HOXB13-mediated suppression of p21WAF1/CIP1 regulates JNK/c-Jun signaling in prostate cancer cells.

abstract：:P5, which is a member of the protein disulfide isomerase family, possesses isomerase and chaperone activity in vitro; however, the physiological functions of this enzyme in cells remain unclear. To understand the important roles of P5 in cancer cells, the present study examined its expression on the surface of normal ...

journal_title：Oncology reports

authors： Horibe T,Torisawa A,Masuda Y,Kawakami K

更新日期：2019-02-01 00:00:00

abstract：:The molecular mechanisms underlying the biological effects of carbon ions are unclear. The aim of this study was to explore the Wnt/β‑catenin pathway in regulating carbon ion (12C6+) radiation‑induced cellular toxicity. HLY78 is a Wnt‑specific small molecular modulator, whose effects on 12C6+ radiation‑induced damage ...

journal_title：Oncology reports

authors： Si J,Zhang J,Gan L,Guo M,Xie Y,Di C,Sun C,Wang F,Yan J,Zhang H

更新日期：2020-07-01 00:00:00

abstract：:Human telomerase reverse transcriptase (hTERT) plays an important role in the development of tumors and has been investigated as a potent target for anticancer therapy. In the present study, we constructed a recombinant adenovirus, Ad-EGFP-C197 which was capable of expressing COOH‑terminal polypeptide of hTERT (amino ...

journal_title：Oncology reports

authors： Wu X,Chen J,Cao Y,Xie B,Li H,Zhou P,Qiu Y,Pang J

更新日期：2015-12-01 00:00:00

abstract：:A phase II trial was conducted to evaluate the tolerability and efficacy of incorporating cetuximab and simultaneous integrated boost intensity-modulated radiation therapy (SIB-IMRT) into a well-described 5-fluorouracil (5-FU) and hydroxyurea (HU)-based chemoradiation regimen. Patients with stage IVa-IVb or high-risk ...

journal_title：Oncology reports

authors： Tong CC,Lau KH,Rivera M,Cannan D,Aguirre-Ghiso J,Sikora AG,Gupta V,Forsythe K,Ko EC,Misiukiewicz K,Gurudutt V,Teng MS,Packer SH,Genden EM,Kao J

更新日期：2012-05-01 00:00:00

abstract：:Associations of functional single nucleotide polymorphisms in cytochrome P450 1B1, epoxide hydrolase 1, NAD(P)H:quinone oxidoreductase 1, glutathione S-transferase Pi-1 and deletions of glutathione S-transferases Mu-1 and θ-1 with colorectal cancer risk were investigated in a hospital-based case-control study on 495 m...

journal_title：Oncology reports

authors： Hlavata I,Vrana D,Smerhovsky Z,Pardini B,Naccarati A,Vodicka P,Novotny J,Mohelnikova-Duchonova B,Soucek P

更新日期：2010-11-01 00:00:00

abstract：:The advent of pathotropic (disease-seeking) targeting has transported genetic medicine across the threshold of history with the progressive clinical validation of Rexin-G, a tumor-targeted nanosized anti-cancer agent. Achieving noteworthy single-agent efficacy and survival benefits in otherwise intractable cancers, th...

journal_title：Oncology reports

authors： Hall FL,Levy JP,Reed RA,Petchpud WN,Chua VS,Chawla SP,Gordon EM

更新日期：2010-10-01 00:00:00

abstract：:Dendritic cells (DCs) as 'professional' antigen-presenting cells (APCs) initiate and regulate immune responses to various antigens. DC-based vaccines have become a promising modality in cancer immunotherapy. Cytokeratin 19 (CK19) protein is expressed at high levels in lung cancer and many other tumor cells, suggesting...

journal_title：Oncology reports

authors： Sun QF,Zhao XN,Peng CL,Hao YT,Zhao YP,Jiang N,Xue H,Guo JZ,Yun CH,Cong B,Zhao XG

更新日期：2015-11-01 00:00:00

abstract：:The inhibitor of differentiation/DNA binding 1 (Id-1), a negative regulator of basic helix-loop-helix transcription factors, plays an important role in the regulation of cell proliferation and differentiation. We examined the Id-1 expression by immunohistochemistry in 9 adenomas, 79 primary colorectal adenocarcinomas ...

journal_title：Oncology reports

authors： Zhao ZR,Zhang ZY,Zhang H,Jiang L,Wang MW,Sun XF

更新日期：2008-02-01 00:00:00

abstract：:Sentinel lymph node (SLN) biopsy is a useful way of assessing axillary nodal status and obviates unnecessary axillary lymph node dissection for patients with node-negative breast cancer. However, SLN can also be located in the internal mammary lymph node (IMN) chain or elsewhere. The practicability and relevance of in...

journal_title：Oncology reports

authors： Noguchi M

更新日期：2002-05-01 00:00:00

abstract：:Immunologic factors that predict survival in patients with lung cancer have not been established. We examined the relationship between the percentage of HLA-DR-positive peripheral leukocytes [HLA-DR+ (%)] and survival of patients with squamous cell carcinoma of the lung. Before initiating therapy, peripheral blood was...

journal_title：Oncology reports

authors： Nakamura H,Idiris A,Kato Y,Kato H

更新日期：2004-03-01 00:00:00

abstract：:Neuroblastoma is an aggressive pediatric tumor that accounts for 15% of cancer-related deaths in children. More than half of high-risk neuroblastoma patients develop tumor relapse that is lethal in most cases. A small population of tumor-initiating cells (TICs), recently identified from high-risk neuroblastoma patient...

journal_title：Oncology reports

authors： Pham TV,Hartomo TB,Lee MJ,Hasegawa D,Ishida T,Kawasaki K,Kosaka Y,Yamamoto T,Morikawa S,Yamamoto N,Kubokawa I,Mori T,Yanai T,Hayakawa A,Takeshima Y,Iijima K,Matsuo M,Nishio H,Nishimura N

更新日期：2012-06-01 00:00:00

abstract：:Intratumoral regions of low extracellular pH and low nutrition are common features of solid tumors. Although cancer cells normally die when they are removed from their environment, a small population of cells survive. In the present study, the subline LNCaP-F10, of the prostate canc...

journal_title：Oncology reports

authors： Iguchi K,Hayakawa Y,Ishii K,Matsumoto K,Usui S,Sugimura Y,Hirano K

更新日期：2012-12-01 00:00:00

abstract：:The S100A2 gene has been reported to be a putative tumor‑suppressor gene. Nevertheless, overexpression of S100A2 has been found in certain types of cancer. This study investigated S100A2 expression in tissue specimens of gastritis, intestinal metaplasia, adenomatous dysplasia and ga...

journal_title：Oncology reports

authors： Zhao Y,Zhang TB,Wang Q

更新日期：2013-04-01 00:00:00

abstract：:The pre-S mutant LHBs, especially the pre-S2 type, is believed to be crucial in HBV-associated hepatocellular carcinogenesis. However, the mechanism of HBV-induced hepatocellular carcinoma is not fully understood. To identify the mechanism, pre-S2 LHBs-interacting proteins were stud...

journal_title：Oncology reports

authors： Lei Y,Liu H,Yang Y,Wang X,Ren N,Li B,Liu S,Cheng J,Fu X,Zhang J

更新日期：2012-01-01 00:00:00

abstract：:Breast cancer is one of the most common malignancies diagnosed in women and it is increasing in incidence. Siegesbeckia glabrescens (SG) has been used in traditional oriental medicine to treat cardiovascular diseases such as hypertension and angina pectoris. This study examined whether or not SG could induce apoptosis...

journal_title：Oncology reports

authors： Jun SY,Choi YH,Shin HM

更新日期：2006-06-01 00:00:00

abstract：:Casticin, a polymethoxyflavone, has been reported to exert anticancer activities. The objectives of this study were to examine the molecular mechanisms by which casticin induces the growth inhibition and cell cycle arrest in human hepatocellular carcinoma (HCC) cells. The HCC cell l...

journal_title：Oncology reports

authors： He L,Yang X,Cao X,Liu F,Quan M,Cao J

更新日期：2013-01-01 00:00:00

abstract：:We have recently shown that covalent attachment of the nitric oxide (NO) moiety to the HIV protease inhibitor Saquinavir (Saq) produced a qualitatively new chemical entity, named Saquinavir-NO (Saq-NO), with enhanced anticancer properties and reduced toxicity both in vitro and in vi...

journal_title：Oncology reports

authors： Donia M,Mangano K,Fagone P,De Pasquale R,Dinotta F,Coco M,Padron J,Al-Abed Y,Giovanni Lombardo GA,Maksimovic-Ivanic D,Mijatovic S,Zocca MB,Perciavalle V,Stosic-Grujicic S,Nicoletti F

更新日期：2012-08-01 00:00:00

abstract：:The thioredoxin (Trx) system is an important enzymatic complex involved in cellular redox homeostasis. Arsenic trioxide (ATO; As2O3) is known to trigger cell death in vascular smooth muscle cells (VSMCs) via oxidative stress. In the present study, the effects of changes in thioredoxin 1 (Trx1) and Trx reductase1 (TrxR...

journal_title：Oncology reports

authors： Park WH

更新日期：2020-01-01 00:00:00

abstract：:The present study aimed to assess the in vitro and in vivo magnetic resonance imaging (MRI) features of chlorotoxin (CTX)-conjugated superparamagnetic iron oxide (SPIO) nanoprobes. CTX-conjugated nanoprobes were composed of SPIO coated with polyethylene glycol (PEG) and conjugated with CTX. The nanoprobes were termed ...

journal_title：Oncology reports

authors： Chen Z,Xiao EH,Kang Z,Zeng WB,Tan HL,Li HB,Bian DJ,Shang QL

更新日期：2016-05-01 00:00:00

abstract：:Treatment of patients affected by advanced or inoperable GIST was revolutionized by the use of the tyrosine kinase inhibitors. Despite the fact that most patients have a good durable response of disease, they develop a resistance to treatments after a median time of 24 months. The acquired resistance is an emerging as...

journal_title：Oncology reports

authors： Maleddu A,Pantaleo MA,Nannini M,Di Battista M,Saponara M,Lolli C,Biasco G

更新日期：2009-06-01 00:00:00

abstract：:Esophageal squamous cell carcinoma (ESCC) is a common cancer with a very poor prognosis. New methods are needed to screen high-risk populations and identify curable tumors and precursor lesions early. Molecular markers may be useful in such screening efforts. This study was designed to determine the prevalence of p16,...

journal_title：Oncology reports

authors： Roth MJ,Abnet CC,Hu N,Wang QH,Wei WQ,Green L,D'Alelio M,Qiao YL,Dawsey SM,Taylor PR,Woodson K

更新日期：2006-06-01 00:00:00

abstract：:Thymic epithelial tumors (TETs) consist of a series of neoplasm that differ morphologically and biologically. Due to its rarity and indolent natural history, large-scale prospective trials have been lacking. This study aimed to evaluate long-term clinical outcomes and clinicopathologic features for TET after surgical ...

journal_title：Oncology reports

authors： Kim BK,Cho BC,Choi HJ,Sohn JH,Park MS,Chang J,Kim SK,Kim DJ,Chung KY,Lee CG,Kim JH,Yoo NC

更新日期：2008-06-01 00:00:00

abstract：:Malignant pleural mesothelioma (MPM) is locally aggressive and challenging to quantitate non-invasively in vivo, particularly in orthotopic models of disease. We describe imaging of extracellular protease activity, typically elevated in locally aggressive tumors, as a novel method f...

journal_title：Oncology reports

authors： Zhou L,El-Deiry W,Wang W,Ingram ME,Katz SI

更新日期：2012-09-01 00:00:00

abstract：:Increasing evidence suggests that tumor necrosis factor receptor-associated factor 4 (TRAF4) is an oncogene which is frequently overexpressed in many human carcinomas. Although TRAF4 was originally identified in breast cancer, the underlying mechanism of TRAF4 in tumorigenesis remains largely unknown. In the present s...

journal_title：Oncology reports

authors： Zhang J,Li X,Yang W,Jiang X,Li N

更新日期：2014-09-01 00:00:00

abstract：:Hypoxia promotes the invasive and metastatic potential of tumour cells. A recent study has shown that the activation of the chemokine receptor CXCR4 by lack of oxygen in breast cancer is HIF-1-dependent. We have previously demonstrated that CXCR4 signalling is involved in the establishment of lymph node metastasis in ...

journal_title：Oncology reports

authors： Ishikawa T,Nakashiro K,Klosek SK,Goda H,Hara S,Uchida D,Hamakawa H

更新日期：2009-03-01 00:00:00

abstract：:We showed that the HER2/Grb2/Akt pathway induces all-trans retinoic acid (ATRA) resistance in breast cancer cells by suppressing the DNA binding activity of retinoic acid receptors (RAR). AP-1 activation was shown to induce ATRA resistance. Here, we determined whether AP-1 binding activity is correlated with ATRA resi...

journal_title：Oncology reports

authors： Mendoza-Gamboa E,Siwak DR,Tari AM

更新日期：2004-10-01 00:00:00

abstract：:The aim of this study is to assess, in squamous cell carcinoma of the cervix, the expression of pan-ras, c-myc and tp53 at protein level using an immunohistochemical (IHC) staining method. One hundred and seven patients with squamous cell carcinoma of the cervix were recruited. Fifty-four patients were of stage 1B/2A ...

journal_title：Oncology reports

authors： Ngan HY,Cheung AN,Liu SS,Cheng DK,Ng TY,Wong LC

更新日期：2001-05-01 00:00:00

abstract：:Genetically modified tumour cells producing cytokines such as interleukin 12 (IL-12) are potent activators of the antitumour immune responses and represent a promising therapeutic modality when combined with chemotherapy. The objective of this study was to examine whether IL-12-producing cellular vaccines can augment ...

journal_title：Oncology reports

authors： Mikyšková R,Indrová M,Símová J,Bieblová J,Bubeník J,Reiniš M

更新日期：2011-06-01 00:00:00

abstract：:Cholangiocarcinoma (CCA) is the second most common hepatic cancer with high resistance to current chemotherapies and extremely poor prognosis. The present study aimed to examine the effects of schisandrin B (Sch B) on CCA cells both in vitro and in vivo and to examine its underlying mechanism. We found that Sch B inhi...

journal_title：Oncology reports

authors： Yang X,Wang S,Mu Y,Zheng Y

更新日期：2016-10-01 00:00:00

abstract：:Zinc finger protein 703 (ZNF703), identified as an oncogene in luminal B breast cancer, is a member of the NET/NlZ family of zinc finger transcription factors. However, the role of ZNF703 in colorectal cancer (CRC) is unknown. We investigated the expression of ZNF703 in paired tumor and corresponding normal tissues us...

journal_title：Oncology reports

authors： Ma F,Bi L,Yang G,Zhang M,Liu C,Zhao Y,Wang Y,Wang J,Bai Y,Zhang Y

更新日期：2014-09-01 00:00:00