Schisandrin B inhibits cell proliferation and induces apoptosis in human cholangiocarcinoma cells.

abstract：:Galla Rhois is a commonly used medicine in East Asia for the treatment of several diseases. However, the effects of Galla Rhois on the metastasis of colorectal cancer (CRC) and the underlying molecular mechanisms have not been studied. We investigated the anti‑metastatic properties of Galla Rhois water extract (GRWE) ...

journal_title：Oncology reports

authors： Mun JG,Kee JY,Han YH,Lee S,Park SH,Jeon HD,Hong SH

更新日期：2019-01-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is different from other solid tumors because it is commonly associated with the occurrence of intrahepatic metastasis. Additionally, the liver, unlike other organs, is the main site of coagulation and fibrinolytic factor production. Therefore, it was speculated that coagulation and fibri...

journal_title：Oncology reports

authors： Li X,Gu B,Wang B,Feng Z,Ma Y,Li H,Lucas A,Chen H

更新日期：2020-12-01 00:00:00

abstract：:The clinicopathological significance of cell-cycle proteins has remained unclear in oral tongue squamous cell carcinomas (OTSCC). In the current study, we evaluated several cell-cycle proteins in relation to clinicopathological parameters and disease outcome for OTSCC. A total of 123 previously untreated patients with...

journal_title：Oncology reports

authors： Goto M,Tsukamoto T,Inada K,Mizoshita T,Ogawa T,Terada A,Hyodo I,Shimozato K,Hasegawa Y,Tatematsu M

更新日期：2005-10-01 00:00:00

abstract：:Colorectal cancer (CRC) is the third most common cancer and the fourth leading cause of cancer-related mortality worldwide. Aberrant expression of miRNAs play important roles in the development and progression of various types of cancers by modulating oncogenic and tumour-suppressor pathways. Therefore, exploring the ...

journal_title：Oncology reports

authors： Zhao J,Xu J,Zhang R

更新日期：2018-02-01 00:00:00

abstract：:Trop2 is considered to have an important function in tumor metastasis and the promotion of epithelial‑mesenchymal transition (EMT). E‑cadherin is a crucial factor in intercellular adhesion and EMT transformation. In the present study, we detected the expression of Trop2 and E‑cadherin in breast cancer (BC) to better d...

journal_title：Oncology reports

authors： Zhao W,Kuai X,Zhou X,Jia L,Wang J,Yang X,Tian Z,Wang X,Lv Q,Wang B,Zhao Y,Huang W

更新日期：2018-08-01 00:00:00

abstract：:In the present study, effectiveness of topical vidarabine or subsequent 5-fluorouracil (5-FU) administration was examined against persistent genital human papillomavirus (HPV) infection after local surgery. Thirty patients underwent local eradication treatment of uterine cervical intra-epithelial neoplasia (CIN) and s...

journal_title：Oncology reports

authors： Niwa K,Tagami K,Lian Z,Gao J,Mori H,Tamaya T

更新日期：2003-09-01 00:00:00

abstract：:Cancer stimulates macrophage infiltration and encourages angiogenesis, which is necessary for tumor growth and invasion. It seems, that the influence of photodynamic therapy (PDT) on immune cells and immune regulators plays a crucial role in this process. In order to study this effect, the influence of δ-aminolevulini...

journal_title：Oncology reports

authors： Kawczyk-Krupka A,Czuba Z,Szliszka E,Król W,Sieroń A

更新日期：2011-07-01 00:00:00

abstract：:Dendropanax morbifera Leveille is found throughout southwestern Korea, and has been used in traditional medicine for various diseases, such as migraine headache, infectious diseases, skin diseases and dysmenorrhea. However, the molecular mechanisms of D. morbifera concerning its biochemical actions in cancer have not ...

journal_title：Oncology reports

authors： Lee JW,Park C,Han MH,Hong SH,Lee TK,Lee SH,Kim GY,Choi YH

更新日期：2013-09-01 00:00:00

abstract：:The number of new lung cancer cases diagnosed yearly is high, and the mortality rate has not substantially declined. Non-small cell lung cancer (NSCLC) is the most common type of lung cancer, and adenocarcinoma accounts for the largest proportion of NSCLC. Currently, platinum-based combined chemotherapy, particularly ...

journal_title：Oncology reports

authors： Cheng R,Lu C,Zhang G,Zhang G,Zhao G

更新日期：2017-04-01 00:00:00

abstract：:The present study aimed to explore the relationship between the efficacy of epidermal growth factor receptor tyrosine kinase inhibitors (EGFR‑TKIs) and the expression of the cancer stem cell (CSC)‑related markers. Specimens of 72 cases of lung adenocarcinoma with significantly different therapeutic effects of the firs...

journal_title：Oncology reports

authors： Hu F,Li C,Zheng X,Zhang H,Shen Y,Zhou L,Yang X,Han B,Zhang X

更新日期：2020-02-01 00:00:00

abstract：:The human homologue of Drosophila disc large tumor suppressor protein (hDlg) is one of the proteins known to act cooperatively in regulating cell polarity and proliferation, suggesting an important connection between epithelial organization and cellular growth control. An abnormal expression of hDlg has been reported ...

journal_title：Oncology reports

authors： Niimi R,Matsumine A,Iino T,Murata T,Shintani K,Nakazora S,Nakamura T,Uehara Y,Kusuzaki K,Akiyama T,Uchida A

更新日期：2010-03-01 00:00:00

abstract：:Although many studies have been conducted on the role of alternative medicine in the treatment of cancer, only a few reports have been published regarding the total regression of malignant tumors. At the PBH Research Foundation (PBHRF), two of the authors have used homoeopathic therapy to treat many patients with vari...

journal_title：Oncology reports

authors： Banerji P,Campbell DR,Banerji P

更新日期：2008-07-01 00:00:00

abstract：:The present study aimed to identify novel histone modification markers in gastric cancer (GC) by chromatin immunoprecipitation microarray (ChIP-chip) analysis and to determine whether these markers were able to discriminate between normal and GC cells. We also tested for correlations with DNA methylation. We probed a ...

journal_title：Oncology reports

authors： Zhu X,Liu J,Xu X,Zhang C,Dai D

更新日期：2015-05-01 00:00:00

abstract：:The epidermal growth factor receptor (EGFR) network has rich targets for prostate cancer killing. Herein we evaluated the effects of combining the EGFR inhibition and radiation on DU145 prostate cancer. We treated DU145 prostate cancer cells with various doses of anti-EGFR antibody (C225) and gamma-irradiation (RAD). ...

journal_title：Oncology reports

authors： Wagener M,Zhang X,Villarreal HG,Levy L,Allen P,Shentu S,Fang B,Krishnan S,Chang JY,Cheung MR

更新日期：2008-05-01 00:00:00

abstract：:Signal transducer and activator of transcription (STAT) 5, including STAT 5a and STAT 5b, was reported to play important roles in the malignant biological behaviors of tumors. However, their roles in gastric cancer, especially for STAT 5b remain unknown. This study aimed to detect the expression of STAT 5b in gastric ...

journal_title：Oncology reports

authors： Sun T,Jia Y,Xiao D

更新日期：2015-07-01 00:00:00

abstract：:MAP kinase signaling proteins have major implications in the molecular oncogenesis of breast cancers and have been extensively investigated as putative targets for therapy. This study reports the investigation of the expression of P38 MAPK and its phosphorylated form (p-P38 MAPK) in clinical specimens of invasive brea...

journal_title：Oncology reports

authors： Merlin JL,Harlé A,Lion M,Ramacci C,Leroux A

更新日期：2013-10-01 00:00:00

abstract：:Hyperplasia suppressor gene (HSG) is a novel gene that markedly suppresses the mitogenetic stimuli or injury mediated by vascular smooth muscle cell proliferation. Herein we provide experimental evidence to show that HSG can also play a key role in tumor proliferation. Down-regulation of HSG protein in hepatocellular ...

journal_title：Oncology reports

authors： Wang W,Zhu F,Wang S,Wei J,Jia C,Zhang Y,Zhou L,Xie H,Zheng S

更新日期：2010-07-01 00:00:00

abstract：:Ginsenoside is known to have potential cancer-preventive activities. The major active components in red ginseng consist of a variety of ginsenosides including Rg3, Rg5 and Rk1, each of which has different pharmacological activities. Among these, Rg3 has been reported to exert anticancer activities through inhibition o...

journal_title：Oncology reports

authors： Choi YJ,Lee HJ,Kang DW,Han IH,Choi BK,Cho WH

更新日期：2013-09-01 00:00:00

abstract：:Lung cancer is the leading cause of cancer-related mortality worldwide. microRNAs (miRNAs) are small post-transcriptional regulatory non-coding RNAs that function as oncogenes or tumor suppressors in human cancers. Emerging evidence reveals that deregulation of miRNAs contributes to the progression of human lung cance...

journal_title：Oncology reports

authors： Jiang X,Chen X,Chen L,Ma Y,Zhou L,Qi Q,Liu Y,Zhang S,Luo J,Zhou X

更新日期：2015-02-01 00:00:00

abstract：:Expression of Src homology phosphotyrosine phosphatase 2 (SHP2) has been observed in human breast cancer. SHP2 is known to promote cell migration and invasiveness. However, the pathophysiologic role of SHP2 and its relevance to tumorigenesis are still largely unknown. In the present study, we aimed to evaluate the eff...

journal_title：Oncology reports

authors： Hu Z,Fang H,Wang X,Chen D,Chen Z,Wang S

更新日期：2014-07-01 00:00:00

abstract：:T cell-mediated cell immunity is the main anti-tumor immunity in which the effector T cells need specific antigen and costimulatory signals. One of the vaccines applied in tumor immunotherapy is the gene-modified tumor cell vaccine. One potential method to increase cell epitope density is to link the antigen with the ...

journal_title：Oncology reports

authors： Fang L,Wang K,Liu X,Zhang L,Zhang X,Qian L,Lu J,Qian G,Ge S

更新日期：2008-06-01 00:00:00

abstract：:Esculetin, a phenolic compound, has been shown to inhibit the growth of colon tumors in animal studies. However, the roles of signaling pathways and cell cycle regulation in the esculetin-induced inhibition of cancer cell growth, remain to be elucidated. The present study suggests a novel mechanism for the Ras/ERK1/2 ...

journal_title：Oncology reports

authors： Park SS,Park SK,Lim JH,Choi YH,Kim WJ,Moon SK

更新日期：2011-01-01 00:00:00

abstract：:Mitochondrial DNA (mtDNA) mutations occur in a variety of human cancers, suggesting a possible role for mitochondrial respiratory functions in tumorigenesis. Recent studies have demonstrated that SDHD, a nuclear gene encoding one of the mitochondrial complex II subunits, acts as a tumor-suppressor for hereditary parag...

journal_title：Oncology reports

authors： Habano W,Sugai T,Nakamura S,Uesugi N,Higuchi T,Terashima M,Horiuchi S

更新日期：2003-09-01 00:00:00

abstract：:The activation of receptor tyrosine kinases (RTKs) results in cellular effects including cell proliferation, survival, migration and invasion; RTKs also play an important role in tumourigenesis. It has been reported that EGFR signalling controls the migration of oral squamous cell carcinoma (OSCC) SAS and HSC3 cells b...

journal_title：Oncology reports

authors： Yasui H,Ohnishi Y,Nakajima M,Nozaki M

更新日期：2017-06-01 00:00:00

abstract：:Telomerase is a ribonucleoprotein enzyme which is endogenously expressed in germ, stem and tumor cells, but absent in benign somatic cells. The two major telomerase components are human telomerase RNA (hTR) and human telomerase reverse transcriptase (hTERT). It has been shown that hTERT is rate-limiting for telomerase...

journal_title：Oncology reports

authors： Schrader M,Burger AM,Müller M,Krause H,Straub B,Smith GL,Newlands ES,Miller K

更新日期：2002-09-01 00:00:00

abstract：:Associations of functional single nucleotide polymorphisms in cytochrome P450 1B1, epoxide hydrolase 1, NAD(P)H:quinone oxidoreductase 1, glutathione S-transferase Pi-1 and deletions of glutathione S-transferases Mu-1 and θ-1 with colorectal cancer risk were investigated in a hospital-based case-control study on 495 m...

journal_title：Oncology reports

authors： Hlavata I,Vrana D,Smerhovsky Z,Pardini B,Naccarati A,Vodicka P,Novotny J,Mohelnikova-Duchonova B,Soucek P

更新日期：2010-11-01 00:00:00

abstract：:The aim of the present study was to investigate the expression, function and underlying molecular mechanism of the long non‑coding (lnc) RNA RP1‑163G9.1 in patients with gastric adenocarcinoma (GA). The expression levels of lncRNA RP1‑163G9.1 were determined in 112 paired clinical GA tissues by reverse transcription‑q...

journal_title：Oncology reports

authors： Sun B,Dang Y,Zhang F,Li K,Ouyang X,Wang K,Huang Q

更新日期：2019-06-01 00:00:00

abstract：:Epigenetic changes as well as genetic changes are mechanisms of tumorigenesis. We aimed to identify novel genes that are silenced by DNA hypermethylation in hepatocellular carcinoma (HCC). We screened for genes with promoter DNA hypermethylation using a genome-wide methylation microarray analysis in primary HCC (the d...

journal_title：Oncology reports

authors： Yamada N,Yasui K,Dohi O,Gen Y,Tomie A,Kitaichi T,Iwai N,Mitsuyoshi H,Sumida Y,Moriguchi M,Yamaguchi K,Nishikawa T,Umemura A,Naito Y,Tanaka S,Arii S,Itoh Y

更新日期：2016-04-01 00:00:00

abstract：:Renal cell carcinoma (RCC) is the most frequent type of renal-originated malignancy. Although nephrectomy is successfully used to save the lives of patients with localized RCC, treatment of advanced and other refractory RCCs is poor and still inadequate. Here, we show that triptolide, a small molecule and a well-known...

journal_title：Oncology reports

authors： Li J,Zhu W,Leng T,Shu M,Huang Y,Xu D,Qiu P,Su X,Yan G

更新日期：2011-04-01 00:00:00

abstract：:Bee venom (BV) therapy is a type of alternative medical treatment used to treat various diseases in oriental medicine. The mechanisms underlying the effects of BV remain poorly understood. In the present study, we evaluated the antiviral effect of BV on cervical carcinoma cell lines (CaSki, HeLa, C33A and TC-1). BV tr...

journal_title：Oncology reports

authors： Kim YW,Chaturvedi PK,Chun SN,Lee YG,Ahn WS

更新日期：2015-04-01 00:00:00