MicroRNA‑mRNA integrated analysis based on a case of well‑differentiated thyroid cancer with both metastasis and metastatic recurrence.

abstract：:Lapatinib, an inhibitor of human epidermal growth factor receptor 2 (HER2) phosphorylation, has been reported to inhibit several types of tumors such as HER2-overexpressing breast cancer. However, the effect of lapatinib on the malignant phenotype of human osteosarcoma (OS) cells and the potential molecular mechanisms...

journal_title：Oncology reports

authors： Long XH,Zhang GM,Peng AF,Luo QF,Zhang L,Wen HC,Zhou RP,Gao S,Zhou Y,Liu ZL

更新日期：2014-01-01 00:00:00

abstract：:Despite the high response rates of small cell lung cancer (SCLC) to first-line cisplatin-based chemotherapies, most patients with SCLC will eventually experience disease progression. Accordingly, novel chemotherapeutic regimens are desired. This in vitro study was carried out in order to develop novel chemotherapeutic...

journal_title：Oncology reports

authors： Takeda K,Suyama H,Igishi T,Shigeoka Y,Matsumoto S,Yamasaki A,Hashimoto K,Sumikawa T,Morita M,Ueda Y,Shimizu E

更新日期：2008-04-01 00:00:00

abstract：:Ovarian cancer is one of the most common gynecological malignancies and its pathogenesis and progression are regulated by multiple genes. MicroRNAs (miRNAs) are endogenous non‑coding RNAs that regulate body function by altering post‑transcriptional gene expression. Previous studies have suggested that miRNAs are close...

journal_title：Oncology reports

authors： Wei L,He Y,Bi S,Li X,Zhang J,Zhang S

更新日期：2020-12-11 00:00:00

abstract：:Dendritic cell-mediated cancer immunotherapy employs several ways to engage tumor antigens. We have demonstrated in both pre-clinical animal studies and early clinical trials that dendritomas, highly purified hybrids between dendritic cells (DC) and tumor cells, are superior activators of anti-tumor immunity. It has b...

journal_title：Oncology reports

authors： Branham-O'Connor M,Li J,Kotturi HS,Yu X,Wagner TE,Wei Y

更新日期：2010-02-01 00:00:00

abstract：:Adoptive immunotherapy requires the isolation of CD8+ T cells specific for tumor-associated antigens, their expansion in vitro and their transfusion to the patient to mediate a therapeutic effect. MUC1 is an important adenocarcinoma antigen immunogenic for T cells. The MUC1-derived SAPDTRPA (MUC1-8-mer) peptide is a p...

journal_title：Oncology reports

authors： Atzin-Méndez JA,López-González JS,Báez R,Arenas-Del Angel MC,Montaño LF,Silva-Adaya D,Lascurain R,Gorocica P

更新日期：2016-01-01 00:00:00

abstract：:CD147, a multifunction glycoprotein of the immuno-globulin family, is associated with many types of tumors, and the overexpression of CD147 can enhance malignancy. However, the role of CD147 in cervical cancer remains unclear. In the present study, cervical cancer cells were found to express much more CD147 protein an...

journal_title：Oncology reports

authors： Wu Y,Zhou X,Zheng PS

更新日期：2011-09-01 00:00:00

abstract：:Human gonadotropin-releasing hormone receptor (GnRHR) and its natural ligand human gonadotropin-releasing hormone (GnRH) were initially described as signaling complexes that play a key role in reproductive functions. By binding to specific receptors present on pituitary gonadotropes, GnRH regulates the sperm and ovum ...

journal_title：Oncology reports

authors： Aguilar-Rojas A,Huerta-Reyes M

更新日期：2009-11-01 00:00:00

abstract：:Activation of ras genes and human papilloma virus (HPV) infection have been extensively described in cervical carcinomas while information concerning their implication in premalignant lesions of the cervix is limited. We investigated the incidence of K-ras codon 12 point mutations and HPV infection in cases of cervici...

journal_title：Oncology reports

authors： Prokopakis P,Sourvinos G,Koumantaki Y,Koumantakis E,Spandidos DA

更新日期：2002-01-01 00:00:00

abstract：:We established a new cell line (ACCNS) from human adenoid cystic carcinoma (AdCC) of the maxilla, using tissue culture techniques and it has been successfully subcultured for more than 100 passages during 2 years. The population doubling time was approximately 39.2 h on a plastic dish. In type I collagen gel culture, ...

journal_title：Oncology reports

authors： Tanaka N,Urabe K,Hashitani S,Sakurai K,Urade M

更新日期：2007-02-01 00:00:00

abstract：:Malnutrition affects 40-50% of patients with ear, nose and throat (ENT) cancer. The aim of this study was to assess changes induced by a specific nutritional supplement enriched with n-3 polyunsaturated fatty acids, fiber and greater amounts of proteins and electrolytes, as compared with a standard nutritional supplem...

journal_title：Oncology reports

authors： Roca-Rodríguez MM,García-Almeida JM,Lupiañez-Pérez Y,Rico JM,Toledo M,Alcaide-Torres J,Cardona F,Medina JA,Tinahones FJ

更新日期：2014-01-01 00:00:00

abstract：:Taxol (paclitaxel) and vinblastine (VBL) are both efficacious chemotherapeutic agents that target the microtubules of tumor cells, but each functions in a mutual antagonistic manner. Op18/stathmin is a small molecular phosphoprotein which promotes depolymerization of microtubules. Non-small cell lung cancer (NSCLC) NC...

journal_title：Oncology reports

authors： Shen F,Long D,Yu T,Chen X,Liao Y,Wu Y,Lin X

更新日期：2017-04-01 00:00:00

abstract：:The novel tumor suppressor RASSF1A is frequently inactivated during human tumorigenesis by promoter methylation. In this study, we detected the RASSF1A promoter methylation by methylated-specific PCR and investigated RASSF1A gene expression by semi-quantitative RT-PCR and immunohistochemical staining in 36 cases of br...

journal_title：Oncology reports

authors： Li Y,Wei Q,Cao F,Cao X

更新日期：2008-05-01 00:00:00

abstract：:Exhausted cluster of differentiation (CD)8+ T cells lose immunological activity due to mitochondrial dysfunction caused by peroxisome proliferator‑activated receptor γ coactivator 1α (PGC‑1α) inactivation, resulting in a poor prognosis in patients with cancer. As hydrogen gas was recently reported to activate PGC‑1α, ...

journal_title：Oncology reports

authors： Akagi J,Baba H

更新日期：2019-01-01 00:00:00

abstract：:Previous studies have shown that S100P contributes to the development of a number of tumors. However, its prognostic significance in colorectal cancer (CRC) has not been demonstrated. This study aimed to confirm the expression of S100P in colorectal cancer as well as the epigenetic mechanism underlying its gene expres...

journal_title：Oncology reports

authors： Wang Q,Zhang YN,Lin GL,Qiu HZ,Wu B,Wu HY,Zhao Y,Chen YJ,Lu CM

更新日期：2012-07-01 00:00:00

abstract：:The 5-year survival rate of nasopharyngeal carcinoma (NPC) is still disappointing despite the much improved technologies in its treatment. Tumor necrosis factor-related apoptosis inducing ligand (TRAIL) can selectively induce apoptosis in most tumor cells while sparing normal cells....

journal_title：Oncology reports

authors： Li SS,Yang S,Wang S,Yang XM,Tang QL,Wang SH

更新日期：2011-12-01 00:00:00

abstract：:Given such differences as relative tumor burden, the optimal dose and schedule for postoperative adjuvant chemotherapy of microscopic disease might be expected to differ significantly from therapy of advanced higher volume disease. We investigated this hypothesis by determining the optimal dose and schedule of the 5-F...

journal_title：Oncology reports

authors： Uchida J,Okabe H,Nakano K,Fujioka A,Saito H,Sugimoto Y,Oka T,Fukushima M

更新日期：2007-08-01 00:00:00

abstract：:Anaplastic thyroid carcinoma (ATC) is a rare type of thyroid carcinoma with a poor prognosis. Thus, suitable preclinical tumor models are required for the development of new ATC therapies. In the present study, orthotopic tumor xenograft models were established using ATC cell lines and SCID mice, and tumor invasion an...

journal_title：Oncology reports

authors： Aoyama M,Takizawa H,Otani T,Inoue S,Kawakita N,Tsuboi M,Bando Y,Uehara H,Kondo K,Tangoku A

更新日期：2020-10-01 00:00:00

abstract：:Immunologic factors that predict survival in patients with lung cancer have not been established. We examined the relationship between the percentage of HLA-DR-positive peripheral leukocytes [HLA-DR+ (%)] and survival of patients with squamous cell carcinoma of the lung. Before initiating therapy, peripheral blood was...

journal_title：Oncology reports

authors： Nakamura H,Idiris A,Kato Y,Kato H

更新日期：2004-03-01 00:00:00

abstract：:Luteolin was recently demonstrated to suppress tumor growth by interfering with nuclear factor (NF)‑κB activation. As the NF‑κB pathway plays a critical role in muscular atrophy associated with cancer cachexia, we aimed to investigate the potential of luteolin to alleviate cancer‑associated cachexia in a Lewis lung ca...

journal_title：Oncology reports

authors： Chen T,Li B,Xu Y,Meng S,Wang Y,Jiang Y

更新日期：2018-08-01 00:00:00

abstract：:Antimycin A (AMA) inhibits the mitochondrial electron transport between cytochromes b and c. However, the relationship between AMA and lung cancer cells is poorly understood. In this study, we investigated the involvement of reactive oxygen species (ROS) and glutathione (GSH) in AMA-treated lung cancer Calu-6 cell dea...

journal_title：Oncology reports

authors： Han YH,Park WH

更新日期：2009-01-01 00:00:00

abstract：:MicroRNAs (miRNAs) are a group of important regulators in human types of cancer including non-small cell lung cancer (NSCLC). miR-616 has been found to be a novel cancer-related miRNA. However, the expression and biological function of miR-616 in NSCLC have not been investigated. In this study, qRT-PCR was performed t...

journal_title：Oncology reports

authors： Wang D,Cao Q,Qu M,Xiao Z,Zhang M,Di S

更新日期：2017-10-01 00:00:00

abstract：:Head and neck squamous cell carcinoma (HNSCC) is the sixth most commonly diagnosed cancer worldwide. It has poor clinical outcome due to intrinsic or acquired drug resistance. Deregulation of both apoptosis and autophagy contributes to chemotherapy resistance and disease progression. A new member of the inhibitors of ...

journal_title：Oncology reports

authors： Frassanito MA,Saltarella I,Vinella A,Muzio LL,Pannone G,Fumarulo R,Vacca A,Mariggiò MA

更新日期：2019-05-01 00:00:00

abstract：:Vasohibin-1 (VASH1) has recently been isolated as a novel inhibitor of angiogenesis. Several studies have demonstrated that VASH1 plays important roles in tumor angiogenesis but the role of this angiogenic inhibitor in renal cell carcinoma (RCC) has not been elucidated. We previously reported that VASH1 expression is ...

journal_title：Oncology reports

authors： Zhao G,Na R,Li L,Xiao H,Ding N,Sun Y,Han R

更新日期：2017-08-01 00:00:00

abstract：:Post-transcriptional modification of p53 by phosphorylation has been proposed as an important mechanism of p53 stabilization and functional regulation. However, little is known about the phosphorylation state of mutant p53 protein overexpressed in human tumors. We evaluated immunohistochemically the p53 phosphorylatio...

journal_title：Oncology reports

authors： Matsumoto M,Furihata M,Kurabayashi A,Ohtsuki Y

更新日期：2004-11-01 00:00:00

abstract：:Distant metastases represent the major cause of death after curative surgery of colorectal cancer. The aim of this study was to evaluate the role of Smad4 and KRAS genetic alterations in colorectal metastases taking into account both the site (hepatic versus extrahepatic) and the time (synchronous versus metachronous)...

journal_title：Oncology reports

authors： Losi L,Bouzourene H,Benhattar J

更新日期：2007-05-01 00:00:00

abstract：:Neuroblastoma is a tumor accounting for approximately 10% of all childhood malignancies and 50% of all childhood cancer-related deaths. MYCN gene copy number variation represents the most important prognostic factor in neuroblastoma. Prognostic significance of MYCN gene expression is more complicated and may depend on...

journal_title：Oncology reports

authors： Prochazka P,Hrabeta J,Vicha A,Cipro S,Stejskalova E,Musil Z,Vodicka P,Eckschlager T

更新日期：2013-06-01 00:00:00

abstract：:The aim of this study was to assess the use of human papillomavirus (HPV) E6/E7 mRNA testing in the follow-up of women treated for cervical intraepithelial neoplasia (CIN) by conization and to compare the prognostic value of HPV E6/E7 mRNA to HPV L1 DNA and cytology. One hundred and...

journal_title：Oncology reports

authors： Persson M,Brismar Wendel S,Ljungblad L,Johansson B,Weiderpass E,Andersson S

更新日期：2012-07-01 00:00:00

abstract：:Chemokine (C-C motif) ligand 2 (CCL2) has been shown to play an important role in the regulation of tumor cell growth, metastasis and host immune response. CCL2 preferentially binds to the C-C chemokine receptor type 2 (CCR2), which is expressed in various tissues. However, the role of the CCL2/CCR2 axis in hepatocell...

journal_title：Oncology reports

authors： Zhuang H,Cao G,Kou C,Liu T

更新日期：2018-01-01 00:00:00

abstract：:Bmi-1, a member of the polycomb family, it is involved in self renewal of stem cells and functions as an oncogene in many malignant human cancer types. Recent studies have demonstrated that Bmi-1 is a predictive factor for poor patient prognosis. However, the underlying mechanisms o...

journal_title：Oncology reports

authors： Liu ZG,Liu L,Xu LH,Yi W,Tao YL,Tu ZW,Li MZ,Zeng MS,Xia YF

更新日期：2012-04-01 00:00:00

abstract：:Chronic hepatitis B virus (HBV) infection is a leading cause of liver cirrhosis and cancer. Among the pathogenic factors of HBV, HBV X protein (HBx) is attracting increased attention. Although it is documented that HBx is a multifunctional regulator that modulates cell inflammation and apoptosis, the exact mechanism r...

journal_title：Oncology reports

authors： Gao WY,Li D,Cai DE,Huang XY,Zheng BY,Huang YH,Chen ZX,Wang XZ

更新日期：2017-01-01 00:00:00