Abstract:
:Gastric cancer (GC), a type of gastric mucosal epithelium disease caused by common malignant tumors, has become a major threat to human health and survival. Tumor necrosis factor‑α‑induced protein‑8 like‑2 (TIPE2) is a negative immune regulatory factor that is selectively expressed in immune organs, immune cells and various epithelial cells and serves an important role in the maintenance of human physiological immune homeostasis. In our preliminary study, we found that the expression of TIPE2 was downregulated or absent in GC tissues compared with normal gastric mucosa tissues, indicating that TIPE2 may play a significant role in the development of GC. To clarify the role of TIPE2 in the progression of human GC and to elucidate the underlying mechanism, the association between TIPE2 and phosphatidylinositol 3‑kinase (PI3K)/AKT, the cell cycle, the caspase‑related apoptosis pathway and the NF‑κB signaling pathway were investigated through western blot and flow cytometric analysis. It was determined that TIPE2 inhibited GC cell proliferation mainly by reducing the expression of phosphorylated AKT and ERK, which caused subsequent inhibition of the PI3K‑AKT and Ras‑Raf‑MEK‑ERK1/2 signaling pathways. Additionally, we investigated the relationship between TIPE2 and GC and discovered that TIPE2 inhibited tumor progression via growth, apoptosis and inflammatory pathways. The results of the present study provided a theoretical basis for the development and application of TIPE2 as an antitumor agent.
journal_name
Oncol Repjournal_title
Oncology reportsauthors
Lin Z,Liu W,Xiao C,Fan Y,Zhuang G,Qi Zdoi
10.3892/or.2018.6576subject
Has Abstractpub_date
2018-09-01 00:00:00pages
1307-1316issue
3eissn
1021-335Xissn
1791-2431journal_volume
40pub_type
杂志文章相关文献
ONCOLOGY REPORTS文献大全abstract::Pancreatic cancer is one of the most lethal cancers, with an incidence equaling mortality. It is a heterogeneous group of neoplasms in which pancreatic ductal adenocarcinoma is most common. Pancreatic cancer cannot be cured even if detected early. When treatment is initiated, a suit...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2012.2020
更新日期:2012-12-01 00:00:00
abstract::The role of vascular endothelial growth factor (VEGF) during peritoneal dissemination of ovarian carcinoma and the association with tumor microvessel density (MVD) and matrix metalloproteinase (MMP) activity was investigated. To this end, MVD, tumor tissue and ascitic fluid levels of VEGF, and MMP activity of ascitic ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2003-01-01 00:00:00
abstract::The interface between malignant melanoma and patient immunity has long been recognised and efforts to treat this most lethal form of skin cancer by activating immune responses with cytokine, vaccine and also antibody immunotherapies have demonstrated promise in limited subsets of patients. In the present study, we dis...
journal_title:Oncology reports
pub_type: 杂志文章,评审
doi:10.3892/or.2014.3275
更新日期:2014-09-01 00:00:00
abstract::The incidence and associated mortality of melanoma continues to increase worldwide. At present, there is no curative therapy for advanced stage of melanoma. It is necessary to find new indicators of prognosis and therapeutic targets. Increasing evidence shows that miRNA can provide potential candidate biomarkers for m...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2016.5020
更新日期:2016-10-01 00:00:00
abstract::Gastric cancer is currently the fourth most common cancer and the third leading cause of cancer‑associated mortality worldwide. Studies have identified that certain biomarkers contribute to the prognosis, diagnosis and treatment of gastric cancer. However, the biomarkers of gastric cancer are rarely used clinically. T...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2018.6794
更新日期:2019-01-01 00:00:00
abstract::Metastatic progression is the cause of most cancer deaths. Host tumour cell separation (fission) is accompanied by simultaneous acquisition of migrating capability of cancer cells, remodeling of cellular architecture and effective 'homing' in body host environment. Cell remodeling involves cytoskeletal protein-protein...
journal_title:Oncology reports
pub_type: 杂志文章,评审
doi:
更新日期:2007-06-01 00:00:00
abstract::We conducted a study to determine whether the expression levels of genes in tumors were correlated with the survival of patients after complete resection of non-small cell lung cancer (NSCLC). The expression levels of 1176 genes in resected tumor specimens from 28 patients were analyzed using the Atlastrade mark Human...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2006-10-01 00:00:00
abstract::MicroRNAs (miRNAs) that negatively regulate gene expression play a key role in the development and progression of cancer. Aberrant expression of hsa-miR-187 (miR-187) has been reported in various malignancies. However, the function of miR-187 in tumor progression remains controversial and its role in non-small cell lu...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2017.5548
更新日期:2017-05-01 00:00:00
abstract::The aim of this study was to assess the use of human papillomavirus (HPV) E6/E7 mRNA testing in the follow-up of women treated for cervical intraepithelial neoplasia (CIN) by conization and to compare the prognostic value of HPV E6/E7 mRNA to HPV L1 DNA and cytology. One hundred and...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2012.1755
更新日期:2012-07-01 00:00:00
abstract::The purpose of this study was to define gene expression profile changes in colorectal tumors in order to identify target genes involved in neoplastic progression. cDNA microarray analysis was used to detect differences in gene expression profiles between colon tumor samples obtained from 20 patients in different tumor...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2004-08-01 00:00:00
abstract::Leptin may be involved in the pathogenesis of numerous cancer types by activation of cellular signal-transduction pathways. In this study, we analyzed the role of leptin and the mechanism(s) underlying its action in cervical carcinoma cells. Firstly, we examined the expression of leptin in 80 cases of cervical carcino...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2013.2390
更新日期:2013-06-01 00:00:00
abstract::High activity 125I brachytherapy has efficacy in selected recurrent malignant brain tumors, but limited efficacy and risk of radiation necrosis have prompted investigation of additional adjunctive therapies. This study aims to assess the toxicity of interstitial conductive hyperthermia used concurrently with 125I brac...
journal_title:Oncology reports
pub_type: 临床试验,杂志文章
doi:
更新日期:2004-01-01 00:00:00
abstract::The challenging possibility of selectively inducing mitotic death in tumor cells by combining genotoxic agents with the inhibition of G2 checkpoints of the cell cycle is the subject of intensive investigation. We show that very low concentrations (3.5 and 5 nM) of okadaic acid induce mitotic death in two glioblastoma ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2006-02-01 00:00:00
abstract::In order to erase reactive oxygen species (ROS) related with the proliferation of tumor cells by reducing activity of hydrogen, we developed functional water containing nano-bubbles (diameters: <900 nm for 71%/population) hydrogen of 1.1-1.5 ppm (the theoretical maximum: 1.6 ppm) with a reducing ability (an oxidation-...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or_00001006
更新日期:2010-12-01 00:00:00
abstract::Poly (aspartic acid-co-lactic acid) (PAL) has been investigated as a new biodegradable material for Drug Delivery Systems (DDS). Similar to the poly (lactic acid-co-glycolic acid) (PLGA) nanospheres, the PAL nanospheres can control-release encapsulated drugs by hydrolysis and adhere to the mucous membranes to improve ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2006-12-01 00:00:00
abstract::The association between inflammatory infiltration, fibrosis, necrosis and mucinous content in rectal cancers, and their relationship to preoperative radiotherapy (RT) clinicopathological and biological factors (p53, apoptosis and Cox-2) is not fully characterised. We analysed these histopathological parameters and the...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2006-08-01 00:00:00
abstract::Cadmium and nickel have been classified as carcinogenic to humans by the World Health Organization's International Agency for Research on Cancer. Given their prevalence in the environment, the fact that cadmium and nickel may cause diseases including cancer even at low doses is a cause for concern. However, the exact ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2013.2587
更新日期:2013-09-01 00:00:00
abstract::Recently, emerging evidence shows that a number of long non‑coding RNAs (lncRNAs) recruit polycomb group (PcG) proteins to specific chromatin loci to silence relevant gene expression. In the present study, we provided evidence that lncRNA candidates, selected by bioinformatic analysis and nervous system polycomb 1 (NS...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2019.7000
更新日期:2019-04-01 00:00:00
abstract::Cetuximab, an IgG1 monoclonal antibody against the epidermal growth factor receptor (EGFR), is widely used for the treatment of metastatic colorectal cancer (mCRC). One of the mechanisms of action is considered to be antibody-dependent cell-mediated cytotoxicity (ADCC) triggered by Fcγ-R on natural killer cells. Howev...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2014.3077
更新日期:2014-05-01 00:00:00
abstract::The actual predictive value of oestrogen receptor (ER) beta for treatment decisions in breast cancer is still unclear. Retrospective studies using preoperative systemic therapy (PST) revealed that chemotherapy but also endocrine therapy can lead to alterations in expression levels of ERalpha and progesterone receptor ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2010-09-01 00:00:00
abstract::The aims of the present study were to review the experience of different surgical reconstruction methods for hypopharyngeal squamous cell carcinoma (HSCC) and compared the survival of patients with and without laryngeal function (LF) preservation. The clinical characteristics of 580 patients were retrospectively obtai...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2015.4313
更新日期:2015-12-01 00:00:00
abstract::It has been revealed by our previous proteomic study that the expression profile is different between well‑differentiated and poorly differentiated hepatocellular carcinoma (HCC). Among those differently expressed proteins, peroxiredoxin2 (PRDX2) was our protein of interest. The present study aimed to further investig...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2019.6977
更新日期:2019-03-01 00:00:00
abstract::Mother-to-infant transmission of hepatitis B virus (HBV) can occur as an intrauterine, intrapartum or postpartum infection. In the present study, we induced a multifunctional viral regulator of HBV gene products, HBx, and its different fragments to overexpress in a tropho-blast cell line, HTR-8/SVneo. We then identifi...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2015.4172
更新日期:2015-10-01 00:00:00
abstract::Treatment of patients affected by advanced or inoperable GIST was revolutionized by the use of the tyrosine kinase inhibitors. Despite the fact that most patients have a good durable response of disease, they develop a resistance to treatments after a median time of 24 months. The acquired resistance is an emerging as...
journal_title:Oncology reports
pub_type: 杂志文章,评审
doi:10.3892/or_00000361
更新日期:2009-06-01 00:00:00
abstract::The esophageal squamous cell carcinoma (ESCC) subtype with STMN1 overexpression has a high likelihood of lymphatic metastatic recurrence. However, the underlying mechanism remains to be further elucidated. We assessed the expression level of STMN1 and PTEN in 96 pN0 ESCC patient tissues using immunohistochemistry and ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2017.6145
更新日期:2018-02-01 00:00:00
abstract::Glioblastoma is the most common type of primary brain tumour in adults, and its pathogenesis is particularly complicated. Among the many possible mechanisms underlying its pathogenesis, hyperactivation of the PI3K/Akt pathway is essential to the occurrence and development of glioma through the loss of PTEN or somatic ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2018.6845
更新日期:2019-01-01 00:00:00
abstract::Deregulation of c-Jun NH2-terminal kinase (JNK) signaling is now increasingly reported in a variety of human malignancies. Non-small cell lung cancer (NSCLC) is among such human malignancies with aberrant JNK activation; yet the exact role(s) of JNK deregulation in NSCLC biology, in particular in vivo, remains unclear...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2013.2655
更新日期:2013-10-01 00:00:00
abstract::The estrogen receptor (ER) expression and HER2 amplification are important factors in determining the prognosis and therapy of breast cancer. Interactions between the two signaling pathways for example resulted in ERalpha-dependent regulation of HER2 expression in breast cancer cells. In this study, we investigated to...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2008-03-01 00:00:00
abstract::Activation of p53-independent pathways plays an important role in phytochemical-induced apoptosis and is considered to be a crucial factor in the invasion and metastasis of cancer. Previous studies have shown that combined effects of Stephania tetrandra with medicinal herbs exhibit beneficial effects in cancer patient...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2013.2352
更新日期:2013-06-01 00:00:00
abstract::MicroRNAs (miRNAs) have been shown to play an important role in diverse biological processes and cancer progression. The objective of the present study was to investigate the role of miR-497 in ovarian cancer angiogenesis. We found that miR-497 expression was downregulated in human ovarian cancer tissues, and the low ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2014.3439
更新日期:2014-11-01 00:00:00