Abstract:
:To determine whether immunohistochemistry can identify BRCA1 mutations, immunohistochemical (IH) analysis was undertaken on paraffin sections of paired ovarian cancer and normal tissue using antibodies against both terminal regions of the BRCA1 protein. Ten patients at risk for BRCA1 mutations were studied. The results of BRCA1 mutation analysis and IH were compared. In tumor, IH correctly identified the presence or absence of loss of heterozygosity in all specimens. In all uninvolved specimens, IH correctly identified the presence or absence of a germline mutation. The sensitivity, specificity, positive and negative predictive values were 100% suggesting promise as a rapid and inexpensive screen.
journal_name
Oncol Repjournal_title
Oncology reportsauthors
Byrne TJ,Reece MT,Adams LA,Lane MA,Cohn GMdoi
10.3892/or.7.5.949keywords:
subject
Has Abstractpub_date
2000-09-01 00:00:00pages
949-53issue
5eissn
1021-335Xissn
1791-2431journal_volume
7pub_type
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