Abstract:
:Despite intense research in the field of breast cancer it still remains the most common cancer in women in the Western world. A decreasing trend in mortality was mainly achieved by improved early detection which led to an increased incidence of ductal carcinoma in situ (DCIS) of the breast. For the patient's prognosis and the administration of a patient-tailored therapy strategy it is crucial to identify diagnostic and prognostic markers for high-risk DCIS patients. MUC1 is associated with tumour aggressiveness in human breast cancer. Recent studies used MUC1 splice variant A to identify malignant thyroid cancer. In the present study we have examined the usefulness of MUC1 splice variants as prognostic markers in DCIS. We used laser capture microdissection of paraffin-embedded tissue to isolate RNA from isolated tumour cells and determined the MUC1 splice variant distribution by RT-PCR. In the majority of cases variant B was more highly expressed than variant A. This was true for pure DCIS (66%) as well as for DCIS with adjacent invasive cancer (66%). In 7 out of 18 cases (38%) of pure DCIS variant A was not expressed at all. In DCIS with adjacent invasive cancer only 2 samples out of 12 showed this expression pattern (16%). The situation that variant A was more highly expressed than B, or that variant B was not expressed at all, was similar for pure DCIS (27%) and for DCIS with adjacent invasive cancer (33%). The present study describes the differences of MUC1 splice variant expression in pure DCIS compared to DCIS with adjacent invasive cancer. A discriminating pattern of MUC1 splice variants could not be demonstrated.
journal_name
Oncol Repjournal_title
Oncology reportsauthors
Schmid BC,Rudas M,Fabjani G,Speiser P,Kaserer K,Leodolter S,Zeillinger Rkeywords:
subject
Has Abstractpub_date
2003-11-01 00:00:00pages
1981-5issue
6eissn
1021-335Xissn
1791-2431journal_volume
10pub_type
杂志文章相关文献
ONCOLOGY REPORTS文献大全abstract::Prostate cancer antigen 3 (PCA3) is a non-coding RNA fragment that is overexpressed in prostate cancer cells. However, the clinical applications of PCA3 are highly limited due to the instability of RNA and the lack of reliable and efficient RNA extraction and purification methods. Thus, in the present study, we compar...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2015.4266
更新日期:2015-11-01 00:00:00
abstract::The aim of this study was to assess the ability of a new magnetic resonance (MR) angiography technique that does not use contrast enhancement medium to depict the vascularity of musculoskeletal neoplasms, and evaluate its clinical utility. We performed 3D fresh blood imaging (FBI) MR angiography in 57 patients with bo...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2006-03-01 00:00:00
abstract::Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases, capable of degrading all the molecular components of extracellular matrix. MMPs have been shown to play critical roles in tumor cell invasion and metastasis. We verified the activity of MMPs in the sera ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2012.1864
更新日期:2012-09-01 00:00:00
abstract::Telomere-associated proteins function as survival factors in telomere maintenance, which are major contributors to radiosensitivity in human cancers. The aim of this study was to investigate the association of telomere-associated gene expression and radiation resistance in human larynx squamous carcinoma. The changes ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or_00000381
更新日期:2009-06-01 00:00:00
abstract::Cadmium and nickel have been classified as carcinogenic to humans by the World Health Organization's International Agency for Research on Cancer. Given their prevalence in the environment, the fact that cadmium and nickel may cause diseases including cancer even at low doses is a cause for concern. However, the exact ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2013.2587
更新日期:2013-09-01 00:00:00
abstract::Colorectal cancer (CRC) is the most commonly diagnosed tumor worldwide. However, the molecular mechanisms and biological processes of CRC remain unknown. The present study used reverse transcription-quantitative polymerase chain reaction to determine the expression levels of microRNA (miR)-296 in CRC cell lines and ti...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2018.6806
更新日期:2019-01-01 00:00:00
abstract::Thyroid cancer is the most commonly diagnosed malignancy of the endocrine system, the incidence of which has increased rapidly in the last 30 years. Genetic alterations in pathways, including the mitogen‑activated protein kinase (MAPK)/extracellular signal‑regulated kinase (Erk) and phosphatidylinositol‑3‑kinase (PI3K...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2018.6807
更新日期:2019-01-01 00:00:00
abstract::A phase II trial was conducted to evaluate the tolerability and efficacy of incorporating cetuximab and simultaneous integrated boost intensity-modulated radiation therapy (SIB-IMRT) into a well-described 5-fluorouracil (5-FU) and hydroxyurea (HU)-based chemoradiation regimen. Patients with stage IVa-IVb or high-risk ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2012.1679
更新日期:2012-05-01 00:00:00
abstract::Podoplanin is a 38 kDa mucin-type transmembrane glycoprotein that was first identified in rat glomerular epithelial cells (podocytes). It is expressed in normal lymphatic endothelium, but is absent from vascular endothelial cells. D2-40 is a commercially available mouse monoclonal antibody which binds to an epitope on...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2011.1141
更新日期:2011-03-01 00:00:00
abstract::The purpose of this study was to define gene expression profile changes in colorectal tumors in order to identify target genes involved in neoplastic progression. cDNA microarray analysis was used to detect differences in gene expression profiles between colon tumor samples obtained from 20 patients in different tumor...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2004-08-01 00:00:00
abstract::The pathogenic mechanisms responsible for inflammatory bowel disease (IBD) are poorly understood. In an IBD animal model, the oral administration of polysaccharides such as dextran sulfate sodium (DSS) induced colitis, which exhibited several clinical and histological features similar to IBD. However, pathogenic facto...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2008-07-01 00:00:00
abstract::Accumulation of an excess amount of reactive oxygen species (ROS) can cause hepatotoxicity that may result in liver damage. Therefore, development of anti-oxidative agents is needed for reducing liver toxicity. This study investigated the anti-oxidative and hepatoprotective activity of lithospermic acid, a plant-deriv...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2015.4068
更新日期:2015-08-01 00:00:00
abstract::Osteosarcoma (OS) is the most common type of bone cancer. Even with early diagnosis and aggressive treatment, the prognosis for OS is poor. In the present study, we investigated the proliferation and invasion inhibitory effect of apigenin on human OS cells and the possible molecular mechanisms involved. The cell viabi...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2015.4022
更新日期:2015-08-01 00:00:00
abstract::It is well known that crucifers have antitumor effects and 3,3'-diindolylmethane (DIM) is one of the major bioactive components, and the associated molecular mechanisms in a short-term high-dose manner are widely discussed. However, the antitumor effects of DIM in a long-term low-dose manner in nasopharyngeal carcinom...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2015.4428
更新日期:2016-02-01 00:00:00
abstract::MicroRNAs (miRNAs) are small non-coding RNAs of 20-25 nucleotides in length that are capable of modulating gene expression post-transcriptionally. The potential roles of miRNAs in the tumorigenesis of glioblastoma (GBM) have been under intensive studies in the past few years. In the present study, we found a positive ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2014.3055
更新日期:2014-05-01 00:00:00
abstract::Resistance to etoposide has been associated with the overexpression of P-glycoprotein and MRP1 in human tumor cells. However, the role of BCRP in resistance to etoposide has not been clearly established, especially the significance of arginine 482 mutations in drug transport (cellul...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2011.1468
更新日期:2012-01-01 00:00:00
abstract::The mechanisms leading to squamous cell carcinoma of head and neck (SCCHN) metastasis are not fully understood. Although evidence shows that the chemokine receptor 7 (CCR7) and its ligand CCL19 may regulate tumor dissemination, their role is not clearly defined in SCCHN. Matrix metalloproteinases break consisting of t...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2014.3242
更新日期:2014-08-01 00:00:00
abstract::EVL belongs to the Ena/VASP (Enabled/vasodilator-stimulated phosphoprotein) family of proteins [Mena (mammalian Ena), VASP and EVL], which have a range of roles in regulating the actin cytoskeleton. Growing evidence suggests that Mena and VASP are involved in carcinogenesis, though little is known about the significan...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2008-04-01 00:00:00
abstract::Somatic mitochondrial DNA (mtDNA) mutations have been found in a subset of endometrial cancers (EC) from different populations. We have investigated the relationship between mtDNA changes and clinical and pathological variables of women affected by EC. mtDNA mutations were detected both in early (3/32; 9%) and in adva...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2006-11-01 00:00:00
abstract::VBP-1 has been isolated as a novel protein binding to the von Hippel-Lindau (VHL) tumor suppressor gene product. The fundamental function of the gene was examined in the nematode, Caenorhabditis elegans (C. elegans). The C. elegans VBP-1 gene was expressed in adults only in the gonads and was also expressed in early s...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2003-03-01 00:00:00
abstract::Adenoid cystic carcinoma (ACC) is a generally slow-growing but highly malignant salivary gland neoplasm with remarkable capacities for local invasion and lung metastasis. The precise characteristics of ACC are not fully understood because there was no suitable animal model. We have successfully established a new human...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2007-01-01 00:00:00
abstract::SRY-box containing gene 17 (Sox17), a transcription factor, is considered as an antagonist to canonical Wnt/β‑catenin signaling in several types of malignant tumors. As the influence of Sox17 in the pathogenesis of human melanoma is still unknown, the investigation of Sox17 expression in melanoma is warranted and its ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2014.3534
更新日期:2014-12-01 00:00:00
abstract::Osteosarcoma (OS) has an unfavorable prognosis and tends to metastasize to lung tissue. Although the CXCL12-CXCR4 axis appears to affect progression and metastasis in numerous tumors, its mechanism and downstream pathways in OS remain unclear. We used western blotting and flow cytometry to detect CXCR4 and CXCR7 expre...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2015.3992
更新日期:2015-07-01 00:00:00
abstract::The components of the Wnt-signaling pathway are mutated in tumors, but the relationship between these components and cervical cancer has not been elucidated. In this study, we used immunohistochemistry, single strand confirmation polymorphism (SSCP) and direct sequencing methods to analyze the mutation and protein exp...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2003-09-01 00:00:00
abstract::The MTA1 gene has been identified as metastasis-associated gene and has been seen to correlate with the degree of invasion and lymphatic metastasis in gastric, colorectal, and esophageal carcinomas. We investigated the possible role of MTA1 gene expression in hepatocellular carcinoma (HCC). The mRNA expression level o...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2003-05-01 00:00:00
abstract::Hepatocellular carcinoma (HCC) and pancreatic cancer are at the forefront of chemotherapy-resistant tumors with poor prognosis. Even with innovative treatment regimens, response rates remain low and the duration of response is short. We examined whether the suppression of DNA methylation was capable of enhancing the s...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2005-10-01 00:00:00
abstract::Ovarian cancer (OC) is a common cancer of the human genital system. Circular RNAs (circRNAs) play an important role in carcinogenesis and progression of various cancers. The present study aimed to clarify the expression profile and functions of circ‑FAM53B in the progression of OC and reveal its underlying mechanisms....
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2019.7366
更新日期:2019-12-01 00:00:00
abstract::HIF-1 is a heterodimer consisting of the HIF-1alpha and HIF-1beta subunits, and HIF-1alpha is the unique oxygen regulated subunit that determines HIF-1 activity. HIF-1alpha upgrades many gene products which include the glucose transporter protein 1 (Glut-1). Immunohistochemical studies using a monoclonal antibody spec...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.14.4.909
更新日期:2005-10-01 00:00:00
abstract::Sirtuin 6 (SIRT6) is a member of the mammalian NAD+‑dependent deacetylase sirtuin family that acts to maintain genomic stability and to repress genes. SIRT6 has recently been reported to be a tumor suppressor that controls cancer metabolism, although this effect of SIRT6 is still in dispute. Moreover, the role of SIRT...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2015.4477
更新日期:2016-03-01 00:00:00
abstract::The endoplasmic reticulum (ER) is a membranous network within cells that is important for several cellular functions including translation and folding of secretory and membrane proteins, lipid biogenesis and sequestration of Ca2+. Disruption of ER structure might affect the normal physiology of the cells. In yeast, ex...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2016.5209
更新日期:2016-12-01 00:00:00