Abstract:
:Hepatocellular carcinoma (HCC) is different from other solid tumors because it is commonly associated with the occurrence of intrahepatic metastasis. Additionally, the liver, unlike other organs, is the main site of coagulation and fibrinolytic factor production. Therefore, it was speculated that coagulation and fibrinolytic factors could be associated with intrahepatic metastasis of HCC. Do the coagulation and fibrinolytic systems protect HCC cells against anoikis during infiltration and metastasis? Conversely, do the coagulation and fibrinolytic systems lead to immune escape of HCC cells by affecting the immune microenvironment of patients? The current review aimed to present a number of novel hypotheses for the treatment of HCC by exploring the mechanisms of coagulation and fibrinolytic factors in the regulation of cancer growth.
journal_name
Oncol Repjournal_title
Oncology reportsauthors
Li X,Gu B,Wang B,Feng Z,Ma Y,Li H,Lucas A,Chen Hdoi
10.3892/or.2020.7800subject
Has Abstractpub_date
2020-12-01 00:00:00pages
2345-2352issue
6eissn
1021-335Xissn
1791-2431journal_volume
44pub_type
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