Abstract:
:MicroRNAs (miRNAs) are small non-coding RNAs of 20-25 nucleotides in length that are capable of modulating gene expression post-transcriptionally. The potential roles of miRNAs in the tumorigenesis of glioblastoma (GBM) have been under intensive studies in the past few years. In the present study, we found a positive correlation between the levels of miR-127-3p and the cell migration and invasion abilities in several human GBM cell lines. We showed that miR-127-3p promoted cell migration and invasion of GBM cells using in vitro cell lines and in vivo mouse models. We identified SEPT7, a known tumor-suppressor gene that has been reported to suppress GBM cell migration and invasion, as a direct target of miR-127-3p. SEPT7 was able to partially abrogate the effect of miR-127-3p on cell migration and invasion. In addition, microarray analysis revealed that miR-127-3p regulated a number of migration and invasion-related genes. Finally, we verified that miR-127-3p affected the remodeling of the actin cytoskeleton mediated by SEPT7 in GBM cells.
journal_name
Oncol Repjournal_title
Oncology reportsauthors
Jiang H,Hua D,Zhang J,Lan Q,Huang Q,Yoon JG,Han X,Li L,Foltz G,Zheng S,Lin Bdoi
10.3892/or.2014.3055subject
Has Abstractpub_date
2014-05-01 00:00:00pages
2261-9issue
5eissn
1021-335Xissn
1791-2431journal_volume
31pub_type
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