Tiron, a ROS scavenger, protects human lung cancer Calu-6 cells against antimycin A-induced cell death.

abstract：:Interleukin-15 (IL-15) has important anabolic effects on muscle protein metabolism through a decrease in the ATP-ubiquitin-dependent proteolytic pathway. The role of IL-15 in human cancer cachexia is unknown. The aim of this study was to assess the relationship between interleukin-1...

journal_title：Oncology reports

authors： Martínez-Hernández PL,Hernanz-Macías Á,Gómez-Candela C,Grande-Aragón C,Feliu-Batlle J,Castro-Carpeño J,Martínez-Muñoz I,Zurita-Rosa L,Villarino-Sanz M,Prados-Sánchez C,Sánchez García-Girón J

更新日期：2012-10-01 00:00:00

abstract：:Oral cancer is one of the leading types of cancer and remains the most common cause of cancer‑related mortality in Asia. The pathogenesis of oral cancer is complicated and, due to lack of accurate diagnostic methods and efficient treatment strategies, oral cancer is responsible for a large number of deaths. Therefore,...

journal_title：Oncology reports

authors： Wang J,Lv N,Lu X,Yuan R,Chen Z,Yu J

更新日期：2021-01-01 00:00:00

abstract：:Cell cycle analysis has become increasingly important in verifying the effect of anti-tumor drugs and cytokinetic research. In the early methods of cell cycle analysis, the flow cytometry relied on DNA content, and therefore, the cell cycle could be only broken into three stages: G(0)/G(1), S, and G(2)/M phase. It cou...

journal_title：Oncology reports

authors： Qin J,Tao D,Duan R,Leng Y,Shen M,Zhou H,Feng Y,Gao C,Yu Y,Li QQ,Hu J,Gong J

更新日期：2002-09-01 00:00:00

abstract：:Casticin, a polymethoxyflavone, has been reported to exert anticancer activities. The objectives of this study were to examine the molecular mechanisms by which casticin induces the growth inhibition and cell cycle arrest in human hepatocellular carcinoma (HCC) cells. The HCC cell l...

journal_title：Oncology reports

authors： He L,Yang X,Cao X,Liu F,Quan M,Cao J

更新日期：2013-01-01 00:00:00

abstract：:Aberrant expression of microRNAs has been identified as regulators of biological processes of hepatocellular carcinoma (HCC) by negatively regulating protein-coding mRNAs. Several studies have demonstrated that miR-638 expression was dysregulated in various human cancers. However, the clinical significance and underly...

journal_title：Oncology reports

authors： Zhang Y,Zhang D,Jiang J,Dong L

更新日期：2017-01-01 00:00:00

abstract：:Non‑small cell lung cancer (NSCLC) is the leading cause of cancer‑related deaths worldwide. Cisplatin‑based chemotherapy currently represents the main treatment option for patients with NSCLC. The aim of the present study was to evaluate effect of single nucleotide polymorphisms (SNPs) within the excision repair cross...

journal_title：Oncology reports

authors： Li M,Chen R,Ji B,Fan C,Wang G,Yue C,Jin G

更新日期：2021-01-14 00:00:00

abstract：:Apoptin, a small protein derived from chicken anemia virus, possesses the capacity to specifically kill tumor cells while leaving normal cells intact. Previous studies have indicated that the subcellular localization of apoptin appears to be crucial for this tumor-selective activity. Apoptin resides in the cytoplasm o...

journal_title：Oncology reports

authors： Peng C,Yang P,Cui Y,He M,Liang L,Di Y

更新日期：2013-06-01 00:00:00

abstract：:Osteosarcoma (OS) has an unfavorable prognosis and tends to metastasize to lung tissue. Although the CXCL12-CXCR4 axis appears to affect progression and metastasis in numerous tumors, its mechanism and downstream pathways in OS remain unclear. We used western blotting and flow cytometry to detect CXCR4 and CXCR7 expre...

journal_title：Oncology reports

authors： Liao YX,Fu ZZ,Zhou CH,Shan LC,Wang ZY,Yin F,Zheng LP,Hua YQ,Cai ZD

更新日期：2015-07-01 00:00:00

abstract：:Matrix metalloproteinases (MMPs) are associated with invasion and metastasis of several human malignant tumors. Especially so MMP-7, as it is mainly produced by the actual cancer cells. However, the expression of MMP-7 in transitional cell carcinoma (TCC) of the urinary bladder has not been previously investigated. We...

journal_title：Oncology reports

authors： Sumi T,Yoshida H,Hyun Y,Yasui T,Matsumoto Y,Hattori K,Sugimura K,Kawashima H,Nakatani T,Ishiko O

更新日期：2003-03-01 00:00:00

abstract：:Esophageal carcinosarcoma (ECS) is a rare malignant neoplasm associated with a poor patient prognosis. It is characterized by the presence of both malignant epithelial and mesenchymal components. Molecular-targeted therapy of several receptor tyrosine kinases (RTKs) has been reported to be effective in the treatment o...

journal_title：Oncology reports

authors： Sano A,Sakurai S,Kato H,Suzuki S,Yokobori T,Sakai M,Tanaka N,Inose T,Sohda M,Nakajima M,Fukai Y,Miyazaki T,Ojima H,Hosoya Y,Enomoto T,Kanda T,Ajioka Y,Kuwano H

更新日期：2013-06-01 00:00:00

abstract：:The signal transducer and activator of transcription 3 (STAT3) are ideal targets for ovarian cancer. Previous studies showed that downregulation of STAT3 using specific short hairpin RNAs (shRNA) can significantly reduce ovarian tumor growth. However, RNA interference does not fully ablate target gene expression due t...

journal_title：Oncology reports

authors： Pan Y,Zhang L,Zhang X,Liu R

更新日期：2015-02-01 00:00:00

abstract：:Mitochondrial DNA (mtDNA) mutations are frequently found in a variety of tumors. However, the role of mtDNA mutations in tumor behavior is poorly understood. We explored the effects of mtDNA mutations on tumor phenotype employing mtDNA-depleted SK-Hep1 rho0 hepatoma cells. Expression of hypoxia inducible factor (HIF)-...

journal_title：Oncology reports

authors： Cheon H,Moon HE,Lee MS,Kim SS

更新日期：2010-03-01 00:00:00

abstract：:The present study aimed to investigate the effects of cold atmospheric plasma (CAP)‑activated Ringer's solution on osteosarcoma cell lines MG63 and U2OS, and to identify the molecular mechanism underlying these effects. CAP‑activated Ringer's solution was used to treat osteosarcoma cell lines MG63 and U2OS for 30 min....

journal_title：Oncology reports

authors： Xu S,Wang Y,Que Y,Ma C,Cai S,Wang H,Yang X,Yang C,Cheng C,Zhao G,Hu Y

更新日期：2020-05-01 00:00:00

abstract：:Despite improvements in immunotherapy, little is known about dendritic cell (DC) subpopulations naturally occurring in the laryngeal cancer tissue (LCT) and peripheral blood (PB) of untreated laryngeal cancer (LC) patients. The purpose of the present study was to evaluate mature, im...

journal_title：Oncology reports

authors： Klatka J,Grywalska E,Tabarkiewicz J,Polak A,Rolinski J

更新日期：2012-07-01 00:00:00

abstract：:Histone deacetylases (HDACs) have been shown to play important roles in the regulation of chromatin remodeling by histone deacetylation, and their expression is induced in several types of cancer. In addition, they are known to be associated with resistance to anticancer drugs. However, the relevance of HDAC4 in chemo...

journal_title：Oncology reports

authors： Yu SL,Lee DC,Son JW,Park CG,Lee HY,Kang J

更新日期：2013-09-01 00:00:00

abstract：:Although radiotherapy is routinely administered to high-risk endometrial carcinoma and offer a significant disease-free survival advantage, the therapeutic effect is sometimes limited by the occurrence of radioresistance. To determine the patterns of gene expression responsible for the radioresistance and to search fo...

journal_title：Oncology reports

authors： Du XL,Jiang T,Wen ZQ,Li QS,Gao R,Wang F

更新日期：2009-03-01 00:00:00

abstract：:Resistance to etoposide has been associated with the overexpression of P-glycoprotein and MRP1 in human tumor cells. However, the role of BCRP in resistance to etoposide has not been clearly established, especially the significance of arginine 482 mutations in drug transport (cellul...

journal_title：Oncology reports

authors： Eddabra L,Wenner T,El Btaouri H,Baranek T,Madoulet C,Cornillet-Lefebvre P,Morjani H

更新日期：2012-01-01 00:00:00

abstract：:Primarily through in vitro studies, the Rho-family of small GTPases and their effector proteins have been implicated in mediating oncogenic properties of cancer cells. We sought to determine if pharmacological inhibition of the RhoA effector proteins known as Rho-kinases (ROCK) with the small molecule inhibitor Y-2763...

journal_title：Oncology reports

authors： Routhier A,Astuccio M,Lahey D,Monfredo N,Johnson A,Callahan W,Partington A,Fellows K,Ouellette L,Zhidro S,Goodrow C,Smith A,Sullivan K,Simone P,Le L,Vezuli B,Zohni M,West E,Gleason D,Bryan B

更新日期：2010-03-01 00:00:00

abstract：:The MSH6 gene is one of the mismatch repair genes involved in Lynch syndrome and its mutations account for 10-20% of Lynch syndrome. Although previous studies suggested that the difference of the geographical region affects the clinical phenotype of Lynch syndrome, there has been no report on the detailed features of ...

journal_title：Oncology reports

authors： Terui H,Tachikawa T,Kakuta M,Nishimura Y,Yatsuoka T,Yamaguchi K,Yura K,Akagi K

更新日期：2013-12-01 00:00:00

abstract：:T cell-mediated cell immunity is the main anti-tumor immunity in which the effector T cells need specific antigen and costimulatory signals. One of the vaccines applied in tumor immunotherapy is the gene-modified tumor cell vaccine. One potential method to increase cell epitope density is to link the antigen with the ...

journal_title：Oncology reports

authors： Fang L,Wang K,Liu X,Zhang L,Zhang X,Qian L,Lu J,Qian G,Ge S

更新日期：2008-06-01 00:00:00

abstract：:An arsenical compound, As2O3 has been reported to be effective for treating acute leukemia and induce apoptosis in many different tumor cell types. In this study we designed a novel arsenical compound, As4O6, and compared its ability to induce cell growth inhibition as well as gene expression profiles along with As2O3...

journal_title：Oncology reports

authors： Ahn WS,Bae SM,Lee KH,Kim YW,Lee JM,Namkoong SE,Lee IP,Kim CK,Seo JS,Sin JI,Kim YW

更新日期：2004-09-01 00:00:00

abstract：:The development and progression of epithelial cancers are the result of an imbalance in signals promoting and inhibiting cellular proliferation and apoptosis. The aim of this study is to evaluate the expression of cell-cycle and apoptosis regulators and correlate them with clinical outcome in the most frequent carcino...

journal_title：Oncology reports

authors： Abdulkader I,Sánchez L,Cameselle-Teijeiro J,Gude F,Chávez JE,López-López R,Forteza J,Fraga M

更新日期：2005-12-01 00:00:00

abstract：:Reactive oxygen species (ROS) have been widely accepted as critical molecules playing regulatory roles in various biological processes, including proliferation, differentiation and apoptotic/ferroptotic/necrotic cell death. Emerging evidence suggests that ROS may be involved in the induction of epithelial‑to‑mesenchym...

journal_title：Oncology reports

authors： Peng G,Tang Z,Xiang Y,Chen W

更新日期：2019-02-01 00:00:00

abstract：:The ability to detect K-ras oncogene may provide additional information for the management of patients with non-small cell lung cancer (NSCLC). In the present study, we detected the K-ras oncogene in 76 patients with NSCLC by two methods: direct sequencing of K-ras in tumor tissues and membrane array detection of the ...

journal_title：Oncology reports

authors： Chong IW,Chang MY,Sheu CC,Wang CY,Hwang JJ,Huang MS,Lin SR

更新日期：2007-07-01 00:00:00

abstract：:Bone morphogenetic proteins (BMPs), which belong to the transforming growth factor-β superfamily, are multifunctional signaling molecules that have become of increasing interest in cancer research. Recent observations suggest that alterations in BMPs and BMP signaling are associated...

journal_title：Oncology reports

authors： Hashida Y,Nemoto Y,Imajoh M,Murakami M,Taniguchi A,Komatsu N,Yokoyama A,Daibata M

更新日期：2012-03-01 00:00:00

abstract：:Previous studies have demonstrated the tremendous tropism of mesenchymal stem cells (MSCs) for malignant gliomas, making these cells a potential vehicle for delivery of therapeutic genes to disseminated glioma cells. However, the mechanisms underlying the tropism of MSCs for gliomas remain poorly defined. It has been ...

journal_title：Oncology reports

authors： Xu F,Shi J,Yu B,Ni W,Wu X,Gu Z

更新日期：2010-06-01 00:00:00

abstract：:Dendropanax morbifera Leveille is found throughout southwestern Korea, and has been used in traditional medicine for various diseases, such as migraine headache, infectious diseases, skin diseases and dysmenorrhea. However, the molecular mechanisms of D. morbifera concerning its biochemical actions in cancer have not ...

journal_title：Oncology reports

authors： Lee JW,Park C,Han MH,Hong SH,Lee TK,Lee SH,Kim GY,Choi YH

更新日期：2013-09-01 00:00:00

abstract：:It has been reported that cimetidine, a histamine type-2 receptor (H2R) antagonist, inhibits the growth of glandular tumors such as colorectal cancer. However, its effects against salivary gland tumors are still unknown. We demonstrated previously that human salivary gland tumor (HSG) cells spontaneously express the n...

journal_title：Oncology reports

authors： Fukuda M,Tanaka S,Suzuki S,Kusama K,Kaneko T,Sakashita H

更新日期：2007-03-01 00:00:00

abstract：:Metastasis is the primary cause of death in lung cancer patients and EMT (epithelial-mesenchymal transition) promotes metastasis. Previous study revealed that DAL-1 (differentially expressed in adenocarcinoma of the lung) could attenuate EMT and metastasis in non-small cell lung cancer (NSCLC). Further study proved th...

journal_title：Oncology reports

authors： Qiu X,Guan X,Liu W,Zhang Y

更新日期：2017-11-01 00:00:00

abstract：:The BRAF T1799A mutation is a heterozygous point mutation and its reported prevalence in papillary thyroid carcinoma (PTC) has varied from 29 to 83%, with an overall mean of 44%. In Korea, the reported mutation rate reached 83% in PTC and 52% in micropapillary carcinoma. We hypothesized that the differences in prevale...

journal_title：Oncology reports

authors： Kim HS,Kim JO,Lee DH,Lee HC,Kim HJ,Kim JH,Jang YS,Lee JM,Kim SY,Kim YS

更新日期：2011-06-01 00:00:00