Silencing MARCH1 suppresses proliferation, migration and invasion of ovarian cancer SKOV3 cells via downregulation of NF-κB and Wnt/β-catenin pathways.

abstract：:Pin-1 has been shown to regulate several phases of the cell cycle and is strikingly overexpressed in many human cancers. Vascular endothelial growth factor (VEGF)-C is a potent lymphangiogenic factor produced by tumor and stromal cells. However, little is known about the roles of Pin-1 and VEGF-C in breast carcinoma. ...

journal_title：Oncology reports

authors： Kim BC,Han SI,Lim SC

更新日期：2009-12-01 00:00:00

abstract：:Enhanced cell migration and invasion play key roles in cancer metastasis. However, the molecules involved in this process are not fully understood. In this study, a full-length human BNIPL-2 (Bcl-2/adenovirus E1B 19 kDa interacting protein 2 like-2) cDNA was transfected into human hepatocellular carcinoma cells with l...

journal_title：Oncology reports

authors： Xie L,Qin W,Li J,He X,Zhang H,Yao G,Shu H,Yao M,Wan D,Gu J

更新日期：2007-03-01 00:00:00

abstract：:B-cell‑specific Moloney murine leukaemia virus integration site-1 (BMI-1) contributes to the growth of tumour cells post-irradiation (IR). The aim of the present study was to characterize the effects of BMI-1 on cell viability, radiosensitivity and its mechanisms of action in oesophageal squamous cell cancer (ESCC). W...

journal_title：Oncology reports

authors： Yang XX,Ma M,Sang MX,Zhang XY,Liu ZK,Song H,Zhu SC

更新日期：2018-02-01 00:00:00

abstract：:The mammalian target of rapamycin (mTOR) is a key kinase acting downstream of growth factor receptor PI3K and AKT signaling, leading to processes resulting in increased cell size and proliferation through translation control. Rapamycin, a specific inhibitor of mTOR, results predomin...

journal_title：Oncology reports

authors： Miyake N,Chikumi H,Takata M,Nakamoto M,Igishi T,Shimizu E

更新日期：2012-09-01 00:00:00

abstract：:Signal transducer and activator of transcription 3 (STAT3) regulates the expression of genes mediating cell survival, proliferation and angiogenesis and is aberrantly activated in various types of malignancies, including bladder cancer. We examined whether it could be a novel therapeutic target for bladder cancer usin...

journal_title：Oncology reports

authors： Tsujita Y,Horiguchi A,Tasaki S,Isono M,Asano T,Ito K,Asano T,Mayumi Y,Kushibiki T

更新日期：2017-10-01 00:00:00

abstract：:The protein p27/kip1 is a cyclin-dependent kinase inhibitor that regulates cell-cycle progression. In the present study, p27/kip1 expression as well as tumor cell proliferation and apoptosis were investigated in 80 colorectal carcinomas, using anti-p27/kip1 antibodies, in situ apoptosis detection kits and anti-PCNA an...

journal_title：Oncology reports

authors： Noguchi T,Kikuchi R,Ono K,Takeno S,Moriyama H,Uchida Y

更新日期：2003-07-01 00:00:00

abstract：:ETS‑domain containing protein (Elk1) is reported to be a member of the ETS oncogene family, and promotes tumorigenesis in cancer such as bladder, prostate and ovarian. Nevertheless, the role of Elk1 in thyroid cancer progression remains unclear. In the present study, we aimed to investigate the role and underlying mol...

journal_title：Oncology reports

authors： Kong Y,Yin J,Fu Y,Chen Y,Zhou Y,Geng X

更新日期：2018-09-01 00:00:00

abstract：:Carboxypeptidase X, M14 family member 2 (CPXM2), has been associated with several human disorders such as developmental diseases. However, whether CPXM2 is involved in oncogenesis or tumor progression remains unclear. In the present study, we used clinical samples from gastric cancer (GC) patients to investigate poten...

journal_title：Oncology reports

authors： Niu G,Yang Y,Ren J,Song T,Hu Z,Chen L,Hong R,Xia J,Ke C,Wang X

更新日期：2019-10-01 00:00:00

abstract：:Despite tremendous effort and progress in the diagnostics of pancreatic cancer with respect to imaging techniques and molecular genetics, only very few patients can be cured by surgery leading to a 5-year survival rate of only 3%. Especially the lack of chemotherapeutical options in this entity requires a better under...

journal_title：Oncology reports

authors： Domagk D,Schaefer KL,Eisenacher M,Braun Y,Wai DH,Schleicher C,Diallo-Danebrock R,Bojar H,Roeder G,Gabbert HE,Domschke W,Poremba C

更新日期：2007-02-01 00:00:00

abstract：:The inhibitor of differentiation/DNA binding 1 (Id-1), a negative regulator of basic helix-loop-helix transcription factors, plays an important role in the regulation of cell proliferation and differentiation. We examined the Id-1 expression by immunohistochemistry in 9 adenomas, 79 primary colorectal adenocarcinomas ...

journal_title：Oncology reports

authors： Zhao ZR,Zhang ZY,Zhang H,Jiang L,Wang MW,Sun XF

更新日期：2008-02-01 00:00:00

abstract：:3,3'-Diindolylmethane (DIM), an active metabolite of indole-3-carbinol, is thought to have antitumor effects in experimental animals and induce apoptosis in various cancer cells. However, the biological functions of DIM in human esophageal cancer cells are unknown. Thus, the purpose...

journal_title：Oncology reports

authors： Kim SJ,Lee JS,Kim SM

更新日期：2012-05-01 00:00:00

abstract：:We investigated a phase III randomized trial to compare efficacy and tolerance of CDDP + 5-FU to CDDP + VP16, both given intravenously in patients with unresectable advanced head and neck cancer. The 197 eligible patients were paired off successively on the basis of tumor sites and UICC stage. Comparisons were made th...

journal_title：Oncology reports

authors： Prévost A,Mérol JC,Aimé P,Moutel K,Roger-Liautaud F,Nasca S,Legros M,Coninx P

更新日期：2005-09-01 00:00:00

abstract：:Bone marrow-derived endothelial progenitor cells (EPC) play an important role in neovascularisation and tumor growth. However, the clinical relevance of EPCs on blood vessel formation in non-small cell lung cancer (NSCLC) is unclear. EPC numbers in circulation are very low and therefore their detection is technically ...

journal_title：Oncology reports

authors： Pircher A,Kähler CM,Skvortsov S,Dlaska M,Kawaguchi G,Schmid T,Gunsilius E,Hilbe W

更新日期：2008-02-01 00:00:00

abstract：:The multi-target kinase inhibitor sorafenib has been approved for the treatment of patients with advanced differentiated thyroid cancer. However, different sensitivities to sorafenib have been observed, and few patients have benefited from sorafenib treatment in the long term. In the event of acquired resistance to so...

journal_title：Oncology reports

authors： Yi H,Ye T,Ge M,Yang M,Zhang L,Jin S,Ye X,Long B,Li L

更新日期：2018-02-01 00:00:00

abstract：:Pancreatic cancer is one of the most fatal types of cancer and is associated with a dismal prognosis. Gemcitabine-based chemotherapy is clinically used for the treatment of advanced pancreatic cancer. However, many forms of pancreatic cancer have acquired resistance to gemcitabine. In order to prevent patients from su...

journal_title：Oncology reports

authors： Zhang YJ,Wen CL,Qin YX,Tang XM,Shi MM,Shen BY,Fang Y

更新日期：2017-12-01 00:00:00

abstract：:The aim of this study was to evaluate the clinicopathological prognostic factors in patients with stage IVb cervical carcinoma (CC). All patients with stage IVb CC included in the study were diagnosed from 1997 to 2006 at the National Cancer Center Hospital. We retrospectively examined clinicopathological parameters i...

journal_title：Oncology reports

authors： Nishio S,Katsumata N,Matsumoto K,Tanabe H,Yonemori K,Kohno T,Shimizu C,Ando M,Kasamatsu T,Fujiwara Y

更新日期：2008-02-01 00:00:00

abstract：:Ovarian cancer is one of the most common gynecological malignancies and its pathogenesis and progression are regulated by multiple genes. MicroRNAs (miRNAs) are endogenous non‑coding RNAs that regulate body function by altering post‑transcriptional gene expression. Previous studies have suggested that miRNAs are close...

journal_title：Oncology reports

authors： Wei L,He Y,Bi S,Li X,Zhang J,Zhang S

更新日期：2020-12-11 00:00:00

abstract：:MHC class I-related chain molecules A and B (MICA and B) expressed on the cell-surface of tumor cells are ligands for an activating receptor, NKG2D, expressed on natural killer (NK) cells and stimulate the NK cell-mediated cytotoxicity. On the other hand, the soluble form of MICA and B produced by proteolytic cleavage...

journal_title：Oncology reports

authors： Yamanegi K,Yamane J,Kobayashi K,Kato-Kogoe N,Ohyama H,Nakasho K,Yamada N,Hata M,Nishioka T,Fukunaga S,Futani H,Okamura H,Terada N

更新日期：2010-12-01 00:00:00

abstract：:Arginine and nitric oxide (NO) are important mediators of tumorigenesis in various types of cancer. Dysregulation of NO content by argininosuccinate lyase (ASL) has been previously demonstrated to inhibit the proliferation of liver and breast cancer cells. However, the function of ASL in colon cancer is not well defin...

journal_title：Oncology reports

authors： Huang HL,Chen WC,Hsu HP,Cho CY,Hung YH,Wang CY,Lai MD

更新日期：2017-01-01 00:00:00

abstract：:Previous studies have suggested that certain genetic polymorphisms, specifically the Xeroderma pigmentosum group D (XPD) gene codon 751 and the X-ray repair cross-complementing group 1 (XRCC1) gene codon 399 polymorphisms, were associated with an increased risk of lung cancer, and, in some studies, with a greater risk...

journal_title：Oncology reports

authors： Gao W,Romkes M,Zhong S,Nukui T,Persad RA,Smith PJ,Branch R,Keohavong P

更新日期：2010-07-01 00:00:00

abstract：:Cisplatin-paclitaxel and cisplatin-etoposide combination therapies were compared in limited and extensive disease in patients with small-cell lung cancer. The primary objectives were to determine median and overall survival, time to tumor progression and tolerance and the secondary objective, the response rate. From J...

journal_title：Oncology reports

authors： Dimitroulis J,Rapti A,Stathopoulos GP,Rigatos S,Stathopoulos J,Koutantos J,Athanasiadis A,Tsikritsaki K,Karaindros D,Katis K,Antoniou D,Toumbis M,Giamboudakis P

更新日期：2008-10-01 00:00:00

abstract：:Colon cancer is the fourth and third most common cancer, respectively in men and women worldwide and its incidence is on the increase. Stress response has been associated with the incidence and development of cancer. The catecholamines (CA), adrenaline (AD) and noradrenaline (NA), are crucial mediators of stress respo...

journal_title：Oncology reports

authors： Coelho M,Moz M,Correia G,Teixeira A,Medeiros R,Ribeiro L

更新日期：2015-05-01 00:00:00

abstract：:Dysregulation of microRNAs (miRNAs) occurs frequently in cervical carcinogenesis. miRNAs function as tumor-suppressors or oncogenes and are involved in tumor behavior. However, the expression and function of miR-27b in cervical carcinogenesis remain unknown. In the present study, we observed that miR-27b was significa...

journal_title：Oncology reports

authors： Yao J,Deng B,Zheng L,Dou L,Guo Y,Guo K

更新日期：2016-03-01 00:00:00

abstract：:The aim of the present study was to evaluate the antitumor effects of the curcumin analogue GL63 on radioresistant nasopharyngeal carcinoma (NPC) CNE2R cells and parental CNE2 cells. The cell viability and proliferation of NPC cells were detected by MTT assay and colony formation assay. The suppressive effect on tumor...

journal_title：Oncology reports

authors： Pan Y,Xiao J,Liang G,Wang M,Wang D,Wang S,Yang H

更新日期：2013-07-01 00:00:00

abstract：:Trop2 is considered to have an important function in tumor metastasis and the promotion of epithelial‑mesenchymal transition (EMT). E‑cadherin is a crucial factor in intercellular adhesion and EMT transformation. In the present study, we detected the expression of Trop2 and E‑cadherin in breast cancer (BC) to better d...

journal_title：Oncology reports

authors： Zhao W,Kuai X,Zhou X,Jia L,Wang J,Yang X,Tian Z,Wang X,Lv Q,Wang B,Zhao Y,Huang W

更新日期：2018-08-01 00:00:00

abstract：:The present study was designed to investigate the effects of Bowman-Birk inhibitor (BBI) on up-regulation of connexin (Cx) expression to estimate BBI's tumor-suppressor effect in mice with M5076 ovarian sarcoma. The relative tumor weight (p<0.05, r(2)=0.301) and proliferating cell nuclear antigen (PCNA, p<0.01, r(2)=0...

journal_title：Oncology reports

authors： Suzuki K,Yano T,Sadzuka Y,Sugiyama T,Seki T,Asano R

更新日期：2005-06-01 00:00:00

abstract：:We investigated whether 18F-fluorothymidine-positron-emission tomography/computed tomography (18F-FLT-PET/CT) is useful for the evaluation of the very early response to anti-epidermal growth factor receptor (EGFR) antibody cetuximab therapy in human lung cancer xenografts. A human tumor xenograft model was established...

journal_title：Oncology reports

authors： Takeuchi S,Zhao S,Kuge Y,Zhao Y,Nishijima K,Hatano T,Shimizu Y,Kinoshita I,Tamaki N,Dosaka-Akita H

更新日期：2011-09-01 00:00:00

abstract：:Hepatocellular carcinoma is the most common type of liver cancer. The risk of hepatocellular carcinoma for type 2 diabetic patients is greater than that for non-diabetic individuals although the mechanism is unclear. The cancer suppressor resveratrol inhibits cancer cell proliferation partly through the STAT3 signalin...

journal_title：Oncology reports

authors： Li Y,Zhu W,Li J,Liu M,Wei M

更新日期：2013-12-01 00:00:00

abstract：:Esophageal squamous cell carcinoma (ESCC), the main subtype of esophageal cancer (EC), is a common lethal type of cancer with a high mortality rate. The aim of the present study was to select key relevant genes and identify potential mechanisms involved in the development of ESCC based on bioinformatics analysis. Mini...

journal_title：Oncology reports

authors： Li X,Ren Z,Xiong C,Geng J,Li Y,Liu C,Ren C,Liu H

更新日期：2020-09-01 00:00:00

abstract：:Quercetin, a naturally occurring flavonoid abundant in fruits and vegetables, has been demonstrated as a multipotent bioflavonoid with great potential for the prevention and treatment of cancer. Apoptosis is thought to be an important response to most chemotherapeutic agents in leukemia cells. However, the underlying ...

journal_title：Oncology reports

authors： Lee WJ,Chen YR,Tseng TH

更新日期：2011-02-01 00:00:00