Abstract:
:Human gonadotropin-releasing hormone receptor (GnRHR) and its natural ligand human gonadotropin-releasing hormone (GnRH) were initially described as signaling complexes that play a key role in reproductive functions. By binding to specific receptors present on pituitary gonadotropes, GnRH regulates the sperm and ovum maturation, as well as steroidogenesis within the context of the hypothalamus-hypophysis axis. The expression of GnRH and its receptor has clearly been established in many extra-pituitary organs. Some of them are tumors from non-reproductive tissues such as liver, larynx, pancreas, colon, lymphoma, kidney, skin, blood and brain as well as tissues from reproductive track, for example ovary, endometrium, prostate and breast or tumors derived from these organs. Expression of GnRH and its receptor in these organs has gained much attention and several research groups have established their role during cell proliferation and cell motility. Although the signaling pathways and their effector proteins in these samples remain unclear, the molecular mechanism employed for GnRH and its receptor in extra-pituitary tissues could be related with non-classical GnRHR-signaling pathways. In the present review, we explore the vast literature reported on GnRH and GnRHR principally in tumors, describing how cross-talk between GnRHR and growth factor receptor, the coupling between GnRHR and many G proteins depending on cell context, and the regulation of several proteins associated with cell proliferation and cell motility are employed by GnRHR/GnRH to regulate their extra-pituitary activities.
journal_name
Oncol Repjournal_title
Oncology reportsauthors
Aguilar-Rojas A,Huerta-Reyes Mdoi
10.3892/or_00000525subject
Has Abstractpub_date
2009-11-01 00:00:00pages
981-90issue
5eissn
1021-335Xissn
1791-2431journal_volume
22pub_type
杂志文章,评审相关文献
ONCOLOGY REPORTS文献大全abstract::The present study demonstrated that chaetocin, a natural small-molecule product produced by Chaetomium fungal species and a potential anticancer agent, inhibited the viability and invasive ability of the human intrahepatic cholangio-carcinoma cell line CCLP-1 in vivo and in vitro as revealed by CCK-8 and Transwell inv...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2017.5921
更新日期:2017-10-01 00:00:00
abstract::Previous studies have suggested that certain genetic polymorphisms, specifically the Xeroderma pigmentosum group D (XPD) gene codon 751 and the X-ray repair cross-complementing group 1 (XRCC1) gene codon 399 polymorphisms, were associated with an increased risk of lung cancer, and, in some studies, with a greater risk...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or_00000854
更新日期:2010-07-01 00:00:00
abstract::In preclinical studies, antagonists of growth hormone-releasing hormone (GHRH) have demonstrated inhibitory effects on the growth of various types of cancers expressing the pituitary type of GHRH receptors (pGHRH-R) and/or its active splice variant 1 (SV1). In this study, we investigated the effectiveness of the treat...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2013.2435
更新日期:2013-07-01 00:00:00
abstract::lncRNA metastasis-associated lung adencarcinoma transcript 1 (MALAT1) plays an important role in the metastasis of lung cancer. Yet, its role in bone metastasis and the related mechanism remain unknown. The present study aimed to investigate the role of lncRNA MALAT1 in the bone metastasis of non-small cell lung cance...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2016.4909
更新日期:2016-09-01 00:00:00
abstract::Glioma is the most common primary brain malignant tumor. Receptor for activated C-kinase 1 (RACK1) is widely expressed in the central nervous system, and regulates multiple cellular processes including cell survival, proliferation, migration and metastasis. However, the role of RACK1 in glioma has never been revealed....
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2013.2723
更新日期:2013-11-01 00:00:00
abstract::Numerous studies have demonstrated that triptolide induces cell cycle arrest and apoptosis in human cancer cell lines. However, triptolide-induced DNA damage and inhibition of DNA repair gene expression in human skin cancer cells has not previously been reported. We sought the effects of triptolide on DNA damage and a...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2012.2170
更新日期:2013-02-01 00:00:00
abstract::It has been revealed by our previous proteomic study that the expression profile is different between well‑differentiated and poorly differentiated hepatocellular carcinoma (HCC). Among those differently expressed proteins, peroxiredoxin2 (PRDX2) was our protein of interest. The present study aimed to further investig...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2019.6977
更新日期:2019-03-01 00:00:00
abstract::It has been shown that deguelin, one of the compounds of rotenoids from flavonoid family, induced cytotoxic effects through induction of cell cycle arrest and apoptosis in many types of human cancer cell lines, but deguelin-affected DNA damage and repair gene expression (mRNA) are not clarified yet. We investigated th...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2012.1622
更新日期:2012-04-01 00:00:00
abstract::The p53 tumor suppressor is a transcription factor that regulates cell cycle and apoptosis in response to a variety of environmental stress conditions. Recent studies indicated that the apoptotic protease activating factor-1 (Apaf-1) is a direct transcriptional target of p53 in DNA damage-induced apoptosis. However, t...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2003-09-01 00:00:00
abstract::To determine whether immunohistochemistry can identify BRCA1 mutations, immunohistochemical (IH) analysis was undertaken on paraffin sections of paired ovarian cancer and normal tissue using antibodies against both terminal regions of the BRCA1 protein. Ten patients at risk for BRCA1 mutations were studied. The result...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.7.5.949
更新日期:2000-09-01 00:00:00
abstract::The degradation of basement membranes by tumor cells involves secretion and activation of proteinases, such as the matrix metalloproteinases (MMPs), and results from an imbalance between their inhibitors and activators that are controlled by various growth factors or cytokines, among which TGF-β(1) may be the most int...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2012.2128
更新日期:2013-02-01 00:00:00
abstract::We hypothesized that expression of multidrug resistance-associated protein 2 (MRP2), a major cisplatin transporter, may determine the efficacy of cisplatin as a treatment for patients with hepatocellular carcinoma (HCC). A prospective analysis was conducted of 49 consecutive patients who underwent resection for HCC (1...
journal_title:Oncology reports
pub_type: 临床试验,杂志文章
doi:10.3892/or_00000721
更新日期:2010-04-01 00:00:00
abstract::Previous studies have shown decreased expression of repulsive guidance molecule member A (RGMa) in colorectal cancer. However, the relationship between the expression levels and promoter DNA methylation status of RGMa and the clinical characteristics of colorectal cancer has not bee...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2012.1693
更新日期:2012-05-01 00:00:00
abstract::A small subset of cells within a malignant neoplasm, named cancer stem cells (CSCs) or tumour initiating cells, are thought to be capable of initiating the neoplasm itself, and of driving its growth and recurrence after treatment. It is unclear whether CSCs can be identified and experimentally induced within oral squa...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2011.1299
更新日期:2011-08-01 00:00:00
abstract::Chemokines have been reported to play crucial roles in tumor progression. Eotaxin-1 (CCL11), a member of the CC chemokine family, is elevated in many types of human cancer. Here, to reveal the molecular mechanisms of eotaxin-1 in prostate cancer cell invasion, the expression of eotaxin-1 receptors [CC chemokine recept...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2014.3060
更新日期:2014-05-01 00:00:00
abstract::Frequent frameshift mutations in the DNA mismatch repair genes hMSH3, and hMSH6, have been reported in colorectal and endometrial cancers with microsatellite instability, however, it is unclear whether they are similarly altered in ovarian endometrioid carcinoma. In this study, we examined frequency of frameshift muta...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2004-12-01 00:00:00
abstract::Nuclear factor (NF)-κB is the key transcription factor involved in the inflammatory responses, and its activation aggravates tumors. Peptidoglycan (PGN), a main cell wall component of Gram-positive bacteria, stimulates Toll-like receptor 2 (TLR-2) and activates a number of inflammat...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2012.1937
更新日期:2012-10-01 00:00:00
abstract::Hyperplasia suppressor gene (HSG) is a novel gene that markedly suppresses the mitogenetic stimuli or injury mediated by vascular smooth muscle cell proliferation. Herein we provide experimental evidence to show that HSG can also play a key role in tumor proliferation. Down-regulation of HSG protein in hepatocellular ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2010-07-01 00:00:00
abstract::Ras-association domain family of proteins (RASSF) is characterized by the Ras-association (RA) domain at the C-terminal. Frequent inactivation of RASSF1A gene in human cancers suggests that other members of the family may also play an important role in tumorigenesis. By in silico gene searches, the number of RASSF fam...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2004-10-01 00:00:00
abstract::Pancreatic cancer is one of the most deadly carcinomas worldwide. Although gemcitabine as the standard chemotherapy agent has been proven to be effective, the response rate remains at 5.4% and the 5-year survival rate is extremely poor. Ursolic acid (UA) is a small molecule compound...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2012.1827
更新日期:2012-08-01 00:00:00
abstract::Mangosteen (Garcinia mangostana) is a tree found in South-East Asia and the pericarp of its fruit has been used in folk medicine for the treatment of many human illnesses. Mangosteen fruit rinds contain a high concentration of xanthone, which is a type of polyphenol. One type of xanthone, α-mangostin, has been reporte...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2017.6030
更新日期:2017-12-01 00:00:00
abstract::Esophageal squamous cell carcinoma (ESCC) is a common cancer with a very poor prognosis. New methods are needed to screen high-risk populations and identify curable tumors and precursor lesions early. Molecular markers may be useful in such screening efforts. This study was designed to determine the prevalence of p16,...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2006-06-01 00:00:00
abstract::The TP53 mutation (R175H) is one of the most common mutations in human cancer. It is a highly attractive strategy for cancer therapy to find the genes that lead the R175H-expressing cancer cells. The aim of this study was to identify the synthetic sick/lethal gene interacting with R175H. Using lentiviral bar-coded com...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2013.2953
更新日期:2014-03-01 00:00:00
abstract::Protease-activated receptor 2 (PAR2) is a G-protein-coupled receptor and its activation has been associated with the pathogenetic progress in certain cancers. Toll-like receptor 4 (TLR4), one member of Toll-like receptors family, is mainly contributed to the innate immune response. However, recent studies have shown t...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2010.1077
更新日期:2011-02-01 00:00:00
abstract::MicroRNAs (miRNAs) are small non-coding RNAs of 20-25 nucleotides in length that are capable of modulating gene expression post-transcriptionally. The potential roles of miRNAs in the tumorigenesis of glioblastoma (GBM) have been under intensive studies in the past few years. In the present study, we found a positive ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2014.3055
更新日期:2014-05-01 00:00:00
abstract::The immune suppression of sentinel lymph node (SN) is directly influenced by primary tumors. It has been reported that the T-helper type 1 (Th1) to T-helper type 2 (Th2) ratio or T-cytotoxic type 1 (Tc1) to T-cytotoxic type 2 (Tc2) ratio of lymph node lymphocytes could be used to evaluate direct immunological circumst...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2008-03-01 00:00:00
abstract::This study was conducted to assess protective effect of an antioxidant protein, sericin, on tumor promotion in the 7,12-dimethylbenz (alpha) anthracene (DMBA)-initiated and 12-O-tetradecanoylphorbol 13-acetate (TPA)-promoted mouse skin tumorigenesis model. In experiment 1, sericin was applied topically to DMBA-initiat...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2003-05-01 00:00:00
abstract::Gliomas are primary brain tumors associated with a poor prognosis partly due to resistance to conventional therapies. To overcome this problem, we investigated the combined effects of gamma knife radiosurgery (GKS) and an antiangiogenic agent, thalidomide (THD), or a chemotherapeutic agent, temozolomide (TMZ), on a ra...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2006-05-01 00:00:00
abstract::Recent research indicates that the Janus kinase/signal transducer and activator of transcription 3 (JAK/STAT3) pathway may play an important role in chronic inflammation which promotes cancer progression, yet the mechanism is not clear. The present study aimed to investigate the role of the JAK/STAT3 pathway in the gr...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2014.3609
更新日期:2015-01-01 00:00:00
abstract::The emerging role of microRNA-181A (miR-181A) in CRC patients with late liver metastases was studied. In the present study we investigated the association between expression and mechanism of miRNA-181A, liver metastasis and prognosis of colorectal cancer (CRC). The expression of miR-181A and PTEN in CRC patients with ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2016.4546
更新日期:2016-03-01 00:00:00