Frequent CYP1A1 expression in gastric cancers and their related lesions.

abstract：:In breast cancer, neuregulin-1 (NRG1) is known as a ligand for the HER3 receptor, which has no intrinsic tyrosine kinase activity. When activated by NRG1 binding, the HER3 receptor forms a heterodimer with other HER family receptors and mediates downstream signaling pathways, leading to multiple effects including grow...

journal_title：Oncology reports

authors： Jeong H,Kim J,Lee Y,Seo JH,Hong SR,Kim A

更新日期：2014-09-01 00:00:00

abstract：:The objective of this study was to investigate the effect of silencing gene protein phosphatase 1H (PPM1H) on malignant phenotype of human pancreatic cancer cell line BxPC-3. In order to explore the function of PPM1H in pancreatic cancer cells, real-time PCR and western blotting were used to detect the expression of P...

journal_title：Oncology reports

authors： Zhu H,Qin H,Li DM,Liu J,Zhao Q

更新日期：2016-11-01 00:00:00

abstract：:Adoptive immunotherapy requires the isolation of CD8+ T cells specific for tumor-associated antigens, their expansion in vitro and their transfusion to the patient to mediate a therapeutic effect. MUC1 is an important adenocarcinoma antigen immunogenic for T cells. The MUC1-derived SAPDTRPA (MUC1-8-mer) peptide is a p...

journal_title：Oncology reports

authors： Atzin-Méndez JA,López-González JS,Báez R,Arenas-Del Angel MC,Montaño LF,Silva-Adaya D,Lascurain R,Gorocica P

更新日期：2016-01-01 00:00:00

abstract：:A phase II trial of vinorelbine and low dose prednisone in hormone-refractory metastatic prostate cancer was conducted in order to investigate its safety, efficacy and impact on quality of life. Vinorelbine was administered at the dose of 25 mg/m(2) i.v. weekly for 12 weeks and then biweekly, along with 10 mg of daily...

journal_title：Oncology reports

authors： Robles C,Furst AJ,Sriratana P,Lai S,Chua L,Donnelly E,Solomon J,Sundaram M,Feun L,Savaraj N

更新日期：2003-07-01 00:00:00

abstract：:Post-transcriptional modification of p53 by phosphorylation has been proposed as an important mechanism of p53 stabilization and functional regulation. However, little is known about the phosphorylation state of mutant p53 protein overexpressed in human tumors. We evaluated immunohistochemically the p53 phosphorylatio...

journal_title：Oncology reports

authors： Matsumoto M,Furihata M,Kurabayashi A,Ohtsuki Y

更新日期：2004-11-01 00:00:00

abstract：:The development and characterization of effective anticancer drugs against colorectal cancer (CRC) is of urgent need since it is the second most common cause of cancer death. The study was designed to evaluate the effects of two IGF-1R antagonists, MK-0646, a recombinant fully humanized monoclonal antibody and OSI-906...

journal_title：Oncology reports

authors： Leiphrakpam PD,Agarwal E,Mathiesen M,Haferbier KL,Brattain MG,Chowdhury S

更新日期：2014-01-01 00:00:00

abstract：:Epithelial to mesenchymal transition (EMT) is a process implicated in cancer progression in which the underlying cellular changes have been identified mainly using in vitro models. We determined the expression of some putative EMT biomarkers including E-cadherin, beta-catenin, zinc finger factor Snail (Snail), transfo...

journal_title：Oncology reports

authors： Logullo AF,Nonogaki S,Pasini FS,Osório CA,Soares FA,Brentani MM

更新日期：2010-02-01 00:00:00

abstract：:Prognostic factors and the role of post-operative radiotherapy (PORT) in patients with pN1 nodal stage following surgery for NSCLC were identified. The clinical course of 211 patients with pN1 nodal involvement following thoracic surgery were reviewed, 97 of them received PORT. Multi-variate survival analysis with res...

journal_title：Oncology reports

authors： Willner J,Wiens V,Jachmann M,Haubitz I,Flentje M

更新日期：2004-09-01 00:00:00

abstract：:Identification of safe, effective radiosensitizing agents is urgently needed to improve the outcome of radiotherapy in nasopharyngeal cancer (NPC). In this study, we assessed the ability of the polyphenol resveratrol to act as a radiosensitizer in vitro and in vivo. CNE-1 cells were treated with 50 µM resveratrol for ...

journal_title：Oncology reports

authors： Tan Y,Wei X,Zhang W,Wang X,Wang K,Du B,Xiao J

更新日期：2017-03-01 00:00:00

abstract：:The cancer stem cell hypothesis suggests that mutated melanocyte stem cells are present in skin as precursors of melanoma cells. Nestin and CD133 have been described as markers of melanocytic stem cells. The aim of this study was to establish if melanocytic stem cells could have a prognostic significance in melanoma p...

journal_title：Oncology reports

authors： Piras F,Perra MT,Murtas D,Minerba L,Floris C,Maxia C,Demurtas P,Ugalde J,Ribatti D,Sirigu P

更新日期：2010-01-01 00:00:00

abstract：:Chromosomal translocations are very common in human cancer. The molecular mechanisms of chromosomal translocations are complex and are not fully understood. Recent studies showed organization of genomes is higher-order in the nucleus and every chromosome or chromatin has its preferential position and territory. These ...

journal_title：Oncology reports

authors： Zheng J

更新日期：2013-11-01 00:00:00

abstract：:The decision to repeat transcatheter arterial chemoembolization (TACE) for hepatocellular carcinoma (HCC) is based on correct evaluation of response to therapy. The purpose of this study was to investigate whether apparent diffusion coefficient (ADC), a quantitative parameter of diffusion-weighted imaging (DWI), can p...

journal_title：Oncology reports

authors： Kubota K,Yamanishi T,Itoh S,Murata Y,Miyatake K,Yasunami H,Morio K,Hamada N,Nishioka A,Ogawa Y

更新日期：2010-09-01 00:00:00

abstract：:The aim of this study was to evaluate variations of O6-methylguanine-DNA methyltransferase (MGMT) promoter methylation and protein expression after adjuvant treatment in glioblastoma patients. Sixteen patients with a glioblastoma underwent 34 microsurgeries including 18 re-operations. After surgery, patients underwent...

journal_title：Oncology reports

authors： Jung TY,Jung S,Moon KS,Kim IY,Kang SS,Kim YH,Park CS,Lee KH

更新日期：2010-05-01 00:00:00

abstract：:The pathogenic mechanisms responsible for inflammatory bowel disease (IBD) are poorly understood. In an IBD animal model, the oral administration of polysaccharides such as dextran sulfate sodium (DSS) induced colitis, which exhibited several clinical and histological features similar to IBD. However, pathogenic facto...

journal_title：Oncology reports

authors： Araki Y,Mukaisyo K,Sugihara H,Hattori T

更新日期：2008-07-01 00:00:00

abstract：:We investigated whether 18F-fluorothymidine-positron-emission tomography/computed tomography (18F-FLT-PET/CT) is useful for the evaluation of the very early response to anti-epidermal growth factor receptor (EGFR) antibody cetuximab therapy in human lung cancer xenografts. A human tumor xenograft model was established...

journal_title：Oncology reports

authors： Takeuchi S,Zhao S,Kuge Y,Zhao Y,Nishijima K,Hatano T,Shimizu Y,Kinoshita I,Tamaki N,Dosaka-Akita H

更新日期：2011-09-01 00:00:00

abstract：:MicroRNA (miRNA) is a type of endogenous non‑coding RNA implicated in various cellular processes. Studies have shown that miR-124 is involved in the malignant progression of cancer, but little is known concerning its potential role in breast cancer. Therefore, the purpose of this study was to conduct a functional anal...

journal_title：Oncology reports

authors： Du S,Li H,Sun X,Li D,Yang Y,Tao Z,Li Q,Liu K

更新日期：2016-12-01 00:00:00

abstract：:Phosphatidylinositol 3 kinases (PI-3 kinases) play a crucial role in the inositol phospholipid signaling pathway. The effect of wortmannin, an inhibitor of PI-3 kinases, on the suppression of thermotolerance development was investigated in the temperature-sensitive cell line tsAF8. When wortmannin was added immediatel...

journal_title：Oncology reports

authors： Shibuya K,Kawasaki S,Kuroda M,Takemoto M,Asaumi J,Hiraki Y

更新日期：2002-01-01 00:00:00

abstract：:Mechanisms of synergistic effect of thermotherapy and chemotherapy on human lung adenocarcinoma cell growth are unclear. The purpose of this study was to investigate these effects and explore the function of ROS, Akt and caspase-3 in relation to these. A549 cells were subjected to different thermochemotherapy treatmen...

journal_title：Oncology reports

authors： Wang L,Liu X,Wu Y,Wu W,Wu Y

更新日期：2012-10-01 00:00:00

abstract：:Aberrant glycosylation, a common feature of malignant alteration, is partly due to changes in the expression of glycosyltransferases, including β1,3-N-acetyl-glucosaminyltrans-ferase 8 (β3Gn‑T8), which synthesizes poly-N-acetyllactosamine (poly-LacNAc) chains on β1,6 branched N‑glycans. Although the role of β3Gn‑T8 in...

journal_title：Oncology reports

authors： Jiang Z,Liu Z,Zou S,Ni J,Shen L,Zhou Y,Hua D,Wu S

更新日期：2016-09-01 00:00:00

abstract：:Epigenetic alterations have been reported in colorectal neoplasia which can either complement or in some cases be predisposed to genetic alterations such as K-ras mutations. We examined the promoter methylation status of the CDKN2A and O6-methylguanine-DNA methyltransferase (MGMT) genes, after sodium bisulfite convers...

journal_title：Oncology reports

authors： Menigatti M,Pedroni M,Verrone AM,Borghi F,Scarselli A,Benatti P,Losi L,Di Gregorio C,Schär P,Marra G,Ponz de Leon M,Roncucci L

更新日期：2007-06-01 00:00:00

abstract：:Aberrant methylation of 5' CpG islands is thought to play an important role in the inactivation of tumor suppressor genes in several types of cancers. In non-small cell lung cancer (NSCLC), several genes are known to be frequently methylated and the correlation of their methylation with clinical features has been stud...

journal_title：Oncology reports

authors： Hanabata T,Tsukuda K,Toyooka S,Yano M,Aoe M,Nagahiro I,Sano Y,Date H,Shimizu N

更新日期：2004-07-01 00:00:00

abstract：:Benign prostatic hyperplasia (BPH) is a common chronic disease in older males. The pathogenesis of BPH remains elusive but may be associated with chronic inflammation. Chemokines and chemokine receptors have been implicated as critical mediators in the immune response and inflammatory processes. In the present study, ...

journal_title：Oncology reports

authors： Pang Y,Li H,Gong Y,Jing S,Peng C,Liu W,Zhao Y,Wang H,Kaushik D,Rodriguez R,Wang Z

更新日期：2019-04-01 00:00:00

abstract：:The purpose of this study was to define gene expression profile changes in colorectal tumors in order to identify target genes involved in neoplastic progression. cDNA microarray analysis was used to detect differences in gene expression profiles between colon tumor samples obtained from 20 patients in different tumor...

journal_title：Oncology reports

authors： Bandres E,Catalan V,Sola I,Honorato B,Cubedo E,Cordeu L,Andion E,Escalada A,Zarate R,Salgado E,Zabalegui N,García F,Garcia-Foncillas J

更新日期：2004-08-01 00:00:00

abstract：:Recent studies suggest that latexin (Lxn) expression is involved in stem cell regulation and that it plays significant roles in tumor cell migration and invasion. The clinicopathological significance of Lxn expression and its possible correlation with CD133 expression in pancreatic ductal adenocarcinoma (PDAC) is curr...

journal_title：Oncology reports

authors： Xue Z,Zhou Y,Wang C,Zheng J,Zhang P,Zhou L,Wu L,Shan Y,Ye M,He Y,Cai Z

更新日期：2016-01-01 00:00:00

abstract：:Casticin, a polymethoxyflavone, has been reported to exert anticancer activities. The objectives of this study were to examine the molecular mechanisms by which casticin induces the growth inhibition and cell cycle arrest in human hepatocellular carcinoma (HCC) cells. The HCC cell l...

journal_title：Oncology reports

authors： He L,Yang X,Cao X,Liu F,Quan M,Cao J

更新日期：2013-01-01 00:00:00

abstract：:Chemotherapy is one of the methods to treat patients with non-small cell lung cancer (NSCLC) developing resistance to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs), such as gefitinib. Previous studies revealed that the sensitivity to chemotherapy may depend on different cellular mechanisms ...

journal_title：Oncology reports

authors： Zhou J,Hu Q,Zhang X,Zheng J,Xie B,Xu Z,Zhang W

更新日期：2018-04-01 00:00:00

abstract：:Fluoroquinolones affect the proliferation and apoptotic cell death of several human malignancies. Therefore, we investigated whether new 6-aminoquinolone derivatives, initially synthesized as anti-HIV agents, could affect the proliferation and apoptotic cell death of human prostate cancer cell lines. PC3 and LNCaP cel...

journal_title：Oncology reports

authors： Minelli A,Bellezza I,Siciliano E,Liguori L,Tabarrini O,Cecchetti V,Fravolini A

更新日期：2005-06-01 00:00:00

abstract：:Inflammasomes can identify endogenous danger signals as an inflammatory immune response. As the most common inflammasome, the NLR pyrin family domain containing 3 (NLRP3) inflammasome is associated with the pathogenesis of different tumors. However, the function of the NLRP3 inflammasome in esophageal cancer (EC) has ...

journal_title：Oncology reports

authors： Yu S,Yin JJ,Miao JX,Li SG,Huang CZ,Huang N,Fan TL,Li XN,Wang YH,Han SN,Zhang LR

更新日期：2020-04-01 00:00:00

abstract：:The actual predictive value of oestrogen receptor (ER) beta for treatment decisions in breast cancer is still unclear. Retrospective studies using preoperative systemic therapy (PST) revealed that chemotherapy but also endocrine therapy can lead to alterations in expression levels of ERalpha and progesterone receptor ...

journal_title：Oncology reports

authors： Wurster M,Ruoff A,Meisner C,Seeger H,Vogel U,Juhasz-Böss I,Solomayer E,Wallwiener D,Fehm T,Neubauer H

更新日期：2010-09-01 00:00:00

abstract：:The peroxisome proliferator-activated receptor-γ (PPAR-γ) coactivator-1β (PGC-1β) is a well-established regulator of mitochondrial biogenesis. However, the underlying mechanism of PGC-1β action remains elusive. This study reveals that knockdown of endogenous PGC-1β by short-hairpin RNA (shRNA) leads to a decrease in t...

journal_title：Oncology reports

authors： Wang L,Liu Q,Li F,Qiu J,Fan H,Ma H,Zhu Y,Wu L,Han X,Yang Z,Jiang H,Wei J,Xia H

更新日期：2013-10-01 00:00:00