E26 transformation (ETS)‑specific related transcription factor‑3 (ELF3) orchestrates a positive feedback loop that constitutively activates the MAPK/Erk pathway to drive thyroid cancer.

abstract：:Store‑operated calcium entry (SOCE) is critical for regulating the proliferation and metastasis of various cancer types. The present study aimed to investigate the role of SOCE on nicotine‑promoted proliferation of non‑small cell lung cancer (NSCLC) A549 cells. Cell proliferation was evaluated by BrdU incorporation as...

journal_title：Oncology reports

authors： Wang Y,He J,Jiang H,Zhang Q,Yang H,Xu X,Zhang C,Xu C,Wang J,Lu W

更新日期：2018-10-01 00:00:00

abstract：:Esophageal squamous cell carcinoma (ESCC) is a common cancer with a very poor prognosis. New methods are needed to screen high-risk populations and identify curable tumors and precursor lesions early. Molecular markers may be useful in such screening efforts. This study was designed to determine the prevalence of p16,...

journal_title：Oncology reports

authors： Roth MJ,Abnet CC,Hu N,Wang QH,Wei WQ,Green L,D'Alelio M,Qiao YL,Dawsey SM,Taylor PR,Woodson K

更新日期：2006-06-01 00:00:00

abstract：:The aim of this study was to better understand the mechanisms of tumor development and disease progression in human epithelial ovarian cancer. Fifty genes were screened for gene signature; 20 expressed genes were assessed in tumor and normal samples of EOC patients by RT-PCR. Expres...

journal_title：Oncology reports

authors： Guo Y,Fu P,Zhu H,Reed E,Remick SC,Petros W,Mueller MD,Yu JJ

更新日期：2012-01-01 00:00:00

abstract：:The usefulness of diagnostic ultrasound in gene transfer was investigated. The hepatocellular carcinoma cell lines PRL/PRF/5 and Hep3B, and the pancreatic carcinoma Panc-1 cells were transfected with lipofectin or irradiated with a linear probe with a frequency of 8 MHz at a mechani...

journal_title：Oncology reports

authors： Tomizawa M,Shinozaki F,Sugiyama T,Yamamoto S,Sueishi M,Yoshida T

更新日期：2012-05-01 00:00:00

abstract：:The identification of the specific molecular targets, which underlie liver carcinogenesis is essential for the establishment of an effective strategy for the prevention and/or treatment of hepatocellular carcinomas (HCCs). We previously found that a malfunction of RXRalpha due to its aberrant phosphorylation was assoc...

journal_title：Oncology reports

authors： Ando N,Shimizu M,Okuno M,Matsushima-Nishiwaki R,Tsurumi H,Tanaka T,Moriwaki H

更新日期：2007-10-01 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) is known to play a central role in tumour angiogenesis. Up to now inconclusive data have been published on the clinical-biological significance of circulating VEGF and on the most suitable blood fraction for measuring it. The aims of this pilot study were to assess VEGF in blo...

journal_title：Oncology reports

authors： Ranieri G,Coviello M,Chiriatti A,Stea B,Montemurro S,Quaranta M,Dittadi R,Paradiso A

更新日期：2004-02-01 00:00:00

abstract：:There has been increasing evidence that numerous bioactive dietary agents can hamper the process of carcinogenesis by targeting epigenetic alterations including DNA methylation. This therapeutic approach is considered as a significant goal for cancer therapy due to the reversible nature of epigenetic-mediated gene sil...

journal_title：Oncology reports

authors： Khan MA,Hussain A,Sundaram MK,Alalami U,Gunasekera D,Ramesh L,Hamza A,Quraishi U

更新日期：2015-04-01 00:00:00

abstract：:Renal cell carcinoma (RCC) is the most frequent type of renal-originated malignancy. Although nephrectomy is successfully used to save the lives of patients with localized RCC, treatment of advanced and other refractory RCCs is poor and still inadequate. Here, we show that triptolide, a small molecule and a well-known...

journal_title：Oncology reports

authors： Li J,Zhu W,Leng T,Shu M,Huang Y,Xu D,Qiu P,Su X,Yan G

更新日期：2011-04-01 00:00:00

abstract：:Apoptosis has to be drastically controlled in organs with important cell turnover such as the colon. Deregulation of this process is often present in tumor progression. Tissues of 82 patients treated for colorectal cancer (CRC) were analyzed using antibodies against AIF, p53, DR4, DR5, cleaved caspase-3 and the TUNEL ...

journal_title：Oncology reports

authors： Perraud A,Akil H,Nouaille M,Petit D,Labrousse F,Jauberteau MO,Mathonnet M

更新日期：2011-11-01 00:00:00

abstract：:Casticin, one of the main components from Fructus Viticis, has been reported to inhibit the growth of various cancer cells, including the human cervical cancer cell line HeLa. The purpose of this study was to examine the apoptotic activity and molecular mechanism of casticin action on human cervical cancer cells. The ...

journal_title：Oncology reports

authors： Chen D,Cao J,Tian L,Liu F,Sheng X

更新日期：2011-11-01 00:00:00

abstract：:The aim of this study is to assess, in squamous cell carcinoma of the cervix, the expression of pan-ras, c-myc and tp53 at protein level using an immunohistochemical (IHC) staining method. One hundred and seven patients with squamous cell carcinoma of the cervix were recruited. Fifty-four patients were of stage 1B/2A ...

journal_title：Oncology reports

authors： Ngan HY,Cheung AN,Liu SS,Cheng DK,Ng TY,Wong LC

更新日期：2001-05-01 00:00:00

abstract：:The development and progression of epithelial cancers are the result of an imbalance in signals promoting and inhibiting cellular proliferation and apoptosis. The aim of this study is to evaluate the expression of cell-cycle and apoptosis regulators and correlate them with clinical outcome in the most frequent carcino...

journal_title：Oncology reports

authors： Abdulkader I,Sánchez L,Cameselle-Teijeiro J,Gude F,Chávez JE,López-López R,Forteza J,Fraga M

更新日期：2005-12-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is different from other solid tumors because it is commonly associated with the occurrence of intrahepatic metastasis. Additionally, the liver, unlike other organs, is the main site of coagulation and fibrinolytic factor production. Therefore, it was speculated that coagulation and fibri...

journal_title：Oncology reports

authors： Li X,Gu B,Wang B,Feng Z,Ma Y,Li H,Lucas A,Chen H

更新日期：2020-12-01 00:00:00

abstract：:Hypoxia always exists in the processes involved in the development of lung cancer and contributes to an acidic microenvironment. Despite that hypoxia in the tumor microenvironment is associated with the formation of chemotherapeutic resistance, the exact role of an acidic microenvironment in the development of hypoxia...

journal_title：Oncology reports

authors： Hu CF,Huang YY,Wang YJ,Gao FG

更新日期：2016-07-01 00:00:00

abstract：:Telomere-associated proteins function as survival factors in telomere maintenance, which are major contributors to radiosensitivity in human cancers. The aim of this study was to investigate the association of telomere-associated gene expression and radiation resistance in human larynx squamous carcinoma. The changes ...

journal_title：Oncology reports

authors： Tang T,Zhou FX,Lei H,Yu HJ,Xie CH,Zhou YF,Liu SQ

更新日期：2009-06-01 00:00:00

abstract：:Glioma is the most common primary brain malignant tumor. Receptor for activated C-kinase 1 (RACK1) is widely expressed in the central nervous system, and regulates multiple cellular processes including cell survival, proliferation, migration and metastasis. However, the role of RACK1 in glioma has never been revealed....

journal_title：Oncology reports

authors： Peng R,Jiang B,Ma J,Ma Z,Wan X,Liu H,Chen Z,Cheng Q,Chen R

更新日期：2013-11-01 00:00:00

abstract：:Metastasis is the main cause of death in osteosarcoma. Targeting the process of metastasis is a main strategy for osteosarcoma therapy. As a traditional Chinese medicine, Zanthoxylum nitidum (Roxb) has been applied to treat various diseases, including cancer. However, no evidence has been shown on the anti-metastasis ...

journal_title：Oncology reports

authors： Cheng Z,Guo Y,Yang Y,Kan J,Dai S,Helian M,Li B,Xu J,Liu C

更新日期：2016-08-01 00:00:00

abstract：:Case 1: a patient was diagnosed as having ascending colon cancer with right ovarian metastasis, and underwent palliative right hemicolectomy plus oophorectomy. The tumor was a well-differentiated adenocarcinoma with right ovarian metastasis, and the disease was classified as stage IV. Oral chemotherapy with UFT plus L...

journal_title：Oncology reports

authors： mukai M,Moriya H,Himeno S,Oida Y,mukohyama S,Nishi T,Nakasaki H,Satoh S,Makuuchi H

更新日期：2001-09-01 00:00:00

abstract：:DNA damage sensor proteins are recognized as upstream components of the DNA damage checkpoint signaling pathway and are required for cell cycle control and the induction of apoptosis. hRad9 plays an important role as an upstream regulator of checkpoint signaling. In our previous studies, we confirmed the significant a...

journal_title：Oncology reports

authors： Yuki T,Maniwa Y,Doi T,Okada K,Nishio W,Hayashi Y,Okita Y

更新日期：2008-11-01 00:00:00

abstract：:It has been demonstrated that homozygous mutations at the L(2)gl locus in Drosophila result in the development of tumor in the presumptive adult optic centers of the larval brain and of the imaginal discs. We previously cloned an L(2)gl homologue, Rgl-1, in the rat brain. In this study, we analyzed the capability of R...

journal_title：Oncology reports

authors： Kim YK,Kim YS,Chung HM,Baek KH

更新日期：2004-11-01 00:00:00

abstract：:Human papillomavirus (HPV) L1 capsid protein is only produced during a productive HPV infection at the end of the natural viral life cycle and is a major target of the immune response in women with HPV-related squamous intraepithelial lesions. We evaluated the usefulness of L1 detection by immunocytochemistry in high-...

journal_title：Oncology reports

authors： Norman I,Hjerpe A,Andersson S

更新日期：2013-08-01 00:00:00

abstract：:Sulforaphane (SFN) was first isolated from broccoli sprout and it is present at high concentrations in plants belonging to the Cruciferae family. The chemotherapeutic and anti‑cancerogenic capacities of SFN have been demonstrated by inhibition of cancer cell proliferation in several cancer cell lines. The aim of the p...

journal_title：Oncology reports

authors： Żuryń A,Krajewski A,Klimaszewska-Wiśniewska A,Grzanka A,Grzanka D

更新日期：2019-02-01 00:00:00

abstract：:Lymph node metastasis is one of the most important prognostic factors for cancer patients. There are few animal models of lymph node metastasis. The purpose of this study was to develop a simple animal model without surgical trauma. B16F10 melanoma (1 x 10(6) cells in 0.1 ml phosphate-buffered saline) were slowly inje...

journal_title：Oncology reports

authors： Ishibashi S,Sonoda K,Fujii K,Ishikawa K,Shiraishi N,Kitano S

更新日期：2004-07-01 00:00:00

abstract：:Mutations in the epidermal growth factor receptor (EGFR) make lung adenocarcinoma cells sensitive to EGFR tyrosine kinase inhibitors (TKIs). Long-term cancer therapy may cause the occurrence of acquired resistance to EGFR TKIs. Long non-coding RNAs (lncRNAs) play important roles in tumor formation, tumor metastasis an...

journal_title：Oncology reports

authors： Wu Y,Yu DD,Hu Y,Yan D,Chen X,Cao HX,Yu SR,Wang Z,Feng JF

更新日期：2016-06-01 00:00:00

abstract：:The aim of this study was to investigate the status of the c‑Myc‑related molecule Mina53 and the clinical impact of Mina53 nuclear localization in patients with stage II and III colorectal cancer (CRC). Patients (n=250) who underwent complete resection of CRC at our department were enrolled in this study, and tissue m...

journal_title：Oncology reports

authors： Fujino S,Kinugasa T,Sudo T,Mizobe T,Yoshida T,Yoshida N,Ohchi T,Tajiri K,Yuge K,Nagasu S,Katagiri M,Akagi Y

更新日期：2018-07-01 00:00:00

abstract：:The present study aimed to explore the relationship between the efficacy of epidermal growth factor receptor tyrosine kinase inhibitors (EGFR‑TKIs) and the expression of the cancer stem cell (CSC)‑related markers. Specimens of 72 cases of lung adenocarcinoma with significantly different therapeutic effects of the firs...

journal_title：Oncology reports

authors： Hu F,Li C,Zheng X,Zhang H,Shen Y,Zhou L,Yang X,Han B,Zhang X

更新日期：2020-02-01 00:00:00

abstract：:The current study characterized peripheral blood mononuclear cells (PBMC) obtained from leukapheresis products of patients with non-small cell lung cancer (NSCLC) for cytokine release, the ability to incorporate tritiated thymidine following stimulation using PHA as well as the levels of both CD4 and CD8 regulatory T ...

journal_title：Oncology reports

authors： Yannelli JR,Tucker JA,Hidalgo G,Perkins S,Kryscio R,Hirschowitz EA

更新日期：2009-12-01 00:00:00

abstract：:The outcome of patients with advanced stage rhabdomyosarcoma (RMS) is still sobering. This outcome has not improved through conservative treatments. Therefore, novel treatment approaches such as immunotherapy need to be evaluated in human-adapted animal models. The aim of this study was to develop a humanized mouse mo...

journal_title：Oncology reports

authors： Seitz G,Pfeiffer M,Fuchs J,Warmann SW,Leuschner I,Vokuhl C,Lang P,Handgretinger R,Armeanu-Ebinger S

更新日期：2010-10-01 00:00:00

abstract：:Hepatocellular carcinoma is the most common type of liver cancer. The risk of hepatocellular carcinoma for type 2 diabetic patients is greater than that for non-diabetic individuals although the mechanism is unclear. The cancer suppressor resveratrol inhibits cancer cell proliferation partly through the STAT3 signalin...

journal_title：Oncology reports

authors： Li Y,Zhu W,Li J,Liu M,Wei M

更新日期：2013-12-01 00:00:00

abstract：:The tumour suppressor protein p53 (wild-type = wt-p53) is of major importance in the genetic integrity of the cell. Mutations of the p53-gene (mt-p53) are the most frequent genetic aberrations identified in different tumour entities. As analyzed in a wide variety of human malignomas, mt-p53 evokes a specific immune re...

journal_title：Oncology reports

authors： Cordes C,Von Lingen J,Görögh T,Ambrosch P,Gottschlich S,Hoffmann M

更新日期：2009-12-01 00:00:00