Correlations among ERCC1, XPB, UBE2I, EGF, TAL2 and ILF3 revealed by gene signatures of histological subtypes of patients with epithelial ovarian cancer.

abstract：:In vivo real-time visualization of chemotherapy response at the cellular level provides us with direct evidence of what happens on the tumor microenvironment of metastatic organs. We imaged the response of metastatic tumor cells and host stromal cells to chemotherapeutics on liver m...

journal_title：Oncology reports

authors： Tanaka K,Okigami M,Toiyama Y,Morimoto Y,Matsushita K,Kawamura M,Hashimoto K,Saigusa S,Okugawa Y,Inoue Y,Uchida K,Araki T,Mohri Y,Mizoguchi A,Kusunoki M

更新日期：2012-11-01 00:00:00

abstract：:Cachexia accompanied by muscle wasting is a key determinant of poor prognosis in cancer patients and cancer‑related death. Previous studies have demonstrated that inflammatory cytokines such as interleukin‑6 (IL‑6), tumor necrosis factor‑α (TNF‑α), IL‑1 and interferon‑γ (IFN‑γ) secreted from host cells and tumor cells...

journal_title：Oncology reports

authors： Kim A,Im M,Ma JY

更新日期：2016-03-01 00:00:00

abstract：:This study was designed to investigate the effect of pseudo-G-Rh2, a novel metabolite of ginsenoside Rh2, on the apoptosis of SGC-7901 human gastric cancer cells. Pseudo-G-Rh2 demonstrated antitumor activity and significantly inhibited the proliferation of SGC-7901 cells in a concen...

journal_title：Oncology reports

authors： Qu X,Qu S,Yu X,Xu H,Chen Y,Ma X,Sui D

更新日期：2011-12-01 00:00:00

abstract：:Breast cancer is the most common cancer in women worldwide. Progression and aggressiveness of breast cancer is usually associated with its migration and invasion abilities. Recently, natural products with potential anticancer activity have become attractive candidates for alternative treatment of cancer. A fungal meta...

journal_title：Oncology reports

authors： Kasorn A,Loison F,Kangsamaksin T,Jongrungruangchok S,Ponglikitmongkol M

更新日期：2018-03-01 00:00:00

abstract：:Using a series of potential biomarkers relevant to mechanisms of protein synthesis, we observed that estrogen receptor (ER)-positive breast tumor cells exist in two distinct yet interconvertible phenotypic states (of roughly equal proportion) which differ in the degree of differentiation and use of IRES-mediated trans...

journal_title：Oncology reports

authors： Vaklavas C,Zinn KR,Samuel SL,Meng Z,Grizzle WE,Choi H,Blume SW

更新日期：2018-06-01 00:00:00

abstract：:Transforming growth factor-β1 (TGF-β1) signaling has been shown to play a critical role in the development of epithelial-mesenchymal transition (EMT). PAI-1 is one of the most important target genes in the TGF-β/Smad signaling pathway, which can hinder the degradation of ECM composition and may promote cell invasion a...

journal_title：Oncology reports

authors： Wang X,Liu C,Wang J,Fan Y,Wang Z,Wang Y

更新日期：2017-02-01 00:00:00

abstract：:Multiple drug resistance (MDR) is considered a major challenge in the clinical treatment of non-small cell lung cancer (NSCLC). Both nitric oxide synthase (iNOS) and Wnt signaling pathway participate in the regulation of drug resistance, but the interaction between them remains unclear. In the present study, we detect...

journal_title：Oncology reports

authors： Li Y,Ma C,Shi X,Wen Z,Li D,Sun M,Ding H

更新日期：2014-10-01 00:00:00

abstract：:Caspases play an essential role in the initiation/regulation of apoptosis. Aberrant apoptotic regulation has been associated with carcinogenesis and therapeutic resistance. To explore the possible involvement of altered caspase expression in breast cancer, we have systematically examined the expression of both protein...

journal_title：Oncology reports

authors： Yang S,Liu J,Thor AD,Yang X

更新日期：2007-05-01 00:00:00

abstract：:MicroRNA-1 (miR-1) has been shown to function as a critical gene regulator in multiple types of cancers. However, the role of miR-1 in osteosarcoma has not been totally clarified. In the present study, we investigated the effects of miR-1 on osteosarcoma and the underlying mechanism. We found that miR-1 was downregula...

journal_title：Oncology reports

authors： Jiang C,Chen H,Shao L,Wang Q

更新日期：2014-09-01 00:00:00

abstract：:It is reported that patients with Huntington's disease (HD) have a low incidence of cancer. In this study, we investigated the expression of huntingtin-associated protein 1 (HAP1), the ligand of HD's production, in breast tumor and normal tissues. We found that HAP1 expression was significantly lower in tumor compared...

journal_title：Oncology reports

authors： Zhu L,Song X,Tang J,Wu J,Ma R,Cao H,Ji M,Jing C,Wang Z

更新日期：2013-05-01 00:00:00

abstract：:In humans, four tropomyosin genes (TPM1, TPM2, TPM3, and TPM4) are known to produce a multitude of isoforms via alternate splicing and/or using alternate promoters. Expression of tropomyosin has been shown to be modulated at both the transcription and the translational levels. Tropomyosins are known to make up some of...

journal_title：Oncology reports

authors： Dube S,Thomas A,Abbott L,Benz P,Mitschow C,Dube DK,Poiesz BJ

更新日期：2016-06-01 00:00:00

abstract：:Vaccine strategies for the treatment of human papillomavirus-induced cervical cancer are based mainly on the human papillomavirus 16 E7 (HPV16 E7) oncoprotein. The immunogenicity of the E7 gene has been enhanced by its fusion to many different genes. Here, we linked a short sequence coding for the E7 peptide (aa 44-60...

journal_title：Oncology reports

authors： Pokorna D,Cerovska N,Smahel M,Moravec T,Ludvikova V,Mackova J,Synkova H,Duskova M,Hozak P,Veleminsky J

更新日期：2005-10-01 00:00:00

abstract：:Vascular endothelial growth factor C (VEGF-C), a member of VEGF gene family, is considered to induce both lymph node metastasis and lymphatic involvement in various cancers related to lymphangiogenesis. We examined the relationship between VEGF-C expression and clinicopathological features in 112 Japanese patients wit...

journal_title：Oncology reports

authors： Kimura Y,Watanabe M,Ohga T,Saeki H,Kakeji Y,Baba H,Maehara Y

更新日期：2003-11-01 00:00:00

abstract：:Bcl-2 is overexpressed in various types of human tumors, including Burkitt's lymphoma, and it is involved in tumorigenesis and chemoresistance, therefore, it is regarded as a potential target of gene therapy. In this study, RNA interference using short hairpin RNA (shRNA)-mediated R...

journal_title：Oncology reports

authors： Liu Y,Shen Y,Qin C,Shi Y,Rong G,Yu X

更新日期：2013-01-01 00:00:00

abstract：:Breast cancer is one of the major health issues confronting women; however, treatment with conventional chemotherapeutic drugs is limited. Currently, paclitaxel is used as a therapeutic clinical agent to treat breast cancer that exerts antitumor activity in numerous types of cancer cell. Curcumin (diferuloylmethane), ...

journal_title：Oncology reports

authors： Calaf GM,Ponce-Cusi R,Carrión F

更新日期：2018-10-01 00:00:00

abstract：:Despite intense research in the field of breast cancer it still remains the most common cancer in women in the Western world. A decreasing trend in mortality was mainly achieved by improved early detection which led to an increased incidence of ductal carcinoma in situ (DCIS) of the breast. For the patient's prognosis...

journal_title：Oncology reports

authors： Schmid BC,Rudas M,Fabjani G,Speiser P,Kaserer K,Leodolter S,Zeillinger R

更新日期：2003-11-01 00:00:00

abstract：:Mesenchymal stem cells (MSCs) are known to migrate to tumor tissues and to play an important role in cancer progression. However, the effects of MSCs on tumor progression remain controversial. The purpose of the present study was to detect the effects of human umbilical cord-derived MSCs (hUC‑MSCs) on the human breast...

journal_title：Oncology reports

authors： Li T,Zhang C,Ding Y,Zhai W,Liu K,Bu F,Tu T,Sun L,Zhu W,Zhou F,Qi W,Hu J,Chen H,Sun X

更新日期：2015-09-01 00:00:00

abstract：:Cisplatin-paclitaxel and cisplatin-etoposide combination therapies were compared in limited and extensive disease in patients with small-cell lung cancer. The primary objectives were to determine median and overall survival, time to tumor progression and tolerance and the secondary objective, the response rate. From J...

journal_title：Oncology reports

authors： Dimitroulis J,Rapti A,Stathopoulos GP,Rigatos S,Stathopoulos J,Koutantos J,Athanasiadis A,Tsikritsaki K,Karaindros D,Katis K,Antoniou D,Toumbis M,Giamboudakis P

更新日期：2008-10-01 00:00:00

abstract：:The aims of the present study were to review the experience of different surgical reconstruction methods for hypopharyngeal squamous cell carcinoma (HSCC) and compared the survival of patients with and without laryngeal function (LF) preservation. The clinical characteristics of 580 patients were retrospectively obtai...

journal_title：Oncology reports

authors： Zhou J,Li Y,Wei D,Qian Y,Li W,Liu D,Li G,Pan X,Lei D

更新日期：2015-12-01 00:00:00

abstract：:The MSH6 gene is one of the mismatch repair genes involved in Lynch syndrome and its mutations account for 10-20% of Lynch syndrome. Although previous studies suggested that the difference of the geographical region affects the clinical phenotype of Lynch syndrome, there has been no report on the detailed features of ...

journal_title：Oncology reports

authors： Terui H,Tachikawa T,Kakuta M,Nishimura Y,Yatsuoka T,Yamaguchi K,Yura K,Akagi K

更新日期：2013-12-01 00:00:00

abstract：:The objective of this study was to examine how splenectomy affects the immune response, particularly T cells, in chemically-induced mammary tumors. Female rats were splenectomized and then exposed to 9,10-dimethyl-1,2-benz(a)anthracene (DMBA) to induce mammary tumors. Splenectomy significantly decreased the rate of tu...

journal_title：Oncology reports

authors： Kossoy G,Ben-Hur H,Lifschitz O,Zusman I

更新日期：2002-01-01 00:00:00

abstract：:The gene Nm23, which encodes for a nucleoside diphosphate kinase, has been defined as a metastasis-suppressor gene because of the inverse correlation between its expression and the metastatic capacity of the tumor cells. For colorectal cancer, however, the findings are equivocal. The aim of our study was to assess, in...

journal_title：Oncology reports

authors： Dusonchet L,Corsale S,Migliavacca M,Calò V,Bazan V,Amato A,Cammareri P,Totaro MS,Agnese V,Cascio S,La Rocca G,Sisto PS,Dardanoni G,Valerio MR,Grassi N,Latteri S,Cajozzo M,Buscemi M,Castorina S,Morello V,Tomasino R

更新日期：2003-09-01 00:00:00

abstract：:Cisplatin (DDP), a cytotoxic antitumor drug, functions in a dose-dependent manner. However, the pursuit for high‑dose therapeutic effects leads to more serious side effects including kidney toxicity. Nephrotoxicity caused due to endothelial cell dysfunction and neutrophils infiltration in kidneys. Interleukin-8 (IL-8)...

journal_title：Oncology reports

authors： Li L,Khan MN,Li Q,Chen X,Wei J,Wang B,Cheng JW,Gordon JR,Li F

更新日期：2015-02-01 00:00:00

abstract：:Glioblastoma (GBM) is the most common type of primary central nervous system tumor in adults, which has high mortality and morbidity rates, and short survival time, namely <15 months after the diagnosis and application of standard therapy, which includes surgery, radiation therapy and chemotherapy; thus, novel therape...

journal_title：Oncology reports

authors： Yang K,Tang XJ,Xu FF,Liu JH,Tan YQ,Gao L,Sun Q,Ding X,Liu BH,Chen QX

更新日期：2020-03-01 00:00:00

abstract：:Telomerase is a ribonucleoprotein enzyme which is endogenously expressed in germ, stem and tumor cells, but absent in benign somatic cells. The two major telomerase components are human telomerase RNA (hTR) and human telomerase reverse transcriptase (hTERT). It has been shown that hTERT is rate-limiting for telomerase...

journal_title：Oncology reports

authors： Schrader M,Burger AM,Müller M,Krause H,Straub B,Smith GL,Newlands ES,Miller K

更新日期：2002-09-01 00:00:00

abstract：:Associations of functional single nucleotide polymorphisms in cytochrome P450 1B1, epoxide hydrolase 1, NAD(P)H:quinone oxidoreductase 1, glutathione S-transferase Pi-1 and deletions of glutathione S-transferases Mu-1 and θ-1 with colorectal cancer risk were investigated in a hospital-based case-control study on 495 m...

journal_title：Oncology reports

authors： Hlavata I,Vrana D,Smerhovsky Z,Pardini B,Naccarati A,Vodicka P,Novotny J,Mohelnikova-Duchonova B,Soucek P

更新日期：2010-11-01 00:00:00

abstract：:The impact of interferon-γ (IFN-γ) late preconditioning on myocardial ischemia-reperfusion injury during cardiopulmonary bypass (CPB) and the underlying mechanism were investigated. Using a porcine model of myocardial ischemia-reperfusion injury during CPB with a 60-min aorta cross-clamp, 20 pigs (15±0.5 kg) were trea...

journal_title：Oncology reports

authors： Yan X,Qiu W,Jia B,Zhong H,Li X,Chen Z

更新日期：2013-11-01 00:00:00

abstract：:Oxymatrine, a traditional Chinese herb extracted from Sophora flavescens Ait., displays strong anti-inflammatory and anticancer activities, but how oxymatrine exhibits anticarcinogenic effects in human colorectal cancer (CRC) remains uncertain. The present study aimed to elucidate the exact mechanism by which oxymatri...

journal_title：Oncology reports

authors： Liang L,Huang J

更新日期：2016-09-01 00:00:00

abstract：:Oral cancer is one of the leading types of cancer and remains the most common cause of cancer‑related mortality in Asia. The pathogenesis of oral cancer is complicated and, due to lack of accurate diagnostic methods and efficient treatment strategies, oral cancer is responsible for a large number of deaths. Therefore,...

journal_title：Oncology reports

authors： Wang J,Lv N,Lu X,Yuan R,Chen Z,Yu J

更新日期：2021-01-01 00:00:00

abstract：:Immunologic factors that predict survival in patients with lung cancer have not been established. We examined the relationship between the percentage of HLA-DR-positive peripheral leukocytes [HLA-DR+ (%)] and survival of patients with squamous cell carcinoma of the lung. Before initiating therapy, peripheral blood was...

journal_title：Oncology reports

authors： Nakamura H,Idiris A,Kato Y,Kato H

更新日期：2004-03-01 00:00:00