Antitumor effects of nano-bubble hydrogen-dissolved water are enhanced by coexistent platinum colloid and the combined hyperthermia with apoptosis-like cell death.

abstract：:Expression of Src homology phosphotyrosine phosphatase 2 (SHP2) has been observed in human breast cancer. SHP2 is known to promote cell migration and invasiveness. However, the pathophysiologic role of SHP2 and its relevance to tumorigenesis are still largely unknown. In the present study, we aimed to evaluate the eff...

journal_title：Oncology reports

authors： Hu Z,Fang H,Wang X,Chen D,Chen Z,Wang S

更新日期：2014-07-01 00:00:00

abstract：:The incidence of well‑differentiated thyroid cancer (WDTC) is rapidly increasing. Poor survival follows distant metastasis (DM) and recurrence. In the present study, we aimed to analyze the expression alterations in different stages of WDTC and the regulatory mechanism of DM and the recurrence of DM. A male patient di...

journal_title：Oncology reports

authors： Zhang YJ,Ma YS,Xia Q,Yu F,Lv ZW,Jia CY,Jiang XX,Zhang L,Shao YC,Xie WT,Lu GX,Yv XQ,Zhong P,Fu D,Wang XF

更新日期：2018-12-01 00:00:00

abstract：:Tumor metastasis is considered the main cause of mortality in cancer patients, thus it is important to investigate the differences between high- and low-metastatic cancer cells. Our previous study showed that the highly metastatic breast cancer cell line MDA-MB-231 released higher levels of ATP and exhibited higher P2...

journal_title：Oncology reports

authors： Eun SY,Ko YS,Park SW,Chang KC,Kim HJ

更新日期：2015-07-01 00:00:00

abstract：:Gallbladder cancer (GBC) is a lethal aggressive malignant neoplasm of the biliary tract. Potential prognostic markers and therapeutic targets for this disease are urgently required. Cancer‑associated fibroblasts (CAFs) play a key role in tumorigenesis and the development of cancer. Nicotinamide adenine dinucleotide ph...

journal_title：Oncology reports

authors： Wang FT,Hassan M,Ansari KH,Xu GL,Li XP,Fan YZ

更新日期：2019-10-01 00:00:00

abstract：:Statins are the most effective drugs used in the reduction of intracellular synthesis of cholesterol. Numerous studies have confirmed that statins reduce the risk of multiple types of cancers. Statin use in cancer patients is associated with reduced cancer-related mortality. Epithelial-to-mesenchymal transition (EMT),...

journal_title：Oncology reports

authors： Fan Z,Jiang H,Wang Z,Qu J

更新日期：2016-08-01 00:00:00

abstract：:Eighteen primary human malignant mesotheliomas obtained from 18 patients were screened for point mutations and microdeletions/insertions in all exons of the tumour suppressor gene PTEN/MMAC1 by SSCP analysis. No mutation could be found. Our preliminary data indicate that disarrangements of PTEN/MMAC1 are at least not ...

journal_title：Oncology reports

authors： Papp T,Schipper H,Pemsel H,Unverricht M,Muller KM,Wiethege T,Schiffmann D,Rahman Q

更新日期：2001-11-01 00:00:00

abstract：:Perylenequinones that generate reactive oxygen species (ROS) when illuminated with visible light have been recommended as photodynamic chemotherapeutic agents. One of these is calphostin C (CalC), the action of the photo-activated derivative of which, CalCphiE, has been ascribed to its ability to selectively and irrev...

journal_title：Oncology reports

authors： Chiarini A,Whitfield JF,Pacchiana R,Marconi M,Armato U,Dal Prà I

更新日期：2010-04-01 00:00:00

abstract：:Metastasis-associated protein 1 (MTA1) is highly upregulated in cancer cells with metastatic potential; however, the molecular mechanism by which MTA1 increases the metastatic potential of cancer cells is far from clear. We characterized the functional consequences of MTA1 overexpression on p53-induced apoptosis of ca...

journal_title：Oncology reports

authors： Moon HE,Cheon H,Lee MS

更新日期：2007-11-01 00:00:00

abstract：:The thioredoxin (Trx) system is an important enzymatic complex involved in cellular redox homeostasis. Arsenic trioxide (ATO; As2O3) is known to trigger cell death in vascular smooth muscle cells (VSMCs) via oxidative stress. In the present study, the effects of changes in thioredoxin 1 (Trx1) and Trx reductase1 (TrxR...

journal_title：Oncology reports

authors： Park WH

更新日期：2020-01-01 00:00:00

abstract：:CYP1A1 expression in various tissues of 43 gastric cancer cases was analyzed with frozen tissue array-based immunohistochemical staining (IHC), RT-PCR, Western blot analysis and EROD (7-ethoxyresourfin-O-deethylase) assay. CYP1A1 was detected immunohistochemically in 86% (37/43) of gastric cancers, in both 57% (4/7) o...

journal_title：Oncology reports

authors： Zhang KL,Ma JX,Chen XY,Sun Y,Kong QY,Liu J,Li H

更新日期：2004-12-01 00:00:00

abstract：:Survivin, an anti-apoptotic protein, is abundantly expressed in a variety of cancer cells, including hepatoma cells, resulting in the resistance of these cells to various apoptotic stimuli. Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is known to induce cancer cell-specific apoptosis, but hepa...

journal_title：Oncology reports

authors： Nakao K,Hamasaki K,Ichikawa T,Arima K,Eguchi K,Ishii N

更新日期：2006-08-01 00:00:00

abstract：:Extracellular matrix remodeling crucial to tumorigenesis involves proteolytic enzymes, primarily matrix metalloproteinases (MMPs). MMP production is stimulated by multiple factors, including the extracellular matrix metallo-proteinase inducer EMMPRIN/CD147. Overexpression of EMMPRIN...

journal_title：Oncology reports

authors： Takahashi M,Suzuki S,Ishikawa K

更新日期：2012-01-01 00:00:00

abstract：:We established a new cell line (ACCNS) from human adenoid cystic carcinoma (AdCC) of the maxilla, using tissue culture techniques and it has been successfully subcultured for more than 100 passages during 2 years. The population doubling time was approximately 39.2 h on a plastic dish. In type I collagen gel culture, ...

journal_title：Oncology reports

authors： Tanaka N,Urabe K,Hashitani S,Sakurai K,Urade M

更新日期：2007-02-01 00:00:00

abstract：:Hepatocyte growth factor (HGF) was suggested to play an important role in the regulation of mitogenesis, motogenesis, angiogenesis, migration and invasion for various types of cells, and acts through a specific membrane receptor encoded by c-met proto-oncogene. However, the mechanism of the effect of HGF on tumor inva...

journal_title：Oncology reports

authors： Fujiuchi Y,Nagakawa O,Murakami K,Fuse H,Saiki I

更新日期：2003-07-01 00:00:00

abstract：:Glucocorticoids (GCs) are known potent clinical drugs, however, their mode of action is still complex and debatable. Macrophages are the most important target of GCs and play a key role in tumor immunity in vivo, but their relationship is also controversial. In the present study, the lentivirus system was used to over...

journal_title：Oncology reports

authors： Ai F,Zhao G,Lv W,Liu B,Lin J

更新日期：2020-02-01 00:00:00

abstract：:More than 80% of hepatocellular carcinoma (HCC) arises in HBV based liver cirrhotic patients, suggesting that patients with cirrhosis form the main risk group of HCC. α fetoprotein (AFP) has poor sensitivity for the detection of AFP-negative and/or small tumors in HCC patients. Screening serum markers, along with HCC ...

journal_title：Oncology reports

authors： Shu H,Kang X,Guo K,Li S,Li M,Sun L,Gan L,Liu Y,Qin X

更新日期：2010-11-01 00:00:00

abstract：:Sentinel lymph node (SLN) biopsy is a useful way of assessing axillary nodal status and obviates unnecessary axillary lymph node dissection for patients with node-negative breast cancer. However, SLN can also be located in the internal mammary lymph node (IMN) chain or elsewhere. The practicability and relevance of in...

journal_title：Oncology reports

authors： Noguchi M

更新日期：2002-05-01 00:00:00

abstract：:This study was conducted to assess protective effect of an antioxidant protein, sericin, on tumor promotion in the 7,12-dimethylbenz (alpha) anthracene (DMBA)-initiated and 12-O-tetradecanoylphorbol 13-acetate (TPA)-promoted mouse skin tumorigenesis model. In experiment 1, sericin was applied topically to DMBA-initiat...

journal_title：Oncology reports

authors： Zhaorigetu S,Yanaka N,Sasaki M,Watanabe H,Kato N

更新日期：2003-05-01 00:00:00

abstract：:A phase I study of S-1 and biweekly docetaxel (DOC) combination therapy was conducted to determine the maximum tolerated dose (MTD) and pharmacokinetic parameters. Fourteen patients with advanced or recurrent gastric cancer were analyzed. The treatment consisted of S-1 [body surface area (BSA) <1.25 m2:80 mg/day, 1.25...

journal_title：Oncology reports

authors： Takahashi I,Emi Y,Kakeji Y,Tokunaga E,Ushiro S,Oki E,Watanabe M,Baba H,Maehara Y

更新日期：2006-04-01 00:00:00

abstract：:Case 1: a patient was diagnosed as having ascending colon cancer with right ovarian metastasis, and underwent palliative right hemicolectomy plus oophorectomy. The tumor was a well-differentiated adenocarcinoma with right ovarian metastasis, and the disease was classified as stage IV. Oral chemotherapy with UFT plus L...

journal_title：Oncology reports

authors： mukai M,Moriya H,Himeno S,Oida Y,mukohyama S,Nishi T,Nakasaki H,Satoh S,Makuuchi H

更新日期：2001-09-01 00:00:00

abstract：:microRNAs (miRNAs), small non-coding RNAs, have emerged as key regulators of a large number of genes. The present study aimed to explore novel biological functions of miR-330 in the human prostate cancer cell lines DU145 and PC3. We confirmed that miR-330 was downregulated and inversely correlated with specificity pro...

journal_title：Oncology reports

authors： Mao Y,Chen H,Lin Y,Xu X,Hu Z,Zhu Y,Wu J,Xu X,Zheng X,Xie L

更新日期：2013-07-01 00:00:00

abstract：:Cancer immunotherapy is a promising new approach to cancer treatment. It has been demonstrated that a high number of tumor-specific cytotoxic T cells (CTLs) is associated with increased disease-specific survival in lung cancer patients. Identification of superior CTL epitopes from tumor antigens is essential for the d...

journal_title：Oncology reports

authors： Yoshimura M,Tada Y,Ofuzi K,Yamamoto M,Nakatsura T

更新日期：2014-07-01 00:00:00

abstract：:The authors of the above article drew to our attention that they had identified three instances of data overlapping between data panels, suggesting that data purportedly showing results obtained under different experimental conditions had been derived from the same original source. Comparing between the two figures, t...

journal_title：Oncology reports

authors： Ji CX,Fan YH,Xu F,Lv SG,Ye MH,Wu MJ,Zh XG,Wu L

更新日期：2020-11-01 00:00:00

abstract：:Activation of ras genes and human papilloma virus (HPV) infection have been extensively described in cervical carcinomas while information concerning their implication in premalignant lesions of the cervix is limited. We investigated the incidence of K-ras codon 12 point mutations and HPV infection in cases of cervici...

journal_title：Oncology reports

authors： Prokopakis P,Sourvinos G,Koumantaki Y,Koumantakis E,Spandidos DA

更新日期：2002-01-01 00:00:00

abstract：:We aimed to examine the relationship between the preoperative GSA index [uptake ratio of the liver to the liver plus heart at 15 min (LHL15) to uptake ratio of the heart at 15 min to that at 3 min (HH15) ratio] calculated from 99mTc‑labeled diethylene triamine pentaacetate-galactosyl human serum albumin (99mTc-GSA) sc...

journal_title：Oncology reports

authors： Nishikawa H,Osaki Y,Komekado H,Sakamoto A,Saito S,Nishijima N,Nasu A,Arimoto A,Kita R,Kimura T

更新日期：2015-03-01 00:00:00

abstract：:Cyclin‑dependent kinase 5 regulatory subunit‑​associated protein 3 (CDK5RAP3 or C53) is involved in the development of various types of tumor, and alternative splicing of C53 results in numerous transcription variants that encode different isoforms. The present study aimed to clone human C53 isoform d (IC53d) and expl...

journal_title：Oncology reports

authors： Lin JX,Xie XS,Weng XF,Qiu SL,Xie JW,Wang JB,Lu J,Chen QY,Cao LL,Lin M,Tu RH,Li P,Huang CM,Zheng CH

更新日期：2019-05-01 00:00:00

abstract：:Colorectal cancer is the second most deadly cancer in the United States. When diagnosed early, current treatments bring a limited success; however, once metastasis occurs, radiation and chemotherapy are generally ineffective. Structural changes in the ECM are necessary for cell migration during tissue remodeling. Matr...

journal_title：Oncology reports

authors： Roomi MW,Ivanov V,Kalinovsky T,Niedzwiecki A,Rath M

更新日期：2005-03-01 00:00:00

abstract：:The present study aimed to explore the relationship between the efficacy of epidermal growth factor receptor tyrosine kinase inhibitors (EGFR‑TKIs) and the expression of the cancer stem cell (CSC)‑related markers. Specimens of 72 cases of lung adenocarcinoma with significantly different therapeutic effects of the firs...

journal_title：Oncology reports

authors： Hu F,Li C,Zheng X,Zhang H,Shen Y,Zhou L,Yang X,Han B,Zhang X

更新日期：2020-02-01 00:00:00

abstract：:Isocitrate dehydrogenase 2 (IDH2) is a mitochondrial NADP-dependent isocitrate dehydrogenase. It is considered to be a novel tumor suppressor in several types of tumors. However, the role and related mechanism of IDH2 in osteosarcoma remain unknown. The expression and significance of IDH2 were investigated by immunohi...

journal_title：Oncology reports

authors： Yi WR,Li ZH,Qi BW,Ernest ME,Hu X,Yu AX

更新日期：2016-04-01 00:00:00

abstract：:The present study aimed to identify novel histone modification markers in gastric cancer (GC) by chromatin immunoprecipitation microarray (ChIP-chip) analysis and to determine whether these markers were able to discriminate between normal and GC cells. We also tested for correlations with DNA methylation. We probed a ...

journal_title：Oncology reports

authors： Zhu X,Liu J,Xu X,Zhang C,Dai D

更新日期：2015-05-01 00:00:00