Abstract:
:Frequent frameshift mutations in the DNA mismatch repair genes hMSH3, and hMSH6, have been reported in colorectal and endometrial cancers with microsatellite instability, however, it is unclear whether they are similarly altered in ovarian endometrioid carcinoma. In this study, we examined frequency of frameshift mutation and protein expression in hMSH3 and hMSH6 in ovarian endometrioid carcinoma with or without microsatellite instability. Only 1 frameshift mutation of the 16 cases with microsatellite instability-high phenotype (6%) was detected in poly(A)8 tract of the hMSH3, but not in poly(C)8 tract of hMSH6 genes. In addition, none of the 6 microsatellite instability-low or 20 microsatellite-stable tumors showed mutations in these regions in either gene. These results indicate that mutations in the mono-nucleotide tracts of hMSH3 and hMSH6 are infrequent in ovarian endometrioid adenocarcinomas, other mechanisms may play a more important role in the development of these tumors.
journal_name
Oncol Repjournal_title
Oncology reportsauthors
Albarracin CT,Silva EG,Malpica A,Luthra R,Liu Jkeywords:
subject
Has Abstractpub_date
2004-12-01 00:00:00pages
1217-9issue
6eissn
1021-335Xissn
1791-2431journal_volume
12pub_type
杂志文章相关文献
ONCOLOGY REPORTS文献大全abstract::Cyclin D1 expression is closely related with ER status in breast cancer. We executed this study to evaluate whether therapeutic response to tamoxifen varies with levels of cyclin D1 expression in 66 ER positive breast cancer patients having solitary bone metastasis. Treatment response to tamoxifen and correlation betw...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2003-01-01 00:00:00
abstract::Telomerase is a ribonucleoprotein enzyme which is endogenously expressed in germ, stem and tumor cells, but absent in benign somatic cells. The two major telomerase components are human telomerase RNA (hTR) and human telomerase reverse transcriptase (hTERT). It has been shown that hTERT is rate-limiting for telomerase...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2002-09-01 00:00:00
abstract::Cisplatin (CDDP)‑based combination chemotherapy is the standard for muscle‑invasive bladder cancer (MIBC). However, nearly all patients undergoing CDDP chemotherapy become refractory due to the development of CDDP resistance. Therefore, clarification of the mechanisms of CDDP resistance is urgently needed. The transcr...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2019.7039
更新日期:2019-05-01 00:00:00
abstract::The immune suppression of sentinel lymph node (SN) is directly influenced by primary tumors. It has been reported that the T-helper type 1 (Th1) to T-helper type 2 (Th2) ratio or T-cytotoxic type 1 (Tc1) to T-cytotoxic type 2 (Tc2) ratio of lymph node lymphocytes could be used to evaluate direct immunological circumst...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2008-03-01 00:00:00
abstract::Chemokines have been reported to play crucial roles in tumor progression. Eotaxin-1 (CCL11), a member of the CC chemokine family, is elevated in many types of human cancer. Here, to reveal the molecular mechanisms of eotaxin-1 in prostate cancer cell invasion, the expression of eotaxin-1 receptors [CC chemokine recept...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2014.3060
更新日期:2014-05-01 00:00:00
abstract::Ligularia fischeri (LF) has been used as an edible herb and traditional medicine for the treatment of inflammatory and infectious diseases. In the present study, we report the effects and molecular mechanism of the ethanolic extract of LF on cell proliferation, invasion and tube formation in human umbilical vein endot...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2015.4000
更新日期:2015-07-01 00:00:00
abstract::Glioblastoma multiforme (GBM) is one of the most malignant and aggressive tumors, and has a very poor prognosis with a mean survival time of <2 years, despite intensive treatment using chemo-radiation. Therefore, novel therapeutic approaches including immunotherapy have been developed against GBM. For the purpose of i...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2014.3049
更新日期:2014-04-01 00:00:00
abstract::Despite improvements in immunotherapy, little is known about dendritic cell (DC) subpopulations naturally occurring in the laryngeal cancer tissue (LCT) and peripheral blood (PB) of untreated laryngeal cancer (LC) patients. The purpose of the present study was to evaluate mature, im...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2012.1754
更新日期:2012-07-01 00:00:00
abstract::Zoledronic acid (Zometa, ZOL) is increasingly used to treat tumour-induced bone disease, and is also reported to have antiangiogenic properties in vivo. In this study, we have investigated the correlations between changes in the proangiogenic cytokine, vascular endothelial growth factor (VEGF), and markers of bone res...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2006-05-01 00:00:00
abstract::Laryngeal squamous cell carcinoma (LSCC) is a common cancer of the upper respiratory tract. The cytogenetic and molecular events involved in the pathogenesis of LSCC are not well understood. In this study, a combined strategy of conventional cytogenetics, fluorescent in situ hybridization (FISH) and microsatellite pol...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2007-12-01 00:00:00
abstract::Prostate cancer is one of the most common age-related malignancies. The occurrence frequency of prostate cancer is very different according to prostate zones. The prostate stroma is an important element in growth and differentiation of the normal prostate and also has a close relationship to the occurrence of benign p...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2003-01-01 00:00:00
abstract::Aberrant expression of microRNAs has been identified as regulators of biological processes of hepatocellular carcinoma (HCC) by negatively regulating protein-coding mRNAs. Several studies have demonstrated that miR-638 expression was dysregulated in various human cancers. However, the clinical significance and underly...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2016.5273
更新日期:2017-01-01 00:00:00
abstract::Mechanisms of synergistic effect of thermotherapy and chemotherapy on human lung adenocarcinoma cell growth are unclear. The purpose of this study was to investigate these effects and explore the function of ROS, Akt and caspase-3 in relation to these. A549 cells were subjected to different thermochemotherapy treatmen...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2012.1954
更新日期:2012-10-01 00:00:00
abstract::Neuropilin-1 (NRP-1), a co-receptor for VEGF165, is overexpressed in various prostate cancer cell lines and in advanced prostate tumors. However, distribution of the NRP-1 in prostate tumors has not yet been evaluated. Using immunohistochemical analysis, we evaluated 21 archival prostate tumors and 5 benign glands for...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2003-09-01 00:00:00
abstract::Esophageal squamous cell carcinoma (ESCC) is the predominant histologic subtype of esophageal cancer and is characterized by a high mortality rate and geographic differences in incidence. microRNAs (miRNAs) are small, non-coding RNAs that play important roles in the regulation of genes associated with cancer developme...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2014.3389
更新日期:2014-10-01 00:00:00
abstract::Apart from genetic mutations, epigenetic alteration is a common phenomenon that contributes to neoplastic transformation in colorectal cancer. Transcriptional silencing of tumor-suppressor genes without changes in the DNA sequence is explained by the existence of promoter hypermethylation. To test this hypothesis, we ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2015.3993
更新日期:2015-07-01 00:00:00
abstract::WNT signaling pathway networks with Hedgehog, Notch and FGF signaling pathways during carcinogenesis and embryogenesis. FZD8 is up-regulated in HeLa S3 and A549 cells. Here we identified and characterized rat Fzd8 gene by using bioinformatics. Rat Fzd8 gene was identified within AC131883.2 genome sequence. Rat Fzd8 (6...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2005-05-01 00:00:00
abstract::Chromosome 13 presents frequent allelic loss in esophageal squamous cell carcinomas (ESCC). However, no ESCC suppressor gene has been identified from this chromosome. To define common deletion regions that possibly contain the ESCC suppressor gene(s), we performed a mapping of allelic loss in 50 esophageal squamous ce...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2005-12-01 00:00:00
abstract::Paired box 6 (PAX6) is a transcription factor that has oncogenic features. In breast cancer, PAX6 facilitates tumor progression; however, the underlying mechanism is largely unknown. The majority of breast cancer‑related mortalities are associated with metastasis of cancer cells. Therefore, the present study aimed to ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2020.7644
更新日期:2020-08-01 00:00:00
abstract::Modulation of the activity of tumor suppressor p53 is a key event in the replication of many viruses. They could manipulate p53 function through modification of phosphorylation for their own purpose. However, there are scarce data on the relationship between high risk human papillomavirus (HPV) E6 protein and p53 phos...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2009-02-01 00:00:00
abstract::Bone morphogenetic proteins (BMPs), which belong to the transforming growth factor-β superfamily, are multifunctional signaling molecules that have become of increasing interest in cancer research. Recent observations suggest that alterations in BMPs and BMP signaling are associated...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2011.1548
更新日期:2012-03-01 00:00:00
abstract::Mutations in the epidermal growth factor receptor (EGFR) make lung adenocarcinoma cells sensitive to EGFR tyrosine kinase inhibitors (TKIs). Long-term cancer therapy may cause the occurrence of acquired resistance to EGFR TKIs. Long non-coding RNAs (lncRNAs) play important roles in tumor formation, tumor metastasis an...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2016.4758
更新日期:2016-06-01 00:00:00
abstract::Peroxiredoxin 1 (Prdx1) is an antioxidant and plays an important role in H2O2-mediated cell signaling. We previously found that the expression level of Prdx1 was elevated in esophagus squamous cell carcinoma (ESCC) tissue using a proteomics approach. Since overexpressed protein can induce an autoimmune response, to fu...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2013.2714
更新日期:2013-11-01 00:00:00
abstract::Histone deacetylase inhibitors (HDIs) as well as non-steroidal anti-inflammatory drugs including aspirin show promise as antineoplastic agents. The treatment with both HDIs and aspirin can result in hyperacetylation of proteins. In this study, we investigated whether HDIs and aspirin interacted in inducing anticancer ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2008-07-01 00:00:00
abstract::Peroxisome proliferator-activated receptor-gamma (PPAR-gamma), a member of the nuclear hormone receptor superfamily, is involved in suppressing the growth of several tumors. We showed that PPAR-gamma is expressed in Barrett's adenocarcinoma cell lines and inhibited the growth of these lines through the induction of G1...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2005-04-01 00:00:00
abstract::Trop2 is considered to have an important function in tumor metastasis and the promotion of epithelial‑mesenchymal transition (EMT). E‑cadherin is a crucial factor in intercellular adhesion and EMT transformation. In the present study, we detected the expression of Trop2 and E‑cadherin in breast cancer (BC) to better d...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2018.6496
更新日期:2018-08-01 00:00:00
abstract::Berbamine is an herbal compound derived from Berberis amurensis, which is used in Chinese traditional medicine. However, few studies have investigated this anti-tumor effect or the underlying mechanisms of berbamine on lymphoma cells. We investigate the effect, as well as the mechanism of action, of 4-chlorobenzoyl be...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or_00000688
更新日期:2010-03-01 00:00:00
abstract::We investigated the correlation between BAG-1 expression and sensitivity to platinum-based chemotherapeutics in patients with non-small cell lung cancer (NSCLC). mRNA and protein expression of BAG-1 in lung tissue of NSCLC postoperative patients (I-IIIA stage) or healthy subjects were detected using reverse transcript...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2011.1591
更新日期:2012-04-01 00:00:00
abstract::The purpose of this study was to investigate the radioprotective effect of HGFs (GM-CSF, IL-3 and SCF) in irradiated human peripheral blood mononuclear cells (PBMCs) in vitro, and the survival effect of lethally irradiated C3H mice in vivo. The irradiation of human PBMCs using a (137)Cs irradiator showed a dose-depend...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2005-06-01 00:00:00
abstract::The effectiveness of granulocyte colony-stimulating factor (G-CSF) for granulocytopenia has been widely recognized. However, although granulocyte counts rapidly increase after a few injection of G-CSF, a large proportion of the increased granulocytes disappear from peripheral blood within a few days following G-CSF wi...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.8.5.1027
更新日期:2001-09-01 00:00:00