Abstract:
:Zoledronic acid (Zometa, ZOL) is increasingly used to treat tumour-induced bone disease, and is also reported to have antiangiogenic properties in vivo. In this study, we have investigated the correlations between changes in the proangiogenic cytokine, vascular endothelial growth factor (VEGF), and markers of bone resorption in a cohort of patients with metastatic bone disease, following a single infusion of ZOL. Twenty-four consecutive selected cancer patients with scintigraphic and radiographic evidence of bone metastases were treated for the first time with a single infusion of 4 mg ZOL. Patients were considered ineligible if they had received any steroid therapy, radiotherapy, chemotherapy, immunotherapy or haemopoietic growth factors in the 4 weeks before or during the study period. Circulating levels of VEGF and beta crosslinked type I collagen C-telopeptide (betaCTX) were measured at base-line and at 1, 2, 7 and 21 days following ZOL infusion. The majority of our patients (23/24) developed a significant reduction in circulating levels of betaCTX at just 1 day after the single zoledronic acid infusion, median percentage decrease 67.05% (95% CI, 52.39%; 76.27%). This reduction persisted at all following time points in almost all subjects in our patient population (day 2, 95.8%; day 7, 100%; day 21, 91.7%). The median decrease at day 2 was 85.67% (95% CI, 78.23%; 90.16%); at day 7, 67.38% (95% CI, 67.38%; 86.98); and at day 21, 76.89% (95% CI, 35.00%; 83.16%). Moreover, a linear regression model with variance analysis demonstrated a statistically significant correlation between median VEGF and betaCTX circulating levels at each of the time points (1, 2, 7 and 21 days after ZOL infusion). The present work demonstrates that a single infusion of ZOL was able to induce a rapid and long lasting decrease of betaCTX plasma levels in the majority (23/24) of the included cancer patients. Furthermore, we found that there is a correlation between the levels of VEGF and betaCTX following ZOL treatment. Future clinical trials should be designed to prospectively evaluate the prognostic role of reduction of betaCTX and VEGF in response to ZOL to predict clinical and skeletal outcome.
journal_name
Oncol Repjournal_title
Oncology reportsauthors
Santini D,Vincenzi B,Hannon RA,Brown JE,Dicuonzo G,Angeletti S,La Cesa A,Coleman RE,Tonini G,Budillon A,Caraglia M,Holen Isubject
Has Abstractpub_date
2006-05-01 00:00:00pages
1351-7issue
5eissn
1021-335Xissn
1791-2431journal_volume
15pub_type
杂志文章相关文献
ONCOLOGY REPORTS文献大全abstract::The objective of this study was to investigate the effect of silencing gene protein phosphatase 1H (PPM1H) on malignant phenotype of human pancreatic cancer cell line BxPC-3. In order to explore the function of PPM1H in pancreatic cancer cells, real-time PCR and western blotting were used to detect the expression of P...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2016.5065
更新日期:2016-11-01 00:00:00
abstract::Hepatocellular carcinoma (HCC) is a major health problem worldwide. CD147 has been reported to be overexpressed in HCC and blocking CD147 expression can decrease tumor growth. (131)I is often used in combination with other drugs to treat HCC and yields positive results. In this study, we combined the (131)I and CD147 ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2013.2418
更新日期:2013-07-01 00:00:00
abstract::Epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase and mutations in this gene are major drivers of lung cancer development. EGFR tyrosine kinase inhibitors (TKIs) are standard first‑line therapies for patients with advanced non‑small cell lung cancer (NSCLC) with activating EGFR mutations, but are n...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2019.7140
更新日期:2019-07-01 00:00:00
abstract::Notable advances in treatment have been made and increases in the cure rates of pediatric leukemia have been achieved. However, the majority of children with relapsed disease are not expected to survive, with chemotherapy resistance acting as the principal cause of treatment failure. Interaction between leukemic cells...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2018.6808
更新日期:2019-01-01 00:00:00
abstract::Statins are the most effective drugs used in the reduction of intracellular synthesis of cholesterol. Numerous studies have confirmed that statins reduce the risk of multiple types of cancers. Statin use in cancer patients is associated with reduced cancer-related mortality. Epithelial-to-mesenchymal transition (EMT),...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2016.4897
更新日期:2016-08-01 00:00:00
abstract::Temozolomide (TMZ), as a kind of alkylating agent, is widely utilized for the treatment of glioblastoma (GBM). However, temozolomide resistance (TR) often develops quickly and results in tumor recurrence and poor outcome. Recent advances have demonstrated that miRNAs exert critical roles in chemoresistance. Downregula...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2017.5970
更新日期:2017-11-01 00:00:00
abstract::AZD8055 is a potent inhibitor of mTORC1 and mTOR2 and shows inhibitory effects in several types of cancer cells in vitro and in vivo. However, the effect of AZD8055 on hepatocellular carcinoma (HCC) cells has not been studied. We report that AZD8055 inhibits cell proliferation and colony formation of Hep3B and Huh7 ce...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2013.2890
更新日期:2014-02-01 00:00:00
abstract::The objective of the study was to investigate the dynamic changes of cortisol and soluble TNF-alpha p-55 and p-75 receptors in serum of advanced cancer patients during 24 h. The examined group consisted of 42 patients suffering from advanced gastrointestinal neoplasms (colorectal, gastric and pancreatic cancer). Serum...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.8.1.207
更新日期:2001-01-01 00:00:00
abstract::As tumor-associated antigens are not well characterized for the majority of human tumors, polyvalent vaccines prepared with whole-tumor antigens are an attractive approach for tumor vaccination. Vascular endothelial growth factor receptor-2 (VEGFR2), as a model antigen with which to...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2013.2282
更新日期:2013-04-01 00:00:00
abstract::The activation of receptor tyrosine kinases (RTKs) results in cellular effects including cell proliferation, survival, migration and invasion; RTKs also play an important role in tumourigenesis. It has been reported that EGFR signalling controls the migration of oral squamous cell carcinoma (OSCC) SAS and HSC3 cells b...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2017.5587
更新日期:2017-06-01 00:00:00
abstract::Although the impact of vascular endothelial growth factor (VEGF) is clearly established in advanced prostate cancer (PCa), its role in localized PCa remains to be determined. The aim of our study was to analyse the plasma levels of VEGF-A and the expression of VEGF-A in prostatic tissue in a population of patients wit...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2007-07-01 00:00:00
abstract::Bone marrow-derived endothelial progenitor cells (EPC) play an important role in neovascularisation and tumor growth. However, the clinical relevance of EPCs on blood vessel formation in non-small cell lung cancer (NSCLC) is unclear. EPC numbers in circulation are very low and therefore their detection is technically ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2008-02-01 00:00:00
abstract::Increasing evidence suggests that microRNAs are involved in human carcinogenesis as tumor suppressors or oncogenes. A growing number of reports has shown that an interest has been sparked in aberrant microRNA expression and how they can be used to treat human diseases, including cancer. However, their precise biologic...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or_00000834
更新日期:2010-07-01 00:00:00
abstract::Telomerase activation is prevalent in most epithelial tumors, and may be a critical step in cellular immortalization and carcinogenesis. However, telomerase activity in tumors of mesenchymal origin is not well understood. In the present study, we examined telomerase activity in clinical samples from osteosarcoma and s...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2004-06-01 00:00:00
abstract::In this study 10(7) peripheral blood mononuclear cells including on average 78.56% CD19+/CD5+ lymphocytes were irradiated, and then administered intradermally as an anti-cancer vaccine to seventeen patients with B-cell chronic lymphocytic leukemia (B-CLL) at early stages (twelve injections, four at a weekly interval f...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2008-08-01 00:00:00
abstract::Prognostic factors and the role of post-operative radiotherapy (PORT) in patients with pN1 nodal stage following surgery for NSCLC were identified. The clinical course of 211 patients with pN1 nodal involvement following thoracic surgery were reviewed, 97 of them received PORT. Multi-variate survival analysis with res...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2004-09-01 00:00:00
abstract::Metastasis‑associated lung adenocarcinoma transcript 1 (MALAT1) is a long non‑coding RNA (lncRNA) that has an oncogenic role in some types of cancers, uncluding breast cancer (BC). To investigate the role of MALAT1 in human BC progression, we detected MALAT1 expression levels based on tissue samples from 20 BC cases a...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2018.6705
更新日期:2018-11-01 00:00:00
abstract::Colon cancer is the fourth and third most common cancer, respectively in men and women worldwide and its incidence is on the increase. Stress response has been associated with the incidence and development of cancer. The catecholamines (CA), adrenaline (AD) and noradrenaline (NA), are crucial mediators of stress respo...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2015.3874
更新日期:2015-05-01 00:00:00
abstract::Lung cancer remains the leading cause of cancer-related mortality worldwide and non-small cell lung cancer (NSCLC) accounts for approximately 80-85% of all cases of lung cancer. Cisplatin plays a significant role in the management of human lung cancer. Translesion DNA synthesis (TLS) is involved in DNA damage repair. ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2015.4121
更新日期:2015-09-01 00:00:00
abstract::Tumor growth is accelerated by induction of angiogenesis regulated by many cytokines and growth factors. In a tumor mass, various angiogenic factors and their receptors are simultaneously expressed and the overlapped expressions of various factors may contribute to the aggressive growth of tumor. However, the possible...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2004-10-01 00:00:00
abstract::P5, which is a member of the protein disulfide isomerase family, possesses isomerase and chaperone activity in vitro; however, the physiological functions of this enzyme in cells remain unclear. To understand the important roles of P5 in cancer cells, the present study examined its expression on the surface of normal ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2018.6868
更新日期:2019-02-01 00:00:00
abstract::Chromosomal translocations are very common in human cancer. The molecular mechanisms of chromosomal translocations are complex and are not fully understood. Recent studies showed organization of genomes is higher-order in the nucleus and every chromosome or chromatin has its preferential position and territory. These ...
journal_title:Oncology reports
pub_type: 杂志文章,评审
doi:10.3892/or.2013.2677
更新日期:2013-11-01 00:00:00
abstract::Tetraspanins are transmembrane adaptor proteins involved in the regulation of various fundamental cellular processes. For a number of malignant diseases, the level of expression of members of the tetraspanin family was found to correlate with tumor cell invasiveness, ability to form metastases, and poor clinical outco...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2003-03-01 00:00:00
abstract::Survivin, an anti-apoptotic protein, is abundantly expressed in a variety of cancer cells, including hepatoma cells, resulting in the resistance of these cells to various apoptotic stimuli. Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is known to induce cancer cell-specific apoptosis, but hepa...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2006-08-01 00:00:00
abstract::Quercetin is a potent cancer therapeutic agent and dietary antioxidant present in fruit and vegetables. Quercetin prevents tumor proliferation by inducing cell cycle arrest and is a well known cancer therapeutic agent and autophagy mediator. We investigated whether quercetin enhances TRAIL-induced tumor cell death and...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2015.3991
更新日期:2015-07-01 00:00:00
abstract::In a human cancer cell line, we previously found a mutation in codon 322 of the extracellular signal-regulated kinase (ERK2E322K), the protein showed a faster migration when compared to wild-type in SDS-PAGE and constitutive phosphorylation. However, the reason for the faster migration, and the biochemical and biologi...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2008-10-01 00:00:00
abstract::Neuropilin-1 (NRP-1), a co-receptor for VEGF165, is overexpressed in various prostate cancer cell lines and in advanced prostate tumors. However, distribution of the NRP-1 in prostate tumors has not yet been evaluated. Using immunohistochemical analysis, we evaluated 21 archival prostate tumors and 5 benign glands for...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2003-09-01 00:00:00
abstract::The majority of patients with hormone receptor-positive metastatic breast cancer die from disease progression despite different types of anti-hormonal treatments. Preclinical studies have indicated that resistance to anti-hormonal therapies may be the result of an activated NF-κB si...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2011.1562
更新日期:2012-03-01 00:00:00
abstract::It has been recently reported that side population (SP) cells in nasopharyngeal carcinoma (NPC) cell lines display characteristics of cancer stem-like cells. However, the biological behavior and the significance of these cells for NPC progression remain unclear. In this study, we is...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2012.1781
更新日期:2012-07-01 00:00:00
abstract::c‑mesenchymal‑epithelial transition (Met) is a transmembrane tyrosine kinase receptor of hepatocyte growth factor (HGF). HGF/Met signaling stimulates numerous pathways, including the Ras/mitogenactivated protein kinase (MAPK), phosphatidylinositol 3‑kinase/protein kinase B and Wnt/β‑catenin pathways, which serve impor...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2020.7799
更新日期:2020-12-01 00:00:00