Abstract:
:Podoplanin is a 38 kDa mucin-type transmembrane glycoprotein that was first identified in rat glomerular epithelial cells (podocytes). It is expressed in normal lymphatic endothelium, but is absent from vascular endothelial cells. D2-40 is a commercially available mouse monoclonal antibody which binds to an epitope on human podoplanin. D2-40 immunoreactivity is therefore highly sensitive and specific for lymphatic endothelium. Recent investigations have shown widespread applications of immunohistochemical staining with D2-40 in evaluating podoplanin expression as an immunohistochemical marker for diagnosis and prognosis in various tumors. To determine whether the podoplanin (D2-40) antibody may be useful for the diagnosis of soft tissue tumors, 125 cases, including 4 kinds of benign tumors, 15 kinds of malignant tumors and 3 kinds of tumor-like lesions were immunostained using the D2-40 antibody. Total RNA was extracted from frozen tumor tissue obtained from 41 corresponding soft tissue tumor patients and 12 kinds of soft tissue tumor cell lines. Quantitative real-time PCR reactions were performed. Immunohistochemical and quantitative real-time RT-PCR analyses demonstrated the expression of the podoplanin protein and mRNA in the majority of benign and malignant soft tissue tumors and tumor-like lesions examined, with the exception of alveolar soft part sarcoma, embryonal and alveolar rhabdomyosarcoma, extraskeletal Ewing's sarcoma/peripheral primitive neuro-ectodermal tumor and lipoma, which were completely negative for podoplanin. Since it is widely and highly expressed in nearly all kinds of soft tissue tumors, especially in spindle cell sarcoma, myxoid type soft tissue tumors and soft tissue tumors of the nervous system, podoplanin is considered to have little value in the differential diagnosis of soft tissue tumors.
journal_name
Oncol Repjournal_title
Oncology reportsauthors
Xu Y,Ogose A,Kawashima H,Hotta T,Ariizumi T,Li G,Umezu H,Endo Ndoi
10.3892/or.2011.1141subject
Has Abstractpub_date
2011-03-01 00:00:00pages
599-607issue
3eissn
1021-335Xissn
1791-2431journal_volume
25pub_type
杂志文章相关文献
ONCOLOGY REPORTS文献大全abstract::Annexin A2 (ANXA2) is a well-known calcium-dependent phospholipid binding protein widely distributed in the nucleus, cytoplasm and extracellular surface of various eukaryotic cells. It has been recognized as a pleiotropic protein affecting a wide range of molecular and cellular processes. Dysregulation and abnormal ex...
journal_title:Oncology reports
pub_type: 杂志文章,评审
doi:10.3892/or.2015.3837
更新日期:2015-05-01 00:00:00
abstract::A phase II trial was conducted to evaluate the tolerability and efficacy of incorporating cetuximab and simultaneous integrated boost intensity-modulated radiation therapy (SIB-IMRT) into a well-described 5-fluorouracil (5-FU) and hydroxyurea (HU)-based chemoradiation regimen. Patients with stage IVa-IVb or high-risk ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2012.1679
更新日期:2012-05-01 00:00:00
abstract::Osteosarcoma harbors highly metastatic properties, accounting for postoperative recurrence and metastasis. Actin-like protein 6A (ACTL6A) regulates cell proliferation, migration and differentiation. However, the biologic role of ACTL6A in osteosarcoma remains unknown. In this study, the results showed that, by analysi...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2017.5473
更新日期:2017-04-01 00:00:00
abstract::This study was conducted to assess protective effect of an antioxidant protein, sericin, on tumor promotion in the 7,12-dimethylbenz (alpha) anthracene (DMBA)-initiated and 12-O-tetradecanoylphorbol 13-acetate (TPA)-promoted mouse skin tumorigenesis model. In experiment 1, sericin was applied topically to DMBA-initiat...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2003-05-01 00:00:00
abstract::Recombinant hirudin (rH) is a highly potent and specific inhibitor of thrombin, and has been shown to inhibit the growth and metastasis of several types of cancers in experimental tumor models. The objective of this study was to evaluate the antitumor effects and explore the underlying mechanisms of rH in Hep-2 human ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2015.3717
更新日期:2015-03-01 00:00:00
abstract::Despite the well-documented advantages of the recombinant adeno-associated virus (rAAV) as a gene delivery vehicle, including its non-pathogenic and long-term therapeutic gene expression, there have been very limited studies on its potential for producing persistent anti-tumor effects, particularly in vivo. To address...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2011.1190
更新日期:2011-05-01 00:00:00
abstract::Lysyl oxidase is an important extracellular matrix remodeling enzyme and plays critical roles in tumor progression and development. Its tumor-suppressor activity has been shown to depend on the propeptide region. Previous studies have reported that the expression levels of lysyl oxidase propeptide (LOX-PP) are associa...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2014.3044
更新日期:2014-04-01 00:00:00
abstract::Synovial sarcomas (SS) consistently show a characteristic chromosomal translocation, t(X;18)(p11;q11), which usually leads to the formation of 2 chimeric fusion transcripts, SYT-SSX1 and -SSX2. A recent multi-institutional retrospective study revealed that the SYT-SSX fusion type emerged as the only independent signif...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2004-05-01 00:00:00
abstract::Targeted gene therapy needs to be implemented for future therapies to ensure efficient activity at the site of patient primary tumors or metastases without causing intolerable side-effects. One of the elements of gene therapy is vector, which includes viral and non-viral vector. In the present study, we constructed a ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2014.3486
更新日期:2014-12-01 00:00:00
abstract::Normal breast development is controlled by a balance between cell proliferation and apoptosis. The balance between the two parameters is crucial for determining the growth or regression of breast tumours in response to therapies and treatments. Therefore, it is necessary to understand the role of apoptosis in tumour p...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2008-09-01 00:00:00
abstract::The aim of this study was to evaluate the clinicopathological prognostic factors in patients with stage IVb cervical carcinoma (CC). All patients with stage IVb CC included in the study were diagnosed from 1997 to 2006 at the National Cancer Center Hospital. We retrospectively examined clinicopathological parameters i...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2008-02-01 00:00:00
abstract::The metastasis-associated (MTA) gene family is a critical component of the nucleosome remodeling and histone deacetylase complex, and plays an important role in metastatic processes. We systematically evaluated dysregulation of the MTA family to clarify their clinical significance in gastric cancer (GC). One hundred a...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2016.5054
更新日期:2016-10-01 00:00:00
abstract::The present study was designed to investigate the effects of Bowman-Birk inhibitor (BBI) on up-regulation of connexin (Cx) expression to estimate BBI's tumor-suppressor effect in mice with M5076 ovarian sarcoma. The relative tumor weight (p<0.05, r(2)=0.301) and proliferating cell nuclear antigen (PCNA, p<0.01, r(2)=0...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2005-06-01 00:00:00
abstract::Vitamin K2 (VK2) has been shown to have a potent anti-tumor effect against several cancer types including hepatocellular carcinoma (HCC), but the mechanisms remain to be elucidated. Matrix metalloproteinase (MMP) plays an important role in the invasion and metastasis of cancer cells, but it is not known whether VK2 re...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or_00000478
更新日期:2009-09-01 00:00:00
abstract::Store‑operated calcium entry (SOCE) is critical for regulating the proliferation and metastasis of various cancer types. The present study aimed to investigate the role of SOCE on nicotine‑promoted proliferation of non‑small cell lung cancer (NSCLC) A549 cells. Cell proliferation was evaluated by BrdU incorporation as...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2018.6580
更新日期:2018-10-01 00:00:00
abstract::microRNAs (miRNAs), a class of small non-coding RNA molecules, can regulate gene expression by interacting with the 3'-untranslated regions (3'UTR) of target genes and influence various biological processes. We investigated the potential role of miR-24-3p in the development of bladder cancer by regulating DEDD, a memb...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2016.5326
更新日期:2017-02-01 00:00:00
abstract::Actin has been studied extensively for decades, but so far its well-defined role has been found localized to the cytoplasm. The present study characterizes the distribution pattern of actin in the nucleus of HL-60 and K-562 cell lines treated with etoposide and doxorubicin. F-actin labeled with TRITC-phalloidin was fo...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2004-04-01 00:00:00
abstract::Increasing evidence suggests that tumor necrosis factor receptor-associated factor 4 (TRAF4) is an oncogene which is frequently overexpressed in many human carcinomas. Although TRAF4 was originally identified in breast cancer, the underlying mechanism of TRAF4 in tumorigenesis remains largely unknown. In the present s...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2014.3304
更新日期:2014-09-01 00:00:00
abstract::We investigated the prevalence of human papillomavirus (HPV) in a clinical series of 72 patients with head and neck squamous cell carcinoma (HNSCC) using a retrospective and prospective study design. The majority of patients were smokers and/or drinkers and were treated with concomitant chemoradiotherapy (CCR). Furthe...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2013.2415
更新日期:2013-07-01 00:00:00
abstract::Resistance to docetaxel, a chemotherapy drug for breast cancer (BC) treatment, occurs in ~50% of patients, and the underlying molecular mechanisms of drug resistance are not fully understood. Gene regulation through miR-141 has been proven to play an important role in cancer drug resistance. The present study investig...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2015.3866
更新日期:2015-05-01 00:00:00
abstract::The present study investigated the effect of macrophage colony-stimulating factor (M-CSF) on the immune functions and blood cell counts of patients with ovarian carcinoma receiving cytotoxic chemotherapy (CTX). Seventy-five consecutive patients with white blood cell counts less than 3,000/microl after CTX were randoml...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.8.4.767
更新日期:2001-07-01 00:00:00
abstract::Elucidating the effects of genes involved in tumors may improve therapeutic strategies for human cancer. Recently, several studies discovered that Akt1 plays a dual role in mediating cell proliferation, migration and invasion, depending on the cell type. However, the pathophysiological role of Akt1 in hepatocellular c...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2013.2879
更新日期:2014-02-01 00:00:00
abstract::Inflammasomes can identify endogenous danger signals as an inflammatory immune response. As the most common inflammasome, the NLR pyrin family domain containing 3 (NLRP3) inflammasome is associated with the pathogenesis of different tumors. However, the function of the NLRP3 inflammasome in esophageal cancer (EC) has ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2020.7493
更新日期:2020-04-01 00:00:00
abstract::Thyroid cancer is the most commonly diagnosed malignancy of the endocrine system, the incidence of which has increased rapidly in the last 30 years. Genetic alterations in pathways, including the mitogen‑activated protein kinase (MAPK)/extracellular signal‑regulated kinase (Erk) and phosphatidylinositol‑3‑kinase (PI3K...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2018.6807
更新日期:2019-01-01 00:00:00
abstract::Aquaporins (AQPs) are a family of small, integral membrane proteins that have been shown to play an important role in tumor development and metastasis. Several studies have demonstrated that expression of AQP3 contributes to the enhanced migration of epithelial cells and is related to differentiation, metastasis and v...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2012.2144
更新日期:2013-02-01 00:00:00
abstract::Mitogenic actions of estrogens are mediated by two distinct estrogen receptors (ERs), which are critical in the progression and therapeutic response of breast cancer. ER expression is a dynamic phenomenon that is regulated by numerous factors, including cytokines, in the tumor microenvironment. Recently, studies have ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2015.4294
更新日期:2015-12-01 00:00:00
abstract::Post-transcriptional modification of p53 by phosphorylation has been proposed as an important mechanism of p53 stabilization and functional regulation. However, little is known about the phosphorylation state of mutant p53 protein overexpressed in human tumors. We evaluated immunohistochemically the p53 phosphorylatio...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2004-11-01 00:00:00
abstract::Immunotherapy with autologous dendritic cells (DCs) loaded with tumor lysate(s) from allogeneic tumor cell lines is a novel strategy to induce immune responses in cancer patients. We report on a pilot trial of autologous DCs pulsed with tumor cell lysate derived from allogeneic medullary thyroid carcinoma (MTC) cell l...
journal_title:Oncology reports
pub_type: 临床试验,杂志文章
doi:10.3892/or_00000391
更新日期:2009-06-01 00:00:00
abstract::Tumor size indicates the extent of cell proliferation in most cases of colorectal cancer (CRC), although there are some advanced small tumors with metastases. Lymph node metastasis is a significant factor that greatly impacts disease prognosis in CRC cases. The underlying factors that cause lymph node metastasis in CR...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2013.2602
更新日期:2013-09-01 00:00:00
abstract::Human Pinx1 protein, associated with shelterin proteins, is widely revealed as a haploinsufficient tumor suppressor. Growing evidence has manifested the deregulation of PinX1 in distinct cancers. Nonetheless, the loss status of PinX1 and its diagnostic, prognostic and clinicopathological significance in Basal-like bre...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2017.5696
更新日期:2017-07-01 00:00:00