Abstract:
:Notable advances in treatment have been made and increases in the cure rates of pediatric leukemia have been achieved. However, the majority of children with relapsed disease are not expected to survive, with chemotherapy resistance acting as the principal cause of treatment failure. Interaction between leukemic cells and the bone marrow microenvironment is the primary cause of relapse. It was identified that a multi‑protein membrane complex, formed by potassium voltage‑gated channel subfamily H member 2 (hERG1) channels, the β1 integrin subunit and the stromal cell‑derived factor 12 (CXCL12) receptor, C‑X‑C chemokine receptor type 4 (CXCR4), exerts a role in mesenchymal stromal cell (MSC)‑mediated chemoresistance in pediatric leukemias. hERG1 blockade was able to overcome chemoresistance in vitro and in vivo. As an alternative strategy to overcome chemoresistance, the present study evaluated the effects of novel tools targeting the CXCR4/CXCL12 axis. The analysis of CXCL12 structural dynamics was used for the selection of a peptide (4‑1‑17) and a small molecule (8673), which interact with a transient hot spot, identified by a dynamic drug design approach. The present findings indicated that peptide 4‑1‑17 and small molecule 8673 inhibited leukemia cell proliferation and induced a pro‑apoptotic effect, which was not reduced by the presence of MSCs. The combined treatment with 4‑1‑17 and 8673 had a stronger pro‑apoptotic effect, particularly on cells cultured on MSCs in normoxic and hypoxic conditions, and was able to overcome MSC‑induced resistance to cytarabine. Overall, the targeting of CXCL12 and the ensuing inhibition of the CXCR4/CXCL12 axis may be proposed as an alternative strategy to overcome chemoresistance in leukemia.
journal_name
Oncol Repjournal_title
Oncology reportsauthors
Pillozzi S,Bernini A,Spiga O,Lelli B,Petroni G,Bracci L,Niccolai N,Arcangeli Adoi
10.3892/or.2018.6808subject
Has Abstractpub_date
2019-01-01 00:00:00pages
312-324issue
1eissn
1021-335Xissn
1791-2431journal_volume
41pub_type
杂志文章相关文献
ONCOLOGY REPORTS文献大全abstract::Activation of p53-independent pathways plays an important role in phytochemical-induced apoptosis and is considered to be a crucial factor in the invasion and metastasis of cancer. Previous studies have shown that combined effects of Stephania tetrandra with medicinal herbs exhibit beneficial effects in cancer patient...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2013.2352
更新日期:2013-06-01 00:00:00
abstract::The deficiencies of nucleotide excision repair (NER) factors are involved in rare genetic diseases such as xeroderma pigmentosum (XP) with increased risk of developing cancer on sun-exposed areas of the skin. However, the abnormality of NER factors in human sporadic carcinoma remains unclear. Loss of heterozygosity (L...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.8.5.1133
更新日期:2001-09-01 00:00:00
abstract::Highly malignant gliomas are characterized by pronounced intra‑ and intertumoral heterogeneity. On the genetic level, this heterogeneity may be caused by spontaneous mutation events, but recent studies have reported distinct mutational signatures that may be caused by an enzyme family with cytidine desaminase activity...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2018.6698
更新日期:2018-11-01 00:00:00
abstract::Thrombospondin-1 (TSP1) is known to possess tumor suppressor functions. In contradiction, TSP1 enhances the stromal vascularization and growth of certain cancers. A cell adhesion receptor, CD36, has been shown to interact with a ligand TSP1. We studied how CD36 affects the growth of the osteosarcoma cell line (HOS) ex...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2004-02-01 00:00:00
abstract::T cell-mediated cell immunity is the main anti-tumor immunity in which the effector T cells need specific antigen and costimulatory signals. One of the vaccines applied in tumor immunotherapy is the gene-modified tumor cell vaccine. One potential method to increase cell epitope density is to link the antigen with the ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2008-06-01 00:00:00
abstract::Drug resistance is one of the major obstacles to chemotherapy of ovarian cancer. Studies with cell lines can serve as an initial screen for agents that might modulate drug resistance. To establish more appropriate models of drug resistance and explore whether the differences exist in the different drug resistant subli...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2007-05-01 00:00:00
abstract::Gastric cancer (GC) is a severe public health problem worldwide, particularly in China. Radiotherapy is the main locoregional treatment for various types of unresectable tumor, including GC. However, many patients fail to respond to radiotherapy due to the intrinsic radioresistance of cancer cells. This study was desi...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2019.7187
更新日期:2019-08-01 00:00:00
abstract::Cigarette smoke has been implicated as a major risk factor for esophageal squamous cell carcinoma (ESCC). Several lines of evidence have suggested that the promoting effect of cigarette smoking extract (CSE) on ESCC is mediated by upregulation of cyclooxygenase-2 (COX-2) expression. Yet, the underlying molecular and c...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2015.4379
更新日期:2016-01-01 00:00:00
abstract::Following the publication of the above paper, an interested reader drew to our attention apparent anomalies associated with Figs. 2, 3 and 4; essentially, these three figures contained panels exhibiting overlapping data, such that data purportedly relating to different experiments were apparently drawn from the same o...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2020.7868
更新日期:2020-11-25 00:00:00
abstract::MicroRNA‑21 (miR‑21) is a potential therapeutic target for melanoma. Whether miR‑21 inhibitor affects the anti‑cancer activity of doxorubicin assisted by c(RGDyK)‑modified liposome (DLN) in melanoma and the underlying mechanisms are largely unknown. In this study, in vitro and animal models were used to explore the ef...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2019.7167
更新日期:2019-07-01 00:00:00
abstract::The expression of the DNA mismatch repair proteins hMSH2 and hMLH1 and p21(waf1) the cyclin G1 inhibitor, may determine response of adult cancers to anti-cancer drugs, that include alkylating agents and platinum-based drugs. The role of DNA mismatch repair proteins (hMSH2 and hMLH1) and p21(waf1) in pediatric tumor re...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.8.5.965
更新日期:2001-09-01 00:00:00
abstract::Metastatic progression is the cause of most cancer deaths. Host tumour cell separation (fission) is accompanied by simultaneous acquisition of migrating capability of cancer cells, remodeling of cellular architecture and effective 'homing' in body host environment. Cell remodeling involves cytoskeletal protein-protein...
journal_title:Oncology reports
pub_type: 杂志文章,评审
doi:
更新日期:2007-06-01 00:00:00
abstract::Tripartite motif containing 28 (TRIM28) is a universal corepressor for Kruppel‑associated box zinc finger proteins. In our previous study, it was shown that expression of TRIM28 is upregulated in non‑small cell lung cancer (NSCLC) cell lines and tissues. Here, we demonstrated that the stable silencing of TRIM28 expres...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2017.5638
更新日期:2017-06-01 00:00:00
abstract::Benign prostatic hyperplasia (BPH) is a common chronic disease in older males. The pathogenesis of BPH remains elusive but may be associated with chronic inflammation. Chemokines and chemokine receptors have been implicated as critical mediators in the immune response and inflammatory processes. In the present study, ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2019.7002
更新日期:2019-04-01 00:00:00
abstract::The aim of the present study was to evaluate human epididymis protein 4 (HE4) as a marker of epithelial ovarian cancer (EOC) relapse and the combination of this biomarker with contrast-enhanced high-resolution multidetector row computed tomography CE CT imaging to impove the monitoring of EOC patients. Twenty-one pati...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2013.2682
更新日期:2013-11-01 00:00:00
abstract::Recently, gene fusions between the androgen responsive gene TMPRSS2 and members of the ETS-family of DNA-binding transcription factor genes were found in prostate cancer. Recurrent fusions were identified between the 5'-noncoding region of TMPRSS2 and ERG, or less frequently ETV1 or ETV4, resulting in overexpression o...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2007-05-01 00:00:00
abstract::Hepatocellular carcinoma (HCC) is a leading cause of cancer‑related morbidity and mortality globally. Despite the remarkable improvements in comprehensive HCC treatment, the underlying mechanistic details of HCC remain elusive. We screened HCC patients for differentially expressed genes (DEGs) using the Gene Expressio...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2020.7779
更新日期:2020-11-01 00:00:00
abstract::Prostate cancer antigen 3 (PCA3) is a non-coding RNA fragment that is overexpressed in prostate cancer cells. However, the clinical applications of PCA3 are highly limited due to the instability of RNA and the lack of reliable and efficient RNA extraction and purification methods. Thus, in the present study, we compar...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2015.4266
更新日期:2015-11-01 00:00:00
abstract::Cytochalasin B (CB) is a cell-permeable mycotoxin. It inhibits cytoplasmic division by blocking the formation of contractile microfilaments, it inhibits cell movement and induces nuclear extrusion. In the present study, we investigated the anticancer activity of CB in HeLa human cervical carcinoma cells. CB showed sig...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2013.2617
更新日期:2013-10-01 00:00:00
abstract::Temozolomide (TMZ), as a kind of alkylating agent, is widely utilized for the treatment of glioblastoma (GBM). However, temozolomide resistance (TR) often develops quickly and results in tumor recurrence and poor outcome. Recent advances have demonstrated that miRNAs exert critical roles in chemoresistance. Downregula...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2017.5970
更新日期:2017-11-01 00:00:00
abstract::Following the publication of this paper, it was drawn to the authors' attention by an interested reader that certain of the tumours featured in Fig. 6A of the above paper were strikingly similar to those featured in Fig. 8A of an article appearing in International Journal of Oncology (Fan F-Y, Deng R, Yi H, Sun H-P, Z...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2020.7828
更新日期:2021-01-01 00:00:00
abstract::Quercetin is a potent cancer therapeutic agent and dietary antioxidant present in fruit and vegetables. Quercetin prevents tumor proliferation by inducing cell cycle arrest and is a well known cancer therapeutic agent and autophagy mediator. We investigated whether quercetin enhances TRAIL-induced tumor cell death and...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2015.3991
更新日期:2015-07-01 00:00:00
abstract::Increased production of reactive oxygen species (ROS) is a distinct feature of various types of cancer. ROS drive tumor progression and render cancer cells vulnerable to additional oxidative insult. The various natural herb compounds have been shown to induce additional production of ROS in cancer cells, although the ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2018.6864
更新日期:2019-02-01 00:00:00
abstract::As part of the efforts to drug repurposing, some HIV drugs have recently been identified to exert anticancer effects. Selected nucleoside analogues of nucleosidic reverse-transcriptase inhibitors (NRTIs) have been shown to interfere with RNA transcription of HI viruses as well as with the replication of DNA in cancer ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2016.5243
更新日期:2017-01-01 00:00:00
abstract::This retrospective study was designed to evaluate the prognostic value of immunohistochemically detected nm23-expression in invasive breast cancer. Cellular expression of nm23 was assessed in 325 primary breast cancer tissues by immunohistochemistry. The data were correlated to established functional factors of progno...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2002-11-01 00:00:00
abstract::Breast cancer metastasizes to the bone in a majority of patients with advanced disease resulting in bone destruction. The underlying mechanisms are complex, and both processes are controlled by an interaction between locally and systemically derived signals. Clinically, breast cancer patients with depression have a hi...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2015.4430
更新日期:2016-02-01 00:00:00
abstract::Vimentin is a member of the intermediate filament family, and the NF-kappaB binding site is located in the human vimentin promoter. To gain insight into the role of NF-kappaB in the regulation of the vimentin gene during 12-O-tetradecanoylphorbol-13-acetate (TPA)-dependent differentiation of HL-60 cells, the effect of...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2005-09-01 00:00:00
abstract::We previously found that oleanolic acid (OA), a naturally pentacyclic triterpenoid, enhances the radiosensitizing effect on tumor cells. However, it is unclear whether or not OA enhances the radiosensitivity of hypoxic cells. Therefore, the aim of the present study was to further observe the influence of OA on hypoxic...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2014.3064
更新日期:2014-05-01 00:00:00
abstract::Doxorubicin (Dox) is one of the most commonly used and highly effective antineoplastic agents, but the clinical application of this broad spectrum drug is largely hampered by its poor stability and serious toxicity to normal tissues. Hence, it is essential to improve the therapeutic effect and decrease the systematic ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2011.1243
更新日期:2011-06-01 00:00:00
abstract::Tumor growth is accelerated by induction of angiogenesis regulated by many cytokines and growth factors. In a tumor mass, various angiogenic factors and their receptors are simultaneously expressed and the overlapped expressions of various factors may contribute to the aggressive growth of tumor. However, the possible...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2004-10-01 00:00:00