Histone deacetylase 4 increases progressive epithelial ovarian cancer cells via repression of p21 on fibrillar collagen matrices.

abstract：:Long non‑coding RNAs (lncRNAs) have emerged as critical regulators of tumor progression. However, the function and mechanism of lncRNA NEAT1 in oral squamous cell carcinoma (OSCC) are unclear. In the present study, NEAT1 was significantly upregulated in OSCC cells and tissues. High expression of NEAT1 was correlated w...

journal_title：Oncology reports

authors： Huang G,He X,Wei XL

更新日期：2018-04-01 00:00:00

abstract：:Gliomas are primary brain tumors associated with a poor prognosis partly due to resistance to conventional therapies. To overcome this problem, we investigated the combined effects of gamma knife radiosurgery (GKS) and an antiangiogenic agent, thalidomide (THD), or a chemotherapeutic agent, temozolomide (TMZ), on a ra...

journal_title：Oncology reports

authors： Lee JI,Itasaka S,Kim JT,Nam DH

更新日期：2006-05-01 00:00:00

abstract：:Anaplastic thyroid carcinoma (ATC) is a rare type of thyroid carcinoma with a poor prognosis. Thus, suitable preclinical tumor models are required for the development of new ATC therapies. In the present study, orthotopic tumor xenograft models were established using ATC cell lines and SCID mice, and tumor invasion an...

journal_title：Oncology reports

authors： Aoyama M,Takizawa H,Otani T,Inoue S,Kawakita N,Tsuboi M,Bando Y,Uehara H,Kondo K,Tangoku A

更新日期：2020-10-01 00:00:00

abstract：:Laryngeal squamous cell carcinoma (LSCC) is a common cancer of the upper respiratory tract. The cytogenetic and molecular events involved in the pathogenesis of LSCC are not well understood. In this study, a combined strategy of conventional cytogenetics, fluorescent in situ hybridization (FISH) and microsatellite pol...

journal_title：Oncology reports

authors： Kang N,Li F,Fu W,Zhang J,Sun K

更新日期：2007-12-01 00:00:00

abstract：:Chromosome 13 presents frequent allelic loss in esophageal squamous cell carcinomas (ESCC). However, no ESCC suppressor gene has been identified from this chromosome. To define common deletion regions that possibly contain the ESCC suppressor gene(s), we performed a mapping of allelic loss in 50 esophageal squamous ce...

journal_title：Oncology reports

authors： Guo GM,Huang XP,Dong JT,Caia Y,Xu X,Han YL,Wu M,Zhan QM,Wang MR

更新日期：2005-12-01 00:00:00

abstract：:Chemotherapy is one of the methods to treat patients with non-small cell lung cancer (NSCLC) developing resistance to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs), such as gefitinib. Previous studies revealed that the sensitivity to chemotherapy may depend on different cellular mechanisms ...

journal_title：Oncology reports

authors： Zhou J,Hu Q,Zhang X,Zheng J,Xie B,Xu Z,Zhang W

更新日期：2018-04-01 00:00:00

abstract：:Drug resistance is one of the major obstacles to chemotherapy of ovarian cancer. Studies with cell lines can serve as an initial screen for agents that might modulate drug resistance. To establish more appropriate models of drug resistance and explore whether the differences exist in the different drug resistant subli...

journal_title：Oncology reports

authors： Yan XD,Li M,Yuan Y,Mao N,Pan LY

更新日期：2007-05-01 00:00:00

abstract：:Somatic inactivation of the von Hippel-Lindau (VHL) gene is the most frequent genetic event observed in clear cell renal cell carcinoma (CC-RCC). However, the prognostic relevance of somatic VHL alteration and its target, hypoxia inducible factor (HIF)-1alpha has not been defined. We investigated the genetic changes i...

journal_title：Oncology reports

authors： Kim JH,Jung CW,Cho YH,Lee J,Lee SH,Kim HY,Park J,Park JO,Kim K,Kim WS,Park YS,Im YH,Kang WK,Park K

更新日期：2005-05-01 00:00:00

abstract：:BTG1, which belongs to the BTG/Tob family, regulates cell cycle progression in a variety of cell types and appears to play roles in inhibiting proliferation, promoting apoptosis and stimulating cellular differentiation in multiple cell types. However, it remains unclear whether BTG1 is a breast cancer suppressor gene,...

journal_title：Oncology reports

authors： Zhu R,Zou ST,Wan JM,Li W,Li XL,Zhu W

更新日期：2013-11-01 00:00:00

abstract：:The isothiocyanates (ITCs) have long been known to possess chemopreventive activities for a variety of neoplasms including breast cancer, but the molecular mechanism by which ITCs prevent breast cancer development has not been established. In this study, we investigated the effects of benzyl and phenethyl isothiocyana...

journal_title：Oncology reports

authors： Kang L,Ding L,Wang ZY

更新日期：2009-01-01 00:00:00

abstract：:hTERTC27, a 27-kDa hTERT C-terminal polypeptide has been demonstrated to cause hTERT-positive HeLa cell apoptosis and inhibits the growth of mouse melanoma. hTERTC27 has been associated with telomere dysfunction, regulation of gene-regulated apoptosis, the cell cycle and activation of natural killer (NK) cells, but it...

journal_title：Oncology reports

authors： Gong HX,He L,Li XP,Wang YD,Li Y,Huang JJ,Wang Z,Xie D,Kung HF,Peng Y

更新日期：2012-04-01 00:00:00

abstract：:The overexpression of EGFR and/or HER-2 is associated with tumor cell resistance to chemotherapy, radiotherapy, disease progression and poor prognosis in patients with a variety of malignant tumors. Treatment combining the EGFR-targeting drug, gefitinib (ZD1839, Iressa) with the HER-2-targeting drug, trastuzumab (Herc...

journal_title：Oncology reports

authors： Kondo N,Ishiguro Y,Kimura M,Sano D,Fujita K,Sakakibara A,Taguchi T,Toth G,Matsuda H,Tsukuda M

更新日期：2008-08-01 00:00:00

abstract：:Implicated in several physiologic processes, including tumour-host, some transglutaminases (TGase) have been noted to play a regulatory role in the extracellular matrix in cell adhesion and migration of cancer cells. This study sought to determine the level of expression of TGases and their possible clinical significa...

journal_title：Oncology reports

authors： Jiang WG,Ablin R,Douglas-Jones A,Mansel RE

更新日期：2003-11-01 00:00:00

abstract：:Post-transcriptional modification of p53 by phosphorylation has been proposed as an important mechanism of p53 stabilization and functional regulation. However, little is known about the phosphorylation state of mutant p53 protein overexpressed in human tumors. We evaluated immunohistochemically the p53 phosphorylatio...

journal_title：Oncology reports

authors： Matsumoto M,Furihata M,Kurabayashi A,Ohtsuki Y

更新日期：2004-11-01 00:00:00

abstract：:Protocadherin-10 (PCDH10), a member of non-clustered protocadherin family which plays important roles in calcium-dependent cell-cell signal transduction and adhesion. PCDH10 functions as a tumor suppressor gene and its expression is downregulated by promoter methylation in many malignances. In the present study, we ex...

journal_title：Oncology reports

authors： Qiu C,Bu X,Jiang Z

更新日期：2016-07-01 00:00:00

abstract：:Distant metastases represent the major cause of death after curative surgery of colorectal cancer. The aim of this study was to evaluate the role of Smad4 and KRAS genetic alterations in colorectal metastases taking into account both the site (hepatic versus extrahepatic) and the time (synchronous versus metachronous)...

journal_title：Oncology reports

authors： Losi L,Bouzourene H,Benhattar J

更新日期：2007-05-01 00:00:00

abstract：:The mechanisms leading to squamous cell carcinoma of head and neck (SCCHN) metastasis are not fully understood. Although evidence shows that the chemokine receptor 7 (CCR7) and its ligand CCL19 may regulate tumor dissemination, their role is not clearly defined in SCCHN. Matrix metalloproteinases break consisting of t...

journal_title：Oncology reports

authors： Guo N,Liu F,Yang L,Huang J,Ding X,Sun C

更新日期：2014-08-01 00:00:00

abstract：:Graft-versus-host disease (GVHD) is a devastating complication of hematopoietic stem cell transplantation (HSCT), and is characterized by systemic inflammation and tissue damage in multiple organs, such as the liver and small intestine. Interleukin-18 (IL-18), an important pro-inflammatory cytokine, is elevated during...

journal_title：Oncology reports

authors： Li X,Zhang C,Chen W,Pan B,Kong F,Zheng K,Tang R,Zeng L

更新日期：2015-10-01 00:00:00

abstract：:Colon cancer is the fourth and third most common cancer, respectively in men and women worldwide and its incidence is on the increase. Stress response has been associated with the incidence and development of cancer. The catecholamines (CA), adrenaline (AD) and noradrenaline (NA), are crucial mediators of stress respo...

journal_title：Oncology reports

authors： Coelho M,Moz M,Correia G,Teixeira A,Medeiros R,Ribeiro L

更新日期：2015-05-01 00:00:00

abstract：:An intestinal bacterial metabolite of ginseng protopanaxadiol saponin, 20-O-(β-D-glucopyranosyl)-20(S)-protopanaxadiol (compound K), has been reported to induce apoptosis in a variety of cancer cells. However, the precise mechanisms induced by compound K in human hepatocellular carcinoma (HCC) cells remain unclear. In...

journal_title：Oncology reports

authors： Zheng ZZ,Ming YL,Chen LH,Zheng GH,Liu SS,Chen QX

更新日期：2014-07-01 00:00:00

abstract：:Chronic pancreatitis/pancreatic cancer (CP/PC) is characterized by fibrous connective tissue proliferation induced by activated pancreatic stellate cells (PSCs). Galectin-1 is upregulated in activated PSCs and is important for the continuing activation of PSCs. The aim of this study was to evaluate the effect of galec...

journal_title：Oncology reports

authors： Tang D,Wu Q,Zhang J,Zhang H,Yuan Z,Xu J,Chong Y,Huang Y,Xiong Q,Wang S,Tian Y,Lu Y,Ge X,Shen W,Wang D

更新日期：2018-03-01 00:00:00

abstract：:Vitamin K2 (VK2) has been shown to have a potent anti-tumor effect against several cancer types including hepatocellular carcinoma (HCC), but the mechanisms remain to be elucidated. Matrix metalloproteinase (MMP) plays an important role in the invasion and metastasis of cancer cells, but it is not known whether VK2 re...

journal_title：Oncology reports

authors： Ide Y,Zhang H,Hamajima H,Kawaguchi Y,Eguchi Y,Mizuta T,Yamamoto K,Fujimoto K,Ozaki I

更新日期：2009-09-01 00:00:00

abstract：:Breast cancer metastasizes to the bone in a majority of patients with advanced disease resulting in bone destruction. The underlying mechanisms are complex, and both processes are controlled by an interaction between locally and systemically derived signals. Clinically, breast cancer patients with depression have a hi...

journal_title：Oncology reports

authors： Zong JC,Wang X,Zhou X,Wang C,Chen L,Yin LJ,He BC,Deng ZL

更新日期：2016-02-01 00:00:00

abstract：:Despite improvements in immunotherapy, little is known about dendritic cell (DC) subpopulations naturally occurring in the laryngeal cancer tissue (LCT) and peripheral blood (PB) of untreated laryngeal cancer (LC) patients. The purpose of the present study was to evaluate mature, im...

journal_title：Oncology reports

authors： Klatka J,Grywalska E,Tabarkiewicz J,Polak A,Rolinski J

更新日期：2012-07-01 00:00:00

abstract：:Loss of proliferative control and failure to undergo cellular differentiation are key events during carcinogenesis. We recently identified a new potential tumor suppressor gene named MTUS1 (mitochondrial tumor suppressor 1), down-regulated in undifferentiated tumor cell lines, inhibiting tumor cell proliferation after...

journal_title：Oncology reports

authors： Zuern C,Heimrich J,Kaufmann R,Richter KK,Settmacher U,Wanner C,Galle J,Seibold S

更新日期：2010-01-01 00:00:00

abstract：:The aberrant expression of miR107‑5p is closely related to the development of several types of human cancers. However, the role of miR‑107‑5p in endometrial carcinoma (EC) has not been fully confirmed. In the present study, we aimed to explore the function of miR‑107‑5p in EC carcinogenesis. EC samples and normal endo...

journal_title：Oncology reports

authors： Bao W,Zhang Y,Li S,Fan Q,Qiu M,Wang Y,Li Y,Ji X,Yang Y,Sang Z,Xu W,Yang Y,Wu S,Zhu Y

更新日期：2019-03-01 00:00:00

abstract：:Cervical cancer is the second most common gynecological malignancy. The mechanisms of the genesis and progression of cervical cancer are complicated and not thoroughly understood. DEK is reported as an oncogene in various cancers, such as acute myeloid leukemia, bladder cancer, breast cancer and hepatocellular cancer....

journal_title：Oncology reports

authors： Xu X,Zou L,Yao Q,Zhang Y,Gan L,Tang L

更新日期：2017-08-01 00:00:00

abstract：:This study was mainly focused on the development of a dual-ligand liposomal delivery system for targeting the delivery of paclitaxel (PTX) to lung cancer. The specific ligand peptide HAIYPRH (T7) and the cationic cell-penetrating peptide TAT were connected with phospholipid via a polyethylene glycol (PEG) spacer to pr...

journal_title：Oncology reports

authors： Wang RH,Cao HM,Tian ZJ,Jin B,Wang Q,Ma H,Wu J

更新日期：2015-02-01 00:00:00

abstract：:It is well known that low-dose metronomic chemotherapy has antiangiogenic activity. The aim of the present trial was to investigate the antiangiogenic properties of weekly docetaxel in patients with metastatic breast cancer. In total, 157 metastatic breast cancer patients received 3...

journal_title：Oncology reports

authors： Pectasides D,Papaxoinis G,Kotoula V,Fountzilas H,Korantzis I,Koutras A,Dimopoulos AM,Papakostas P,Aravantinos G,Varthalitis I,Kosmidis P,Skarlos D,Bournakis E,Bafaloukos D,Kalofonos HP,Kalogeras KT,Fountzilas G

更新日期：2012-01-01 00:00:00

abstract：:The components of the Wnt-signaling pathway are mutated in tumors, but the relationship between these components and cervical cancer has not been elucidated. In this study, we used immunohistochemistry, single strand confirmation polymorphism (SSCP) and direct sequencing methods to analyze the mutation and protein exp...

journal_title：Oncology reports

authors： Su TH,Chang JG,Yeh KT,Lin TH,Lee TP,Chen JC,Lin CC

更新日期：2003-09-01 00:00:00