Abstract:
:Epithelial ovarian cancer (EOC) is the most common cause of gynecological cancer-related mortality. Clear cell EOC (cEOC) has a number of clinical features distinguishing it from other EOC because of frequent concurrence of endometriosis and highly chemoresistant nature resulting in a poor prognosis. Recent biochemical studies based on genome-wide expression analysis technology have noted specific expression of a transcription factor, hepatocyte nuclear factor-1beta (HNF-1beta), in cEOC and genetic alteration may be involved in oxidative stress. We describe the HNF-1beta-dependent pathophysiology of cEOC and discuss its role in oxidative stress-induced carcinogenesis. A systematic search was performed in the electronic databases PubMed and ScienceDirect up to July 2009, combining the keywords, genome-wide, microarray, epithelial ovarian cancer, clear cell carcinoma, oxidative stress, and detoxification, with specific expression profiles of genes. The catalog of cEOC-specificity might be a manifestation of six essential alterations in cell physiology: oxidative stress and detoxification, proteases, signal transduction, adhesion, transcription, and metabolism. Among 54 genes highly upregulated in cEOC, 47 genes (87.0%) were associated with the redox-related genes. Several important cEOC-related genes overlap with those known to be regulated by HNF-1beta. Twenty-two (40.7%) of the 54 genes predominantly identified in cEOC were involved in downstream targets of HNF-1beta. The HNF-1beta-dependent pathway might provide new insights into regulation of glycogen synthesis, detoxification and resistance to anticancer agents. This review summarizes recent advances in the understanding of oxidative stress and antioxidant mechanisms in pathogenesis of cEOC. A redox-sensitive subset of cEOC genes linked to oxidative and detoxification pathways was identified and associated with HNF-1beta-specific downstream targets.
journal_name
Oncol Repjournal_title
Oncology reportsauthors
Kajihara H,Yamada Y,Kanayama S,Furukawa N,Noguchi T,Haruta S,Yoshida S,Sado T,Oi H,Kobayashi Hdoi
10.3892/or_00000750subject
Has Abstractpub_date
2010-05-01 00:00:00pages
1193-203issue
5eissn
1021-335Xissn
1791-2431journal_volume
23pub_type
杂志文章,评审相关文献
ONCOLOGY REPORTS文献大全abstract::Gasdermin D (GSDMD) is a newly discovered pyroptosis executive protein, which can be cleaved by inflammatory caspases and is essential for secretion of IL‑1β, making it a critical mediator of inflammation. However, the precise role of GSDMD in carcinogenesis remains nearly unknown. Considering the vital role of inflam...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2018.6634
更新日期:2018-10-01 00:00:00
abstract::Anaplastic thyroid carcinoma (ATC) is a rare type of thyroid carcinoma with a poor prognosis. Thus, suitable preclinical tumor models are required for the development of new ATC therapies. In the present study, orthotopic tumor xenograft models were established using ATC cell lines and SCID mice, and tumor invasion an...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2020.7720
更新日期:2020-10-01 00:00:00
abstract::Cell cycle control is a promising target in cancer treatments, and some small-molecule cyclin-dependent kinase (CDK) inhibitors have exhibited clinical effectiveness. However, no biomarkers predictive of efficacy have been developed. Recent studies have revealed that CDK inhibitor (CKI) proteins, such as p27 and p16, ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2017.5684
更新日期:2017-07-01 00:00:00
abstract::The activation of receptor tyrosine kinases (RTKs) results in cellular effects including cell proliferation, survival, migration and invasion; RTKs also play an important role in tumourigenesis. It has been reported that EGFR signalling controls the migration of oral squamous cell carcinoma (OSCC) SAS and HSC3 cells b...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2017.5587
更新日期:2017-06-01 00:00:00
abstract::Protease-activated receptor 2 (PAR2) is a G-protein-coupled receptor and its activation has been associated with the pathogenetic progress in certain cancers. Toll-like receptor 4 (TLR4), one member of Toll-like receptors family, is mainly contributed to the innate immune response. However, recent studies have shown t...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2010.1077
更新日期:2011-02-01 00:00:00
abstract::Tumor size indicates the extent of cell proliferation in most cases of colorectal cancer (CRC), although there are some advanced small tumors with metastases. Lymph node metastasis is a significant factor that greatly impacts disease prognosis in CRC cases. The underlying factors that cause lymph node metastasis in CR...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2013.2602
更新日期:2013-09-01 00:00:00
abstract::Purvalanol, a novel cyclin-dependent kinase inhibitor, is referred to as a strong apoptotic inducer which causes cell cycle arrest in various cancer cells such as prostate, breast and colon cancer cell lines. Various physiological and pathological conditions such as glucose starvation, inhibition of protein glycosylat...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2015.3918
更新日期:2015-06-01 00:00:00
abstract::Bone morphogenetic protein 9 (BMP9) is a member of the BMP family, which is involved in the regulation of tumor biogenesis, development and metastasis. The present study aimed to investigate whether BMP9 inhibits the growth of MDA‑MB‑231 breast cancer cells via the phosphoinositide 3‑kinase (PI3K)/Akt signaling pathwa...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2018.6572
更新日期:2018-09-01 00:00:00
abstract::Mice are particularly susceptible to carcinogens when exposure starts early in life. We evaluated the expression of stem cell antigen-1 (Sca-1) gene in the lung of variously aged CD-1 mice, either untreated or exposed to environmental cigarette smoke (ECS) and/or to a light source. Sca-1 expression progressively decre...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or_00000458
更新日期:2009-09-01 00:00:00
abstract::The present study aimed to evaluate a previously reported predictive formula of output-limiting symptoms induced by radiofrequency (RF) to determine the efficacy of this neoadjuvant chemoradiation (NACR) and concurrent RF thermal therapy. The present study included 81 consecutive patients with confirmed diagnoses of r...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2016.5300
更新日期:2017-02-01 00:00:00
abstract::Highly malignant gliomas are characterized by pronounced intra‑ and intertumoral heterogeneity. On the genetic level, this heterogeneity may be caused by spontaneous mutation events, but recent studies have reported distinct mutational signatures that may be caused by an enzyme family with cytidine desaminase activity...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2018.6698
更新日期:2018-11-01 00:00:00
abstract::A growing body of evidence suggests that microRNA-365 (miR-365) played crucial role in the initiation and development of many types of cancers. However, the biological role of miR-365 in human glioma remains unclear. Herein, the aims of this study were to investigate the role and underlying mechanisms of miR-365 in gl...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2017.5458
更新日期:2017-04-01 00:00:00
abstract::Mutations in the epidermal growth factor receptor (EGFR) make lung adenocarcinoma cells sensitive to EGFR tyrosine kinase inhibitors (TKIs). Long-term cancer therapy may cause the occurrence of acquired resistance to EGFR TKIs. Long non-coding RNAs (lncRNAs) play important roles in tumor formation, tumor metastasis an...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2016.4758
更新日期:2016-06-01 00:00:00
abstract::Prostate cancer (PCa) is the second most common type of male malignancy worldwide. The transcription factor zinc finger E‑box binding homeobox 1 (ZEB1) is associated with epithelial‑mesenchymal transition and is also involved in regulation of androgen receptor (AR) expression, the main ligands of which are testosteron...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2018.6885
更新日期:2019-02-01 00:00:00
abstract::Despite the high response rates of small cell lung cancer (SCLC) to first-line cisplatin-based chemotherapies, most patients with SCLC will eventually experience disease progression. Accordingly, novel chemotherapeutic regimens are desired. This in vitro study was carried out in order to develop novel chemotherapeutic...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2008-04-01 00:00:00
abstract::Acquired chemoresistance refers to tumor cells gradually losing their sensitivity to anticancer drugs during the course of treatment, resulting in tumor progression or recurrence. This phenomenon, which has deleterious outcomes for the patient, has long been observed in patients with glioblastoma receiving temozolomid...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2018.6322
更新日期:2018-05-01 00:00:00
abstract::Cigarette smoke has been implicated as a major risk factor for esophageal squamous cell carcinoma (ESCC). Several lines of evidence have suggested that the promoting effect of cigarette smoking extract (CSE) on ESCC is mediated by upregulation of cyclooxygenase-2 (COX-2) expression. Yet, the underlying molecular and c...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2015.4379
更新日期:2016-01-01 00:00:00
abstract::Tetraarsenic oxide (As4O6, TAO) is a new arsenic compound that inhibits cell growth and induces apoptosis in human cervical cancer cell lines. In the present study, we report that the growth of tumor cells (CaSki) was inhibited by treatment with TAO alone or in combination with cisp...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2013.2243
更新日期:2013-04-01 00:00:00
abstract::In vivo real-time visualization of chemotherapy response at the cellular level provides us with direct evidence of what happens on the tumor microenvironment of metastatic organs. We imaged the response of metastatic tumor cells and host stromal cells to chemotherapeutics on liver m...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2012.1983
更新日期:2012-11-01 00:00:00
abstract::Orofacial viral infections are common in immunocompromised patients. Herpes simplex virus (HSV) infections are the most common. Varicella-Zoster virus (VZV) infections are less common, but usually more severe. Epstein-Barr virus (EBV) may produce ulcers, lymphoproliferative syndromes or oral hairy leukoplakia (HL). Hu...
journal_title:Oncology reports
pub_type: 杂志文章,评审
doi:10.3892/or.7.6.1389
更新日期:2000-11-01 00:00:00
abstract::Eighteen primary human malignant mesotheliomas obtained from 18 patients were screened for point mutations and microdeletions/insertions in all exons of the tumour suppressor gene PTEN/MMAC1 by SSCP analysis. No mutation could be found. Our preliminary data indicate that disarrangements of PTEN/MMAC1 are at least not ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.8.6.1375
更新日期:2001-11-01 00:00:00
abstract::Garlic and its constituents are reported to have a preventive effect against colorectal cancer in animal models. Aged garlic extract (AGE), which is produced by natural extraction from fresh garlic for more than 10 months in aqueous ethanol, also has reputed chemopreventive effects on colon carcinogenesis, but has nev...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2014.3705
更新日期:2015-03-01 00:00:00
abstract::Genetically modified tumour cells producing cytokines such as interleukin 12 (IL-12) are potent activators of the antitumour immune responses and represent a promising therapeutic modality when combined with chemotherapy. The objective of this study was to examine whether IL-12-producing cellular vaccines can augment ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2011.1221
更新日期:2011-06-01 00:00:00
abstract::The long non‑coding RNA (lncRNA) PVT1 plays vital roles in the tumorigenesis and development of various types of cancer. However, the potential expression profiling, functions and pathways of PVT1 in HCC remain unknown. PVT1 was knocked down in SMMC‑7721 cells, and a miRNA microarray analysis was performed to detect t...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2018.6410
更新日期:2018-07-01 00:00:00
abstract::Though patients with EGFR mutations are initially responsive to EGFR-tyrosine kinase inhibitors (TKIs), most tumors ultimately acquire resistance to EGFR-TKIs. The most frequently reported mechanism is EGFR T790M mutation. In this study, using a droplet digital PCR (ddPCR) system, we assessed optimal conditions for a ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2017.5567
更新日期:2017-05-01 00:00:00
abstract::Pancreatic cancer is the fourth most common cause of cancer-related mortality. In the present study, we employed 2 types of therapeutic stem cells expressing cytosine deaminase (CD) with or without human interferon-β (IFN‑β), HB1.F3.CD and HB1.F3.CD.IFN-β cells, respectively, to selectively treat pancreatic cancer. Th...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2013.2564
更新日期:2013-09-01 00:00:00
abstract::We investigated whether 18F-fluorothymidine-positron-emission tomography/computed tomography (18F-FLT-PET/CT) is useful for the evaluation of the very early response to anti-epidermal growth factor receptor (EGFR) antibody cetuximab therapy in human lung cancer xenografts. A human tumor xenograft model was established...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2011.1338
更新日期:2011-09-01 00:00:00
abstract::MicroRNAs (miRNAs) play an important role in the genesis and development of gastric cancer. In the present study, we determined whether miRNA-135a-5p expression was increased in gastric cancer compared with adjacent non-tumor tissues using 20 pairs of gastric cancer and para-carcinoma tissue samples which were assesse...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2014.3546
更新日期:2014-12-01 00:00:00
abstract::We investigated the microsatellite alterations in mitochondrial DNA (mtDNA) and in TP53 in thoracic esophageal squamous cell carcinomas (TESCC). Using laser microdissection, 66 paired non-cancerous esophageal muscles, non-cancerous esophageal mucosa, cancerous TESCC nests plus 35 metastatic lymph nodes harvested from ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2012.1761
更新日期:2012-07-01 00:00:00
abstract::Signaling pathways that activate mTOR (mammalian target of rapamycin) are altered in many human cancers and these alterations are associated with prognosis and treatment response. mTOR inhibition can restore sensitivity to DNA damaging agents such as cisplatin. The rapamycin derivat...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2012.1666
更新日期:2012-05-01 00:00:00