Triptolide-induced cell cycle arrest and apoptosis in human renal cell carcinoma cells.

abstract：:The promigratory molecule L1CAM is overexpressed in various tumors, often representing an unfavorable prognostic marker. Recently, we identified L1CAM expression in pancreatic ductal adenocarcinoma (PDAC) cells accounting for chemoresistance and increased cell migration. Thus, the present study aims at further elucida...

journal_title：Oncology reports

authors： Bergmann F,Wandschneider F,Sipos B,Moldenhauer G,Schniewind B,Welsch T,Schirrmacher P,Klöppel G,Altevogt P,Schäfer H,Sebens Müerköster S

更新日期：2010-10-01 00:00:00

abstract：:In a human cancer cell line, we previously found a mutation in codon 322 of the extracellular signal-regulated kinase (ERK2E322K), the protein showed a faster migration when compared to wild-type in SDS-PAGE and constitutive phosphorylation. However, the reason for the faster migration, and the biochemical and biologi...

journal_title：Oncology reports

authors： Mahalingam M,Arvind R,Ida H,Murugan AK,Yamaguchi M,Tsuchida N

更新日期：2008-10-01 00:00:00

abstract：:To elucidate the mechanism of resistance to 5-fluorouracil (5-FU) in human gastric cancer cells, we established a cell line MKN45/F2R, which acquired 5-FU resistance as a result of continuous exposure to increasing dosages of 5-FU over a year. The cell line showed 157-fold elevated 5-FU resistance compared to the MKN4...

journal_title：Oncology reports

authors： Tsutani Y,Yoshida K,Sanada Y,Wada Y,Konishi K,Fukushima M,Okada M

更新日期：2008-12-01 00:00:00

abstract：:TRIM58 (tripartite motif containing 58) has been reported as a novel methylated gene in hepatocellular carcinoma (HCC) by methylation microarrays. However, its associations with mRNA expression and clinicopathological characteristics have not been evaluated. In this study, we explored the potential clinical implicatio...

journal_title：Oncology reports

authors： Qiu X,Huang Y,Zhou Y,Zheng F

更新日期：2016-08-01 00:00:00

abstract：:The incidence of well‑differentiated thyroid cancer (WDTC) is rapidly increasing. Poor survival follows distant metastasis (DM) and recurrence. In the present study, we aimed to analyze the expression alterations in different stages of WDTC and the regulatory mechanism of DM and the recurrence of DM. A male patient di...

journal_title：Oncology reports

authors： Zhang YJ,Ma YS,Xia Q,Yu F,Lv ZW,Jia CY,Jiang XX,Zhang L,Shao YC,Xie WT,Lu GX,Yv XQ,Zhong P,Fu D,Wang XF

更新日期：2018-12-01 00:00:00

abstract：:Bmal1 is a core factor in the regulation of circadian rhythms. Previous studies have shown that Bmal1 suppresses tumor growth in cell culture and animal models and is downregulated in certain types of cancer. The aim of the present study was to investigated whether Bmal1 influences the invasiveness of cancer cells. We...

journal_title：Oncology reports

authors： Jung CH,Kim EM,Park JK,Hwang SG,Moon SK,Kim WJ,Um HD

更新日期：2013-06-01 00:00:00

abstract：:We previously reported that chromosome arm 10q is one of the target regions of allelic loss in human endometrial cancer. To identify the gene in this region responsible for endometrial cancer, we further characterized this region and localized the hBRAG gene. The function of hBRAG has not yet been fully studied, and t...

journal_title：Oncology reports

authors： Yuki M,Yoshinaga K,Yamakawa H,Sakurada K,Sato S,Yajima A,Horii A

更新日期：2000-11-01 00:00:00

abstract：:Despite the well-documented advantages of the recombinant adeno-associated virus (rAAV) as a gene delivery vehicle, including its non-pathogenic and long-term therapeutic gene expression, there have been very limited studies on its potential for producing persistent anti-tumor effects, particularly in vivo. To address...

journal_title：Oncology reports

authors： Kim JY,Kim JH,Khim M,Lee HS,Jung JH,Moon DH,Jeong S,Lee H

更新日期：2011-05-01 00:00:00

abstract：:Caspases play an essential role in the initiation/regulation of apoptosis. Aberrant apoptotic regulation has been associated with carcinogenesis and therapeutic resistance. To explore the possible involvement of altered caspase expression in breast cancer, we have systematically examined the expression of both protein...

journal_title：Oncology reports

authors： Yang S,Liu J,Thor AD,Yang X

更新日期：2007-05-01 00:00:00

abstract：:Glucocorticoids (GCs) are known potent clinical drugs, however, their mode of action is still complex and debatable. Macrophages are the most important target of GCs and play a key role in tumor immunity in vivo, but their relationship is also controversial. In the present study, the lentivirus system was used to over...

journal_title：Oncology reports

authors： Ai F,Zhao G,Lv W,Liu B,Lin J

更新日期：2020-02-01 00:00:00

abstract：:Garlic and its constituents are reported to have a preventive effect against colorectal cancer in animal models. Aged garlic extract (AGE), which is produced by natural extraction from fresh garlic for more than 10 months in aqueous ethanol, also has reputed chemopreventive effects on colon carcinogenesis, but has nev...

journal_title：Oncology reports

authors： Jikihara H,Qi G,Nozoe K,Hirokawa M,Sato H,Sugihara Y,Shimamoto F

更新日期：2015-03-01 00:00:00

abstract：:T cell-mediated cell immunity is the main anti-tumor immunity in which the effector T cells need specific antigen and costimulatory signals. One of the vaccines applied in tumor immunotherapy is the gene-modified tumor cell vaccine. One potential method to increase cell epitope density is to link the antigen with the ...

journal_title：Oncology reports

authors： Fang L,Wang K,Liu X,Zhang L,Zhang X,Qian L,Lu J,Qian G,Ge S

更新日期：2008-06-01 00:00:00

abstract：:Although the human telomerase reverse transcriptase (hTERT) promoter can regulate cancer-specific genes, it is generally too weak to be effective. We therefore attempted to improve the potency of synthetic hTERT promoters by fusing the core element (E) of the hTERT promoter (H) and the tripartite leader sequence (T) f...

journal_title：Oncology reports

authors： Kim SJ,Lee HS,Shin JH,Kim CG,Jeong S,Park K,Choe H,Lee H

更新日期：2006-11-01 00:00:00

abstract：:The effectiveness of granulocyte colony-stimulating factor (G-CSF) for granulocytopenia has been widely recognized. However, although granulocyte counts rapidly increase after a few injection of G-CSF, a large proportion of the increased granulocytes disappear from peripheral blood within a few days following G-CSF wi...

journal_title：Oncology reports

authors： Ogawa Y,Kobayashi T,Nishioka A,Kariya S,Garcia Del Saz E,Seguchi H,Yoshida S

更新日期：2001-09-01 00:00:00

abstract：:In the development and progression of cancer, tumor suppressor genes may be silenced by mechanisms such as methylation. Thus the discovery of new genes silenced by methylation may uncover new tumor suppressor genes, and improve our understanding of cancer biology. In this study we investigated the methylation of 19 ge...

journal_title：Oncology reports

authors： Tsunoda S,Smith E,De Young NJ,Wang X,Tian ZQ,Liu JF,Jamieson GG,Drew PA

更新日期：2009-04-01 00:00:00

abstract：:Glioma is the most frequent and aggressive primary tumor of the brain in humans. Over the last few decades, significant progress has been made in early detection and multi-mode treatments, but the prognosis of gliomas is still extremely poor. MicroRNAs are endogenously expressed non-coding, single strand and short RNA...

journal_title：Oncology reports

authors： Ma J,Yu J,Liu J,Yang X,Lou M,Liu J,Feng F,Ji P,Wang L

更新日期：2017-02-01 00:00:00

abstract：:Photodynamic therapy (PDT) using photosensitizer can induce diverse cellular responses, including apoptosis. Recently, it has been reported that PDT using methylaminolaevulinate may be effective in basal cell carcinoma. However, it is largely unknown whether PDT using a natural product such as curcumin can induce apop...

journal_title：Oncology reports

authors： Park K,Lee JH

更新日期：2007-03-01 00:00:00

abstract：:Tamoxifen and raloxifene are widely used in clinical practice. It has been found that tamoxifen treatment increases the risk of development of endometrial cancer. The effects of tamoxifen and raloxifene on endometrium might be caused by different estrogen receptor expression. The aim of the present study was immunohis...

journal_title：Oncology reports

authors： Koda M,Jarzabek K,Haczynski J,Knapp P,Sulkowski S,Wolczynski S

更新日期：2004-09-01 00:00:00

abstract：:Numerous studies have demonstrated that triptolide induces cell cycle arrest and apoptosis in human cancer cell lines. However, triptolide-induced DNA damage and inhibition of DNA repair gene expression in human skin cancer cells has not previously been reported. We sought the effects of triptolide on DNA damage and a...

journal_title：Oncology reports

authors： Chueh FS,Chen YL,Hsu SC,Yang JS,Hsueh SC,Ji BC,Lu HF,Chung JG

更新日期：2013-02-01 00:00:00

abstract：:Epithelial to mesenchymal transition (EMT) is a process implicated in cancer progression in which the underlying cellular changes have been identified mainly using in vitro models. We determined the expression of some putative EMT biomarkers including E-cadherin, beta-catenin, zinc finger factor Snail (Snail), transfo...

journal_title：Oncology reports

authors： Logullo AF,Nonogaki S,Pasini FS,Osório CA,Soares FA,Brentani MM

更新日期：2010-02-01 00:00:00

abstract：:MicroRNA-374a (miR-374a) is involved in the progress of various types of cancer, and may indicate a poor prognosis. However, its role in esophageal cancer remains to be determined. In the present study, the role of miR-374a in esophageal cancers and cancer cell growth was examined using miR-374a overexpression and und...

journal_title：Oncology reports

authors： Wang Y,Xin H,Han Z,Sun H,Gao N,Yu H

更新日期：2015-10-01 00:00:00

abstract：:Complement system activation contributes to various immune and inflammatory diseases, as well as cancers.However, the role of complement activation in the proliferation of cancer cells is not clear. In the present study, we investigated the consequences of complement activation on the proliferation of breast cancer ce...

journal_title：Oncology reports

authors： Lu Y,Hu XB

更新日期：2014-12-01 00:00:00

abstract：:One of the possible ways to augment dendritic cell (DC) efficacy in presentation of tumor antigens to effector T cells is pulsing them with tumor-cell lysates and incubation with certain immunostimulators. We present the results of an immunotherapeutic approach in a murine B78-H1 mo...

journal_title：Oncology reports

authors： Zapała Ł,Wolny R,Wachowska M,Jakóbisiak M,Lasek W

更新日期：2013-03-01 00:00:00

abstract：:The authors of the above article drew to our attention that they had identified three instances of data overlapping between data panels, suggesting that data purportedly showing results obtained under different experimental conditions had been derived from the same original source. Comparing between the two figures, t...

journal_title：Oncology reports

authors： Ji CX,Fan YH,Xu F,Lv SG,Ye MH,Wu MJ,Zh XG,Wu L

更新日期：2020-11-01 00:00:00

abstract：:The usefulness of diagnostic ultrasound in gene transfer was investigated. The hepatocellular carcinoma cell lines PRL/PRF/5 and Hep3B, and the pancreatic carcinoma Panc-1 cells were transfected with lipofectin or irradiated with a linear probe with a frequency of 8 MHz at a mechani...

journal_title：Oncology reports

authors： Tomizawa M,Shinozaki F,Sugiyama T,Yamamoto S,Sueishi M,Yoshida T

更新日期：2012-05-01 00:00:00

abstract：:Hyaluronan (HA), a component of the extracellular matrix, plays an important role in cell-cell adhesion and cell migration. Membrane type 1-matrix metalloproteinase (MT1‑MMP) is often expressed in invasive cancer cells. CD44, a transmembrane receptor for HA, is implicated in various adhesion-dependent cellular process...

journal_title：Oncology reports

authors： Kung CI,Chen CY,Yang CC,Lin CY,Chen TH,Wang HS

更新日期：2012-11-01 00:00:00

abstract：:The 5-year survival rate of nasopharyngeal carcinoma (NPC) is still disappointing despite the much improved technologies in its treatment. Tumor necrosis factor-related apoptosis inducing ligand (TRAIL) can selectively induce apoptosis in most tumor cells while sparing normal cells....

journal_title：Oncology reports

authors： Li SS,Yang S,Wang S,Yang XM,Tang QL,Wang SH

更新日期：2011-12-01 00:00:00

abstract：:The aim of this study was to verify whether histopathological features of extratumoral and of primary tumor breast tissue could play a role in identifying patients with familial characteristics. We examined the clinicopathological features of 504 patients with sporadic or familial breast cancer stratified for risk of ...

journal_title：Oncology reports

authors： Mangia A,Tommasi S,Bruno M,Malfettone A,D'Amico C,Zito FA,Paradiso A,Simone G

更新日期：2010-06-01 00:00:00

abstract：:We conducted a clinical pharmacological evaluation of paclitaxel/carboplatin combination in Japanese patients with non-small cell lung cancer. The purpose of this study was to identify the optimal dose of this combination and to investigate the relationships between the pharmacokinetic profiles of these 2 drugs, serum...

journal_title：Oncology reports

authors： Daga H,Isobe T,Miyazaki M,Fujitaka K,Kondo K,Kohno N

更新日期：2004-06-01 00:00:00

abstract：:The aim of the present study was to search for an effective regimen among existing chemotherapies for head and neck squamous cell carcinoma (HNSCC). Among the tested drugs, we focused on combined SN-38, which is the active metabolite produced from irinotecan hydrochloride - a type I DNA topoisomerase inhibitor - after...

journal_title：Oncology reports

authors： Nanbu T,Umemura N,Ohkoshi E,Nanbu K,Sakagami H,Shimada J

更新日期：2018-01-01 00:00:00