer cells via the phosphoinositide 3‑kinase (PI3K)/Akt signaling pathwa...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2018.6572
更新日期:2018-09-01 00:00:00
abstract::Oral lichen planus (OLP) is a chronic inflammatory disease that may transform to oral squamous cell carcinoma (OSCC), while its carcinogenesis mechanisms are not entirely clear. This study was designed to identify the important genes involved in the malignant transformation of OLP to OSCC. After RNA-sequencing, the di...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2017.5487
更新日期:2017-04-01 00:00:00
abstract::Epigenetic alterations have been reported in colorectal neoplasia which can either complement or in some cases be predisposed to genetic alterations such as K-ras mutations. We examined the promoter methylation status of the CDKN2A and O6-methylguanine-DNA methyltransferase (MGMT) genes, after sodium bisulfite convers...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2007-06-01 00:00:00
abstract::The present study explored the correlation of ecotropic viral integration site 5 (EVI5) expression with clinicopathological features and prognosis in hepatocellular carcinoma (HCC). A total of 205 HCC patients were included retrospectively. Quantitative real-time polymerase chain reaction (RT-qPCR) and western blottin...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2017.5862
更新日期:2017-10-01 00:00:00
abstract::EVL belongs to the Ena/VASP (Enabled/vasodilator-stimulated phosphoprotein) family of proteins [Mena (mammalian Ena), VASP and EVL], which have a range of roles in regulating the actin cytoskeleton. Growing evidence suggests that Mena and VASP are involved in carcinogenesis, though little is known about the significan...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2008-04-01 00:00:00
abstract::Glioblastoma is the most common type of primary brain tumour in adults, and its pathogenesis is particularly complicated. Among the many possible mechanisms underlying its pathogenesis, hyperactivation of the PI3K/Akt pathway is essential to the occurrence and development of glioma through the loss of PTEN or somatic ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2018.6845
更新日期:2019-01-01 00:00:00
abstract::Colon cancer is the fourth and third most common cancer, respectively in men and women worldwide and its incidence is on the increase. Stress response has been associated with the incidence and development of cancer. The catecholamines (CA), adrenaline (AD) and noradrenaline (NA), are crucial mediators of stress respo...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2015.3874
更新日期:2015-05-01 00:00:00
abstract::The aim of the present study was to uncover potential prognostic microRNA (miRNA) markers in head and neck squamous cell carcinoma (HNSCC). miRNA expression profile and clinical data were obtained from The Cancer Genome Atlas (TCGA) database. Survival analysis was conducted by Kaplan-Meier method. Then, candidate prog...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2016.4698
更新日期:2016-06-01 00:00:00
abstract::The TP53 mutation (R175H) is one of the most common mutations in human cancer. It is a highly attractive strategy for cancer therapy to find the genes that lead the R175H-expressing cancer cells. The aim of this study was to identify the synthetic sick/lethal gene interacting with R175H. Using lentiviral bar-coded com...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2013.2953
更新日期:2014-03-01 00:00:00
abstract::miR-367 is one of the most abundant miRNAs in human embryonic stem cells (hESCs) and is mainly involved in maintaining the pluripotency of stem cells. However, its role in cancer development remains poorly understood. In the present study, we explored the function and mechanism of the endogenous miR-367 in non-small c...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2017.5755
更新日期:2017-08-01 00:00:00
abstract::HIF-1 is a heterodimer consisting of the HIF-1alpha and HIF-1beta subunits, and HIF-1alpha is the unique oxygen regulated subunit that determines HIF-1 activity. HIF-1alpha upgrades many gene products which include the glucose transporter protein 1 (Glut-1). Immunohistochemical studies using a monoclonal antibody spec...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.14.4.909
更新日期:2005-10-01 00:00:00
abstract::As part of the efforts to drug repurposing, some HIV drugs have recently been identified to exert anticancer effects. Selected nucleoside analogues of nucleosidic reverse-transcriptase inhibitors (NRTIs) have been shown to interfere with RNA transcription of HI viruses as well as with the replication of DNA in cancer ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2016.5243
更新日期:2017-01-01 00:00:00
abstract::Regulated intramembrane proteolysis of epithelial cell adhesion molecule (EpCAM) results in shedding of the extracellular domain (EpEX) and release of the intra-cellular domain (EpICD) into the cytoplasm. Released EpICD associates with FHL2, β-catenin and Lef-1 to form a nuclear complex and triggers oncogenic signalin...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2016.4789
更新日期:2016-07-01 00:00:00
abstract::Ras-association domain family of proteins (RASSF) is characterized by the Ras-association (RA) domain at the C-terminal. Frequent inactivation of RASSF1A gene in human cancers suggests that other members of the family may also play an important role in tumorigenesis. By in silico gene searches, the number of RASSF fam...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2004-10-01 00:00:00
abstract::The expression of CDR1‑AS, a representative circular RNA, is closely linked with poor prognosis in gastrointestinal cancers, such as colon, liver, and pancreatic cancers. Although it is well known that CDR1‑AS antagonizes microRNA‑7 function through its sequence similarities in the brain, its biological function and l...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2019.7244
更新日期:2019-10-01 00:00:00
abstract::The pre-S mutant LHBs, especially the pre-S2 type, is believed to be crucial in HBV-associated hepatocellular carcinogenesis. However, the mechanism of HBV-induced hepatocellular carcinoma is not fully understood. To identify the mechanism, pre-S2 LHBs-interacting proteins were stud...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2011.1489
更新日期:2012-01-01 00:00:00
abstract::Phosphoinositide‑dependent kinase 1 (PDK1) is generally active in multiple myeloma (MM) and higher expression than other hematopoietic cells, which is associated with the drug resistance and the disease progression. Previous studies have demonstrated that PDK1 can be targeted therapeutically in MM. In the present stud...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2018.6369
更新日期:2018-06-01 00:00:00
abstract::Numerous studies have demonstrated that triptolide induces cell cycle arrest and apoptosis in human cancer cell lines. However, triptolide-induced DNA damage and inhibition of DNA repair gene expression in human skin cancer cells has not previously been reported. We sought the effects of triptolide on DNA damage and a...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2012.2170
更新日期:2013-02-01 00:00:00
abstract::MicroRNAs (miRNAs) are a class of highly conserved, small endogenous single-strand non-coding RNAs. They are aberrantly expressed in the circulation and tissue of patients with cancer. Therefore, it has been suggested that they may act as key regulators of carcinogenesis. The aim of the present study was to examine th...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2014.2971
更新日期:2014-03-01 00:00:00
abstract::Chronic lymphocytic leukemia (CLL) is the most common leukemia in Western countries, and mainly originates from an accumulation of abnormal B cells caused by the dysregulation of cell proliferation and apoptosis rates. The aberration of apoptosis-related genes in CLL cells results in defective apoptosis of CLL cells i...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2016.4950
更新日期:2016-09-01 00:00:00
abstract::Reactive oxygen species (ROS) can drive the de‑differentiation of tumor cells leading to the process of epithelial-to-mesenchymal transition (EMT) to enhance invasion and metastasis. The invasive and metastatic phenotype of malignant cells is often linked to loss of E-cadherin expression, a hallmark of EMT. Recent stu...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2014.3448
更新日期:2014-11-01 00:00:00
abstract::Primary and metastatic cancers that affect bones are frequently associated with severe and intractable pain. The mechanisms underlying the development of bone cancer pain are largely unknown. In the present study, we investigated whether inhibition of KCNQ/M (Kv7) potassium channels in the spinal cord contributes to t...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2015.3718
更新日期:2015-03-01 00:00:00
abstract::Glucocorticoids (GCs) are known potent clinical drugs, however, their mode of action is still complex and debatable. Macrophages are the most important target of GCs and play a key role in tumor immunity in vivo, but their relationship is also controversial. In the present study, the lentivirus system was used to over...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2019.7434
更新日期:2020-02-01 00:00:00