Abstract:
:The present study was designed to investigate the effects of Bowman-Birk inhibitor (BBI) on up-regulation of connexin (Cx) expression to estimate BBI's tumor-suppressor effect in mice with M5076 ovarian sarcoma. The relative tumor weight (p<0.05, r(2)=0.301) and proliferating cell nuclear antigen (PCNA, p<0.01, r(2)=0.493) were negatively correlated with the doses of BBI. In contrast, the relative density of Cx43 was positively correlated with the doses of BBI (p<0.05, r(2)=0.351). Therefore, it suggests that the anti-carcinogenic effects of BBI induced negative growth control caused by the expression of Cx43 genes in mice with M5076 ovarian sarcoma.
journal_name
Oncol Repjournal_title
Oncology reportsauthors
Suzuki K,Yano T,Sadzuka Y,Sugiyama T,Seki T,Asano Rkeywords:
subject
Has Abstractpub_date
2005-06-01 00:00:00pages
1247-50issue
6eissn
1021-335Xissn
1791-2431journal_volume
13pub_type
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