Latexin exhibits tumor-suppressor potential in pancreatic ductal adenocarcinoma.

abstract：:It has been reported that cimetidine, a histamine type-2 receptor (H2R) antagonist, inhibits the growth of glandular tumors such as colorectal cancer. However, its effects against salivary gland tumors are still unknown. We demonstrated previously that human salivary gland tumor (HSG) cells spontaneously express the n...

journal_title：Oncology reports

authors： Fukuda M,Tanaka S,Suzuki S,Kusama K,Kaneko T,Sakashita H

更新日期：2007-03-01 00:00:00

abstract：:Tumor size indicates the extent of cell proliferation in most cases of colorectal cancer (CRC), although there are some advanced small tumors with metastases. Lymph node metastasis is a significant factor that greatly impacts disease prognosis in CRC cases. The underlying factors that cause lymph node metastasis in CR...

journal_title：Oncology reports

authors： Takahashi Y,Sawada G,Sato T,Kurashige J,Mima K,Matsumura T,Uchi R,Ueo H,Ishibashi M,Takano Y,Akiyoshi S,Eguchi H,Sudo T,Sugimachi K,Tanaka J,Kudo SE,Doki Y,Mori M,Mimori K

更新日期：2013-09-01 00:00:00

abstract：:The changes of the microtubular network induced by microtubule destabilizing (Vinblastine, VBL) and stabilizing (Taxol, TAX) agents were studied in NIH/3T3 fibroblastic cells in conventional culture conditions (NIHb) and in a subpopulation (NIHs), obtained after serum deprivation and expressing different morphofunctio...

journal_title：Oncology reports

authors： Spano A,Monaco G,Barni S,Sciola L

更新日期：2008-12-01 00:00:00

abstract：:miR-367 is one of the most abundant miRNAs in human embryonic stem cells (hESCs) and is mainly involved in maintaining the pluripotency of stem cells. However, its role in cancer development remains poorly understood. In the present study, we explored the function and mechanism of the endogenous miR-367 in non-small c...

journal_title：Oncology reports

authors： Xiao G,Gao X,Sun X,Yang C,Zhang B,Sun R,Huang G,Li X,Liu J,Du N,Liu D,Liang R,Ren H,Qin S

更新日期：2017-08-01 00:00:00

abstract：:Emerging evidence suggests that cancer cells present profound epigenetic alterations in addition to featuring classic genetic mutations. Valproic acid (VPA), a histone deacetylase inhibitor, can potently inhibit tumor growth and induce differentiation. However, the effect and underlying mechanism of VPA on head and ne...

journal_title：Oncology reports

authors： Lee SH,Nam HJ,Kang HJ,Samuels TL,Johnston N,Lim YC

更新日期：2015-10-01 00:00:00

abstract：:Emodin is an active ingredient derived from root and rhizome of Rheum palmatum L and many studies have reported that it exhibits anticancer effects in a number of human tumors. However, there is little information demonstrating the possible effects of emodin on the proliferation and apoptosis of hepatocellular carcino...

journal_title：Oncology reports

authors： Lin W,Zhong M,Yin H,Chen Y,Cao Q,Wang C,Ling C

更新日期：2016-08-01 00:00:00

abstract：:Like many other solid tumors, cervical cancer contains a heterogeneous population of cancer cells. Several investigators have identified putative stem cells from solid tumors and cancer cell lines via the capacity to self renew and drive tumor formation. The aim of this study was to identify and characterize a cancer ...

journal_title：Oncology reports

authors： Feng D,Peng C,Li C,Zhou Y,Li M,Ling B,Wei H,Tian Z

更新日期：2009-11-01 00:00:00

abstract：:Telomerase is a ribonucleoprotein enzyme which is endogenously expressed in germ, stem and tumor cells, but absent in benign somatic cells. The two major telomerase components are human telomerase RNA (hTR) and human telomerase reverse transcriptase (hTERT). It has been shown that hTERT is rate-limiting for telomerase...

journal_title：Oncology reports

authors： Schrader M,Burger AM,Müller M,Krause H,Straub B,Smith GL,Newlands ES,Miller K

更新日期：2002-09-01 00:00:00

abstract：:In recent years an extensive series of synthetic combretastatin A-4 (CA-4)-azetidinone (β-lactam) hybrids were designed and synthesised with a view to improve the stability, therapeutic efficacy and aqueous solubility of CA-4. Lead compounds containing a 3,4,5-trimethoxy aromatic ring at position 1 and a variety of su...

journal_title：Oncology reports

authors： Greene LM,Wang S,O'Boyle NM,Bright SA,Reid JE,Kelly P,Meegan MJ,Zisterer DM

更新日期：2013-06-01 00:00:00

abstract：:To elucidate the potential etiological role of RUNX3 in the development of salivary gland adenoid cystic carcinoma (ACC), we analyzed the methylation status of RUNX3 in a series of 114 ACC tissues and 3 ACC cell lines. Results showed that the methylated rate of RUNX3 was 50.9 and 3.5% in the 114 ACC samples and the co...

journal_title：Oncology reports

authors： Ge MH,Chen C,Xu JJ,Ling ZQ

更新日期：2011-08-01 00:00:00

abstract：:Immunotherapy with autologous dendritic cells (DCs) loaded with tumor lysate(s) from allogeneic tumor cell lines is a novel strategy to induce immune responses in cancer patients. We report on a pilot trial of autologous DCs pulsed with tumor cell lysate derived from allogeneic medullary thyroid carcinoma (MTC) cell l...

journal_title：Oncology reports

authors： Bachleitner-Hofmann T,Friedl J,Hassler M,Hayden H,Dubsky P,Sachet M,Rieder E,Pfragner R,Brostjan C,Riss S,Niederle B,Gnant M,Stift A

更新日期：2009-06-01 00:00:00

abstract：:The efficacy of chemotherapy for hepatocellular carcinoma (HCC) remains unsatisfactory, primarily due to inherent self‑defense mechanisms (e.g., mitophagy and autophagy). In the present study, we aimed to explore the pro‑apoptotic effects of targeting mitophagy to potentiate the efficacy of chemotherapy for HCC. HCC c...

journal_title：Oncology reports

authors： Ma M,Lin XH,Liu HH,Zhang R,Chen RX

更新日期：2020-03-01 00:00:00

abstract：:Patients with ulcerative colitis (UC) exhibit an increased risk for the development of cancer of the colon and rectum. This association is widely attributed to colonic inflammation. However, the severity of colonic inflammation necessary for the development of dysplasia and/or cancer remains unknown. In this study, we...

journal_title：Oncology reports

authors： Inoue T,Murano M,Kuramoto T,Ishida K,Kawakami K,Abe Y,Morita E,Murano N,Toshina K,Nishikawa T,Maemura K,Shimamoto C,Hirata I,Katsu K,Higuchi K

更新日期：2007-12-01 00:00:00

abstract：:Benign prostatic hyperplasia (BPH) is a common chronic disease in older males. The pathogenesis of BPH remains elusive but may be associated with chronic inflammation. Chemokines and chemokine receptors have been implicated as critical mediators in the immune response and inflammatory processes. In the present study, ...

journal_title：Oncology reports

authors： Pang Y,Li H,Gong Y,Jing S,Peng C,Liu W,Zhao Y,Wang H,Kaushik D,Rodriguez R,Wang Z

更新日期：2019-04-01 00:00:00

abstract：:New therapeutic strategies are needed for colorectal cancer (CRC) treatment. MicroRNAs are involved in cancer‑pertinent cellular processes, including chemoresistance. As miR‑302a is an embryonic stem cell‑specific microRNA, studies on miR‑302a have focused on its role in human stem cells. Studies analyzing miR‑302 fun...

journal_title：Oncology reports

authors： Liu N,Li J,Zhao Z,Han J,Jiang T,Chen Y,Hou N,Huang C

更新日期：2017-01-01 00:00:00

abstract：:Inflammation is regarded as one of the major hallmarks of tumors, and has a very close relationship with gastric cancer. Interleukin-33 (IL-33), a new member of the IL-1 family, plays an important role in both inflammatory disease and tumors. The present study was designed to explore the effects of IL-33 on the prolif...

journal_title：Oncology reports

authors： Ye XL,Zhao YR,Weng GB,Chen YC,Wei XN,Shao JP,Ji H

更新日期：2015-06-01 00:00:00

abstract：:Vaccine strategies for the treatment of human papillomavirus-induced cervical cancer are based mainly on the human papillomavirus 16 E7 (HPV16 E7) oncoprotein. The immunogenicity of the E7 gene has been enhanced by its fusion to many different genes. Here, we linked a short sequence coding for the E7 peptide (aa 44-60...

journal_title：Oncology reports

authors： Pokorna D,Cerovska N,Smahel M,Moravec T,Ludvikova V,Mackova J,Synkova H,Duskova M,Hozak P,Veleminsky J

更新日期：2005-10-01 00:00:00

abstract：:Lung cancer is still the leading cause of cancer-related deaths worldwide. Identifying new oncogenic drivers and developing efficient inhibitors through molecular targeting approaches are crucial for improving therapies. The aim of this study was to investigate whether targeting fibroblast growth factor receptor 1 (FG...

journal_title：Oncology reports

authors： Ren M,Hong M,Liu G,Wang H,Patel V,Biddinger P,Silva J,Cowell J,Hao Z

更新日期：2013-06-01 00:00:00

abstract：:We previously reported that chromosome arm 10q is one of the target regions of allelic loss in human endometrial cancer. To identify the gene in this region responsible for endometrial cancer, we further characterized this region and localized the hBRAG gene. The function of hBRAG has not yet been fully studied, and t...

journal_title：Oncology reports

authors： Yuki M,Yoshinaga K,Yamakawa H,Sakurada K,Sato S,Yajima A,Horii A

更新日期：2000-11-01 00:00:00

abstract：:In the present study, effectiveness of topical vidarabine or subsequent 5-fluorouracil (5-FU) administration was examined against persistent genital human papillomavirus (HPV) infection after local surgery. Thirty patients underwent local eradication treatment of uterine cervical intra-epithelial neoplasia (CIN) and s...

journal_title：Oncology reports

authors： Niwa K,Tagami K,Lian Z,Gao J,Mori H,Tamaya T

更新日期：2003-09-01 00:00:00

abstract：:Bisphosphonates (BPs) inhibit bone resorption by preventing osteoclast maturation and apoptosis induction. Recently, BPs have also been shown to have antitumor effects against various types of carcinomas in vitro and in vivo. In this study, we investigated the antitumor effect of zoledronic acid (ZOL), a third generat...

journal_title：Oncology reports

authors： Tamura T,Shomori K,Nakabayashi M,Fujii N,Ryoke K,Ito H

更新日期：2011-04-01 00:00:00

abstract：:Esophageal cancer is one of the most aggressive cancers in the world. Novel preventive and therapeutic strategies tend to target the key molecules involved in the signaling transduction pathways for cell growth. It is known that FAK and mTOR are important controllers of cell growth. TAE226, a novel small molecule comp...

journal_title：Oncology reports

authors： Wang ZG,Fukazawa T,Nishikawa T,Watanabe N,Sakurama K,Motoki T,Takaoka M,Hatakeyama S,Omori O,Ohara T,Tanabe S,Fujiwara Y,Shirakawa Y,Yamatsuji T,Tanaka N,Naomoto Y

更新日期：2008-12-01 00:00:00

abstract：:Taxanes, a new class of antitumor drugs, are effective against a large number of human tumors, although there are problems with drug resistance. The novel taxane, IDN5109, is characterized by its high tolerability, antitumor efficacy, ability to overcome multidrug resistance, and oral bioavailabilty. We investigated t...

journal_title：Oncology reports

authors： Sano D,Matsuda H,Ishiguro Y,Nishimura G,Kawakami M,Tsukuda M

更新日期：2006-02-01 00:00:00

abstract：:Complement system activation contributes to various immune and inflammatory diseases, as well as cancers.However, the role of complement activation in the proliferation of cancer cells is not clear. In the present study, we investigated the consequences of complement activation on the proliferation of breast cancer ce...

journal_title：Oncology reports

authors： Lu Y,Hu XB

更新日期：2014-12-01 00:00:00

abstract：:In the present study, the preliminary results of the first stereotactic body radiosurgery (SRS) experience with volumetric intensity modulated arc therapy (VMAT) in oligometastatic breast and recurrent gynecological tumors (OBRGT) are reported in terms of feasibility, toxicity and efficacy. Patients were treated in a ...

journal_title：Oncology reports

authors： Macchia G,Deodato F,Cilla S,Torre G,Corrado G,Legge F,Gambacorta MA,Tagliaferri L,Mignogna S,Scambia G,Valentini V,Morganti AG,Ferrandina G

更新日期：2014-11-01 00:00:00

abstract：:Tropomodulin 3 (TMOD3) is a member of the pointed‑end capping protein family that contributes to invasion and metastasis in several types of malignancies. TMOD3 has been found to be crucial for membranous skeleton and embryonic development; however, little is known regarding the role of TMOD3 in liver cancer progressi...

journal_title：Oncology reports

authors： Jin C,Chen Z,Shi W,Lian Q

更新日期：2019-05-01 00:00:00

abstract：:Reactive oxygen species (ROS) can drive the de‑differentiation of tumor cells leading to the process of epithelial-to-mesenchymal transition (EMT) to enhance invasion and metastasis. The invasive and metastatic phenotype of malignant cells is often linked to loss of E-cadherin expression, a hallmark of EMT. Recent stu...

journal_title：Oncology reports

authors： Wang Y,Ma J,Shen H,Wang C,Sun Y,Howell SB,Lin X

更新日期：2014-11-01 00:00:00

abstract：:The Chinese medicinal herb Sorbaria sorbifolia, native to Changbai Mountain, can induce apoptosis in HepG-2 cells. We studied the mechanism by which 5, 2', 4'-trihydroxy-6,7, 5'-trimethoxyflavone (TTF1) isolated from acetic ether extracts of Sorbaria sorbifolia induces apoptosis in HepG-2 cells. The results showed tha...

journal_title：Oncology reports

authors： Li Y,Bian L,Cui F,Li L,Zhang X

更新日期：2011-09-01 00:00:00

abstract：:The Houttuynia cordata Thunb (HCT) extract has been used as a traditional Chinese herb medicine and as well as an effective drug for treating allergic inflammation for thousands of years. In this study, we investigated the anti-cancer activity of HCT and its molecular mechanisms in the human colon adenocarcinoma cell ...

journal_title：Oncology reports

authors： Tang YJ,Yang JS,Lin CF,Shyu WC,Tsuzuki M,Lu CC,Chen YF,Lai KC

更新日期：2009-11-01 00:00:00

abstract：:Head and neck squamous cell carcinoma (HNSCC) is an aggressive epithelial malignancy. It is known to be the most common neoplasm appearing in the upper aerodigestive tract. The poor 5‑year survival rate has remained unchanged in the last decades even though improved techniques in su...

journal_title：Oncology reports

authors： Faber A,Sauter A,Hoedt S,Hoermann K,Erben P,Hofheinz RD,Sommer U,Stern-Straeter J,Schultz DJ

更新日期：2012-07-01 00:00:00