Triptolide induced DNA damage in A375.S2 human malignant melanoma cells is mediated via reduction of DNA repair genes.

abstract：:The pathogenic mechanisms responsible for inflammatory bowel disease (IBD) are poorly understood. In an IBD animal model, the oral administration of polysaccharides such as dextran sulfate sodium (DSS) induced colitis, which exhibited several clinical and histological features similar to IBD. However, pathogenic facto...

journal_title：Oncology reports

authors： Araki Y,Mukaisyo K,Sugihara H,Hattori T

更新日期：2008-07-01 00:00:00

abstract：:Anaplastic thyroid carcinoma (ATC) is a rare type of thyroid carcinoma with a poor prognosis. Thus, suitable preclinical tumor models are required for the development of new ATC therapies. In the present study, orthotopic tumor xenograft models were established using ATC cell lines and SCID mice, and tumor invasion an...

journal_title：Oncology reports

authors： Aoyama M,Takizawa H,Otani T,Inoue S,Kawakita N,Tsuboi M,Bando Y,Uehara H,Kondo K,Tangoku A

更新日期：2020-10-01 00:00:00

abstract：:Notable advances in treatment have been made and increases in the cure rates of pediatric leukemia have been achieved. However, the majority of children with relapsed disease are not expected to survive, with chemotherapy resistance acting as the principal cause of treatment failure. Interaction between leukemic cells...

journal_title：Oncology reports

authors： Pillozzi S,Bernini A,Spiga O,Lelli B,Petroni G,Bracci L,Niccolai N,Arcangeli A

更新日期：2019-01-01 00:00:00

abstract：:Human leukocyte antigen B (HLA-B), a novel member of the NF-kappaB signal pathway in laryngeal squamous cell carcinoma (LSCC), mediates immunological surveillance of tumor cells by presenting peptides to cytotoxic T-lymphocytes (CTLs) together with S100 calcium binding protein A8 (S100A8). The objective of this study ...

journal_title：Oncology reports

authors： Guo Y,Liu J,Xu Z,Sun K,Fu W

更新日期：2008-06-01 00:00:00

abstract：:Invasiveness and metastasis may seriously affect the prognosis of small cell lung cancer (SCLC). In the present study, we analyzed the effects and inherent mechanisms of action of polysialic acid-modified neural cell adhesion molecule (NCAM) on the invasive and metastatic potential of SCLC. Gene transfection and short...

journal_title：Oncology reports

authors： Gong L,Zhou X,Yang J,Jiang Y,Yang H

更新日期：2017-01-01 00:00:00

abstract：:Ampelopsis sinica root (ASR) is a known hepatoprotective folk traditional Chinese medicine. The anti‑hepatoma activity of ethyl acetate extract from A. sinica root (ASRE) in vitro and in vivo and its possible mechanism were explored. This study was designed to investigate cytotoxicity by MTT assay, induction of apopto...

journal_title：Oncology reports

authors： Wang JZ,Huang BS,Cao Y,Chen KL,Li J

更新日期：2017-04-01 00:00:00

abstract：:Activation of ras genes and human papilloma virus (HPV) infection have been extensively described in cervical carcinomas while information concerning their implication in premalignant lesions of the cervix is limited. We investigated the incidence of K-ras codon 12 point mutations and HPV infection in cases of cervici...

journal_title：Oncology reports

authors： Prokopakis P,Sourvinos G,Koumantaki Y,Koumantakis E,Spandidos DA

更新日期：2002-01-01 00:00:00

abstract：:Gastric cancer (GC) is a severe public health problem worldwide, particularly in China. Radiotherapy is the main locoregional treatment for various types of unresectable tumor, including GC. However, many patients fail to respond to radiotherapy due to the intrinsic radioresistance of cancer cells. This study was desi...

journal_title：Oncology reports

authors： Geng W,Tian D,Wang Q,Shan S,Zhou J,Xu W,Shan H

更新日期：2019-08-01 00:00:00

abstract：:Patients with ulcerative colitis (UC) exhibit an increased risk for the development of cancer of the colon and rectum. This association is widely attributed to colonic inflammation. However, the severity of colonic inflammation necessary for the development of dysplasia and/or cancer remains unknown. In this study, we...

journal_title：Oncology reports

authors： Inoue T,Murano M,Kuramoto T,Ishida K,Kawakami K,Abe Y,Morita E,Murano N,Toshina K,Nishikawa T,Maemura K,Shimamoto C,Hirata I,Katsu K,Higuchi K

更新日期：2007-12-01 00:00:00

abstract：:Statins are the most effective drugs used in the reduction of intracellular synthesis of cholesterol. Numerous studies have confirmed that statins reduce the risk of multiple types of cancers. Statin use in cancer patients is associated with reduced cancer-related mortality. Epithelial-to-mesenchymal transition (EMT),...

journal_title：Oncology reports

authors： Fan Z,Jiang H,Wang Z,Qu J

更新日期：2016-08-01 00:00:00

abstract：:Berbamine is an herbal compound derived from Berberis amurensis, which is used in Chinese traditional medicine. However, few studies have investigated this anti-tumor effect or the underlying mechanisms of berbamine on lymphoma cells. We investigate the effect, as well as the mechanism of action, of 4-chlorobenzoyl be...

journal_title：Oncology reports

authors： Du HP,Shen JK,Yang M,Wang YQ,Yuan XQ,Ma QL,Jin J

更新日期：2010-03-01 00:00:00

abstract：:Secreted protein acidic and rich in cysteine (SPARC) is a glycoprotein which plays multiple roles in different types of cancer. Our previous study showed that SPARC overexpression inhibited the growth and angiogenesis of tumors, and reduced expression of vascular endothelial growth factor (VEGF). However, the relation...

journal_title：Oncology reports

authors： Zhang J,Wang P,Zhu J,Wang W,Yin J,Zhang C,Chen Z,Sun L,Wan Y,Wang X,Chen G,Liu Y

更新日期：2014-05-01 00:00:00

abstract：:Hypoxia was shown to increase tumor cell invasion into the extracellular matrix in vitro. This result suggests that heparanase (Hpa), one of the key enzymes involved in tumor invasion and metastasis, may be regulated by hypoxia. RT-PCR, Western blot and Matrigel invasive assays were used to study the regulation of Hpa...

journal_title：Oncology reports

authors： Wu W,Pan C,Meng K,Zhao L,Du L,Liu Q,Lin R

更新日期：2010-01-01 00:00:00

abstract：:Chronic myelogenous leukemia (CML) has a typical progressive course with transition from a chronic phase to a terminal blast crisis phase. However, the mechanisms that lead to disease progression remain unclear. Bone marrow mesenchymal stem cells (BMMSCs) play important roles in maintaining the bone marrow microenviro...

journal_title：Oncology reports

authors： Han Y,Wang Y,Xu Z,Li J,Yang J,Li Y,Shang Y,Luo J

更新日期：2013-08-01 00:00:00

abstract：:We evaluated the efficacy of anti-human VEGF antibody (bevacizumab) with or without irinotecan (CPT-11) against lung metastases in which neovascularization was already induced, as a postoperative adjuvant therapy using orthotopically implanted colon cancer in rat. The high VEGF productive KM12SM human colon cancer cel...

journal_title：Oncology reports

authors： Mizobe T,Ogata Y,Murakami H,Akagi Y,Ishibashi N,Mori S,Sasatomi T,Shirouzu K

更新日期：2008-09-01 00:00:00

abstract：:Arginine is a critical amino acid in specific cancer types including hepatocellular carcinoma (HCC) and melanoma. Novel molecular mechanisms and therapeutic targets in arginine metabolism-mediated cancer formation await further identification. Our laboratory has previously demonstrated that arginine metabolic enzyme a...

journal_title：Oncology reports

authors： Hung YH,Huang HL,Chen WC,Yen MC,Cho CY,Weng TY,Wang CY,Chen YL,Chen LT,Lai MD

更新日期：2017-02-01 00:00:00

abstract：:Three cases of benign pelvic tumors are presented (2 leiomyomas and 1 fibroma). All three tumors were suspected of being malignant neoplasms because they were visualized as heterogeneous high signal intensity on T2-weighted images, and thus they were difficult to diagnose preoperatively. One of the leiomyomas was loca...

journal_title：Oncology reports

authors： Kojima T,Ishiko O,Ichimura T,Nishimura S,Sumi T,Ueda J,Tsujimura T,Shimura K

更新日期：2001-07-01 00:00:00

abstract：:Apoptosis repressor with caspase recruitment domain (ARC), an inhibitor of apoptosis, is primarily expressed in terminally differentiated tissues. Recent studies have revealed that ARC is highly expressed in a variety of human cancer cell lines and epithelial-derived cancers, which suggests that ARC plays an important...

journal_title：Oncology reports

authors： Wu P,Tang Y,He J,Qi L,Jiang W,Zhao S

更新日期：2013-10-01 00:00:00

abstract：:To investigate the antitumor action of arsenic trioxide (As2O3) by intratumoral injection into solid tumors, tumor growth inhibition (TGI) and angiogenesis of heterotransplanted esophageal carcinoma in mice was carried out. The cultured human esophageal carcinoma cells were inoculated into both laterals of the abdomin...

journal_title：Oncology reports

authors： Shen ZY,Shen J,Chen MH,Wu XY,Wu MH,Zeng Y

更新日期：2003-11-01 00:00:00

abstract：:As one of the most common malignancies, esophageal squamous cell carcinoma (ESCC) is ranked as the sixth leading cause of cancer-related death worldwide. In our previous study, by employing cDNA microarray analysis, semaphorin 3B (SEMA3B) was found to be significantly downregulated in ESCC. In the present study, SEMA3...

journal_title：Oncology reports

authors： Tang H,Wu Y,Liu M,Qin Y,Wang H,Wang L,Li S,Zhu H,He Z,Luo J,Wang H,Wang Q,Luo S

更新日期：2016-08-01 00:00:00

abstract：:Gastric cancer is a common malignancy worldwide. The prognosis of early stage gastric cancer patients has significantly improved in recent years. However, in progressive stage gastric cancer patients, the prognosis remains relatively poor due to tumor metastases. In our previous study, we showed that the expression of...

journal_title：Oncology reports

authors： Xiao WS,Li DF,Tang YP,Chen YZ,Deng WB,Chen J,Zhou WW,Liao AJ

更新日期：2018-11-01 00:00:00

abstract：:Recently, gene fusions between the androgen responsive gene TMPRSS2 and members of the ETS-family of DNA-binding transcription factor genes were found in prostate cancer. Recurrent fusions were identified between the 5'-noncoding region of TMPRSS2 and ERG, or less frequently ETV1 or ETV4, resulting in overexpression o...

journal_title：Oncology reports

authors： Winnes M,Lissbrant E,Damber JE,Stenman G

更新日期：2007-05-01 00:00:00

abstract：:Lymph node metastasis is one of the most important prognostic factors in malignant tumors. In this study, we investigated vascular endothelial growth factor (VEGF)-C expression in human gastric cancer using immunohistochemical techniques and determined the number of microvessels in peritumoral tissue. VEGF-C expressio...

journal_title：Oncology reports

authors： Hachisuka T,Narikiyo M,Yamada Y,Ishikawa H,Ueno M,Uchida H,Yoriki R,Ohigashi Y,Miki K,Tamaki H,Mizuno T,Nakajima Y

更新日期：2005-04-01 00:00:00

abstract：:MicroRNAs (miRNAs) are novel tools for cancer therapy. Frizzled7 (FZD7) is an important co-receptor in the WNT signaling pathway. The WNT signaling pathway is aberrantly activated in Helicobacter pylori (H. pylori)‑infected gastric cancer cells. However, the role of FZD7 in H. pylori‑induced gastric tumorigenesis rema...

journal_title：Oncology reports

authors： Geng Y,Lu X,Wu X,Xue L,Wang X,Xu J

更新日期：2016-04-01 00:00:00

abstract：:Effective therapy for advanced hepatocellular carcinoma (HCC) is lacking. Conventional chemotherapy was judged to be ineffective. We previously demonstrated that the histone deacetylase inhibitor Trichostatin A (TSA) blocks growth of HCC cells in vitro. The anti-tumoral effect of a combination of more than 2 classes o...

journal_title：Oncology reports

authors： Ganslmayer M,Ocker M,Zopf S,Leitner S,Hahn EG,Schuppan D,Herold C

更新日期：2004-05-01 00:00:00

abstract：:Ovarian cancer (OC) is one of the most lethal gynecological malignancies in the world. The aim of the present study was to examine the role of microRNA (miR)-134-3p in OC. Reverse transcription-quantitative PCR was used to measure the expression levels of miR-134-3p. Cell Counting Kit-8, TUNEL, flow cytometric and col...

journal_title：Oncology reports

authors： Zhao M,Ji H,Fu Q,Cheng Q,Zhang Y,Yang Y

更新日期：2021-01-01 00:00:00

abstract：:Ulcerative colitis (UC) is an important risk factor for colorectal cancer (CRC). Histone modifications are one of the epigenetic mechanisms that may have key roles in the carcinogenesis of CRC. At present, there are no studies comparing histone modification patterns of UC and CRC in the literature. Therefore the aim o...

journal_title：Oncology reports

authors： Gerçeker E,Boyacıoglu SO,Kasap E,Baykan A,Yuceyar H,Yıldırım H,Ayhan S,Ellidokuz E,Korkmaz M

更新日期：2015-10-01 00:00:00

abstract：:Fat accumulation in adipose tissues is a risk factor for the development of human cancers. However, there are no studies describing the fat accumulation in adipose tissue or its distribution in human endometrial cancer. We first examined fat accumulation in adipose tissues separately on CT images of 122 patients with ...

journal_title：Oncology reports

authors： Nakamura K,Hongo A,Kodama J,Hiramatsu Y

更新日期：2011-07-01 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) is known to play a central role in tumour angiogenesis. Up to now inconclusive data have been published on the clinical-biological significance of circulating VEGF and on the most suitable blood fraction for measuring it. The aims of this pilot study were to assess VEGF in blo...

journal_title：Oncology reports

authors： Ranieri G,Coviello M,Chiriatti A,Stea B,Montemurro S,Quaranta M,Dittadi R,Paradiso A

更新日期：2004-02-01 00:00:00

abstract：:Emodin is an active ingredient derived from root and rhizome of Rheum palmatum L and many studies have reported that it exhibits anticancer effects in a number of human tumors. However, there is little information demonstrating the possible effects of emodin on the proliferation and apoptosis of hepatocellular carcino...

journal_title：Oncology reports

authors： Lin W,Zhong M,Yin H,Chen Y,Cao Q,Wang C,Ling C

更新日期：2016-08-01 00:00:00