Histone deacetylase inhibitors and aspirin interact synergistically to induce cell death in ovarian cancer cells.

abstract：:The efficacy of chemotherapy for hepatocellular carcinoma (HCC) remains unsatisfactory, primarily due to inherent self‑defense mechanisms (e.g., mitophagy and autophagy). In the present study, we aimed to explore the pro‑apoptotic effects of targeting mitophagy to potentiate the efficacy of chemotherapy for HCC. HCC c...

journal_title：Oncology reports

authors： Ma M,Lin XH,Liu HH,Zhang R,Chen RX

更新日期：2020-03-01 00:00:00

abstract：:Bisphosphonates (BPs) inhibit bone resorption by preventing osteoclast maturation and apoptosis induction. Recently, BPs have also been shown to have antitumor effects against various types of carcinomas in vitro and in vivo. In this study, we investigated the antitumor effect of zoledronic acid (ZOL), a third generat...

journal_title：Oncology reports

authors： Tamura T,Shomori K,Nakabayashi M,Fujii N,Ryoke K,Ito H

更新日期：2011-04-01 00:00:00

abstract：:Angiogenesis is crucial for the development and metastasis of human brain glioma. Based on our previous successful construction of a lentivirus-mediated alphastatin (an endogenous angiogenesis inhibitor) gene transfer system and our findings that alphastatin exhibited potent inhibit...

journal_title：Oncology reports

authors： Che H,Song J,Guo S,Wang W,Gao G

更新日期：2013-03-01 00:00:00

abstract：:Glucose intolerance frequently is found in hepatocellular carcinoma (HCC) patients with hepatitis C virus (HCV) infection; however, the significance of glucose intolerance remains unclear. In addition, SH2 domain-containing inositol phosphatase (SHIP) 2 is a negative regulator of intracellular insulin signaling; howev...

journal_title：Oncology reports

authors： Sumie S,Kawaguchi T,Komuta M,Kuromatsu R,Itano S,Okuda K,Taniguchi E,Ando E,Takata A,Fukushima N,Koga H,Torimura T,Kojiro M,Sata M

更新日期：2007-09-01 00:00:00

abstract：:Somatic mitochondrial DNA (mtDNA) mutations have been found in a subset of endometrial cancers (EC) from different populations. We have investigated the relationship between mtDNA changes and clinical and pathological variables of women affected by EC. mtDNA mutations were detected both in early (3/32; 9%) and in adva...

journal_title：Oncology reports

authors： Semczuk A,Lorenc A,Putowski L,Futyma K,Bryk J,Miotla P,Bartnik E

更新日期：2006-11-01 00:00:00

abstract：:Oncolytic vaccinia virus is currently undergoing evaluation as a biological anticancer agent in clinical trials. This treatment exploits the lytic nature of a viral infection to eradicate the tumor mass in a cancer cell‑specific manner. So far, various vaccinia strains have been used as backbones in the design of onco...

journal_title：Oncology reports

authors： Deng L,Fan J,Ding Y,Zhang J,Zhou B,Zhang Y,Huang B,Hu Z

更新日期：2019-01-01 00:00:00

abstract：:Carboxypeptidase X, M14 family member 2 (CPXM2), has been associated with several human disorders such as developmental diseases. However, whether CPXM2 is involved in oncogenesis or tumor progression remains unclear. In the present study, we used clinical samples from gastric cancer (GC) patients to investigate poten...

journal_title：Oncology reports

authors： Niu G,Yang Y,Ren J,Song T,Hu Z,Chen L,Hong R,Xia J,Ke C,Wang X

更新日期：2019-10-01 00:00:00

abstract：:Patients with ulcerative colitis (UC) exhibit an increased risk for the development of cancer of the colon and rectum. This association is widely attributed to colonic inflammation. However, the severity of colonic inflammation necessary for the development of dysplasia and/or cancer remains unknown. In this study, we...

journal_title：Oncology reports

authors： Inoue T,Murano M,Kuramoto T,Ishida K,Kawakami K,Abe Y,Morita E,Murano N,Toshina K,Nishikawa T,Maemura K,Shimamoto C,Hirata I,Katsu K,Higuchi K

更新日期：2007-12-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is one of the most common tumors in the world. At present, the details of the mechanism responsible for HCC formation and maintenance remain unclear. However, the cancer stem cell (CSC) theory suggests that liver cancer stem cells (LCSCs) may be respon...

journal_title：Oncology reports

authors： Song K,Wu J,Jiang C

更新日期：2013-01-01 00:00:00

abstract：:This study assessed the prediction of gastric cancer recurrence based on detection of occult neoplastic cells (ONCs) in lymph nodes, and by using criteria that were developed to identify patients with a high risk of recurrence/metastasis. The subjects were 60 patients of stage II or III gastric cancer with lymph node ...

journal_title：Oncology reports

authors： Mukai M,Sato S,Komatsu N,Kimura T,Ninomiya H,Kawada M,Nakasaki H,Ogoshi K,Makuuchi H

更新日期：2004-07-01 00:00:00

abstract：:Gallbladder cancer (GBC) is a rare disease associated with an extremely poor patient prognosis, and occasionally, aberrant expression of p53 is present. Considering that p53 is one of the most widely studied tumor‑suppressor genes, we used a cell-penetrating peptide, 11R, to enhance the transferring efficiency of the ...

journal_title：Oncology reports

authors： Wang J,Yu Y,Yan Z,Hu Z,Li L,Li J,Jiang X,Qian Q

更新日期：2013-08-01 00:00:00

abstract：:Aberrant methylation of 5' CpG islands is thought to play an important role in the inactivation of tumor suppressor genes in several types of cancers. In non-small cell lung cancer (NSCLC), several genes are known to be frequently methylated and the correlation of their methylation with clinical features has been stud...

journal_title：Oncology reports

authors： Hanabata T,Tsukuda K,Toyooka S,Yano M,Aoe M,Nagahiro I,Sano Y,Date H,Shimizu N

更新日期：2004-07-01 00:00:00

abstract：:Histone deacetylase (HDAC) 4 is an emerging target in cancer therapeutics, but little is known about the function of HDAC4 in gynecologic malignancies. Therefore we investigated the mechanism of HDAC4 promoting the proliferation of epithelial ovarian cancer cells (OV). In this study, we observed that the proliferation...

journal_title：Oncology reports

authors： Shen YF,Wei AM,Kou Q,Zhu QY,Zhang L

更新日期：2016-02-01 00:00:00

abstract：:The aim of this study was to assess the anti-tumor effect and mechanisms of cimetidine in N-butyl-N-(4-hydroxybutyl) nitrosamine (BBN)-induced bladder carcinogenesis model. Sixty-three male BALB/c mice and 67 male Wister rats were treated with BBN and cimetidine to examine the anti-tumor effect of cimetidine. Immunohi...

journal_title：Oncology reports

authors： Chihara Y,Fujimoto K,Miyake M,Hiasa Y,Hirao Y

更新日期：2009-07-01 00:00:00

abstract：:The human Igf-1 gene not only produces insulin‑like growth factor-I (IGF-I), but also different carboxy‑terminal extensions, known as E peptides, through alternative splicing. We and others have shown that human Eb peptide (hEb) derived from Igf-1 has intrinsic biological activity and is localized to nuclei of transfe...

journal_title：Oncology reports

authors： Durzyńska J,Barton E

更新日期：2014-09-01 00:00:00

abstract：:MicroRNAs (miRNAs) are a group of important regulators in human types of cancer including non-small cell lung cancer (NSCLC). miR-616 has been found to be a novel cancer-related miRNA. However, the expression and biological function of miR-616 in NSCLC have not been investigated. In this study, qRT-PCR was performed t...

journal_title：Oncology reports

authors： Wang D,Cao Q,Qu M,Xiao Z,Zhang M,Di S

更新日期：2017-10-01 00:00:00

abstract：:Cisplatin (DDP), a cytotoxic antitumor drug, functions in a dose-dependent manner. However, the pursuit for high‑dose therapeutic effects leads to more serious side effects including kidney toxicity. Nephrotoxicity caused due to endothelial cell dysfunction and neutrophils infiltration in kidneys. Interleukin-8 (IL-8)...

journal_title：Oncology reports

authors： Li L,Khan MN,Li Q,Chen X,Wei J,Wang B,Cheng JW,Gordon JR,Li F

更新日期：2015-02-01 00:00:00

abstract：:Ovarian cancer is the leading cause of death among malignancies of the female reproductive system. The 5-year survival rates of ovarian cancer (OC) patients are very poor as a result of recurrent disease and emergence of drug resistance; thus, studies to find predictive markers and factors for drug resistance are ongo...

journal_title：Oncology reports

authors： Gao Y,Liu X,Li T,Wei L,Yang A,Lu Y,Zhang J,Li L,Wang S,Yin F

更新日期：2017-05-01 00:00:00

abstract：:We conducted a clinical pharmacological evaluation of paclitaxel/carboplatin combination in Japanese patients with non-small cell lung cancer. The purpose of this study was to identify the optimal dose of this combination and to investigate the relationships between the pharmacokinetic profiles of these 2 drugs, serum...

journal_title：Oncology reports

authors： Daga H,Isobe T,Miyazaki M,Fujitaka K,Kondo K,Kohno N

更新日期：2004-06-01 00:00:00

abstract：:IncRNAs play an important role in the regulation of gene expression. The present study profiled differentially expressed lncRNAs (DELs) and mRNAs (DEMs) in myelodysplastic syndrome (MDS) to construct a 4‑aminobutyrate aminotransferase (ABAT)‑DEL‑DEM co‑expression network in MDS development using the Agilent human Bead...

journal_title：Oncology reports

authors： Chen Y,Zhao G,Li N,Luo Z,Wang X,Gu J

更新日期：2019-08-01 00:00:00

abstract：:We investigated the correlation between BAG-1 expression and sensitivity to platinum-based chemotherapeutics in patients with non-small cell lung cancer (NSCLC). mRNA and protein expression of BAG-1 in lung tissue of NSCLC postoperative patients (I-IIIA stage) or healthy subjects were detected using reverse transcript...

journal_title：Oncology reports

authors： Wang YD,Ha MW,Cheng J,Zhang WL,Cong X,Tong CY,Sun J

更新日期：2012-04-01 00:00:00

abstract：:Insulin-like growth factor (IGF)-mediated signaling is a newly recognized clinical target in prostate cancer, and it is hypothesized that blockade of the IGF receptor (IGF1R) will impair downstream signaling and slow tumor growth. In this study the efficacy of nordihydroguaiaretic a...

journal_title：Oncology reports

authors： Friedlander TW,Weinberg VK,Huang Y,Mi JT,Formaker CG,Small EJ,Harzstark AL,Lin AM,Fong L,Ryan CJ

更新日期：2012-01-01 00:00:00

abstract：:Although the human telomerase reverse transcriptase (hTERT) promoter can regulate cancer-specific genes, it is generally too weak to be effective. We therefore attempted to improve the potency of synthetic hTERT promoters by fusing the core element (E) of the hTERT promoter (H) and the tripartite leader sequence (T) f...

journal_title：Oncology reports

authors： Kim SJ,Lee HS,Shin JH,Kim CG,Jeong S,Park K,Choe H,Lee H

更新日期：2006-11-01 00:00:00

abstract：:Lung cancer is one of the most common cancers worldwide and accounts for 28% of all cancer-related deaths. The expression of the β2‑adrenergic receptor (β2‑AR), one of the stress‑inducible receptors, has been reported to be closely correlated with malignant tumors. However, the role of β2‑AR activation in human lung e...

journal_title：Oncology reports

authors： Hu P,He J,Liu S,Wang M,Pan B,Zhang W

更新日期：2016-09-01 00:00:00

abstract：:Hydrogen sulfide (H2S), regarded as the third gaseous transmitter, mediates and induces various biological effects. The present study investigated the effects of H2S on multiple myeloma cell progression via amplifying the activation of Akt pathway in multiple myeloma cells. The level of H2S produced in multiple myelom...

journal_title：Oncology reports

authors： Zheng D,Chen Z,Chen J,Zhuang X,Feng J,Li J

更新日期：2016-10-01 00:00:00

abstract：:Laryngeal squamous cell carcinoma (LSCC) is a common cancer of the upper respiratory tract. The cytogenetic and molecular events involved in the pathogenesis of LSCC are not well understood. In this study, a combined strategy of conventional cytogenetics, fluorescent in situ hybridization (FISH) and microsatellite pol...

journal_title：Oncology reports

authors： Kang N,Li F,Fu W,Zhang J,Sun K

更新日期：2007-12-01 00:00:00

abstract：:Epidemiologic studies indicate the use of either statins or aspirin have beneficial effects in prostate cancer patients. The present study was undertaken to evaluate the effects and mechanisms of atorvastatin and aspirin alone or in combination in human prostate cancer cells cultured in vitro and grown as xenograft tu...

journal_title：Oncology reports

authors： He Y,Huang H,Farischon C,Li D,Du Z,Zhang K,Zheng X,Goodin S

更新日期：2017-02-01 00:00:00

abstract：:Investigations into the cellular processing of radiolabeled monoclonal antibodies (mAbs) for their further use in radioimmunodiagnosis and cancer therapy are needed in order to understand the fate of internalized and catabolized mAbs. The anti-colorectal cancer mAb, A33, was labelled with 76Br and 125I using the direc...

journal_title：Oncology reports

authors： Höglund J,Orlova A,Sundin A,Lundqvist H,Tolmachev V

更新日期：2006-07-01 00:00:00

abstract：:Normal breast development is controlled by a balance between cell proliferation and apoptosis. The balance between the two parameters is crucial for determining the growth or regression of breast tumours in response to therapies and treatments. Therefore, it is necessary to understand the role of apoptosis in tumour p...

journal_title：Oncology reports

authors： Puertollano MA,Carrera MP,Puertollano E,Alvarez de Cienfuegos G,Ramirez-Expósito MJ,De Pablo MA,Martinez-Martos JM

更新日期：2008-09-01 00:00:00

abstract：:Differentiation of breast cancer has been receiving increasing attention in attempts to minimize the numbers of excisional biopsies for benign tumors. Doppler spectral parameters, such as peak systolic velocity (PSV) and pulsatility index (PI), have been used but these are unable to differentiate breast cancers and be...

journal_title：Oncology reports

authors： Mesaki K,Hisa N,Kubota K,Hisa N,Ogawa Y,Yoshida S

更新日期：2003-07-01 00:00:00