Minichromosome maintenance 6 complex component identified by bioinformatics analysis and experimental validation in esophageal squamous cell carcinoma.

abstract：:There is increasing evidence of an angiogenic response of irradiated tumors resulting in decreased radiation sensitivity. However, little is known about the contribution of tumor vascular endothelial growth factor (VEGF) or basic fibroblast growth factor (bFGF)-release induced by irradiation to the individual level of...

journal_title：Oncology reports

authors： Brieger J,Kattwinkel J,Berres M,Gosepath J,Mann WJ

更新日期：2007-12-01 00:00:00

abstract：:Androgen receptor (AR) expression in prostate cancer (CaP) cells varies due to the multiple changes including epigenetic modifications such as DNA methylation and histone deacetylation. DNA methyltransferase and histone deacetylase inhibitors are promising for the treatment of CaP. The aim of our study was to analyze ...

journal_title：Oncology reports

authors： Fialova B,Smesny Trtkova K,Paskova L,Langova K,Kolar Z

更新日期：2013-05-01 00:00:00

abstract：:One of the dose-limiting toxicities of irinotecan (CPT-11) is delayed-onset diarrhea, which is the greatest barrier to treatment with CPT-11-containing regimens. CPT-11 is converted to its active metabolite, SN-38, which is conjugated by hepatic uridine diphosphate glucuronosyl transferase to SN-38 glucuronide (SN-38G...

journal_title：Oncology reports

authors： Yamamoto M,Kurita A,Asahara T,Takakura A,Katono K,Iwasaki M,Ryuge S,Wada M,Onoda S,Yanaihara T,Yokoba M,Mitsufuji H,Nishii Y,Fukui T,Masuda N

更新日期：2008-10-01 00:00:00

abstract：:The present study aimed to assess the in vitro and in vivo magnetic resonance imaging (MRI) features of chlorotoxin (CTX)-conjugated superparamagnetic iron oxide (SPIO) nanoprobes. CTX-conjugated nanoprobes were composed of SPIO coated with polyethylene glycol (PEG) and conjugated with CTX. The nanoprobes were termed ...

journal_title：Oncology reports

authors： Chen Z,Xiao EH,Kang Z,Zeng WB,Tan HL,Li HB,Bian DJ,Shang QL

更新日期：2016-05-01 00:00:00

abstract：:Following the publication of this paper, it was drawn to the authors' attention by an interested reader that certain of the tumours featured in Fig. 6A of the above paper were strikingly similar to those featured in Fig. 8A of an article appearing in International Journal of Oncology (Fan F-Y, Deng R, Yi H, Sun H-P, Z...

journal_title：Oncology reports

authors： Zhang L,Liang X,Li Y

更新日期：2021-01-01 00:00:00

abstract：:Gastric cancer (GC) is one of the most lethal malignancies worldwide. To reduce its high mortality, sensitive and specific biomarkers for early detection are urgently needed. Recent studies have reported that tumor-specific long non-coding RNAs (lncRNAs) seem to be potential biomarkers for the early diagnosis and trea...

journal_title：Oncology reports

authors： Li C,Liang G,Yao W,Sui J,Shen X,Zhang Y,Ma S,Ye Y,Zhang Z,Zhang W,Yin L,Pu Y

更新日期：2016-03-01 00:00:00

abstract：:Implicated in several physiologic processes, including tumour-host, some transglutaminases (TGase) have been noted to play a regulatory role in the extracellular matrix in cell adhesion and migration of cancer cells. This study sought to determine the level of expression of TGases and their possible clinical significa...

journal_title：Oncology reports

authors： Jiang WG,Ablin R,Douglas-Jones A,Mansel RE

更新日期：2003-11-01 00:00:00

abstract：:Sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) 3 is involved in calcium mobilization from the endoplasmic reticulum into the cytosol and is closely linked to metabolism, neuronal plasticity, gene transcription, cell growth, differentiation, apoptosis, protein folding and carcinogenesis. In order to elucidate the role...

journal_title：Oncology reports

authors： Gou WF,Niu ZF,Zhao S,Takano Y,Zheng HC

更新日期：2014-01-01 00:00:00

abstract：:The development of drug resistance represents a major complication in the effective treatment of breast cancer. Epigenetic therapy, through the use of histone deacetylase inhibitors (HDACi) or demethylation agents, is an emerging area of therapeutic targeting in a number of ontologi...

journal_title：Oncology reports

authors： Rhodes LV,Nitschke AM,Segar HC,Martin EC,Driver JL,Elliott S,Nam SY,Li M,Nephew KP,Burow ME,Collins-Burow BM

更新日期：2012-01-01 00:00:00

abstract：:MicroRNA-154 (miR-154) has been identified as a tumor suppressor in several types of human cancers; however, its clinical significance and function in human hepatocellular carcinoma (HCC) remain unclear. The aim of the present study was to analyze the clinical significance and cellular function of miR-154 in HCC patie...

journal_title：Oncology reports

authors： Pang X,Huang K,Zhang Q,Zhang Y,Niu J

更新日期：2015-12-01 00:00:00

abstract：:Muscle atrophy F-Box (MAFbx)/atrogin-1 and muscle ring-finger-1 (MuRF-1) have been identified as two muscle-specific E3 ubiquitin ligases that are highly expressed in skeletal muscle during muscle atrophy. However, the role of muscle-specific E3 ubiquitin ligases during the process of muscle atrophy of cancer cachexia...

journal_title：Oncology reports

authors： Yuan L,Han J,Meng Q,Xi Q,Zhuang Q,Jiang Y,Han Y,Zhang B,Fang J,Wu G

更新日期：2015-05-01 00:00:00

abstract：:In this study, we demonstrate an important role of activation of the hypoxia-inducible factor-1 (HIF-1) pathway in endometrial carcinogenesis and tumor phenotype development of endometrial carcinoma, and suggest a unique role of the HIF-1-target gene, differentiated embryo chondrocyte 2 (DEC2), in carcinogenesis. Hypo...

journal_title：Oncology reports

authors： Yunokawa M,Tanimoto K,Nakamura H,Nagai N,Kudo Y,Kawamoto T,Kato Y,Hiyama E,Hiyama K,Nishiyama M

更新日期：2007-04-01 00:00:00

abstract：:Fluoroquinolones affect the proliferation and apoptotic cell death of several human malignancies. Therefore, we investigated whether new 6-aminoquinolone derivatives, initially synthesized as anti-HIV agents, could affect the proliferation and apoptotic cell death of human prostate cancer cell lines. PC3 and LNCaP cel...

journal_title：Oncology reports

authors： Minelli A,Bellezza I,Siciliano E,Liguori L,Tabarrini O,Cecchetti V,Fravolini A

更新日期：2005-06-01 00:00:00

abstract：:Angiogenesis is crucial for the development and metastasis of human brain glioma. Based on our previous successful construction of a lentivirus-mediated alphastatin (an endogenous angiogenesis inhibitor) gene transfer system and our findings that alphastatin exhibited potent inhibit...

journal_title：Oncology reports

authors： Che H,Song J,Guo S,Wang W,Gao G

更新日期：2013-03-01 00:00:00

abstract：:Lung cancer is the leading cause of cancer-related mortality in humans. Exploration of the mechanisms underlying the self-renewal and stemness maintenance of cancer stem-like cells (CSLCs) will open new avenues in lung cancer diagnosis and therapy. Here, we isolated and identified a subpopulation of lung cancer stem-l...

journal_title：Oncology reports

authors： Lu C,Huang T,Chen W,Lu H

更新日期：2015-07-01 00:00:00

abstract：:We radiographically evaluated the response of primary lesions to chemotherapy in 101 patients with inoperable advanced gastric cancer. The median survival time in the 50 responders (49.5%) was 379 days, as compared with only 210 days in the 51 non-responders (50.1%) (p<0. 001). Morphologic changes of the gastric mucos...

journal_title：Oncology reports

authors： Yamazaki I,Koizumi W,Kondo I,Saigenji K

更新日期：2000-11-01 00:00:00

abstract：:It has been demonstrated that microRNA‑192 (miR‑192) serves important roles in different cancer types, including breast cancer, prostate cancer and colorectal cancer. However, its biological role and function in breast cancer remains largely unknown. The present study aimed to determine the role of miR‑192 in breast c...

journal_title：Oncology reports

authors： Chen P,Feng Y,Zhang H,Shi X,Li B,Ju W,Yu X,Zhang N,Luo X

更新日期：2019-11-01 00:00:00

abstract：:During the initial emergency operation, a temporary loop colostomy (TLC) was constructed at the oral border of the region for subsequent radical resection. Then, radical surgery was performed by hybrid 2-port HALS (Mukai's operation) using the TLC as the hand access site. Left hemicolectomy was done in three patients,...

journal_title：Oncology reports

authors： Mukai M,Sekido Y,Hoshikawa T,Yazawa N,Fukumitsu H,Okada K,Tajima T,Nakamura M,Ogoshi K

更新日期：2010-07-01 00:00:00

abstract：:The immunohistochemical expression of type 1 blood group antigens (type 1 BGAs) was analyzed for 30 cases of testicular germ cell tumors (TGCTs), using monoclonal antibodies against DU-PAN-2, CA19-9, Lewis(a) (Le(a)), and Lewis(b) (Le(b)). DU-PAN-2 was expressed very frequently in all of the embryonal carcinomas (ECs)...

journal_title：Oncology reports

authors： Kamoshida S,Satoh Y,Yasuda M,Kajiwara H,Tsukinoki K,Osamura RY

更新日期：2002-07-01 00:00:00

abstract：:Although surgery and high‑dose radiotherapy have been the standard treatments for glioblastoma multiforme (GBM), these therapies are palliative, due to the high risk of local relapse. Emerging evidence has demonstrated that DNA double‑strand break (DSB) repair serves a critical role in resistance to radiotherapy. Prev...

journal_title：Oncology reports

authors： Mu F,Liu T,Zheng H,Xie X,Lei T,He X,Du S,Tong R,Wang Y

更新日期：2018-12-01 00:00:00

abstract：:New therapeutic approaches are mandatory for anaplastic thyroid cancer. We investigated the ability of a new combined treatment using valproic acid (VPA), the only clinically available histone deacetylase inhibitor, and the tyrosine-kinase inhibitor imatinib mesylate to control the cell growth of anaplastic thyroid ca...

journal_title：Oncology reports

authors： Catalano MG,Pugliese M,Poli R,Bosco O,Bertieri R,Fortunati N,Boccuzzi G

更新日期：2009-02-01 00:00:00

abstract：:Homeobox containing 1 (HMBOX1) is a novel transcription repressor that is significantly downregulated in human liver cancer tissues and cell lines, but the exact biological function of HMBOX1 in liver cancer is still unknown. We observed a negative association between HMBOX1 expression level and the clinical stages of...

journal_title：Oncology reports

authors： Zhao H,Jia H,Han Q,Zhang J

更新日期：2018-09-01 00:00:00

abstract：:Previously, we showed that the herbal extract EYK (Epimedium koreanum Nakai) can regulate the immune response. Other studies showed that EYK has beneficial effects in human lung cancer, angiogenesis and Alzheimer's disease (AD). However, it remains unknown whether EYK can affect cancer cell migration and invasion in h...

journal_title：Oncology reports

authors： Lee W,Nam JH,Cho HJ,Lee JY,Cho WK,Kim Υ,We YM,Ma JY,Hoe HS

更新日期：2017-12-01 00:00:00

abstract：:WNT signaling pathway networks with Hedgehog, Notch and FGF signaling pathways during carcinogenesis and embryogenesis. FZD8 is up-regulated in HeLa S3 and A549 cells. Here we identified and characterized rat Fzd8 gene by using bioinformatics. Rat Fzd8 gene was identified within AC131883.2 genome sequence. Rat Fzd8 (6...

journal_title：Oncology reports

authors： Katoh Y,Katoh M

更新日期：2005-05-01 00:00:00

abstract：:The protein p27/kip1 is a cyclin-dependent kinase inhibitor that regulates cell-cycle progression. In the present study, p27/kip1 expression as well as tumor cell proliferation and apoptosis were investigated in 80 colorectal carcinomas, using anti-p27/kip1 antibodies, in situ apoptosis detection kits and anti-PCNA an...

journal_title：Oncology reports

authors： Noguchi T,Kikuchi R,Ono K,Takeno S,Moriyama H,Uchida Y

更新日期：2003-07-01 00:00:00

abstract：:Epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase and mutations in this gene are major drivers of lung cancer development. EGFR tyrosine kinase inhibitors (TKIs) are standard first‑line therapies for patients with advanced non‑small cell lung cancer (NSCLC) with activating EGFR mutations, but are n...

journal_title：Oncology reports

authors： Ota K,Okuma T,Lorenzo A,Yokota A,Hino H,Kazama H,Moriya S,Takano N,Hiramoto M,Miyazawa K

更新日期：2019-07-01 00:00:00

abstract：:Glucocorticoids (GCs) are known potent clinical drugs, however, their mode of action is still complex and debatable. Macrophages are the most important target of GCs and play a key role in tumor immunity in vivo, but their relationship is also controversial. In the present study, the lentivirus system was used to over...

journal_title：Oncology reports

authors： Ai F,Zhao G,Lv W,Liu B,Lin J

更新日期：2020-02-01 00:00:00

abstract：:Epithelial ovarian cancer (EOC) is the most common cause of gynecological cancer-related mortality. Clear cell EOC (cEOC) has a number of clinical features distinguishing it from other EOC because of frequent concurrence of endometriosis and highly chemoresistant nature resulting in a poor prognosis. Recent biochemica...

journal_title：Oncology reports

authors： Kajihara H,Yamada Y,Kanayama S,Furukawa N,Noguchi T,Haruta S,Yoshida S,Sado T,Oi H,Kobayashi H

更新日期：2010-05-01 00:00:00

abstract：:Progestin and adipoQ receptor family member III (PAQR3) is a regulator that negatively modulates the Ras/Raf/MEK/ERK signaling cascade and the GPCR Gβγ subunit signaling pathway. The role of PAQR3 in hepatocellular carcinoma (HCC) has not been elucidated. The present study investigated the expression of PAQR3 and its ...

journal_title：Oncology reports

authors： Wu HG,Zhang WJ,Ding Q,Peng G,Zou ZW,Liu T,Cao RB,Fei SJ,Li PC,Yang KY,Hu JL,Dai XF,Wu G,Li PD

更新日期：2014-12-01 00:00:00

abstract：:The present study was designed to investigate the effects of Bowman-Birk inhibitor (BBI) on up-regulation of connexin (Cx) expression to estimate BBI's tumor-suppressor effect in mice with M5076 ovarian sarcoma. The relative tumor weight (p<0.05, r(2)=0.301) and proliferating cell nuclear antigen (PCNA, p<0.01, r(2)=0...

journal_title：Oncology reports

authors： Suzuki K,Yano T,Sadzuka Y,Sugiyama T,Seki T,Asano R

更新日期：2005-06-01 00:00:00