Association of CCL2, CCR2 and CCL5 genetic polymorphisms with the development and progression of benign prostatic hyperplasia.

Abstract:

:Benign prostatic hyperplasia (BPH) is a common chronic disease in older males. The pathogenesis of BPH remains elusive but may be associated with chronic inflammation. Chemokines and chemokine receptors have been implicated as critical mediators in the immune response and inflammatory processes. In the present study, the aim was to evaluate the association of three polymorphisms in chemokine genes, namely C‑C motif chemokine ligand (CCL)2 rs1024611, CC chemokine receptor 2 (CCR2) rs1799864 and CCL5 rs2107538, with BPH risk. These polymorphisms were genotyped in 109 patients with BPH and 160 control subjects, using the polymerase chain reaction and multiple ligase detection reaction method. The CCL5 rs2107538 polymorphism was identified to be associated with a significantly lower risk of BPH [A/G vs. G/G: odds ratio (OR)=0.37, 95% confidence interval (CI)=0.17‑0.78; A/A + A/G vs. G/G: OR=0.39, 95% CI=0.19‑0.79; A vs. G: OR=0.58, 95% CI=0.35‑0.96). However, this polymorphism was also associated with the development of larger prostate volumes in patients with BPH (A/G vs. G/G: OR=3.02, 95% CI=1.28‑7.11; AA + AG vs. GG: OR=2.83, 95% CI=1.28‑6.26; A vs. G: OR=1.94, 95% CI=1.08‑3.49). The CCR2 rs1799864 polymorphism was associated with lower International Prostate Symptom Score values (A/A + A/G vs. G/G: OR=0.39, 95% CI=0.17‑0.91; A vs. G: OR=0.43, 95% CI=0.20‑0.90) and low Qmax (A/G vs. G/G: OR=0.38, 95% CI=0.16‑0.92; AA + AG vs. GG: OR=0.39, 95% CI=0.17‑0.91) in the patients. No association was observed between the CCL2 rs1024611 polymorphism and BPH. These results suggest that the CCR2 and CCL5 genes may contribute to the occurrence and progression of BPH.

journal_name

Oncol Rep

journal_title

Oncology reports

authors

Pang Y,Li H,Gong Y,Jing S,Peng C,Liu W,Zhao Y,Wang H,Kaushik D,Rodriguez R,Wang Z

doi

10.3892/or.2019.7002

subject

Has Abstract

pub_date

2019-04-01 00:00:00

pages

2491-2501

issue

4

eissn

1021-335X

issn

1791-2431

journal_volume

41

pub_type

杂志文章
  • Genome-wide cDNA microarray screening of genes related to survival in patients after curative resection of non-small cell lung cancer.

    abstract::We conducted a study to determine whether the expression levels of genes in tumors were correlated with the survival of patients after complete resection of non-small cell lung cancer (NSCLC). The expression levels of 1176 genes in resected tumor specimens from 28 patients were analyzed using the Atlastrade mark Human...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:

    authors: Oshita F,Sekiyama A,Ito H,Kameda Y,Miyagi Y

    更新日期:2006-10-01 00:00:00

  • Schisandrin B inhibits cell proliferation and induces apoptosis in human cholangiocarcinoma cells.

    abstract::Cholangiocarcinoma (CCA) is the second most common hepatic cancer with high resistance to current chemotherapies and extremely poor prognosis. The present study aimed to examine the effects of schisandrin B (Sch B) on CCA cells both in vitro and in vivo and to examine its underlying mechanism. We found that Sch B inhi...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or.2016.4992

    authors: Yang X,Wang S,Mu Y,Zheng Y

    更新日期:2016-10-01 00:00:00

  • Chemotherapy under cachectic conditions and the possibility of cachexia-controlled chemotherapy.

    abstract::We studied the role of chemotherapy in cancer cachexia, which is well known to lower QOL and responsiveness to chemotherapy. In BALB/c mice we used two clones derived from the murine colon 26 adenocarcinoma cell line; clone 5, a non-cachexigenic tumor and clone 20, a cachexigenic tumor, in which IL-6 mRNA was selectiv...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:

    authors: Takahashi Y,Yasumoto K,Mai M

    更新日期:2005-07-01 00:00:00

  • Cucurbitacin D impedes gastric cancer cell survival via activation of the iNOS/NO and inhibition of the Akt signalling pathway.

    abstract::Cucurbitacin D (CuD), isolated from plants from the Cucurbitaceae family, is a potential antitumour agent since it inhibits proliferation, migration and metastasis of cancer cells. Despite CuD antitumour activity in cancer cells, the effects of CuD on gastric cancer cell lines remain unclear. The present study aimed t...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or.2018.6361

    authors: Zhang YZ,Wang CF,Zhang LF

    更新日期:2018-06-01 00:00:00

  • The bacterial polysaccharide tecogalan blocks growth of breast cancer cells in vivo.

    abstract::The growth of supportive tissue during the progression of solid tumors is an absolute requirement for the nourishment of the tumor. The blockade of this proliferative response of normal tissues to the growing tumor should hence inhibit tumor progression. We have shown earlier, that the heparinoid pentosan polysulfate ...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:

    authors: Yunmbam MK,Wellstein A

    更新日期:2001-01-01 00:00:00

  • A study on the mechanism of 5-aminolevulinic acid photodynamic therapy in vitro and in vivo in cervical cancer.

    abstract::5-Aminolevulinic acid-mediated photodynamic therapy (ALA-PDT) is a new ablation treatment for tumors, while its function mechanism in cervical cancer has not been elucidated. In this study, we investigated the effects of ALA-PDT on the cervical cancer cell line Me180, to search for optimal parameters of PDT. ALA-PDT o...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or_00000295

    authors: He GF,Bian ML,Zhao YW,Xiang Q,Li HY,Xiao C

    更新日期:2009-04-01 00:00:00

  • Caudatin inhibits human hepatoma cell growth and metastasis through modulation of the Wnt/β-catenin pathway.

    abstract::In the present study, we investigated the antitumor activity of caudatin in the human hepatoma cell line SMMC‑7721 by analysis of cell viability, cell cycle distribution, apoptosis and metastasis. The results showed that caudatin impaired the cell viability and inhibited the growth of SMMC-7721 cells in a time- and do...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or.2013.2749

    authors: Luo Y,Sun Z,Li Y,Liu L,Cai X,Li Z

    更新日期:2013-12-01 00:00:00

  • Changes in MYCN expression in human neuroblastoma cell lines following cisplatin treatment may not be related to MYCN copy numbers.

    abstract::Neuroblastoma is a tumor accounting for approximately 10% of all childhood malignancies and 50% of all childhood cancer-related deaths. MYCN gene copy number variation represents the most important prognostic factor in neuroblastoma. Prognostic significance of MYCN gene expression is more complicated and may depend on...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or.2013.2383

    authors: Prochazka P,Hrabeta J,Vicha A,Cipro S,Stejskalova E,Musil Z,Vodicka P,Eckschlager T

    更新日期:2013-06-01 00:00:00

  • A combined strategy of conventional cytogenetics, fluorescent in situ hybridization and microsatellite polymerase chain reaction to analyze the deletion of chromosome 6 in laryngeal squamous cell carcinoma.

    abstract::Laryngeal squamous cell carcinoma (LSCC) is a common cancer of the upper respiratory tract. The cytogenetic and molecular events involved in the pathogenesis of LSCC are not well understood. In this study, a combined strategy of conventional cytogenetics, fluorescent in situ hybridization (FISH) and microsatellite pol...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:

    authors: Kang N,Li F,Fu W,Zhang J,Sun K

    更新日期:2007-12-01 00:00:00

  • Orofacial viral infections in the immunocompromised host.

    abstract::Orofacial viral infections are common in immunocompromised patients. Herpes simplex virus (HSV) infections are the most common. Varicella-Zoster virus (VZV) infections are less common, but usually more severe. Epstein-Barr virus (EBV) may produce ulcers, lymphoproliferative syndromes or oral hairy leukoplakia (HL). Hu...

    journal_title:Oncology reports

    pub_type: 杂志文章,评审

    doi:10.3892/or.7.6.1389

    authors: Samonis G,Mantadakis E,Maraki S

    更新日期:2000-11-01 00:00:00

  • Tumor-associated macrophages induce the expression of FOXQ1 to promote epithelial-mesenchymal transition and metastasis in gastric cancer cells.

    abstract::Gastric cancer (GC) is one of the most common malignancies, and is the second leading cause of cancer-related deaths worldwide. Macrophages infiltrated in the tumor microenvironment (TME) called tumor-associated macrophages (TAMs) are key orchestrators in TME. In GC, it has been reported that infiltration of TAMs is a...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or.2017.5877

    authors: Guo J,Yan Y,Yan Y,Guo Q,Zhang M,Zhang J,Goltzman D

    更新日期:2017-10-01 00:00:00

  • Survivin downregulation by siRNA sensitizes human hepatoma cells to TRAIL-induced apoptosis.

    abstract::Survivin, an anti-apoptotic protein, is abundantly expressed in a variety of cancer cells, including hepatoma cells, resulting in the resistance of these cells to various apoptotic stimuli. Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is known to induce cancer cell-specific apoptosis, but hepa...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:

    authors: Nakao K,Hamasaki K,Ichikawa T,Arima K,Eguchi K,Ishii N

    更新日期:2006-08-01 00:00:00

  • Effects of zinc finger protein 403 on the proliferation, migration and invasion abilities of prostate cancer cells.

    abstract::Zinc finger protein 403 (ZFP403), located on human chromosome 17q12‑21, is closely associated with the development of cancer. However, to date, there are a limited number of studies on the biological functions of this gene, particularly in prostate cancer (PCa). The results of the present study demonstrated that compa...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or.2020.7786

    authors: Xu X,Zhu Z,Xu Y,Tian S,Jiang Y,Zhao H

    更新日期:2020-12-01 00:00:00

  • Differential enhancement of the anti-cancer effect of doxorubicin by Akt inhibitors on human breast cancer cells with differing genetic backgrounds.

    abstract::The phosphatidylinositol 3 OH-kinase (PI3K) pathway is a key intracellular signalling cascade in cellular survival. Our previous studies indicated that specific blockade of this enzyme led to sensitisation of human breast carcinoma cells to killing by doxorubicin through induction of both G2 arrest and apoptosis in so...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:

    authors: Wang YA,Johnson SK,Brown BL,Dobson PR

    更新日期:2009-02-01 00:00:00

  • The effects of the Wnt/β‑catenin signaling pathway on apoptosis in HeLa cells induced by carbon ion irradiation.

    abstract::The molecular mechanisms underlying the biological effects of carbon ions are unclear. The aim of this study was to explore the Wnt/β‑catenin pathway in regulating carbon ion (12C6+) radiation‑induced cellular toxicity. HLY78 is a Wnt‑specific small molecular modulator, whose effects on 12C6+ radiation‑induced damage ...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or.2020.7581

    authors: Si J,Zhang J,Gan L,Guo M,Xie Y,Di C,Sun C,Wang F,Yan J,Zhang H

    更新日期:2020-07-01 00:00:00

  • Primary carcinoid tumor of the common hepatic duct: A rare case with immunohistochemical and molecular findings.

    abstract::We report immunohistochemical (IHC) and molecular findings in a rare case of a carcinoid tumor of the extrahepatic bile ducts in a 33-year-old woman, who presented with a 3.9x2.8x2.6 cm mass within the right and common hepatic ducts. She underwent surgery and a carcinoid tumor was identified. This lesion is of interes...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:

    authors: Ligato S,Furmaga W,Cartun RW,Hull D,Tsongalis GJ

    更新日期:2005-03-01 00:00:00

  • CHST15 promotes the proliferation of TE‑1 cells via multiple pathways in esophageal cancer.

    abstract::Esophageal squamous cell carcinoma (ESCC) is a common type of esophageal cancer and is prevalent worldwide. Understanding the mechanisms underlying its formation and the search for more effective therapeutic strategies are critical due to the occurrence of chemotherapeutic drug resistance. The aim of the present study...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or.2019.7395

    authors: Wang X,Cheng G,Zhang T,Deng L,Xu K,Xu X,Wang W,Zhou Z,Feng Q,Chen D,Bi N,Wang L

    更新日期:2020-01-01 00:00:00

  • Epigenetic changes of tumor suppressor genes, P15, P16, VHL and P53 in oral cancer.

    abstract::We performed methylation specific PCR to explore the mechanism of inactivation of tumor suppressor genes P15, P16, P53 and VHL in 48 oral SCC. The frequencies of aberrant methylation on the promoter of the P15, the P16, the P53 and the VHL genes were 0.27 (13/48), 0.42 (20/48), 0.04 (2/48) and none, respectively. Alto...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:

    authors: Yeh KT,Chang JG,Lin TH,Wang YF,Tien N,Chang JY,Chen JC,Shih MC

    更新日期:2003-05-01 00:00:00

  • Mitochondrial pyruvate carrier modulates the epithelial-mesenchymal transition in cholangiocarcinoma.

    abstract::Intrahepatic cholangiocarcinoma (ICC) is known to have a high malignant potential. Because of its high recurrence rate, ICC has a poor prognosis even after complete tumor resection. Compared with normal differentiated cells, cancer cells have an altered metabolism for supporting their survival in severe conditions. Ca...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or.2017.6172

    authors: Ohashi T,Eguchi H,Kawamoto K,Konno M,Asai A,Colvin H,Ueda Y,Takaoka H,Iwagami Y,Yamada D,Asaoka T,Noda T,Wada H,Gotoh K,Kobayashi S,Koseki J,Satoh T,Ogawa K,Doki Y,Mori M,Ishii H

    更新日期:2018-03-01 00:00:00

  • GnRH agonists and antagonists decrease the metastatic progression of human prostate cancer cell lines by inhibiting the plasminogen activator system.

    abstract::Prostate cancer (PCa) growth initially depends on circulating androgens. Gonadotropin-releasing hormone (GnRH) agonists are currently used for the treatment of PCa. However, after an initial responsiveness to hormonal deprivation, PCa progresses and metastasizes. Recently, also GnRH antagonists have been used for clin...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or.15.2.393

    authors: Dondi D,Festuccia C,Piccolella M,Bologna M,Motta M

    更新日期:2006-02-01 00:00:00

  • Overexpression of SHP2 tyrosine phosphatase promotes the tumorigenesis of breast carcinoma.

    abstract::Expression of Src homology phosphotyrosine phosphatase 2 (SHP2) has been observed in human breast cancer. SHP2 is known to promote cell migration and invasiveness. However, the pathophysiologic role of SHP2 and its relevance to tumorigenesis are still largely unknown. In the present study, we aimed to evaluate the eff...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or.2014.3201

    authors: Hu Z,Fang H,Wang X,Chen D,Chen Z,Wang S

    更新日期:2014-07-01 00:00:00

  • Effect of bone marrow mesenchymal stem cells from blastic phase chronic myelogenous leukemia on the growth and apoptosis of leukemia cells.

    abstract::Chronic myelogenous leukemia (CML) has a typical progressive course with transition from a chronic phase to a terminal blast crisis phase. However, the mechanisms that lead to disease progression remain unclear. Bone marrow mesenchymal stem cells (BMMSCs) play important roles in maintaining the bone marrow microenviro...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or.2013.2518

    authors: Han Y,Wang Y,Xu Z,Li J,Yang J,Li Y,Shang Y,Luo J

    更新日期:2013-08-01 00:00:00

  • Effect of combined treatment with progesterone and tamoxifen on the growth and apoptosis of human ovarian cancer cells.

    abstract::Progesterone has a potential protective effect against ovarian carcinoma induced by estrogen. Progesterone is also known to cause apoptosis while tamoxifen induces growth arrest. Therefore, we attempted to determine whether combined treatment with progesterone and tamoxifen has a sy...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or.2011.1460

    authors: Lee JY,Shin JY,Kim HS,Heo JI,Kho YJ,Kang HJ,Park SH,Lee JY

    更新日期:2012-01-01 00:00:00

  • Downregulation of occludin affects the proliferation, apoptosis and metastatic properties of human lung carcinoma.

    abstract::Lung cancer is the most frequent and deadliest cancer in the world, especially in China. However, the molecular mechanisms involved in lung cancer remain unclear. Occludin (OCLN), one of the first identified tight junction proteins, has been revealed to be a necessary integral protein for tight junction structure and ...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or.2018.6408

    authors: Wang M,Liu Y,Qian X,Wei N,Tang Y,Yang J

    更新日期:2018-07-01 00:00:00

  • Subdivision of molecularly-classified groups by new gene signatures in breast cancer patients.

    abstract::Gene expression patterns as well as gene interactions are under investigation for their involvement in tumour heterogeneity. The molecular classification of breast cancer based on hormone receptor expression, grade and HER2 receptor levels, is indicative but not adequate enough to c...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or.2012.2018

    authors: Armakolas A,Stathopoulos GP,Nezos A,Theos A,Stathaki M,Koutsilieris M

    更新日期:2012-12-01 00:00:00

  • Ligularia fischeri inhibits endothelial cell proliferation, invasion and tube formation through the inactivation of mitogenic signaling pathways and regulation of vascular endothelial cadherin distribution and matrix metalloproteinase expression.

    abstract::Ligularia fischeri (LF) has been used as an edible herb and traditional medicine for the treatment of inflammatory and infectious diseases. In the present study, we report the effects and molecular mechanism of the ethanolic extract of LF on cell proliferation, invasion and tube formation in human umbilical vein endot...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or.2015.4000

    authors: Kim JH,Kim HJ,Kim JK,Ahn EK,Ko HJ,Cho YR,Lee SJ,Bae GU,Kim YK,Park JW,Oh JS,Seo DW

    更新日期:2015-07-01 00:00:00

  • Interference of STAT 5b expression enhances the chemo-sensitivity of gastric cancer cells to gefitinib by promoting mitochondrial pathway-mediated cell apoptosis.

    abstract::Signal transducer and activator of transcription (STAT) 5, including STAT 5a and STAT 5b, was reported to play important roles in the malignant biological behaviors of tumors. However, their roles in gastric cancer, especially for STAT 5b remain unknown. This study aimed to detect the expression of STAT 5b in gastric ...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or.2015.3994

    authors: Sun T,Jia Y,Xiao D

    更新日期:2015-07-01 00:00:00

  • Effect of a specific supplement enriched with n-3 polyunsaturated fatty acids on markers of inflammation, oxidative stress and metabolic status of ear, nose and throat cancer patients.

    abstract::Malnutrition affects 40-50% of patients with ear, nose and throat (ENT) cancer. The aim of this study was to assess changes induced by a specific nutritional supplement enriched with n-3 polyunsaturated fatty acids, fiber and greater amounts of proteins and electrolytes, as compared with a standard nutritional supplem...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or.2013.2806

    authors: Roca-Rodríguez MM,García-Almeida JM,Lupiañez-Pérez Y,Rico JM,Toledo M,Alcaide-Torres J,Cardona F,Medina JA,Tinahones FJ

    更新日期:2014-01-01 00:00:00

  • Transcriptional repression of vimentin gene expression by pyrroline dithiocarbamate during 12-O-tetradecanoylphorbol-13-acetate-dependent differentiation of HL-60 cells.

    abstract::Vimentin is a member of the intermediate filament family, and the NF-kappaB binding site is located in the human vimentin promoter. To gain insight into the role of NF-kappaB in the regulation of the vimentin gene during 12-O-tetradecanoylphorbol-13-acetate (TPA)-dependent differentiation of HL-60 cells, the effect of...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:

    authors: Zheng M,Son MY,Park C,Park JI,Jo EK,Yoon WH,Park SK,Hwang BD,Lim K

    更新日期:2005-09-01 00:00:00

  • Upregulation of stem cell antigen-1 in the lung of neonatal mice exposed to environmental cigarette smoke.

    abstract::Mice are particularly susceptible to carcinogens when exposure starts early in life. We evaluated the expression of stem cell antigen-1 (Sca-1) gene in the lung of variously aged CD-1 mice, either untreated or exposed to environmental cigarette smoke (ECS) and/or to a light source. Sca-1 expression progressively decre...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or_00000458

    authors: Izzotti A,D'Agostini F,Larghero P,Cartiglia C,Travaini G,Balansky R,Steele VE,De Flora S

    更新日期:2009-09-01 00:00:00