Photosensitizer effect of curcumin on UVB-irradiated HaCaT cells through activation of caspase pathways.

abstract：:Thymidine phosphorylase (TP) and dihydropyrimidine dehydrogenase (DPD) are considered to be key enzymes affecting the prognosis for patients with various cancers. We tried to prove the correlation of TP and DPD expression in hepatocellular carcinoma (HCC) and liver metastasis. We quantified TP and DPD levels by an enz...

journal_title：Oncology reports

authors： Hotta T,Kobayashi Y,Taniguchi K,Johata K,Sahara M,Watanabe T,Ochiai M,Tanimura H,Tsubota YT

更新日期：2004-08-01 00:00:00

abstract：:B7-H1 is a co-inhibitory molecule belonging to the B7 family. The B7-H1 protein is only expressed on macrophage lineage of cells in normal tissues, but is overexpressed in most types of tumor. The aberrant expression of cell surface B7-H1 on cancer cells is generally associated with high-risk prognostic factors. The t...

journal_title：Oncology reports

authors： Zhang C,Wang W,Qin X,Xu Y,Huang T,Hao Q,Li W,Wu S,Zhang Y

更新日期：2013-11-01 00:00:00

abstract：:Numerous studies have demonstrated that triptolide induces cell cycle arrest and apoptosis in human cancer cell lines. However, triptolide-induced DNA damage and inhibition of DNA repair gene expression in human skin cancer cells has not previously been reported. We sought the effects of triptolide on DNA damage and a...

journal_title：Oncology reports

authors： Chueh FS,Chen YL,Hsu SC,Yang JS,Hsueh SC,Ji BC,Lu HF,Chung JG

更新日期：2013-02-01 00:00:00

abstract：:DNA double-strand breaks (DSBs) induced by ionizing radiation (IR) are among the most cytotoxic types of DNA damage. The DNA damage response (DDR) may be a reason for the cancer cell resistance to radiotherapy using IR. Identified as critical upstream mediators of the phosphorylation of ataxia telangiectasia-mutated (...

journal_title：Oncology reports

authors： Gou Q,Xie Y,Liu L,Xie K,Wu Y,Wang Q,Wang Z,Li P

更新日期：2015-07-01 00:00:00

abstract：:It has been reported that granulocyte-colony stimulating factor (G-CSF) and granulocyte-macrophage-colony stimulating factor (GM-CSF) can mobilize endothelial progenitor cells (EPCs) in bone marrow cells (BMCs) into peripheral blood (PB) in vivo. Previously, we also reported that macrophage-colony stimulating factor (...

journal_title：Oncology reports

authors： Zhang Y,Adachi Y,Iwasaki M,Minamino K,Suzuki Y,Nakano K,Koike Y,Mukaide H,Shigematsu A,Kiriyama N,Li C,Ikehara S

更新日期：2006-06-01 00:00:00

abstract：:Multigene-based combination therapy may be an effective practice in cancer gene therapy. Substantial studies have demonstrated that tumor suppressor p53 acetylation is indispensable for p53 activation. Inhibitor of growth 4 (ING4), as a novel tumor suppressor, is capable of remarkably enhancing p53 acetylation and its...

journal_title：Oncology reports

authors： Wu J,Zhu Y,Xu C,Xu H,Zhou X,Yang J,Xie Y,Tao M

更新日期：2016-01-01 00:00:00

abstract：:Dysregulation of microRNAs (miRNAs) occurs frequently in cervical carcinogenesis. miRNAs function as tumor-suppressors or oncogenes and are involved in tumor behavior. However, the expression and function of miR-27b in cervical carcinogenesis remain unknown. In the present study, we observed that miR-27b was significa...

journal_title：Oncology reports

authors： Yao J,Deng B,Zheng L,Dou L,Guo Y,Guo K

更新日期：2016-03-01 00:00:00

abstract：:Agaricus blazei is well known as a traditional medicinal mushroom and it has been shown to exhibit immunostimulatory and anti-cancer activity. However, the cellular and molecular mechanism of cell cycle arrest and apoptosis of cancer cells is poorly understood. In this study, we have investigated whether A. blazei ext...

journal_title：Oncology reports

authors： Jin CY,Choi YH,Moon DO,Park C,Park YM,Jeong SC,Heo MS,Lee TH,Lee JD,Kim GY

更新日期：2006-12-01 00:00:00

abstract：:The model animal of renal cell carcinoma (RCC), the Eker rat, has a germline mutation in the tuberous sclerosis 2 (Tsc2) gene. Heterozygous mutants develop RCCs by second hit in the wild-type Tsc2 allele, whereas homozygous mutants are embryonic lethal. In the present study, a new cell differentiation model was develo...

journal_title：Oncology reports

authors： Kawano H,Ito Y,Kanai F,Nakamura E,Tada N,Takai S,Horie S,Kobayashi T,Hino O

更新日期：2015-11-01 00:00:00

abstract：:Mitogenic actions of estrogens are mediated by two distinct estrogen receptors (ERs), which are critical in the progression and therapeutic response of breast cancer. ER expression is a dynamic phenomenon that is regulated by numerous factors, including cytokines, in the tumor microenvironment. Recently, studies have ...

journal_title：Oncology reports

authors： Niu XL,Wang Y,Yao Z,Duan H,Li Z,Liu W,Zhang H,Deng WM

更新日期：2015-12-01 00:00:00

abstract：:Following the publication of the above paper, an interested reader drew to our attention apparent anomalies associated with Figs. 2, 3 and 4; essentially, these three figures contained panels exhibiting overlapping data, such that data purportedly relating to different experiments were apparently drawn from the same o...

journal_title：Oncology reports

authors： Yang H,Zhan L,Yang T,Wang L,Li C,Zhao J,Lei Z,Li X,Zhang HT

更新日期：2020-11-25 00:00:00

abstract：:We have recently shown that covalent attachment of the nitric oxide (NO) moiety to the HIV protease inhibitor Saquinavir (Saq) produced a qualitatively new chemical entity, named Saquinavir-NO (Saq-NO), with enhanced anticancer properties and reduced toxicity both in vitro and in vi...

journal_title：Oncology reports

authors： Donia M,Mangano K,Fagone P,De Pasquale R,Dinotta F,Coco M,Padron J,Al-Abed Y,Giovanni Lombardo GA,Maksimovic-Ivanic D,Mijatovic S,Zocca MB,Perciavalle V,Stosic-Grujicic S,Nicoletti F

更新日期：2012-08-01 00:00:00

abstract：:Lapatinib, an inhibitor of human epidermal growth factor receptor 2 (HER2) phosphorylation, has been reported to inhibit several types of tumors such as HER2-overexpressing breast cancer. However, the effect of lapatinib on the malignant phenotype of human osteosarcoma (OS) cells and the potential molecular mechanisms...

journal_title：Oncology reports

authors： Long XH,Zhang GM,Peng AF,Luo QF,Zhang L,Wen HC,Zhou RP,Gao S,Zhou Y,Liu ZL

更新日期：2014-01-01 00:00:00

abstract：:The human Igf-1 gene not only produces insulin‑like growth factor-I (IGF-I), but also different carboxy‑terminal extensions, known as E peptides, through alternative splicing. We and others have shown that human Eb peptide (hEb) derived from Igf-1 has intrinsic biological activity and is localized to nuclei of transfe...

journal_title：Oncology reports

authors： Durzyńska J,Barton E

更新日期：2014-09-01 00:00:00

abstract：:Thyroid cancer is the most commonly diagnosed malignancy of the endocrine system, the incidence of which has increased rapidly in the last 30 years. Genetic alterations in pathways, including the mitogen‑activated protein kinase (MAPK)/extracellular signal‑regulated kinase (Erk) and phosphatidylinositol‑3‑kinase (PI3K...

journal_title：Oncology reports

authors： Chen H,Chen W,Zhang X,Hu L,Tang G,Kong J,Wang Z

更新日期：2019-01-01 00:00:00

abstract：:Breast cancer metastasizes to the bone in a majority of patients with advanced disease resulting in bone destruction. The underlying mechanisms are complex, and both processes are controlled by an interaction between locally and systemically derived signals. Clinically, breast cancer patients with depression have a hi...

journal_title：Oncology reports

authors： Zong JC,Wang X,Zhou X,Wang C,Chen L,Yin LJ,He BC,Deng ZL

更新日期：2016-02-01 00:00:00

abstract：:The degradation of basement membranes by tumor cells involves secretion and activation of proteinases, such as the matrix metalloproteinases (MMPs), and results from an imbalance between their inhibitors and activators that are controlled by various growth factors or cytokines, among which TGF-β(1) may be the most int...

journal_title：Oncology reports

authors： Jin H,Xie X,Hu B,Gao F,Zhou J,Zhang Y,Du L,Wang X,Zhao L,Zhang X,Shen L,Liao Y,Tang J

更新日期：2013-02-01 00:00:00

abstract：:Enolase-phosphatase 1 (ENOPH1), is an enzyme that is involved in polyamine biosynthesis and is associated with stress responses. However, little is known about its role in the pathophysiology of glioma. In the present study, we examined the expression and function of ENOPH1 in human glioma tissues and cell lines. West...

journal_title：Oncology reports

authors： Su L,Yang K,Li S,Liu C,Han J,Zhang Y,Xu G

更新日期：2018-10-01 00:00:00

abstract：:The long non‑coding RNA (lncRNA) PVT1 plays vital roles in the tumorigenesis and development of various types of cancer. However, the potential expression profiling, functions and pathways of PVT1 in HCC remain unknown. PVT1 was knocked down in SMMC‑7721 cells, and a miRNA microarray analysis was performed to detect t...

journal_title：Oncology reports

authors： Zhang Y,Mo WJ,Wang X,Zhang TT,Qin Y,Wang HL,Chen G,Wei DM,Dang YW

更新日期：2018-07-01 00:00:00

abstract：:Burkitt's lymphoma (BL) is a fast growing cancer of the human lymphatic system, and an extremely invasive B-cell non-Hodgkin's lymphoma. We explored the mechanism of apoptosis in Raji cells associated with the post-transcriptional regulation factors. To confirm that the predicted microRNA-520a (miR-520a) is matched wi...

journal_title：Oncology reports

authors： Wang X,Wang P,Zhu Y,Zhang Z,Zhang J,Wang H

更新日期：2016-09-01 00:00:00

abstract：:Studies of tumor-infiltrating immune cells have revealed that immune escape plays an important role in tumor growth. The aim of the present study was to investigate the impact of metastasis affecting CD4+ T cell subsets in human clinical samples. Single-cell suspensions derived from tumor-draining lymph node (TDLN) an...

journal_title：Oncology reports

authors： Okita Y,Ohira M,Tanaka H,Tokumoto M,Go Y,Sakurai K,Toyokawa T,Kubo N,Muguruma K,Sawada T,Maeda K,Hirakawa K

更新日期：2015-08-01 00:00:00

abstract：:The majority of patients with hormone receptor-positive metastatic breast cancer die from disease progression despite different types of anti-hormonal treatments. Preclinical studies have indicated that resistance to anti-hormonal therapies may be the result of an activated NF-κB si...

journal_title：Oncology reports

authors： Trinh XB,Sas L,Van Laere SJ,Prové A,Deleu I,Rasschaert M,Van de Velde H,Vinken P,Vermeulen PB,Van Dam PA,Wojtasik A,De Mesmaeker P,Tjalma WA,Dirix LY

更新日期：2012-03-01 00:00:00

abstract：:CYP1A1 expression in various tissues of 43 gastric cancer cases was analyzed with frozen tissue array-based immunohistochemical staining (IHC), RT-PCR, Western blot analysis and EROD (7-ethoxyresourfin-O-deethylase) assay. CYP1A1 was detected immunohistochemically in 86% (37/43) of gastric cancers, in both 57% (4/7) o...

journal_title：Oncology reports

authors： Zhang KL,Ma JX,Chen XY,Sun Y,Kong QY,Liu J,Li H

更新日期：2004-12-01 00:00:00

abstract：:Quercetin, a kind of flavonoid, is found in edible fruits and vegetables and has anti-tumorigenic activity. However, the mechanism of activity has not been elucidated. We show for the first time that gadd45 is a molecular target of quercetin, which inhibits growth of human cervical cancer HeLa cells. Apoptosis was det...

journal_title：Oncology reports

authors： Yoshida T,Maeda A,Horinaka M,Shiraishi T,Nakata S,Wakada M,Yogosawa S,Sakai T

更新日期：2005-11-01 00:00:00

abstract：:AZD8055 is a potent inhibitor of mTORC1 and mTOR2 and shows inhibitory effects in several types of cancer cells in vitro and in vivo. However, the effect of AZD8055 on hepatocellular carcinoma (HCC) cells has not been studied. We report that AZD8055 inhibits cell proliferation and colony formation of Hep3B and Huh7 ce...

journal_title：Oncology reports

authors： Hu M,Huang H,Zhao R,Li P,Li M,Miao H,Chen N,Chen M

更新日期：2014-02-01 00:00:00

abstract：:Fecal microRNAs (miRNAs) are increasingly explored as non-invasive markers of colorectal cancer (CRC). However, its holistic profile in Asian CRC patients remains elusive. In the present study, the global human fecal miRNAs in Asian Chinese CRC patients was assayed to elucidate novel diagnostic fecal markers. Addition...

journal_title：Oncology reports

authors： Phua LC,Chue XP,Koh PK,Cheah PY,Chan EC,Ho HK

更新日期：2014-07-01 00:00:00

abstract：:Cervical cancer is the second most commonly diagnosed cancer in women. Novel prognostic biomarkers are required to predict the progression of cervical cancer. Cervical cancer expression data were obtained from The Cancer Genome Atlas (TCGA) database. MicroRNAs (miRNAs) significantly differentially expressed between ea...

journal_title：Oncology reports

authors： Shi C,Yang Y,Zhang L,Zhang T,Yu J,Qin S,Gao Y

更新日期：2019-06-01 00:00:00

abstract：:Vaccine strategies for the treatment of human papillomavirus-induced cervical cancer are based mainly on the human papillomavirus 16 E7 (HPV16 E7) oncoprotein. The immunogenicity of the E7 gene has been enhanced by its fusion to many different genes. Here, we linked a short sequence coding for the E7 peptide (aa 44-60...

journal_title：Oncology reports

authors： Pokorna D,Cerovska N,Smahel M,Moravec T,Ludvikova V,Mackova J,Synkova H,Duskova M,Hozak P,Veleminsky J

更新日期：2005-10-01 00:00:00

abstract：:Colorectal carcinoma (CRC) is a major type of malignancy worldwide. Ellagic acid (EA), a natural phenolic constituent, has been shown to exhibit anticancer effects. In our previous study, it was shown that EA inhibited proliferation of CRC cells. Additionally, microarray analysis revealed 4,738 differentially expresse...

journal_title：Oncology reports

authors： Zhao J,Li G,Wei J,Dang S,Yu X,Ding L,Shang C,Zhang H,Zhang Z,Chen H,Liu M

更新日期：2020-08-01 00:00:00

abstract：:A small subset of cells within a malignant neoplasm, named cancer stem cells (CSCs) or tumour initiating cells, are thought to be capable of initiating the neoplasm itself, and of driving its growth and recurrence after treatment. It is unclear whether CSCs can be identified and experimentally induced within oral squa...

journal_title：Oncology reports

authors： Qiao B,Johnson NW,Chen X,Li R,Tao Q,Gao J

更新日期：2011-08-01 00:00:00