Aged garlic extract inhibits 1,2-dimethylhydrazine-induced colon tumor development by suppressing cell proliferation.

abstract：:The BRAF T1799A mutation is a heterozygous point mutation and its reported prevalence in papillary thyroid carcinoma (PTC) has varied from 29 to 83%, with an overall mean of 44%. In Korea, the reported mutation rate reached 83% in PTC and 52% in micropapillary carcinoma. We hypothesized that the differences in prevale...

journal_title：Oncology reports

authors： Kim HS,Kim JO,Lee DH,Lee HC,Kim HJ,Kim JH,Jang YS,Lee JM,Kim SY,Kim YS

更新日期：2011-06-01 00:00:00

abstract：:Acute pancreatitis (AP) is an inflammatory disease with high morbidity and mortality rates. Pancreatic ductal cells are the most susceptible of all cell types that are exposed to the noxious stimuli of pancreatitis. Our previous studies demonstrated that emodin, a natural product extracted from Rheum palmatum L., prot...

journal_title：Oncology reports

authors： Zhang Q,Hu F,Guo F,Zhou Q,Xiang H,Shang D

更新日期：2019-08-08 00:00:00

abstract：:A phase II trial of vinorelbine and low dose prednisone in hormone-refractory metastatic prostate cancer was conducted in order to investigate its safety, efficacy and impact on quality of life. Vinorelbine was administered at the dose of 25 mg/m(2) i.v. weekly for 12 weeks and then biweekly, along with 10 mg of daily...

journal_title：Oncology reports

authors： Robles C,Furst AJ,Sriratana P,Lai S,Chua L,Donnelly E,Solomon J,Sundaram M,Feun L,Savaraj N

更新日期：2003-07-01 00:00:00

abstract：:The objective of this study was to examine how splenectomy affects the immune response, particularly T cells, in chemically-induced mammary tumors. Female rats were splenectomized and then exposed to 9,10-dimethyl-1,2-benz(a)anthracene (DMBA) to induce mammary tumors. Splenectomy significantly decreased the rate of tu...

journal_title：Oncology reports

authors： Kossoy G,Ben-Hur H,Lifschitz O,Zusman I

更新日期：2002-01-01 00:00:00

abstract：:Few studies have examined apoptosis induced by low-voltage electric pulses (LVEPs). LVEP-induce changes in membrane potential that are below the membrane breakdown threshold and increase membrane permeability without electroporation (pore formation) through the transport of extracellular substances via phagocytosis. W...

journal_title：Oncology reports

authors： Matsuki N,Takeda M,Ishikawa T,Kinjo A,Hayasaka T,Imai Y,Yamaguchi T

更新日期：2010-05-01 00:00:00

abstract：:Phosphatidylinositol 3 kinases (PI-3 kinases) play a crucial role in the inositol phospholipid signaling pathway. The effect of wortmannin, an inhibitor of PI-3 kinases, on the suppression of thermotolerance development was investigated in the temperature-sensitive cell line tsAF8. When wortmannin was added immediatel...

journal_title：Oncology reports

authors： Shibuya K,Kawasaki S,Kuroda M,Takemoto M,Asaumi J,Hiraki Y

更新日期：2002-01-01 00:00:00

abstract：:The changes of the microtubular network induced by microtubule destabilizing (Vinblastine, VBL) and stabilizing (Taxol, TAX) agents were studied in NIH/3T3 fibroblastic cells in conventional culture conditions (NIHb) and in a subpopulation (NIHs), obtained after serum deprivation and expressing different morphofunctio...

journal_title：Oncology reports

authors： Spano A,Monaco G,Barni S,Sciola L

更新日期：2008-12-01 00:00:00

abstract：:Actin has been studied extensively for decades, but so far its well-defined role has been found localized to the cytoplasm. The present study characterizes the distribution pattern of actin in the nucleus of HL-60 and K-562 cell lines treated with etoposide and doxorubicin. F-actin labeled with TRITC-phalloidin was fo...

journal_title：Oncology reports

authors： Grzanka A,Grzanka D,Orlikowska M

更新日期：2004-04-01 00:00:00

abstract：:VBP-1 has been isolated as a novel protein binding to the von Hippel-Lindau (VHL) tumor suppressor gene product. The fundamental function of the gene was examined in the nematode, Caenorhabditis elegans (C. elegans). The C. elegans VBP-1 gene was expressed in adults only in the gonads and was also expressed in early s...

journal_title：Oncology reports

authors： Ichimiya H,Hino O,Kohara Y,Ishii N

更新日期：2003-03-01 00:00:00

abstract：:Cancer cachexia is a life‑threatening syndrome associated with myofiber damage. Tumor factors impair muscle regeneration by promoting myoblast apoptosis. Ghrelin is a multifunctional hormone with an anti‑apoptotic effect, but its mechanism of action is not fully understood. In the present study, we investigated whethe...

journal_title：Oncology reports

authors： Zeng X,Chen S,Lin Y,Ke Z

更新日期：2018-03-01 00:00:00

abstract：:Hereditary multiple exostoses (HME) is an autosomal dominant bone disorder characterized by the presence of multiple benign cartilage-capped tumors. EXT1 located on chromosome 8q23-q24 and EXT2 located on 11p11-p12 are the main disease-causing genes which are responsible for ~90% of HME cases. Mutations of EXT1 or EXT...

journal_title：Oncology reports

authors： Cao L,Liu F,Kong M,Fang Y,Gu H,Chen Y,Zhao C,Zhang S,Bi Q

更新日期：2014-02-01 00:00:00

abstract：:Photodynamic therapy (PDT) using photosensitizer can induce diverse cellular responses, including apoptosis. Recently, it has been reported that PDT using methylaminolaevulinate may be effective in basal cell carcinoma. However, it is largely unknown whether PDT using a natural product such as curcumin can induce apop...

journal_title：Oncology reports

authors： Park K,Lee JH

更新日期：2007-03-01 00:00:00

abstract：:Peroxisome proliferator-activated receptor-gamma (PPAR-gamma), a member of the nuclear hormone receptor superfamily, is involved in suppressing the growth of several tumors. We showed that PPAR-gamma is expressed in Barrett's adenocarcinoma cell lines and inhibited the growth of these lines through the induction of G1...

journal_title：Oncology reports

authors： Takashima T,Fujiwara Y,Hamaguchi M,Sasaki E,Tominaga K,Watanabe T,Oshitani N,Higuchi K,Arakawa T

更新日期：2005-04-01 00:00:00

abstract：:The human multidrug resistance gene 1 (MDR-1) encodes a plasma membrane P-glycoprotein (P-gp) that functions as the transmembrane efflux pump for various structurally unrelated anticancer agents and toxins. Polymorphisms in the MDR-1 gene may have an impact on the expression and function of P-gp, thereby influencing t...

journal_title：Oncology reports

authors： Zubor P,Lasabova Z,Hatok J,Stanclova A,Danko J

更新日期：2007-07-01 00:00:00

abstract：:The carcinogenic process in previously normal human colonic mucosa involves hyperproliferation and adenoma formation, but it is not known why only a tiny proportion of adenomas undergo malignant transformation. There is accumulating evidence in favour of the hypothesis that inflammatory processes are a prerequisite fo...

journal_title：Oncology reports

authors： Sharma RA,Dalgleish AG,Steward WP,O'Byrne KJ

更新日期：2003-09-01 00:00:00

abstract：:In the present study, the preliminary results of the first stereotactic body radiosurgery (SRS) experience with volumetric intensity modulated arc therapy (VMAT) in oligometastatic breast and recurrent gynecological tumors (OBRGT) are reported in terms of feasibility, toxicity and efficacy. Patients were treated in a ...

journal_title：Oncology reports

authors： Macchia G,Deodato F,Cilla S,Torre G,Corrado G,Legge F,Gambacorta MA,Tagliaferri L,Mignogna S,Scambia G,Valentini V,Morganti AG,Ferrandina G

更新日期：2014-11-01 00:00:00

abstract：:Human glioblastoma is a malignant and aggressive primary human brain solid tumor characterized by severe hypoxia. Hypoxia can induce autophagy, which may result in chemoresistance and malignant progression of cancer cells. MicroRNAs (miRNAs) have been reported to modulate hypoxia‑induced autophagy in various types of ...

journal_title：Oncology reports

authors： Huang S,Qi P,Zhang T,Li F,He X

更新日期：2019-03-01 00:00:00

abstract：:The abilities of 5,6-benzoflavone (5,6-BF, a synthetic flavonoid), indole-3-carbinol (I3C, a plant derived product) or diindolylmethane (DIM, a condensation product of I3C) to alter the induction of mammary cancers induced by the carcinogens 7,12-dimethylbenzanthracene (DMBA) or N-methyl-N-nitrosourea (MNU) were evalu...

journal_title：Oncology reports

authors： Lubet RA,Heckman BM,De Flora SL,Steele VE,Crowell JA,Juliana MM,Grubbs CJ

更新日期：2011-09-01 00:00:00

abstract：:We have previously reported a high prevalence of hypothyroidism among patients with uveal melanoma. The objectives of the present study were to determine if a similar pattern of thyroid pathology exists among patients with cutaneous melanoma as well. To address this question, the medical records of all patients regist...

journal_title：Oncology reports

authors： Ellerhorst JA,Cooksley CD,Broemeling L,Johnson MM,Grimm EA

更新日期：2003-09-01 00:00:00

abstract：:To investigate whether the expression of Topoisomerase II-alpha (TII-alpha) can serve as a prognostic factor in renal cell carcinoma (RCC), histological sections from 27 renal tumors were stained immunohistochemically for TII-alpha expression. The percentage of positive cells in the area of greatest staining was recor...

journal_title：Oncology reports

authors： Dekel Y,Frede T,Kugel V,Neumann G,Rassweiler J,Koren R

更新日期：2005-07-01 00:00:00

abstract：:Breast cancer is one of the most malignant diseases world-wide and it ranks the first among female cancers. Masses of intrinsic and extrinsic factors, especially the inflammatory factors can lead to breast cancer. Aberrant activation and accumulation of key molecules can lead to inflammation associated carcinogenesis....

journal_title：Oncology reports

authors： Wang N,Wei L,Huang Y,Wu Y,Su M,Pang X,Wang N,Ji F,Zhong C,Chen T,Li B

更新日期：2017-03-01 00:00:00

abstract：:In this study, we applied near-infrared fluorescent quantum dots (NIRF-QDs) for non-invasive in vivo and in situ imaging of head and neck squamous cell carcinoma (HNSCC). The U14 squamous cancer cell line with high expression of epidermal growth factor receptor (EGFR) was implanted subcutaneously into the head and nec...

journal_title：Oncology reports

authors： Yang K,Zhao C,Cao YA,Tang H,Bai YL,Huang H,Zhao CR,Chen R,Zhao D

更新日期：2012-06-01 00:00:00

abstract：:Epithelial to mesenchymal transition (EMT) is a process implicated in cancer progression in which the underlying cellular changes have been identified mainly using in vitro models. We determined the expression of some putative EMT biomarkers including E-cadherin, beta-catenin, zinc finger factor Snail (Snail), transfo...

journal_title：Oncology reports

authors： Logullo AF,Nonogaki S,Pasini FS,Osório CA,Soares FA,Brentani MM

更新日期：2010-02-01 00:00:00

abstract：:Toll-like receptor (TLR)-mediated signaling induces cell migration or invasion in several tumors and various stages of cancer. Interactions of mesothelin, a 40-kDa cell surface glycoprotein, with cancer antigen 125 (CA125) is associated with drug resistance, metastasis, and poor clinical outcome of ovarian cancer pati...

journal_title：Oncology reports

authors： Park GB,Kim D

更新日期：2017-11-01 00:00:00

abstract：:Transitional cell carcinomas (TCCs) of the urinary bladder are common malignancies with a high recurrence rate. Since microRNA-21 (miR-21) may contribute to tumorigenesis and chemoresistance in many cancer types, we aimed to investigate its efficacy in TCCs. The expression of miR-21 and its target PTEN was determined ...

journal_title：Oncology reports

authors： Tao J,Lu Q,Wu D,Li P,Xu B,Qing W,Wang M,Zhang Z,Zhang W

更新日期：2011-06-01 00:00:00

abstract：:Minimal residual disease (MRD) is derived from tumor-initiating cells (TICs) and is responsible for tumor relapse. Neuroblastoma is characterized by extreme tumor heterogeneity, and more than half of high-risk patients experience tumor relapse. To overcome tumor heterogeneity and ac...

journal_title：Oncology reports

authors： Hartomo TB,Kozaki A,Hasegawa D,Van Huyen Pham T,Yamamoto N,Saitoh A,Ishida T,Kawasaki K,Kosaka Y,Ohashi H,Yamamoto T,Morikawa S,Hirase S,Kubokawa I,Mori T,Yanai T,Hayakawa A,Takeshima Y,Iijima K,Matsuo M,Nishio H

更新日期：2013-04-01 00:00:00

abstract：:Histone deacetylase (HDAC) inhibitors exert potent inhibitory effects on various types of human cancer. The pioneer drug suberoylanilide hydroxamic acid (SAHA) is currently used in the clinic for cancer treatment. However, the effect of SAHA on tumor lymphangiogenesis is unclear. We recently showed that SAHA suppresse...

journal_title：Oncology reports

authors： Cheng HT,Hung WC

更新日期：2013-08-01 00:00:00

abstract：:MicroRNA-17-5p has been proven upregulated in many human malignancies and correlated with tumor progression. However, its expression and clinical significance in osteosarcoma is still unclear. Thus, the aim of the present study was to explore the effects of miR-17-5p in osteosarcoma tumorigenesis and development. The ...

journal_title：Oncology reports

authors： Wang W,Zhang L,Zheng K,Zhang X

更新日期：2016-03-01 00:00:00

abstract：:This study evaluates and compares the accuracy of positron emission tomography with 18F-fluoro-2-deoxyglucose (FDG-PET) and gallium-67 citrate (Ga-67) scintigraphy in identifying disease sites in patients with malignant lymphoma at initial diagnosis or relapse. Histology subgroups included low (n=5), intermediate (n=6...

journal_title：Oncology reports

authors： Shen YY,Kao A,Yen RF

更新日期：2002-03-01 00:00:00

abstract：:In a screen for thoracic malignancy-associated markers, thyroid stimulating hormone receptor (TSHR) was identified as a candidate as it binds to the previously-characterized lung cancer marker NKX2-1. We screened for mutations in all coding regions of the TSHR gene in 96 lung adenoc...

journal_title：Oncology reports

authors： Kim JW,Lee S,Lui N,Choi H,Mulvihill M,Fang LT,Kang HC,Kwon YW,Jablons D,Kim IJ

更新日期：2012-10-01 00:00:00