Abstract:
:Hepatocellular carcinoma (HCC) and pancreatic cancer are at the forefront of chemotherapy-resistant tumors with poor prognosis. Even with innovative treatment regimens, response rates remain low and the duration of response is short. We examined whether the suppression of DNA methylation was capable of enhancing the sensitivity of hepatoma and pancreatic cancer cell lines to 5-fluorouracil (5-FU). 5-aza-2'-deoxycytidine (5-aza-dC) at 2 microM, a specific DNA methylation inhibitor, did not induce cell death in Huh-7 with or without HCV, HLE, HepG2 and MIA PaCa-2 cells. However, a combination of 5-aza-dC with 5-FU showed a reduction in cell viability and induction of apoptosis in these cell lines to a greater degree than with 5-FU only. These findings underline the fact that DNA methylation plays a key role in conferring chemoresistance to hepatoma and pancreatic cancer, and the combination of DNA methylation inhibitor with chemotherapy could be a novel and highly effective tool for future targeted therapy of chemoresistant tumors.
journal_name
Oncol Repjournal_title
Oncology reportsauthors
Kanda T,Tada M,Imazeki F,Yokosuka O,Nagao K,Saisho Hkeywords:
subject
Has Abstractpub_date
2005-10-01 00:00:00pages
975-9issue
4eissn
1021-335Xissn
1791-2431journal_volume
14pub_type
杂志文章相关文献
ONCOLOGY REPORTS文献大全abstract::Lymph node metastasis is one of the most important prognostic factors for cancer patients. There are few animal models of lymph node metastasis. The purpose of this study was to develop a simple animal model without surgical trauma. B16F10 melanoma (1 x 10(6) cells in 0.1 ml phosphate-buffered saline) were slowly inje...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2004-07-01 00:00:00
abstract::Monoclonal antibody therapy for immune checkpoint blockade has achieved promising results for several types of malignant tumors. For the future treatment of gastrointestinal stromal tumors (GISTs) by immune checkpoint blockade, expression of immune checkpoint-related molecules that suppress antitumor immunity in GISTs...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2015.4149
更新日期:2015-10-01 00:00:00
abstract::Although the human telomerase reverse transcriptase (hTERT) promoter can regulate cancer-specific genes, it is generally too weak to be effective. We therefore attempted to improve the potency of synthetic hTERT promoters by fusing the core element (E) of the hTERT promoter (H) and the tripartite leader sequence (T) f...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2006-11-01 00:00:00
abstract::MicroRNAs (miRs) have emerged as prospective tools for human cancer therapy, including hepatocellular carcinoma (HCC) therapy. Previous studies have suggested that miR-381 functions as oncogenic or tumor-suppressive miRs in other cancer types. However, the role of miR-381 in HCC remains unknown. The present study inve...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2015.4491
更新日期:2016-03-01 00:00:00
abstract::Enhancer of zeste homolog 2 (EZH2) is involved in malignant transformation and the biological aggressiveness of several human malignancies. Growing evidence indicates that EZH2 may be an appropriate therapeutic target for malignancies, including cholangiocarcinoma. Recently, an S-adenosyl-L-homocysteine hydrolase inhi...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2013.2922
更新日期:2014-02-01 00:00:00
abstract::Accumulation of an excess amount of reactive oxygen species (ROS) can cause hepatotoxicity that may result in liver damage. Therefore, development of anti-oxidative agents is needed for reducing liver toxicity. This study investigated the anti-oxidative and hepatoprotective activity of lithospermic acid, a plant-deriv...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2015.4068
更新日期:2015-08-01 00:00:00
abstract::Chemokines are small chemotactic cytokines that can induce the migration of leukocytes, activate inflammatory/immune responses and have recently been implicated in the regulation of tumor growth and organ-specific spread. In this setting, the macrophage inflammatory protein-1alpha (CCL3) chemokine displays a diversity...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2007-11-01 00:00:00
abstract::Hydrogen sulfide (H2S), regarded as the third gaseous transmitter, mediates and induces various biological effects. The present study investigated the effects of H2S on multiple myeloma cell progression via amplifying the activation of Akt pathway in multiple myeloma cells. The level of H2S produced in multiple myelom...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2016.5014
更新日期:2016-10-01 00:00:00
abstract::Gastric cancer (GC) is a severe public health problem worldwide, particularly in China. Radiotherapy is the main locoregional treatment for various types of unresectable tumor, including GC. However, many patients fail to respond to radiotherapy due to the intrinsic radioresistance of cancer cells. This study was desi...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2019.7187
更新日期:2019-08-01 00:00:00
abstract::HIF-1 is a heterodimer consisting of the HIF-1alpha and HIF-1beta subunits, and HIF-1alpha is the unique oxygen regulated subunit that determines HIF-1 activity. HIF-1alpha upgrades many gene products which include the glucose transporter protein 1 (Glut-1). Immunohistochemical studies using a monoclonal antibody spec...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.14.4.909
更新日期:2005-10-01 00:00:00
abstract::Oral cancer is one of the leading types of cancer and remains the most common cause of cancer‑related mortality in Asia. The pathogenesis of oral cancer is complicated and, due to lack of accurate diagnostic methods and efficient treatment strategies, oral cancer is responsible for a large number of deaths. Therefore,...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2020.7854
更新日期:2021-01-01 00:00:00
abstract::We have previously demonstrated that gastric and intestinal endocrine cell (End-cell) marker expression is important for assessment of the histogenesis of endocrine cell tumors. However, the End-cell phenotypes of carcinoid tumors in the rectum remain largely unclear. We therefore examined marker expression of rectal ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2009-01-01 00:00:00
abstract::All-trans retinoic acid (ATRA) is a potent chemopreventive and therapeutic agent and exerts its effects by inducing growth arrest. In the present study, we demonstrated that ATRA activated the expression of p53 via Axin and induced cell cycle arrest at the G1/S phase and apoptosis of glioma cells. Briefly, C6 cells we...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2013.2391
更新日期:2013-06-01 00:00:00
abstract::The aim of this study is to evaluate characteristics in lung cancer patients with chronic obstructive pulmonary disease (COPD). Among 966 lung cancer patients admitted to our division over a period of 24 years, 73 patients were diagnosed as having COPD. There were 68 (93.2%) men and 5 women; of the tumors 43 (58.9%) w...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2001-01-01 00:00:00
abstract::Breast cancer is the most common cancer in women worldwide. Progression and aggressiveness of breast cancer is usually associated with its migration and invasion abilities. Recently, natural products with potential anticancer activity have become attractive candidates for alternative treatment of cancer. A fungal meta...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2018.6189
更新日期:2018-03-01 00:00:00
abstract::Cancer immunotherapy is a promising new approach to cancer treatment. It has been demonstrated that a high number of tumor-specific cytotoxic T cells (CTLs) is associated with increased disease-specific survival in lung cancer patients. Identification of superior CTL epitopes from tumor antigens is essential for the d...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2014.3198
更新日期:2014-07-01 00:00:00
abstract::Many prostate cancer (PCa) patients die of recurrent disease due to the emergence of hormone-independent cancer cells of which the mechanism is not fully understood. Our previous studies demonstrated that most castration- resistant prostate cancers (CRPC) overexpress the HOXB13 transcription factor to confer positive ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2016.4563
更新日期:2016-04-01 00:00:00
abstract::The characteristics of ovarian cancers that showed low activation of glycolysis were investigated. Using medical records of patients with ovarian cancers who had undergone fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) prior to their primary surgery at the University of Tokyo Hospital...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2017.5398
更新日期:2017-03-01 00:00:00
abstract::Epigenetic mechanisms of histone acetylation/deacetylation play an important role in the regulation of gene expression associated with the cell cycle and apoptosis. Recently, sodium butyrate, a histone deacetylase (HDAC) inhibitor, has been shown to exhibit anticancer effects via di...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2011.1585
更新日期:2012-04-01 00:00:00
abstract::Human papillomavirus (HPV) L1 capsid protein is only produced during a productive HPV infection at the end of the natural viral life cycle and is a major target of the immune response in women with HPV-related squamous intraepithelial lesions. We evaluated the usefulness of L1 detection by immunocytochemistry in high-...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2013.2538
更新日期:2013-08-01 00:00:00
abstract::MicroRNA (miRNA) is a type of endogenous non‑coding RNA implicated in various cellular processes. Studies have shown that miR-124 is involved in the malignant progression of cancer, but little is known concerning its potential role in breast cancer. Therefore, the purpose of this study was to conduct a functional anal...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2016.5163
更新日期:2016-12-01 00:00:00
abstract::Progestin and adipoQ receptor family member III (PAQR3) is a regulator that negatively modulates the Ras/Raf/MEK/ERK signaling cascade and the GPCR Gβγ subunit signaling pathway. The role of PAQR3 in hepatocellular carcinoma (HCC) has not been elucidated. The present study investigated the expression of PAQR3 and its ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2014.3532
更新日期:2014-12-01 00:00:00
abstract::Head and neck squamous cell carcinoma (HNSCC) is the sixth most commonly diagnosed cancer worldwide. It has poor clinical outcome due to intrinsic or acquired drug resistance. Deregulation of both apoptosis and autophagy contributes to chemotherapy resistance and disease progression. A new member of the inhibitors of ...
journal_title:Oncology reports
pub_type: 杂志文章,评审
doi:10.3892/or.2019.7082
更新日期:2019-05-01 00:00:00
abstract::We performed methylation specific PCR to explore the mechanism of inactivation of tumor suppressor genes P15, P16, P53 and VHL in 48 oral SCC. The frequencies of aberrant methylation on the promoter of the P15, the P16, the P53 and the VHL genes were 0.27 (13/48), 0.42 (20/48), 0.04 (2/48) and none, respectively. Alto...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2003-05-01 00:00:00
abstract::Platinum compounds and vinorelbine (VNB) are active in the treatment of non-small cell lung cancer (NSCLC), but moderate toxicity has been reported. The aims of the present study were to assess activity and tolerability of low dose carboplatin (CBDCA): 4.5 AUC according to Calvert formula on day 1, combined with vinor...
journal_title:Oncology reports
pub_type: 临床试验,杂志文章
doi:10.3892/or.8.2.381
更新日期:2001-03-01 00:00:00
abstract::The association between inflammatory infiltration, fibrosis, necrosis and mucinous content in rectal cancers, and their relationship to preoperative radiotherapy (RT) clinicopathological and biological factors (p53, apoptosis and Cox-2) is not fully characterised. We analysed these histopathological parameters and the...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2006-08-01 00:00:00
abstract::Gasdermin D (GSDMD) is a newly discovered pyroptosis executive protein, which can be cleaved by inflammatory caspases and is essential for secretion of IL‑1β, making it a critical mediator of inflammation. However, the precise role of GSDMD in carcinogenesis remains nearly unknown. Considering the vital role of inflam...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2018.6634
更新日期:2018-10-01 00:00:00
abstract::The Bcl10 gene was recently isolated from the breakpoint region of t(1;14)(p22;q32) in mucosa-associated lymphoid tissue (MALT) lymphomas. Somatic mutations of Bcl10 were found in not only t(1;14)-bearing MALT lymphomas, but also a wide range of other tumors. To clarify the actual frequency and spectrum of Bcl10 mutat...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.8.6.1333
更新日期:2001-11-01 00:00:00
abstract::The present study was carried out to investigate the clinical significance of TMPRSS3 and TNFRSF11B in breast cancer. Thus, the expression levels of TMPRSS3 and TNFRSF11B and the correlation with prognosis in patients with breast cancer were analyzed in silico using gene microarray and hierarchical clustering analysis...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2017.5449
更新日期:2017-04-01 00:00:00
abstract::By combining suppression subtractive hybridization and microarray to examine gene expressions between metastatic and non-metastatic non-small cell lung cancer (NSCLC), we have identified differential expression spectra of matrix metalloproteinases (MMP). Among MMPs, expressions of MMP-13, -14, -15 and -24 decreased, t...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2004-10-01 00:00:00