Expression of HIF-1alpha and Glut-1 in human bladder cancer.

Abstract:

:HIF-1 is a heterodimer consisting of the HIF-1alpha and HIF-1beta subunits, and HIF-1alpha is the unique oxygen regulated subunit that determines HIF-1 activity. HIF-1alpha upgrades many gene products which include the glucose transporter protein 1 (Glut-1). Immunohistochemical studies using a monoclonal antibody specific for HIF-1alpha indicate that the overexpression of HIF-1alpha occurs in the most common forms of human cancer, including bladder cancer. The expression of Glut-1 in human bladder cancer is associated with poor prognosis and a low survival rate. To our knowledge, this is the first study to compare the expression of both HIF-1alpha and Glut-1 with clinicopathological characteristics in superficial and invasive human bladder cancer (all invasive bladder cancer patients received radical radiotherapy). The Kaplan-Meier survival analysis curve shows a significant association of HIF-1alpha expression with recurrence and survival in superficial bladder cancer and shows a significant association of Glut-1 with survival in invasive bladder cancer [chi2 (4)=10.52; Pr >chi2 =0.0012].

journal_name

Oncol Rep

journal_title

Oncology reports

authors

Palit V,Phillips RM,Puri R,Shah T,Bibby MC

doi

10.3892/or.14.4.909

keywords:

subject

Has Abstract

pub_date

2005-10-01 00:00:00

pages

909-13

issue

4

eissn

1021-335X

issn

1791-2431

journal_volume

14

pub_type

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