Concomitant expression of epithelial-mesenchymal transition biomarkers in breast ductal carcinoma: association with progression.

abstract：:Colorectal cancer is the second most deadly cancer in the United States. When diagnosed early, current treatments bring a limited success; however, once metastasis occurs, radiation and chemotherapy are generally ineffective. Structural changes in the ECM are necessary for cell migration during tissue remodeling. Matr...

journal_title：Oncology reports

authors： Roomi MW,Ivanov V,Kalinovsky T,Niedzwiecki A,Rath M

更新日期：2005-03-01 00:00:00

abstract：:Despite intense research in the field of breast cancer it still remains the most common cancer in women in the Western world. A decreasing trend in mortality was mainly achieved by improved early detection which led to an increased incidence of ductal carcinoma in situ (DCIS) of the breast. For the patient's prognosis...

journal_title：Oncology reports

authors： Schmid BC,Rudas M,Fabjani G,Speiser P,Kaserer K,Leodolter S,Zeillinger R

更新日期：2003-11-01 00:00:00

abstract：:We report immunohistochemical (IHC) and molecular findings in a rare case of a carcinoid tumor of the extrahepatic bile ducts in a 33-year-old woman, who presented with a 3.9x2.8x2.6 cm mass within the right and common hepatic ducts. She underwent surgery and a carcinoid tumor was identified. This lesion is of interes...

journal_title：Oncology reports

authors： Ligato S,Furmaga W,Cartun RW,Hull D,Tsongalis GJ

更新日期：2005-03-01 00:00:00

abstract：:Many prostate cancer (PCa) patients die of recurrent disease due to the emergence of hormone-independent cancer cells of which the mechanism is not fully understood. Our previous studies demonstrated that most castration- resistant prostate cancers (CRPC) overexpress the HOXB13 transcription factor to confer positive ...

journal_title：Oncology reports

authors： Kim YR,Kang TW,To PK,Xuan Nguyen NT,Cho YS,Jung C,Kim MS

更新日期：2016-04-01 00:00:00

abstract：:A phase II trial was conducted to evaluate the tolerability and efficacy of incorporating cetuximab and simultaneous integrated boost intensity-modulated radiation therapy (SIB-IMRT) into a well-described 5-fluorouracil (5-FU) and hydroxyurea (HU)-based chemoradiation regimen. Patients with stage IVa-IVb or high-risk ...

journal_title：Oncology reports

authors： Tong CC,Lau KH,Rivera M,Cannan D,Aguirre-Ghiso J,Sikora AG,Gupta V,Forsythe K,Ko EC,Misiukiewicz K,Gurudutt V,Teng MS,Packer SH,Genden EM,Kao J

更新日期：2012-05-01 00:00:00

abstract：:Hepatocyte growth factor (HGF) was suggested to play an important role in the regulation of mitogenesis, motogenesis, angiogenesis, migration and invasion for various types of cells, and acts through a specific membrane receptor encoded by c-met proto-oncogene. However, the mechanism of the effect of HGF on tumor inva...

journal_title：Oncology reports

authors： Fujiuchi Y,Nagakawa O,Murakami K,Fuse H,Saiki I

更新日期：2003-07-01 00:00:00

abstract：:Several studies have shown that curcumin can induce apoptosis and inhibit growth in human A549 lung adenocarcinoma cells. However, the mechanism is not completely understood yet. The present study was designed to investigate the effects of curcumin on A549 cells to better understand its apoptosis and apoptosis-related...

journal_title：Oncology reports

authors： Chen Q,Wang Y,Xu K,Lu G,Ying Z,Wu L,Zhan J,Fang R,Wu Y,Zhou J

更新日期：2010-02-01 00:00:00

abstract：:Eighteen primary human malignant mesotheliomas obtained from 18 patients were screened for point mutations and microdeletions/insertions in all exons of the tumour suppressor gene PTEN/MMAC1 by SSCP analysis. No mutation could be found. Our preliminary data indicate that disarrangements of PTEN/MMAC1 are at least not ...

journal_title：Oncology reports

authors： Papp T,Schipper H,Pemsel H,Unverricht M,Muller KM,Wiethege T,Schiffmann D,Rahman Q

更新日期：2001-11-01 00:00:00

abstract：:It has been reported that cimetidine, a histamine type-2 receptor (H2R) antagonist, inhibits the growth of glandular tumors such as colorectal cancer. However, its effects against salivary gland tumors are still unknown. We demonstrated previously that human salivary gland tumor (HSG) cells spontaneously express the n...

journal_title：Oncology reports

authors： Fukuda M,Tanaka S,Suzuki S,Kusama K,Kaneko T,Sakashita H

更新日期：2007-03-01 00:00:00

abstract：:Esophageal squamous cell carcinoma (ESCC) is the predominant histologic subtype of esophageal cancer and is characterized by a high mortality rate and geographic differences in incidence. microRNAs (miRNAs) are small, non-coding RNAs that play important roles in the regulation of genes associated with cancer developme...

journal_title：Oncology reports

authors： Zhang N,Fu H,Song L,Ding Y,Wang X,Zhao C,Zhao Y,Jiao F,Zhao Y

更新日期：2014-10-01 00:00:00

abstract：:The present study was designed to investigate the effects of Bowman-Birk inhibitor (BBI) on up-regulation of connexin (Cx) expression to estimate BBI's tumor-suppressor effect in mice with M5076 ovarian sarcoma. The relative tumor weight (p<0.05, r(2)=0.301) and proliferating cell nuclear antigen (PCNA, p<0.01, r(2)=0...

journal_title：Oncology reports

authors： Suzuki K,Yano T,Sadzuka Y,Sugiyama T,Seki T,Asano R

更新日期：2005-06-01 00:00:00

abstract：:The estrogen receptor (ER) expression and HER2 amplification are important factors in determining the prognosis and therapy of breast cancer. Interactions between the two signaling pathways for example resulted in ERalpha-dependent regulation of HER2 expression in breast cancer cells. In this study, we investigated to...

journal_title：Oncology reports

authors： Lattrich C,Juhasz-Boess I,Ortmann O,Treeck O

更新日期：2008-03-01 00:00:00

abstract：:Breast cancer is the most common cancer in women worldwide. Progression and aggressiveness of breast cancer is usually associated with its migration and invasion abilities. Recently, natural products with potential anticancer activity have become attractive candidates for alternative treatment of cancer. A fungal meta...

journal_title：Oncology reports

authors： Kasorn A,Loison F,Kangsamaksin T,Jongrungruangchok S,Ponglikitmongkol M

更新日期：2018-03-01 00:00:00

abstract：:The lipogenic enzyme fatty acid synthase (FAS) is differentially overexpressed and hyperactivated in a biologically aggressive subset of breast carcinomas and minimally in most normal adult tissues, rendering it an interesting target for anti-neoplastic therapy development. Current trends in the treatment of human bre...

journal_title：Oncology reports

authors： Menendez JA,Colomer R,Lupu R

更新日期：2004-08-01 00:00:00

abstract：:Anti-cytotoxic T lymphocyte antigen-4 (CTLA-4) treatment is effective for the treatment of primary tumors, but not sufficient for the treatment of metastatic tumors, likely owing to the effects of the tumor microenvironment. In this study, we aimed to determine the therapeutic effects of combined treatment with a matr...

journal_title：Oncology reports

authors： Li M,Xing S,Zhang H,Shang S,Li X,Ren B,Li G,Chang X,Li Y,Li W

更新日期：2016-03-01 00:00:00

abstract：:Recombinant hirudin (rH) is a highly potent and specific inhibitor of thrombin, and has been shown to inhibit the growth and metastasis of several types of cancers in experimental tumor models. The objective of this study was to evaluate the antitumor effects and explore the underlying mechanisms of rH in Hep-2 human ...

journal_title：Oncology reports

authors： Lu Q,Lv M,Xu E,Shao F,Feng Y,Yang J,Shi L

更新日期：2015-03-01 00:00:00

abstract：:In a human cancer cell line, we previously found a mutation in codon 322 of the extracellular signal-regulated kinase (ERK2E322K), the protein showed a faster migration when compared to wild-type in SDS-PAGE and constitutive phosphorylation. However, the reason for the faster migration, and the biochemical and biologi...

journal_title：Oncology reports

authors： Mahalingam M,Arvind R,Ida H,Murugan AK,Yamaguchi M,Tsuchida N

更新日期：2008-10-01 00:00:00

abstract：:Breast cancer mortality is strongly related to the invasive and metastatic potential of tumor cells. We previously showed that an active mutant of H-Ras induced invasive phenotype of MCF10A human breast epithelial cells. Membrane anchoring of Ras requires isoprenylation which involves the activity of 3-hydroxy 3-methy...

journal_title：Oncology reports

authors： Kang S,Kim ES,Moon A

更新日期：2009-05-01 00:00:00

abstract：:Resolvins, an endogenous lipid mediator derived from eicosapentaenoic acid (EPA) or docosahexaenoic acid (DHA) of fish oil, has been reported to have anti-inflammatory and antitumor effect in various pathogenic processes. However, there are no studies about the effects of resolvin D1 and E1 on concanavalin A-induced h...

journal_title：Oncology reports

authors： Kuang H,Hua X,Zhou J,Yang R

更新日期：2016-01-01 00:00:00

abstract：:To determine whether immunohistochemistry can identify BRCA1 mutations, immunohistochemical (IH) analysis was undertaken on paraffin sections of paired ovarian cancer and normal tissue using antibodies against both terminal regions of the BRCA1 protein. Ten patients at risk for BRCA1 mutations were studied. The result...

journal_title：Oncology reports

authors： Byrne TJ,Reece MT,Adams LA,Lane MA,Cohn GM

更新日期：2000-09-01 00:00:00

abstract：:Adenoid cystic carcinoma (ACC) is a generally slow-growing but highly malignant salivary gland neoplasm with remarkable capacities for local invasion and lung metastasis. The precise characteristics of ACC are not fully understood because there was no suitable animal model. We have successfully established a new human...

journal_title：Oncology reports

authors： Hashitani S,Urade M,Zushi Y,Segawa E,Okui S,Sakurai K

更新日期：2007-01-01 00:00:00

abstract：:Previous studies have demonstrated the tremendous tropism of mesenchymal stem cells (MSCs) for malignant gliomas, making these cells a potential vehicle for delivery of therapeutic genes to disseminated glioma cells. However, the mechanisms underlying the tropism of MSCs for gliomas remain poorly defined. It has been ...

journal_title：Oncology reports

authors： Xu F,Shi J,Yu B,Ni W,Wu X,Gu Z

更新日期：2010-06-01 00:00:00

abstract：:To evaluate the efficacy of long-term postoperative adjuvant chemotherapy with low-dose cisplatin (CDDP) plus 5-fluorouracil (5-FU) (CDDP/5-FU), we retrospectively examined 167 patients with squamous cell carcinoma of the esophagus who received the treatment after curative surgery (R0 resection). We classified the pat...

journal_title：Oncology reports

authors： Shiozaki A,Yamagishi H,Itoi H,Fujiwara H,Kikuchi S,Okamoto K,Ichikawa D,Fuji N,Ochiai T,Sonoyama T,Ueda Y

更新日期：2005-04-01 00:00:00

abstract：:EGFR, p27kip1 and Skp2, have been implicated in human cancer development. We have studied these molecules in a search for molecular markers that may have prognostic value in head and neck squamous cell carcinomas (HNSCC). Tissue samples of 62 patients were collected and immunohistochemical analysis was carried out for...

journal_title：Oncology reports

authors： Carracedo DG,Astudillo A,Rodrigo JP,Suarez C,Gonzalez MV

更新日期：2008-09-01 00:00:00

abstract：:Cisplatin, an important chemotherapeutic agent against testicular germ cell cancer, induces testicular toxicity on Leydig and Sertoli cells, leading to serious side-effects such as azoospermia and infertility. In a previous study, it was found that simvastatin enhanced the sensitivity of Leydig tumor cells to chemothe...

journal_title：Oncology reports

authors： Wang L,Peng J,Huang H,Wang Q,Yu M,Tao L

更新日期：2015-10-01 00:00:00

abstract：:A number of possible preventive agents for cancers in different organs have been reported, however, little information is available regarding the effective agents for the development of gastric cancers. The rice components are known to be effective for the prevention of the development of cancers. Our group has demons...

journal_title：Oncology reports

authors： Tomita H,Kuno T,Yamada Y,Oyama T,Asano N,Miyazaki Y,Baba S,Taguchi A,Hara A,Iwasaki T,Kobayashi H,Mori H

更新日期：2008-01-01 00:00:00

abstract：:Endometrial cancer is a common gynecological malignancy with a good prognosis in early stages of the disease. The CpG island in the promoter region of tumor-suppressor genes are frequently methylated in various types of human cancers. In the present study, we examined the methylation status of the GSTP1, CDH1 and RASS...

journal_title：Oncology reports

authors： Fiolka R,Zubor P,Janusicova V,Visnovsky J,Mendelova A,Kajo K,Lasabova Z,Plank L,Danko J

更新日期：2013-12-01 00:00:00

abstract：:Pancreatic cancer is usually diagnosed in the advanced stages and is sensitive to only few therapies. The forkhead box L1 (FOXL1) and protein phosphatase 2A (PP2A) have been recognized to be tumor suppressive in human pancreatic cancers. In the present study, we co-expressed the two tumor suppressive molecules with a ...

journal_title：Oncology reports

authors： Li Y,Yu D,Sheng W,Song H,Li Y,Dong M

更新日期：2016-04-01 00:00:00

abstract：:Hypoxia always exists in the processes involved in the development of lung cancer and contributes to an acidic microenvironment. Despite that hypoxia in the tumor microenvironment is associated with the formation of chemotherapeutic resistance, the exact role of an acidic microenvironment in the development of hypoxia...

journal_title：Oncology reports

authors： Hu CF,Huang YY,Wang YJ,Gao FG

更新日期：2016-07-01 00:00:00

abstract：:Metastasis‑associated lung adenocarcinoma transcript 1 (MALAT1) is a long non‑coding RNA (lncRNA) that has an oncogenic role in some types of cancers, uncluding breast cancer (BC). To investigate the role of MALAT1 in human BC progression, we detected MALAT1 expression levels based on tissue samples from 20 BC cases a...

journal_title：Oncology reports

authors： Huang XJ,Xia Y,He GF,Zheng LL,Cai YP,Yin Y,Wu Q

更新日期：2018-11-01 00:00:00