Latexin exhibits tumor-suppressor potential in pancreatic ductal adenocarcinoma.

abstract：:Lung cancer is the leading cause of cancer-related mortality in humans. Exploration of the mechanisms underlying the self-renewal and stemness maintenance of cancer stem-like cells (CSLCs) will open new avenues in lung cancer diagnosis and therapy. Here, we isolated and identified a subpopulation of lung cancer stem-l...

journal_title：Oncology reports

authors： Lu C,Huang T,Chen W,Lu H

更新日期：2015-07-01 00:00:00

abstract：:Protease-activated receptor 2 (PAR2) is a G-protein-coupled receptor and its activation has been associated with the pathogenetic progress in certain cancers. Toll-like receptor 4 (TLR4), one member of Toll-like receptors family, is mainly contributed to the innate immune response. However, recent studies have shown t...

journal_title：Oncology reports

authors： Zhou B,Zhou H,Ling S,Guo D,Yan Y,Zhou F,Wu Y

更新日期：2011-02-01 00:00:00

abstract：:Orofacial viral infections are common in immunocompromised patients. Herpes simplex virus (HSV) infections are the most common. Varicella-Zoster virus (VZV) infections are less common, but usually more severe. Epstein-Barr virus (EBV) may produce ulcers, lymphoproliferative syndromes or oral hairy leukoplakia (HL). Hu...

journal_title：Oncology reports

authors： Samonis G,Mantadakis E,Maraki S

更新日期：2000-11-01 00:00:00

abstract：:Tongue cancer is one of the most common types of cancer, but its molecular etiology and pathogenesis remain unclear. The aim of the present study was to elucidate the pathogenesis of tongue cancer and investigate novel potential diagnostic and therapeutic targets. Four matched pairs of tongue cancer and paracancerous ...

journal_title：Oncology reports

authors： Tang M,Dai W,Wu H,Xu X,Jiang B,Wei Y,Qian H,Han L

更新日期：2020-06-01 00:00:00

abstract：:Migration and adhesion of tumor cells are essential prerequisites for the formation of metastases in malignant diseases. Chemokine receptor 7 (CCR7) has been shown to regulate integrin which can then facilitate adhesion of cancer cells to and/or migration through the extracellular matrix (ECM). In order to identify th...

journal_title：Oncology reports

authors： Li P,Zhao ZJ,Liu FY,Sun LY,Ding X,Zhang WZ,Shang DH,Sun CF

更新日期：2010-10-01 00:00:00

abstract：:Orotate phosphoribosyl transferase (OPRT) is an enzyme playing an important role in exertion of the effect of 5-fluorouracil (5-FU). A type of gene polymorphism, single nucleotide polymorphism (SNP), is considered to be a factor affecting individual differences in exertion of drug effects, and its analysis has recentl...

journal_title：Oncology reports

authors： Kitajima M,Takita N,Hata M,Maeda T,Sakamoto K,Kamano T,Ochiai T

更新日期：2006-01-01 00:00:00

abstract：:The endoplasmic reticulum (ER) is a membranous network within cells that is important for several cellular functions including translation and folding of secretory and membrane proteins, lipid biogenesis and sequestration of Ca2+. Disruption of ER structure might affect the normal physiology of the cells. In yeast, ex...

journal_title：Oncology reports

authors： Li X,Kang Y,Jiao B,Xia M,Wu Y,Sun L

更新日期：2016-12-01 00:00:00

abstract：:Tubulin is a major component of microtubules. Class III beta-tubulin (beta III) is a neuron-associated beta-tubulin isotype and expressed in the normal central and peripheral nervous systems. According to a previous study, beta III is not expressed in normal skin and squamous cell carcinoma. However, its expression ha...

journal_title：Oncology reports

authors： Ishida M,Kushima R,Okabe H

更新日期：2009-10-01 00:00:00

abstract：:The isothiocyanates (ITCs) have long been known to possess chemopreventive activities for a variety of neoplasms including breast cancer, but the molecular mechanism by which ITCs prevent breast cancer development has not been established. In this study, we investigated the effects of benzyl and phenethyl isothiocyana...

journal_title：Oncology reports

authors： Kang L,Ding L,Wang ZY

更新日期：2009-01-01 00:00:00

abstract：:We investigated the role of mitochondrial function in the invasiveness of human colorectal cancer (CRC) cell lines, using paired primary SW480 and metastatic SW620 cells, and appraised the clinical relevance of the alteration of mtDNA copy number in 33 pairs of CRC specimens after surgical resection. Suppression of mi...

journal_title：Oncology reports

authors： Lin CS,Liu LT,Ou LH,Pan SC,Lin CI,Wei YH

更新日期：2018-01-01 00:00:00

abstract：:Long non‑coding RNA (lncRNA) forkhead box P4 antisense RNA 1 (FOXP4‑AS1) has been determined to function as an oncogene in various types of cancer. However, the biological function and the underlying mechanisms of FOXP4‑AS1 in mantle cell lymphoma (MCL) remain to be uncovered. The expression and the associated clinico...

journal_title：Oncology reports

authors： Tao HF,Shen JX,Hou ZW,Chen SY,Su YZ,Fang JL

更新日期：2020-12-11 00:00:00

abstract：:Recombinant hirudin (rH) is a highly potent and specific inhibitor of thrombin, and has been shown to inhibit the growth and metastasis of several types of cancers in experimental tumor models. The objective of this study was to evaluate the antitumor effects and explore the underlying mechanisms of rH in Hep-2 human ...

journal_title：Oncology reports

authors： Lu Q,Lv M,Xu E,Shao F,Feng Y,Yang J,Shi L

更新日期：2015-03-01 00:00:00

abstract：:This study was designed to investigate the effect of pseudo-G-Rh2, a novel metabolite of ginsenoside Rh2, on the apoptosis of SGC-7901 human gastric cancer cells. Pseudo-G-Rh2 demonstrated antitumor activity and significantly inhibited the proliferation of SGC-7901 cells in a concen...

journal_title：Oncology reports

authors： Qu X,Qu S,Yu X,Xu H,Chen Y,Ma X,Sui D

更新日期：2011-12-01 00:00:00

abstract：:Associations of functional single nucleotide polymorphisms in cytochrome P450 1B1, epoxide hydrolase 1, NAD(P)H:quinone oxidoreductase 1, glutathione S-transferase Pi-1 and deletions of glutathione S-transferases Mu-1 and θ-1 with colorectal cancer risk were investigated in a hospital-based case-control study on 495 m...

journal_title：Oncology reports

authors： Hlavata I,Vrana D,Smerhovsky Z,Pardini B,Naccarati A,Vodicka P,Novotny J,Mohelnikova-Duchonova B,Soucek P

更新日期：2010-11-01 00:00:00

abstract：:Cyclin Y (CCNY) is a newly identified PFTK1 interacting protein and has been found to be associated with the proliferation and tumorigenesis of human non-small cell lung cancer. In the present study, we analyzed the expression levels of CCNY in 65 cases of breast cancer (BC) tissues and in four BC cell lines, BT-474, ...

journal_title：Oncology reports

authors： Yan F,Wang X,Zhu M,Hu X

更新日期：2016-11-01 00:00:00

abstract：:Survivin, an anti-apoptotic protein, is abundantly expressed in a variety of cancer cells, including hepatoma cells, resulting in the resistance of these cells to various apoptotic stimuli. Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is known to induce cancer cell-specific apoptosis, but hepa...

journal_title：Oncology reports

authors： Nakao K,Hamasaki K,Ichikawa T,Arima K,Eguchi K,Ishii N

更新日期：2006-08-01 00:00:00

abstract：:In the present study, we investigated the antitumor activity of caudatin in the human hepatoma cell line SMMC‑7721 by analysis of cell viability, cell cycle distribution, apoptosis and metastasis. The results showed that caudatin impaired the cell viability and inhibited the growth of SMMC-7721 cells in a time- and do...

journal_title：Oncology reports

authors： Luo Y,Sun Z,Li Y,Liu L,Cai X,Li Z

更新日期：2013-12-01 00:00:00

abstract：:The incidence of malignant melanoma has increased greatly in recent decades presenting a high mortality rate despite intensive efforts in this area of research. Recent studies indicate that the chemokine receptor 4 (CXCR4) plays a critical role in cancer. Thus, it has been reported that CXCL12 binding to CXCR4 initiat...

journal_title：Oncology reports

authors： André ND,Silva VA,Watanabe MA,De Lucca FL

更新日期：2016-04-01 00:00:00

abstract：:Epithelial to mesenchymal transition (EMT) is a process implicated in cancer progression in which the underlying cellular changes have been identified mainly using in vitro models. We determined the expression of some putative EMT biomarkers including E-cadherin, beta-catenin, zinc finger factor Snail (Snail), transfo...

journal_title：Oncology reports

authors： Logullo AF,Nonogaki S,Pasini FS,Osório CA,Soares FA,Brentani MM

更新日期：2010-02-01 00:00:00

abstract：:Acquisition of resistance to paclitaxel is a major obstacle to successful treatment of breast cancer patients, but the molecular mechanisms underlying the development of drug resistance remain largely unclear. The aim of the present study was to investigate the role and mechanism of action of miR‑200c‑3p in the resist...

journal_title：Oncology reports

authors： Chen J,Tian W,He H,Chen F,Huang J,Wang X,Chen Z

更新日期：2018-12-01 00:00:00

abstract：:Insulin resistance (IR) is reportedly involved in the progression of hepatocellular carcinoma (HCC). Since neovascularization plays an important role in hepatocarcinogenesis and IR, an angiostatic therapy may be considered as one of the promising approaches for chemoprevention again...

journal_title：Oncology reports

authors： Yoshiji H,Noguchi R,Ikenaka Y,Kaji K,Aihara Y,Yamazaki M,Yamao J,Toyohara M,Mitoro A,Sawai M,Yoshida M,Morioka C,Fujimoto M,Uemura M,Fukui H

更新日期：2011-12-01 00:00:00

abstract：:The global rising incidence of hepatocellular carcinoma (HCC), which parallels the increase of hepatitis C virus (HCV) prevalence, has sparked a renewed interest in discovering additional HCC serum markers. In this study, we investigated the clinical use of serum E-cadherin, ICAM, MMP-2, VEGF, OPN and β-catenin as pot...

journal_title：Oncology reports

authors： Zekri AR,Bahnassy AA,Alam El-Din HM,Morsy HM,Shaarawy S,Moharram NZ,Daoud SS

更新日期：2011-10-01 00:00:00

abstract：:LKB1 encodes a serine/threonine kinase generally inactivated in human lung cancers, which mediates cancer cell proliferation, migration and differentiation, but its biological function has not been completely elucidated. In this study, we demonstrated that LKB1 was associated with a substantial reduction of c-myc expr...

journal_title：Oncology reports

authors： Liang X,Nan KJ,Li ZL,Xu QZ

更新日期：2009-04-01 00:00:00

abstract：:Cancer immunotherapy is a promising new approach to cancer treatment. It has been demonstrated that a high number of tumor-specific cytotoxic T cells (CTLs) is associated with increased disease-specific survival in lung cancer patients. Identification of superior CTL epitopes from tumor antigens is essential for the d...

journal_title：Oncology reports

authors： Yoshimura M,Tada Y,Ofuzi K,Yamamoto M,Nakatsura T

更新日期：2014-07-01 00:00:00

abstract：:The aim of this study was to look for a new medicine in diagnosing and treating of glioblastoma. Radioiodine-labeled anti-epidermal growth factor receptor (EGFR) binding nanoparticles were constructed. In vitro cell-binding assays were confirmed by confocal microscopy and flow cytometry. Cell cytotoxicity assays were ...

journal_title：Oncology reports

authors： Li C,Tan J,Chang J,Li W,Liu Z,Li N,Ji Y

更新日期：2017-11-01 00:00:00

abstract：:MicroRNAs (miRNAs) play important roles in the the gene regulation of carcinogenesis including breast cancer. miR‑519d has been studied in various types of cancer, but its role in breast cancer remains unclear. In the present study, we investigated the expression and biological function of miR-519d in breast cancer. U...

journal_title：Oncology reports

authors： Deng X,Zhao Y,Wang B

更新日期：2015-10-01 00:00:00

abstract：:The roles and mechanisms of mini-chromosome maintenance complex component 7 (MCM7) amplification and overexpression in esophageal carcinogenesis were investigated. By analyzing the TCGA datasets, we found that MCM7 was amplified in approximately 12% of esophageal squamous cell carcinomas (ESCCs), and in more than 4% o...

journal_title：Oncology reports

authors： Qiu YT,Wang WJ,Zhang B,Mei LL,Shi ZZ

更新日期：2017-06-01 00:00:00

abstract：:H-, K- and N-ras gene mutations were analyzed in lung cancer from Thai patients. Thirteen out of 58 cases (22%) harbored the mutations. Ten cases showed K-ras gene mutations at codon 12, 1 case presented a mutation at codon 13 and another case exhibited a mutation at codon 63. Silent mutations of N-ras gene in codons ...

journal_title：Oncology reports

authors： Petmitr S,Wongsommart D,Chaksangchaichot P,Pakeetoot T,Sutinont P,Sirivaidyapong P,Karalak A

更新日期：2003-09-01 00:00:00

abstract：:The progress of the application of adenovirus in cancer gene therapy is hindered by the lack of expression of native adenovirus receptor on a variety of cancer types. Hence, strategies are needed to retarget the adenoviral vector to non-native cellular surface receptors. In the present study, a new peptide SWDIAWPPLKV...

journal_title：Oncology reports

authors： Wang D,Li W,Zhang H,Mao Q,Xia H

更新日期：2014-05-01 00:00:00

abstract：:The tumor microenvironment plays an important role in cancer growth, invasion and metastasis. The stroma surrounding a tumor is known to contain a variety of factors that can increase angiogenesis, cancer growth and tumor progression. The aim of the present study was to determine the role of fascin in cancer growth an...

journal_title：Oncology reports

authors： Zhang X,Cho IH,Park JH,Lee MK,Hwang YS

更新日期：2019-01-01 00:00:00