Lapatinib alters the malignant phenotype of osteosarcoma cells via downregulation of the activity of the HER2-PI3K/AKT-FASN axis in vitro.

abstract：:The Houttuynia cordata Thunb (HCT) extract has been used as a traditional Chinese herb medicine and as well as an effective drug for treating allergic inflammation for thousands of years. In this study, we investigated the anti-cancer activity of HCT and its molecular mechanisms in the human colon adenocarcinoma cell ...

journal_title：Oncology reports

authors： Tang YJ,Yang JS,Lin CF,Shyu WC,Tsuzuki M,Lu CC,Chen YF,Lai KC

更新日期：2009-11-01 00:00:00

abstract：:The Chinese medicinal herb Sorbaria sorbifolia, native to Changbai Mountain, can induce apoptosis in HepG-2 cells. We studied the mechanism by which 5, 2', 4'-trihydroxy-6,7, 5'-trimethoxyflavone (TTF1) isolated from acetic ether extracts of Sorbaria sorbifolia induces apoptosis in HepG-2 cells. The results showed tha...

journal_title：Oncology reports

authors： Li Y,Bian L,Cui F,Li L,Zhang X

更新日期：2011-09-01 00:00:00

abstract：:Cancer represents a significant challenge for humankind, as early diagnosis and treatment are difficult to achieve. To systemically investigate the effect of sex, body mass index (BMI) and age on cancer incidence and prognosis, the data from 14,504 cases of cancer were downloaded from The Cancer Genome Atlas (TCGA). B...

journal_title：Oncology reports

authors： Huang X,Shu C,Chen L,Yao B

更新日期：2018-09-01 00:00:00

abstract：:Increasing evidence suggests that microRNAs are involved in human carcinogenesis as tumor suppressors or oncogenes. A growing number of reports has shown that an interest has been sparked in aberrant microRNA expression and how they can be used to treat human diseases, including cancer. However, their precise biologic...

journal_title：Oncology reports

authors： Pan J,Hu H,Zhou Z,Sun L,Peng L,Yu L,Sun L,Liu J,Yang Z,Ran Y

更新日期：2010-07-01 00:00:00

abstract：:Recently, gene fusions between the androgen responsive gene TMPRSS2 and members of the ETS-family of DNA-binding transcription factor genes were found in prostate cancer. Recurrent fusions were identified between the 5'-noncoding region of TMPRSS2 and ERG, or less frequently ETV1 or ETV4, resulting in overexpression o...

journal_title：Oncology reports

authors： Winnes M,Lissbrant E,Damber JE,Stenman G

更新日期：2007-05-01 00:00:00

abstract：:The usefulness of the in vitro chemosensitivity test, the collagen gel droplet embedded culture drug- sensitivity test (CD-DST, Int J Oncol 11: 449, 1997), in cisplatin-based combined chemotherapy for postoperative recurrent tumors in non-small cell lung cancer (NSCLC) patients was retrospectively analyzed. CD-DST dat...

journal_title：Oncology reports

authors： Higashiyama M,Kodama K,Yokouchi H,Takami K,Nakagawa H,Imamura F,Minamigawa K,Kobayashi H

更新日期：2001-03-01 00:00:00

abstract：:Large‑scale projects, such as The Cancer Genome Atlas (TCGA), Human Epigenome Project (HEP) and Human Epigenome Atlas (HEA), provide an insight into DNA methylation and histone modification markers. Changes in the epigenome significantly contribute to the initiation and progression of cancer. The goal of the present s...

journal_title：Oncology reports

authors： Kamińska K,Białkowska A,Kowalewski J,Huang S,Lewandowska MA

更新日期：2019-07-01 00:00:00

abstract：:The characteristics of ovarian cancers that showed low activation of glycolysis were investigated. Using medical records of patients with ovarian cancers who had undergone fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) prior to their primary surgery at the University of Tokyo Hospital...

journal_title：Oncology reports

authors： Sato M,Kawana K,Adachi K,Fujimoto A,Taguchi A,Fujikawa T,Yoshida M,Nakamura H,Nishida H,Inoue T,Ogishima J,Eguchi S,Yamashita A,Tomio K,Arimoto T,Wada-Hiraike O,Oda K,Nagamatsu T,Osuga Y,Fujii T

更新日期：2017-03-01 00:00:00

abstract：:It has been shown that overexpression of signal transducer and activator of transcription 3 (Stat3) contribute to the progression and metastasis of various solid tumors and that silencing Stat3 inhibits tumor growth in several types of cancer. Gene associated with retinoid-IFN-induced mortality 19 (GRIM-19), a Stat3-i...

journal_title：Oncology reports

authors： Wang GM,Ren ZX,Wang PS,Su C,Zhang WX,Liu ZG,Zhang L,Zhao XJ,Chen G

更新日期：2014-08-01 00:00:00

abstract：:The p16 protein is a cyclin-dependent kinase (CDK) inhibitor, which plays an important role in the regulation of the cell cycle by inactivating the cyclin-dependent kinase (CDK) that phosphorylates the retinoblastoma (Rb) protein. Overexpression of p16 protein has been found in many types of human malignancy. Autoanti...

journal_title：Oncology reports

authors： Looi K,Megliorino R,Shi FD,Peng XX,Chen Y,Zhang JY

更新日期：2006-11-01 00:00:00

abstract：:In a screen for thoracic malignancy-associated markers, thyroid stimulating hormone receptor (TSHR) was identified as a candidate as it binds to the previously-characterized lung cancer marker NKX2-1. We screened for mutations in all coding regions of the TSHR gene in 96 lung adenoc...

journal_title：Oncology reports

authors： Kim JW,Lee S,Lui N,Choi H,Mulvihill M,Fang LT,Kang HC,Kwon YW,Jablons D,Kim IJ

更新日期：2012-10-01 00:00:00

abstract：:Chemokines are small chemotactic cytokines that can induce the migration of leukocytes, activate inflammatory/immune responses and have recently been implicated in the regulation of tumor growth and organ-specific spread. In this setting, the macrophage inflammatory protein-1alpha (CCL3) chemokine displays a diversity...

journal_title：Oncology reports

authors： Silva TA,Ribeiro FL,Oliveira-Neto HH,Watanabe S,Alencar Rde C,Fukada SY,Cunha FQ,Leles CR,Mendonça EF,Batista AC

更新日期：2007-11-01 00:00:00

abstract：:Neurofibromatosis type 1 (NF1) caused by NF1 gene mutation is a commonly inherited autosomal dominant disorder. Malignant peripheral nerve sheath tumors (MPNSTs), a type of aggressive sarcoma, are a major cause of mortality in NF1 patients. The malignant transformation of benign plexiform neurofibromas (PNs) to MPNSTs...

journal_title：Oncology reports

authors： Park GH,Lee SJ,Yim H,Han JH,Kim HJ,Sohn YB,Ko JM,Jeong SY

更新日期：2014-10-01 00:00:00

abstract：:Squamous cell carcinoma (SCC) is histologically the most prominent type of cervical cancer. There is accumulating evidence suggesting that microRNAs (miRNAs) play important regulatory roles in the biological processes of cervical squamous cell carcinoma (CSCC). Deciphering the miRNA regulatory network in CSCC could de...

journal_title：Oncology reports

authors： Lin W,Feng M,Chen G,Zhou Z,Li J,Ye Y

更新日期：2017-03-01 00:00:00

abstract：:Early detection of transitional cell carcinoma (TCC) of the urinary bladder is essential for effective treatment. While several serum markers have been evaluated, none have been widely accepted for practical clinical use. Thus, urinary markers have been introduced and investigated to detect the evidence of bladder can...

journal_title：Oncology reports

authors： Wunderlich H,Reichelt O,Zermann DH,Schubert J,Berndt A,Kosmehl H

更新日期：2001-05-01 00:00:00

abstract：:Dysregulated metabolism is an emerging hallmark of cancer development, and upregulated lipid synthesis is one of the important tumor metabolic features. However, lipolysis may also contribute to cancer pathogenesis by altering free fatty acid (FFA) metabolism. In the present study, we investigated the importance of th...

journal_title：Oncology reports

authors： Hung YH,Chan YS,Chang YS,Lee KT,Hsu HP,Yen MC,Chen WC,Wang CY,Lai MD

更新日期：2014-06-01 00:00:00

abstract：:Despite significant advances in micro-metastasis detection methods, little is known about the relationship between micro-metastasis and primary tumors. The purpose of this study was to assess the ability of expression of the breast cancer-related markers, HER-2/neu, COX-2, VEGF and PDGF-B, as a predictor for micro-met...

journal_title：Oncology reports

authors： Zhu L,Loo WT,Cheng CW,Chow LW

更新日期：2006-05-01 00:00:00

abstract：:Reactive oxygen species (ROS) can drive the de‑differentiation of tumor cells leading to the process of epithelial-to-mesenchymal transition (EMT) to enhance invasion and metastasis. The invasive and metastatic phenotype of malignant cells is often linked to loss of E-cadherin expression, a hallmark of EMT. Recent stu...

journal_title：Oncology reports

authors： Wang Y,Ma J,Shen H,Wang C,Sun Y,Howell SB,Lin X

更新日期：2014-11-01 00:00:00

abstract：:The morbidity and mortality of prostate cancer have been increasing recently, and the comprehensive treatment for prostate cancer is unable to achieve satisfactory outcomes. Quercetin is a natural flavonoid compound that has attracted increased interest and attention due to its anticancer activity. In vitro and in viv...

journal_title：Oncology reports

authors： Yang F,Song L,Wang H,Wang J,Xu Z,Xing N

更新日期：2015-06-01 00:00:00

abstract：:The objective of our study was to define a neural network for predicting recurrence and progression-free probability in patients affected by recurrent pTaG3 urothelial bladder cancer to use in everyday clinical practice. Among all patients who had undergone transurethral resection for bladder tumors, 143 were finally ...

journal_title：Oncology reports

authors： Cai T,Conti G,Nesi G,Lorenzini M,Mondaini N,Bartoletti R

更新日期：2007-10-01 00:00:00

abstract：:Renal cell carcinoma (RCC) is the most common type of kidney cancer in adults and has been described as one of the deadliest of cancers affecting the genitourinary tract. Tropomyosin is a two-stranded α-helical coiled coil protein found in cell cytoskeletons. One of its isoforms, tropomyosin-1 (TPM1) has been reported...

journal_title：Oncology reports

authors： Wang J,Guan J,Lu Z,Jin J,Cai Y,Wang C,Wang F

更新日期：2015-03-01 00:00:00

abstract：:Matrine is a traditional Chinese herbal medicine that shows antitumor efficacy for many types of cancer. The present study evaluated the antitumor efficacy of matrine on cervical cancer and to investigate the underlying mechanisms. We performed MTT assays, and in vitro invasion and migration assays, and P1 L6 found th...

journal_title：Oncology reports

authors： Wu X,Zhou J,Cai D,Li M

更新日期：2017-08-01 00:00:00

abstract：:In this study, a total of 108 patients with primary colorectal cancer who underwent hybrid 2-port hand-assisted laparoscopic surgery (HALS) were classified as 58 patients with colon cancer and 50 patients with rectal cancer. The mean operating time, mean blood loss, postoperative complications, and mean postoperative ...

journal_title：Oncology reports

authors： Mukai M,Kishima K,Tajima T,Hoshikawa T,Yazawa N,Fukumitsu H,Okada K,Ogoshi K,Makuuchi H

更新日期：2009-10-01 00:00:00

abstract：:Mitogenic actions of estrogens are mediated by two distinct estrogen receptors (ERs), which are critical in the progression and therapeutic response of breast cancer. ER expression is a dynamic phenomenon that is regulated by numerous factors, including cytokines, in the tumor microenvironment. Recently, studies have ...

journal_title：Oncology reports

authors： Niu XL,Wang Y,Yao Z,Duan H,Li Z,Liu W,Zhang H,Deng WM

更新日期：2015-12-01 00:00:00

abstract：:Combined chemotherapy with 5-fluorouracil and leucovorin (LV) has been widely used for the treatment of patients with colorectal cancer. Given that LV effects are attributable to increased levels of reduced folate in cancer cells, we attempted here to show the in vivo role of folylpolyglutamate synthetase (FPGS), whic...

journal_title：Oncology reports

authors： Tsukioka S,Sakamoto E,Tsujimoto H,Nakagawa F,Saito H,Uchida J,Kiniwa M,Fukushima M

更新日期：2011-05-01 00:00:00

abstract：:Tumor growth is accelerated by induction of angiogenesis regulated by many cytokines and growth factors. In a tumor mass, various angiogenic factors and their receptors are simultaneously expressed and the overlapped expressions of various factors may contribute to the aggressive growth of tumor. However, the possible...

journal_title：Oncology reports

authors： Lee YM,Bae MH,Lee OH,Moon EJ,Moon CK,Kim WH,Kim KW

更新日期：2004-10-01 00:00:00

abstract：:The present study aimed to investigate the role of miR‑181a in multiple myeloma (MM) cell lines. Reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR) was used to detect the expression of microRNA (miR)‑181a. The MM cell line RPMI 8226 stably transduced with miR‑181a mimics or inhibitor was establishe...

journal_title：Oncology reports

authors： Liu N,Yang J,Yuan R,Peng J,Liu L,Guo X

更新日期：2019-07-01 00:00:00

abstract：:Bufalin, a major digoxin-like immunoreactive component of the Chinese medicine Chansu, is prepared from toad venom. This compound has been shown to exert a potential for anticancer activity against various human cancer cell lines in vitro. However, the detailed molecular mechanisms ...

journal_title：Oncology reports

authors： Hong SH,Choi YH

更新日期：2012-01-01 00:00:00

abstract：:The BRAF T1799A mutation is a heterozygous point mutation and its reported prevalence in papillary thyroid carcinoma (PTC) has varied from 29 to 83%, with an overall mean of 44%. In Korea, the reported mutation rate reached 83% in PTC and 52% in micropapillary carcinoma. We hypothesized that the differences in prevale...

journal_title：Oncology reports

authors： Kim HS,Kim JO,Lee DH,Lee HC,Kim HJ,Kim JH,Jang YS,Lee JM,Kim SY,Kim YS

更新日期：2011-06-01 00:00:00

abstract：:Colorectal cancer (CRC) is a common gastrointestinal malignancy worldwide and is a lethal and aggressive malignancy with a dismal prognosis. EphrinB2 is a membrane-bound ligand and has an intracellular domain that also possesses an intrinsic signaling capacity called 'reverse signaling'. In the present study, CRC cell...

journal_title：Oncology reports

authors： Li P,Chen W,Wang Y,Fu X,Wen K,Qian J,Huang C,Fu Z

更新日期：2015-02-01 00:00:00