Abstract:
:The components of the Wnt-signaling pathway are mutated in tumors, but the relationship between these components and cervical cancer has not been elucidated. In this study, we used immunohistochemistry, single strand confirmation polymorphism (SSCP) and direct sequencing methods to analyze the mutation and protein expressions of both CTNNB1 and AXIN1 in cervical cancer. Among the 30 tested cervical cancers, no mutation of CTNNB1 but 3 polymorphisms were found. Mutation analysis of AXIN1 revealed that one specimen had a heterozygous mutation at codon 740 (GCC right curved arrow ACC) and six polymorphisms were also found. Immunohistochemistry showed no relationship between the protein expression patterns and mutation of AXIN1 and CTNNB1. Mutations of CTNNB1 may not be a factor, whereas mutations of AXIN1 may play a limited role in tumorigenesis of cervical cancer. In addition, aberrant expression patterns are not mutation related, so that other factors may be responsible for these changes.
journal_name
Oncol Repjournal_title
Oncology reportsauthors
Su TH,Chang JG,Yeh KT,Lin TH,Lee TP,Chen JC,Lin CCkeywords:
subject
Has Abstractpub_date
2003-09-01 00:00:00pages
1195-200issue
5eissn
1021-335Xissn
1791-2431journal_volume
10pub_type
杂志文章相关文献
ONCOLOGY REPORTS文献大全abstract::MicroRNAs (miRNAs) are reported to be involved in renal hypoxia/reoxygenation (H/R) damage. To investigate this further, human kidney (HK‑2) cells were cultured, subjected to H/R and the function of miR‑30a‑5p and glutamate dehydrogenase 1 (GLUD1) was evaluated. The results showed that, miR‑30‑5p was downregulated and...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2020.7718
更新日期:2020-10-01 00:00:00
abstract::The nitrostyrene scaffold was previously identified as a lead target structure for the development of effective compounds targeting Burkitt's lymphoma. The present study aimed to develop these compounds further in haematological malignancies, including chronic lymphocytic leukaemia (CLL). Cellular viability, flow cyto...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2019.7068
更新日期:2019-05-01 00:00:00
abstract::A number of possible preventive agents for cancers in different organs have been reported, however, little information is available regarding the effective agents for the development of gastric cancers. The rice components are known to be effective for the prevention of the development of cancers. Our group has demons...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2008-01-01 00:00:00
abstract::A phase II trial was conducted to evaluate the tolerability and efficacy of incorporating cetuximab and simultaneous integrated boost intensity-modulated radiation therapy (SIB-IMRT) into a well-described 5-fluorouracil (5-FU) and hydroxyurea (HU)-based chemoradiation regimen. Patients with stage IVa-IVb or high-risk ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2012.1679
更新日期:2012-05-01 00:00:00
abstract::The 5-year survival rate of nasopharyngeal carcinoma (NPC) is still disappointing despite the much improved technologies in its treatment. Tumor necrosis factor-related apoptosis inducing ligand (TRAIL) can selectively induce apoptosis in most tumor cells while sparing normal cells....
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2011.1423
更新日期:2011-12-01 00:00:00
abstract::Non‑small cell lung cancer (NSCLC) is the leading cause of cancer‑related deaths worldwide. Cisplatin‑based chemotherapy currently represents the main treatment option for patients with NSCLC. The aim of the present study was to evaluate effect of single nucleotide polymorphisms (SNPs) within the excision repair cross...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2021.7935
更新日期:2021-01-14 00:00:00
abstract::ZNF652, a DNA binding transcription factor, was previously suggested to be differentially expressed in prostate cancer. This study investigated if the expressions of ZNF652 and androgen receptor (AR) in prostate cancer are associated with prostate specific antigen (PSA) defined relapse. ZNF652 and AR immunoreactivity ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or_00000731
更新日期:2010-04-01 00:00:00
abstract::Purvalanol, a novel cyclin-dependent kinase inhibitor, is referred to as a strong apoptotic inducer which causes cell cycle arrest in various cancer cells such as prostate, breast and colon cancer cell lines. Various physiological and pathological conditions such as glucose starvation, inhibition of protein glycosylat...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2015.3918
更新日期:2015-06-01 00:00:00
abstract::CXC chemokine receptor 4 (CXCR4) is associated with poor clinical outcomes and decreased survival in hepatocellular carcinoma (HCC). In the present study, we targeted CXCR4 by CRISPR/Cas9 in HepG2 cells and observed the effects both in vitro and in vivo. The results indicated that after targeting CXCR4 the expression ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2017.5601
更新日期:2017-06-01 00:00:00
abstract::miR-95 has been revealed to be aberrantly expressed in multiple types of cancer and to regulate tumor development. Moreover, miR-95 has been revealed to be downregulated in gastric cancer. However, the detailed function of miR-95 in gastric cancer has remained largely unknown. In the present study, we found that miR-9...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2018.6911
更新日期:2019-02-01 00:00:00
abstract::During the initial emergency operation, a temporary loop colostomy (TLC) was constructed at the oral border of the region for subsequent radical resection. Then, radical surgery was performed by hybrid 2-port HALS (Mukai's operation) using the TLC as the hand access site. Left hemicolectomy was done in three patients,...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or_00000824
更新日期:2010-07-01 00:00:00
abstract::Cellular senescence is a state of irreversible growth arrest that can be triggered by multiple mechanisms, including telomere shortening, the epigenetic derepression of the INK4α/ARF locus and DNA damage. Senescence has been considered a tumor‑suppressing mechanism that permanently arrests cells at risk for malignant ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2015.4473
更新日期:2016-02-01 00:00:00
abstract::By combining suppression subtractive hybridization and microarray to examine gene expressions between metastatic and non-metastatic non-small cell lung cancer (NSCLC), we have identified differential expression spectra of matrix metalloproteinases (MMP). Among MMPs, expressions of MMP-13, -14, -15 and -24 decreased, t...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2004-10-01 00:00:00
abstract::Although antiestrogens significantly improve the survival of patients with ER-positive breast cancer, therapeutic resistance remains a major limitation. The combinatorial use of antiestrogen with other therapies was proposed to increase their efficiency and more importantly, to prevent or delay the resistance phenomen...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2016.4873
更新日期:2016-08-01 00:00:00
abstract::This study was mainly focused on the development of a dual-ligand liposomal delivery system for targeting the delivery of paclitaxel (PTX) to lung cancer. The specific ligand peptide HAIYPRH (T7) and the cationic cell-penetrating peptide TAT were connected with phospholipid via a polyethylene glycol (PEG) spacer to pr...
journal_title:Oncology reports
pub_type: 杂志文章,收录出版
doi:10.3892/or.2014.3644
更新日期:2015-02-01 00:00:00
abstract::The purpose of this study was to define gene expression profile changes in colorectal tumors in order to identify target genes involved in neoplastic progression. cDNA microarray analysis was used to detect differences in gene expression profiles between colon tumor samples obtained from 20 patients in different tumor...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2004-08-01 00:00:00
abstract::Renal cell carcinoma (RCC) is the most frequent type of renal-originated malignancy. Although nephrectomy is successfully used to save the lives of patients with localized RCC, treatment of advanced and other refractory RCCs is poor and still inadequate. Here, we show that triptolide, a small molecule and a well-known...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2011.1158
更新日期:2011-04-01 00:00:00
abstract::Pancreatic cancer is one of the most fatal types of cancer and is associated with a dismal prognosis. Gemcitabine-based chemotherapy is clinically used for the treatment of advanced pancreatic cancer. However, many forms of pancreatic cancer have acquired resistance to gemcitabine. In order to prevent patients from su...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2017.6026
更新日期:2017-12-01 00:00:00
abstract::Membrane-associated RING-CH (MARCH) belongs to the family of RING-CH type E3 ubiquitin ligases. MARCH1 ubiquitinates and downregulates MHC class II expression in APCs and targets major players of the immune system. However, the role of MARCH1 in ovarian cancer has not been elucidated. The present study investigated th...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2016.5076
更新日期:2016-11-01 00:00:00
abstract::Telomere-associated proteins function as survival factors in telomere maintenance, which are major contributors to radiosensitivity in human cancers. The aim of this study was to investigate the association of telomere-associated gene expression and radiation resistance in human larynx squamous carcinoma. The changes ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or_00000381
更新日期:2009-06-01 00:00:00
abstract::Interleukin-15 (IL-15) has important anabolic effects on muscle protein metabolism through a decrease in the ATP-ubiquitin-dependent proteolytic pathway. The role of IL-15 in human cancer cachexia is unknown. The aim of this study was to assess the relationship between interleukin-1...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2012.1928
更新日期:2012-10-01 00:00:00
abstract::Esculetin, a phenolic compound, has been shown to inhibit the growth of colon tumors in animal studies. However, the roles of signaling pathways and cell cycle regulation in the esculetin-induced inhibition of cancer cell growth, remain to be elucidated. The present study suggests a novel mechanism for the Ras/ERK1/2 ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2011-01-01 00:00:00
abstract::DNA double-strand breaks (DSBs) induced by ionizing radiation (IR) are among the most cytotoxic types of DNA damage. The DNA damage response (DDR) may be a reason for the cancer cell resistance to radiotherapy using IR. Identified as critical upstream mediators of the phosphorylation of ataxia telangiectasia-mutated (...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2015.3980
更新日期:2015-07-01 00:00:00
abstract::Neuroblastoma is an aggressive pediatric tumor that accounts for 15% of cancer-related deaths in children. More than half of high-risk neuroblastoma patients develop tumor relapse that is lethal in most cases. A small population of tumor-initiating cells (TICs), recently identified from high-risk neuroblastoma patient...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2012.1731
更新日期:2012-06-01 00:00:00
abstract::Immature colon carcinoma transcript-1 (ICT1) is a newly identified oncogene, which regulates proliferation, cell cycle progression and apoptosis of cancer cells. However, the clinical significance, biological function and underlying mechanisms of ICT1 in hepatocellular carcinoma (HCC) remain poorly known. In the prese...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2017.6046
更新日期:2017-12-01 00:00:00
abstract::The aim of the present study was to screen gastric cancer (GC) tissue and adjacent tissue for differences in mRNA and circular (circRNA) expression, to analyze the differences in circRNA and mRNA expression, and to investigate the circRNA expression in gastric carcinoma and its mechanism. circRNA and mRNA differential...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2017.5415
更新日期:2017-03-01 00:00:00
abstract::Epithelial-to-mesenchymal transition (EMT) endows cancer cells with enhanced invasive and metastatic potential during cancer progression. Fractalkine, also known as chemokine (C-X3-C motif) ligand 1 (CX3CL1), the only member recognized so far that belongs to the CX3C chemokine subfamily, was reported to participate in...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2015.4470
更新日期:2016-02-01 00:00:00
abstract::Combined chemotherapy with 5-fluorouracil and leucovorin (LV) has been widely used for the treatment of patients with colorectal cancer. Given that LV effects are attributable to increased levels of reduced folate in cancer cells, we attempted here to show the in vivo role of folylpolyglutamate synthetase (FPGS), whic...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2011.1206
更新日期:2011-05-01 00:00:00
abstract::Signal transducer and activator of transcription 3 (STAT3) is an oncogene that promotes cell survival, proliferation, and motility. In the present study, we explored the mechanism involved in the inhibition by epigallocatechin-3-gallate (EGCG) of STAT3 signaling as detected by surface plasmon resonance (SPR)-binding a...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2013.2743
更新日期:2013-12-01 00:00:00
abstract::Cisplatin (DDP), a cytotoxic antitumor drug, functions in a dose-dependent manner. However, the pursuit for high‑dose therapeutic effects leads to more serious side effects including kidney toxicity. Nephrotoxicity caused due to endothelial cell dysfunction and neutrophils infiltration in kidneys. Interleukin-8 (IL-8)...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2014.3659
更新日期:2015-02-01 00:00:00