The expression of hDlg as a biomarker of the outcome in malignant fibrous histiocytomas.

abstract：:Gastric cancer (GC), a type of gastric mucosal epithelium disease caused by common malignant tumors, has become a major threat to human health and survival. Tumor necrosis factor‑α‑induced protein‑8 like‑2 (TIPE2) is a negative immune regulatory factor that is selectively expressed in immune organs, immune cells and v...

journal_title：Oncology reports

authors： Lin Z,Liu W,Xiao C,Fan Y,Zhuang G,Qi Z

更新日期：2018-09-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is a leading cause of cancer-related death. Tumor specific cellular and humoral immunotherapy may be a viable approach for the treatment of HCC. This study investigated specific inhibitory and cytotoxic effects on hepatocellular carcinoma (HCC) induced by the peptide, designated HBc Delt...

journal_title：Oncology reports

authors： Kong J,Diao Z,Deng X,Zhong H,Yao W,Hu X

更新日期：2007-07-01 00:00:00

abstract：:Neuroblastoma is an aggressive pediatric tumor that accounts for 15% of cancer-related deaths in children. More than half of high-risk neuroblastoma patients develop tumor relapse that is lethal in most cases. A small population of tumor-initiating cells (TICs), recently identified from high-risk neuroblastoma patient...

journal_title：Oncology reports

authors： Pham TV,Hartomo TB,Lee MJ,Hasegawa D,Ishida T,Kawasaki K,Kosaka Y,Yamamoto T,Morikawa S,Yamamoto N,Kubokawa I,Mori T,Yanai T,Hayakawa A,Takeshima Y,Iijima K,Matsuo M,Nishio H,Nishimura N

更新日期：2012-06-01 00:00:00

abstract：:Esculetin, a phenolic compound, has been shown to inhibit the growth of colon tumors in animal studies. However, the roles of signaling pathways and cell cycle regulation in the esculetin-induced inhibition of cancer cell growth, remain to be elucidated. The present study suggests a novel mechanism for the Ras/ERK1/2 ...

journal_title：Oncology reports

authors： Park SS,Park SK,Lim JH,Choi YH,Kim WJ,Moon SK

更新日期：2011-01-01 00:00:00

abstract：:Peroxiredoxin 1 (Prdx1) is an antioxidant and plays an important role in H2O2-mediated cell signaling. We previously found that the expression level of Prdx1 was elevated in esophagus squamous cell carcinoma (ESCC) tissue using a proteomics approach. Since overexpressed protein can induce an autoimmune response, to fu...

journal_title：Oncology reports

authors： Ren P,Ye H,Dai L,Liu M,Liu X,Chai Y,Shao Q,Li Y,Lei N,Peng B,Yao W,Zhang J

更新日期：2013-11-01 00:00:00

abstract：:Colon cancer (CC) is one of the leading causes of cancer‑related mortality in China and western countries. Several studies have demonstrated that long non‑coding RNAs (lncRNAs) play critical roles in cancer development. However, the function of lncRNA RP11‑619L19.2 in colon cancer remains unclear. The aim of the prese...

journal_title：Oncology reports

authors： Zhang XW,Li SL,Zhang D,Sun XL,Zhai HJ

更新日期：2020-12-01 00:00:00

abstract：:While Taxol has been reported to improve the clinical survival of breast cancer patients, subsequently developed drug-resistance of the cancer cells limits its final efficacy and applications. Previous studies suggested that Aurora A is involved in the development of the Taxol-resistance of breast cancer. We establish...

journal_title：Oncology reports

authors： Li Y,Zhou W,Tang K,Chen X,Feng Z,Chen J

更新日期：2017-10-01 00:00:00

abstract：:Triple-negative breast cancer is a highly aggressive type of mammalian carcinoma. It is defined by a rather weak expression of estrogen-, progesterone- and Her2-receptor, and is thus difficult to treat, resulting in low disease-free and overall survival rates of the affected patients. Hence it is important to find new...

journal_title：Oncology reports

authors： Andergassen U,Kölbl AC,Mumm JN,Mahner S,Jeschke U

更新日期：2017-05-01 00:00:00

abstract：:IFN-alpha regulates tumor cell growth at least through induction of apoptosis. We have recently demonstrated that IFN-alpha causes apoptosis through upregulation of TNF-related apoptosis-inducing ligand (TRAIL) in Daudi B lymphoma and U266 myeloma cells. However, other cell lines such as Ramos and RPMI 8226 underwent ...

journal_title：Oncology reports

authors： Yanase N,Kanetaka Y,Mizuguchi J

更新日期：2007-10-01 00:00:00

abstract：:Post-transcriptional modification of p53 by phosphorylation has been proposed as an important mechanism of p53 stabilization and functional regulation. However, little is known about the phosphorylation state of mutant p53 protein overexpressed in human tumors. We evaluated immunohistochemically the p53 phosphorylatio...

journal_title：Oncology reports

authors： Matsumoto M,Furihata M,Kurabayashi A,Ohtsuki Y

更新日期：2004-11-01 00:00:00

abstract：:Colorectal cancer is the second most deadly cancer in the United States. When diagnosed early, current treatments bring a limited success; however, once metastasis occurs, radiation and chemotherapy are generally ineffective. Structural changes in the ECM are necessary for cell migration during tissue remodeling. Matr...

journal_title：Oncology reports

authors： Roomi MW,Ivanov V,Kalinovsky T,Niedzwiecki A,Rath M

更新日期：2005-03-01 00:00:00

abstract：:Depressed and flat surface lesions are not easy to identify with routine colonoscopies during screening for colorectal cancer (CRC). Identifying clinically relevant genes that influence tumor shape could be useful when screening for the presence of depressed lesions. Total RNA was extracted from tumor cells collected ...

journal_title：Oncology reports

authors： Kida H,Takano Y,Yamamoto K,Mori M,Yanaga K,Tanaka J,Kudo SE,Mimori K

更新日期：2014-08-01 00:00:00

abstract：:The present study evaluated activity and toxicity of modulated doses of gemcitabine associated to oxaliplatin in patients with secondary CIRS and with locally advanced pancreatic adenocarcinoma (LAPC) and metastatic pancreatic adenocarcinoma (MPC). Since January 2006, untreated LAPC and MPC patients have been assessed...

journal_title：Oncology reports

authors： Tudini M,Palluzzi E,Cannita K,Mancini M,Santomaggio A,Bruera G,Baldi PL,Pelliccione M,Ricevuto E,Ficorella C

更新日期：2012-02-01 00:00:00

abstract：:It has been revealed that the induction of epithelial‑mesenchymal transition (EMT) is associated with drug resistance, leading to tumor recurrence and metastasis. Recent studies have shown that chemotherapeutic agents, besides their therapeutic effects, can induce EMT and enhance invasive and metastatic properties of ...

journal_title：Oncology reports

authors： Chun SY,Kim S,Nam KS

更新日期：2017-08-01 00:00:00

abstract：:We investigated whether 18F-fluorothymidine-positron-emission tomography/computed tomography (18F-FLT-PET/CT) is useful for the evaluation of the very early response to anti-epidermal growth factor receptor (EGFR) antibody cetuximab therapy in human lung cancer xenografts. A human tumor xenograft model was established...

journal_title：Oncology reports

authors： Takeuchi S,Zhao S,Kuge Y,Zhao Y,Nishijima K,Hatano T,Shimizu Y,Kinoshita I,Tamaki N,Dosaka-Akita H

更新日期：2011-09-01 00:00:00

abstract：:The objective of this study was to examine how splenectomy affects the immune response, particularly T cells, in chemically-induced mammary tumors. Female rats were splenectomized and then exposed to 9,10-dimethyl-1,2-benz(a)anthracene (DMBA) to induce mammary tumors. Splenectomy significantly decreased the rate of tu...

journal_title：Oncology reports

authors： Kossoy G,Ben-Hur H,Lifschitz O,Zusman I

更新日期：2002-01-01 00:00:00

abstract：:The outcome of patients with advanced stage rhabdomyosarcoma (RMS) is still sobering. This outcome has not improved through conservative treatments. Therefore, novel treatment approaches such as immunotherapy need to be evaluated in human-adapted animal models. The aim of this study was to develop a humanized mouse mo...

journal_title：Oncology reports

authors： Seitz G,Pfeiffer M,Fuchs J,Warmann SW,Leuschner I,Vokuhl C,Lang P,Handgretinger R,Armeanu-Ebinger S

更新日期：2010-10-01 00:00:00

abstract：:Increasing evidence suggests that microRNAs are involved in human carcinogenesis as tumor suppressors or oncogenes. A growing number of reports has shown that an interest has been sparked in aberrant microRNA expression and how they can be used to treat human diseases, including cancer. However, their precise biologic...

journal_title：Oncology reports

authors： Pan J,Hu H,Zhou Z,Sun L,Peng L,Yu L,Sun L,Liu J,Yang Z,Ran Y

更新日期：2010-07-01 00:00:00

abstract：:Pancreatic cancer is one of the most deadly carcinomas worldwide. Although gemcitabine as the standard chemotherapy agent has been proven to be effective, the response rate remains at 5.4% and the 5-year survival rate is extremely poor. Ursolic acid (UA) is a small molecule compound...

journal_title：Oncology reports

authors： Li J,Liang X,Yang X

更新日期：2012-08-01 00:00:00

abstract：:Thymidylate synthase (TS) is the rate-limiting enzyme in the synthesis of pyrimidine nucleotides, required for DNA synthesis, and is also a critical target for fluoropyrimidines, which are widely used in the treatment of gastrointestinal tumours. We examined TS expression in tumours from 86 patients with advanced colo...

journal_title：Oncology reports

authors： Bendardaf R,Lamlum H,Elzagheid A,Ristamäki R,Pyrhönen S

更新日期：2005-09-01 00:00:00

abstract：:We have previously demonstrated that gastric and intestinal endocrine cell (End-cell) marker expression is important for assessment of the histogenesis of endocrine cell tumors. However, the End-cell phenotypes of carcinoid tumors in the rectum remain largely unclear. We therefore examined marker expression of rectal ...

journal_title：Oncology reports

authors： Hirata Y,Mizoshita T,Mizushima T,Shimura T,Mori Y,Kubota E,Wada T,Ogasawara N,Tanida S,Kataoka H,Sasaki M,Kamiya T,Tsukamoto T,Tatematsu M,Joh T

更新日期：2009-01-01 00:00:00

abstract：:In this study, we applied near-infrared fluorescent quantum dots (NIRF-QDs) for non-invasive in vivo and in situ imaging of head and neck squamous cell carcinoma (HNSCC). The U14 squamous cancer cell line with high expression of epidermal growth factor receptor (EGFR) was implanted subcutaneously into the head and nec...

journal_title：Oncology reports

authors： Yang K,Zhao C,Cao YA,Tang H,Bai YL,Huang H,Zhao CR,Chen R,Zhao D

更新日期：2012-06-01 00:00:00

abstract：:The high activation of protein kinase B (AKT)/nuclear factor‑κB (NF‑κB) signaling has often been associated with the induction of non‑small cell lung cancer (NSCLC) cell survival and resistance to cisplatin, which is one of the most widely used chemotherapeutic drugs in the treatment of NSCLC. The inhibition of AKT/NF...

journal_title：Oncology reports

authors： Dukaew N,Chairatvit K,Pitchakarn P,Imsumran A,Karinchai J,Tuntiwechapikul W,Wongnoppavich A

更新日期：2020-10-01 00:00:00

abstract：:MHC class I-related chain molecules A and B (MICA and B) expressed on the cell-surface of tumor cells are ligands for an activating receptor, NKG2D, expressed on natural killer (NK) cells and stimulate the NK cell-mediated cytotoxicity. On the other hand, the soluble form of MICA and B produced by proteolytic cleavage...

journal_title：Oncology reports

authors： Yamanegi K,Yamane J,Kobayashi K,Kato-Kogoe N,Ohyama H,Nakasho K,Yamada N,Hata M,Nishioka T,Fukunaga S,Futani H,Okamura H,Terada N

更新日期：2010-12-01 00:00:00

abstract：:Eighteen primary human malignant mesotheliomas obtained from 18 patients were screened for point mutations and microdeletions/insertions in all exons of the tumour suppressor gene PTEN/MMAC1 by SSCP analysis. No mutation could be found. Our preliminary data indicate that disarrangements of PTEN/MMAC1 are at least not ...

journal_title：Oncology reports

authors： Papp T,Schipper H,Pemsel H,Unverricht M,Muller KM,Wiethege T,Schiffmann D,Rahman Q

更新日期：2001-11-01 00:00:00

abstract：:Astilbin exhibits several pharmacological activities, including hypoglycemic, anti-oxidant and anti-inflammatory properties. The aim of the present study was to investigate the pro-apoptotic activities of astilbin on breast cancer in cells and mice. It was demonstrated that astilbin significantly reduced the cell viab...

journal_title：Oncology reports

authors： Sun X,Zhang H,Zhang Y,Yang Q,Zhao S

更新日期：2018-10-01 00:00:00

abstract：:DNA damage sensor proteins are recognized as upstream components of the DNA damage checkpoint signaling pathway and are required for cell cycle control and the induction of apoptosis. hRad9 plays an important role as an upstream regulator of checkpoint signaling. In our previous studies, we confirmed the significant a...

journal_title：Oncology reports

authors： Yuki T,Maniwa Y,Doi T,Okada K,Nishio W,Hayashi Y,Okita Y

更新日期：2008-11-01 00:00:00

abstract：:Antineoplastons are naturally occurring peptides and amino acid derivatives found in human blood and urine. antineoplastons have been shown to control neoplastic growth. In the present study, we investigated demethylation effect of the antineoplaston AS2-1 (a mixture of phenylacetylglutamine and phenylacetate in the r...

journal_title：Oncology reports

authors： Ushijima M,Ogata Y,Tsuda H,Akagi Y,Matono K,Shirouzu K

更新日期：2014-01-01 00:00:00

abstract：:The aim of the present study was to search for an effective regimen among existing chemotherapies for head and neck squamous cell carcinoma (HNSCC). Among the tested drugs, we focused on combined SN-38, which is the active metabolite produced from irinotecan hydrochloride - a type I DNA topoisomerase inhibitor - after...

journal_title：Oncology reports

authors： Nanbu T,Umemura N,Ohkoshi E,Nanbu K,Sakagami H,Shimada J

更新日期：2018-01-01 00:00:00

abstract：:Secreted protein acidic and rich in cysteine (SPARC) is a glycoprotein which plays multiple roles in different types of cancer. Our previous study showed that SPARC overexpression inhibited the growth and angiogenesis of tumors, and reduced expression of vascular endothelial growth factor (VEGF). However, the relation...

journal_title：Oncology reports

authors： Zhang J,Wang P,Zhu J,Wang W,Yin J,Zhang C,Chen Z,Sun L,Wan Y,Wang X,Chen G,Liu Y

更新日期：2014-05-01 00:00:00