Abstract:
:Post-transcriptional modification of p53 by phosphorylation has been proposed as an important mechanism of p53 stabilization and functional regulation. However, little is known about the phosphorylation state of mutant p53 protein overexpressed in human tumors. We evaluated immunohistochemically the p53 phosphorylation state of Ser392 and Ser15 sites in 44 actinic keratoses (AKs), 62 squamous cell carcinomas (SCCs), 23 Bowen's disease (BDs) and 43 basal cell carcinomas (BCCs). The mean labeling index (LI) of phospho-Ser392-p53 was significantly higher than that of phospho-Ser15-p53 in all cases. Phospho-Ser392-p53 protein was frequently overexpressed in not only SCCs but also AKs and BDs, revealing no significant difference in the immunoreactivity among them. In BCCs, phospho-Ser392-p53 immunoreactivity was significantly lower than that in BDs, and phospho-Ser15-p53 immunoreactivity was significantly lower than that in SCCs. Ser15 phosphorylation was significantly correlated with a high level of Ki-67 LI in BCCs. These results suggest that p53 overexpressed in skin tumors is more frequently phosphorylated at Ser392 residue than Ser15, and that the Ser392 phosphorylation is more likely to occur early in the pathogenesis of SCC. Moreover, the decreased level of the phosphorylation might be characteristic of BCC, but the Ser15 phosphorylation seems to have an influence on BCC development.
journal_name
Oncol Repjournal_title
Oncology reportsauthors
Matsumoto M,Furihata M,Kurabayashi A,Ohtsuki Ykeywords:
subject
Has Abstractpub_date
2004-11-01 00:00:00pages
1039-43issue
5eissn
1021-335Xissn
1791-2431journal_volume
12pub_type
杂志文章相关文献
ONCOLOGY REPORTS文献大全abstract::Gastric cancer (GC), a type of gastric mucosal epithelium disease caused by common malignant tumors, has become a major threat to human health and survival. Tumor necrosis factor‑α‑induced protein‑8 like‑2 (TIPE2) is a negative immune regulatory factor that is selectively expressed in immune organs, immune cells and v...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2018.6576
更新日期:2018-09-01 00:00:00
abstract::EGFR and KRAS mutations are the two most common driver mutations in non-small cell lung cancer (NSCLC). Molecular target-based therapy using small molecules such as gefitinib has been used for inhibiting EGFR with good initial responses; however, drug resistance is common when using a mono-targeting strategy. At prese...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2016.4770
更新日期:2016-07-01 00:00:00
abstract::We have recently shown that covalent attachment of the nitric oxide (NO) moiety to the HIV protease inhibitor Saquinavir (Saq) produced a qualitatively new chemical entity, named Saquinavir-NO (Saq-NO), with enhanced anticancer properties and reduced toxicity both in vitro and in vi...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2012.1840
更新日期:2012-08-01 00:00:00
abstract::MicroRNAs (miRNAs) play crucial roles in the initiation and progression of various cancers, including melanoma. Recently, the genetic variants and deregulation of miR-605 have been reported to participate in carcinogenesis. However, the expression status of the miR-605 in melanoma tissues and its role in melanoma prog...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2017.5740
更新日期:2017-08-01 00:00:00
abstract::Galectin-3 is a soluble endogenous lectin in vertebrates and is implicated in a variety of biological functions, including tumor cell adhesion, proliferation, differentiation, apoptosis, cancer progression and metastasis. In the present study, we analyzed the role of galectin-3 in apoptosis in human malignant lymphoma...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2008-03-01 00:00:00
abstract::In this study, we demonstrate an important role of activation of the hypoxia-inducible factor-1 (HIF-1) pathway in endometrial carcinogenesis and tumor phenotype development of endometrial carcinoma, and suggest a unique role of the HIF-1-target gene, differentiated embryo chondrocyte 2 (DEC2), in carcinogenesis. Hypo...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2007-04-01 00:00:00
abstract::Apoptosis is a crucial event for anticancer drug efficacy. The signal pathways activated by anticancer drugs are classified as death receptor (DR) -dependent or -independent. The mechanisms by which anticancer drugs induce apoptosis via DR-dependent pathways are not fully understood. In the present study, we assessed ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2003-11-01 00:00:00
abstract::Glioblastoma (GBM) is the most common type of primary central nervous system tumor in adults, which has high mortality and morbidity rates, and short survival time, namely <15 months after the diagnosis and application of standard therapy, which includes surgery, radiation therapy and chemotherapy; thus, novel therape...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2020.7472
更新日期:2020-03-01 00:00:00
abstract::Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) holds promise for cancer therapy due to its unique capacity to selectively trigger apoptosis in cancer cells. However, TRAIL therapy is greatly hampered by its resistance. A preclinical successful strategy is to identify combination treatments that sensit...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2016.4666
更新日期:2016-05-01 00:00:00
abstract::Breast cancer is the most common type of cancer among women worldwide. Research using breast cancer cell lines derived from primary tumors may provide valuable additional knowledge regarding this type of cancer. Therefore, the aim of this study was to investigate the phenotypic prof...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2013.2284
更新日期:2013-04-01 00:00:00
abstract::Quercetin, a naturally occurring flavonoid abundant in fruits and vegetables, has been demonstrated as a multipotent bioflavonoid with great potential for the prevention and treatment of cancer. Apoptosis is thought to be an important response to most chemotherapeutic agents in leukemia cells. However, the underlying ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2010.1097
更新日期:2011-02-01 00:00:00
abstract::The objective of this study was to examine how splenectomy affects the immune response, particularly T cells, in chemically-induced mammary tumors. Female rats were splenectomized and then exposed to 9,10-dimethyl-1,2-benz(a)anthracene (DMBA) to induce mammary tumors. Splenectomy significantly decreased the rate of tu...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.9.1.185
更新日期:2002-01-01 00:00:00
abstract::Nucleotide excision repair (NER) is the DNA repair pathway through which cisplatin-DNA intrastrand adduct is repaired. Clinical studies have shown that increased mRNA expression of selected genes involved in the rate-limiting step of NER, appear to be closely associated with clinical resistance to platinum agents. The...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.7.5.1123
更新日期:2000-09-01 00:00:00
abstract::Sentinel lymph node (SLN) biopsy is a useful way of assessing axillary nodal status and obviates unnecessary axillary lymph node dissection for patients with node-negative breast cancer. However, SLN can also be located in the internal mammary lymph node (IMN) chain or elsewhere. The practicability and relevance of in...
journal_title:Oncology reports
pub_type: 杂志文章,评审
doi:
更新日期:2002-05-01 00:00:00
abstract::A 69-year-old woman presented to her local clinic with vomiting and abdominal distension. Since a bowel obstruction by left colon cancer was suspected due to a marked dilation of the transverse colon, she was referred to our hospital. On admission, an enema disclosed a complete obstruction at the splenic flexure of th...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2008-04-01 00:00:00
abstract::To elucidate the potential etiological role of RUNX3 in the development of salivary gland adenoid cystic carcinoma (ACC), we analyzed the methylation status of RUNX3 in a series of 114 ACC tissues and 3 ACC cell lines. Results showed that the methylated rate of RUNX3 was 50.9 and 3.5% in the 114 ACC samples and the co...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2011.1282
更新日期:2011-08-01 00:00:00
abstract::Previous studies have shown that S100P contributes to the development of a number of tumors. However, its prognostic significance in colorectal cancer (CRC) has not been demonstrated. This study aimed to confirm the expression of S100P in colorectal cancer as well as the epigenetic mechanism underlying its gene expres...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2012.1794
更新日期:2012-07-01 00:00:00
abstract::Esophageal cancer (EC) has a globally increasing incidence with poor curative treatment options and survival rates. Crucial risk factors are exposure to toxins or carcinogens. Microsomal epoxide hydrolase (mEH) is a biotransformation enzyme essential for the detoxification of xenobiotics. Polymorphisms in exon 3 and e...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2012.1734
更新日期:2012-06-01 00:00:00
abstract::It has been reported that granulocyte-colony stimulating factor (G-CSF) and granulocyte-macrophage-colony stimulating factor (GM-CSF) can mobilize endothelial progenitor cells (EPCs) in bone marrow cells (BMCs) into peripheral blood (PB) in vivo. Previously, we also reported that macrophage-colony stimulating factor (...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2006-06-01 00:00:00
abstract::Many prostate cancer (PCa) patients die of recurrent disease due to the emergence of hormone-independent cancer cells of which the mechanism is not fully understood. Our previous studies demonstrated that most castration- resistant prostate cancers (CRPC) overexpress the HOXB13 transcription factor to confer positive ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2016.4563
更新日期:2016-04-01 00:00:00
abstract::Numerous studies have suggested that increased sialylation and fucosylation levels are signs of cancer progression. The majority of studies have focused on cell surface and bloodstream glycosylation changes associated with cancer progression, while little attention has been paid to changes in the glycosylation of cyto...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2013.2938
更新日期:2014-03-01 00:00:00
abstract::Angiogenesis is crucial for the development and metastasis of human brain glioma. Based on our previous successful construction of a lentivirus-mediated alphastatin (an endogenous angiogenesis inhibitor) gene transfer system and our findings that alphastatin exhibited potent inhibit...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2012.2187
更新日期:2013-03-01 00:00:00
abstract::Hepatocellular carcinoma (HCC) is a highly vascular tumor, and treatment options for patients of advanced-stage are limited. Nitric oxide (NO), which is derived from endothelial nitric oxide synthase (eNOS), provides crucial signals for angiogenesis in the tumor microenvironment. Tetrahydrobiopterin (BH4) is an essent...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2016.4850
更新日期:2016-08-01 00:00:00
abstract::Few studies have examined apoptosis induced by low-voltage electric pulses (LVEPs). LVEP-induce changes in membrane potential that are below the membrane breakdown threshold and increase membrane permeability without electroporation (pore formation) through the transport of extracellular substances via phagocytosis. W...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or_00000780
更新日期:2010-05-01 00:00:00
abstract::Inhibins are dimeric glycoproteins, composed of an α-subunit and one of two possible β-subunits (βA or βB), with substantial roles in human reproduction and in endocrine-responsive tumours. Recently a novel β subunit named βC was described, although it is still unclear if normal or cancerous cervical epithelial cells ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2011-01-01 00:00:00
abstract::Hepatocellular carcinoma (HCC) is a common malignant cancer worldwide characterized by high metastatic potential and poor prognosis following radical resection. Metastasin is a Ca(2+)-binding protein associated with tumor metastasis. However, the expression and function of metastasin remain unknown. In the present stu...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2013.2341
更新日期:2013-05-01 00:00:00
abstract::During the last decade, microRNAs (miRNAs) have been identified as potential biomarkers and therapeutic targets for multiple malignancies; yet, few studies exist on intrahepatic cholangiocarcinoma (ICC). In the present study, a miRNA microarray was applied to determine the significant miRNAs involved in ICC. miR-150 w...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2014.3641
更新日期:2015-02-01 00:00:00
abstract::There has been increasing evidence that numerous bioactive dietary agents can hamper the process of carcinogenesis by targeting epigenetic alterations including DNA methylation. This therapeutic approach is considered as a significant goal for cancer therapy due to the reversible nature of epigenetic-mediated gene sil...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2015.3802
更新日期:2015-04-01 00:00:00
abstract::Prostate cancer (PCa) remains a leading cause of mortality among men in the United States and Western Europe. The molecular mechanism of PCa pathogenesis has not been fully elucidated. In the present study, the expression profile of E2F transcription factor 7 (E2F7) in PCa was examined using immunohistochemistry and r...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2020.7659
更新日期:2020-09-01 00:00:00
abstract::Dysregulation of microRNAs (miRNAs) occurs frequently in cervical carcinogenesis. miRNAs function as tumor-suppressors or oncogenes and are involved in tumor behavior. However, the expression and function of miR-27b in cervical carcinogenesis remain unknown. In the present study, we observed that miR-27b was significa...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2015.4500
更新日期:2016-03-01 00:00:00