Huntingtin-associated protein 1: a potential biomarker of breast cancer.

abstract：:Autophagy is an intracellular multi-step catabolic degradation process that involves the degradation and recycling of cellular proteins and cytoplasmic damaged organelles to maintain cellular homeostasis and reduction of metabolic stress. Numerous studies have indicated the importance of autophagy in cancer, but the r...

journal_title：Oncology reports

authors： Zhang L,Zhang J,Chen L,Wang J

更新日期：2015-12-01 00:00:00

abstract：:The metabolism of arachidonic acid by either the cyclooxygenase or lipoxygenase (LOX) pathway is believed to play an important role in tumor promotion. We investigated the expression of 5- and 12-LOX in renal cell carcinoma (RCC), as well as the effects of their inhibitors on cell proliferation in 2 RCC cell lines (Ca...

journal_title：Oncology reports

authors： Matsuyama M,Yoshimura R,Mitsuhashi M,Tsuchida K,Takemoto Y,Kawahito Y,Sano H,Nakatani T

更新日期：2005-07-01 00:00:00

abstract：:Elevated serum CA15‑3 assessed by enzyme‑linked immunosorbent assay (ELISA) has been considered a diagnostic marker of breast cancer. However, accumulating data indicate that the current ELISA system for detecting CA15‑3, which targets the peptide backbone of CA15‑3, is not sufficiently sensitive to detect early or lo...

journal_title：Oncology reports

authors： Choi JW,Moon BI,Lee JW,Kim HJ,Jin Y,Kim HJ

更新日期：2018-07-01 00:00:00

abstract：:Thyroid cancer (TC) is the most frequent endocrine malignancy, accounting however for only 1-2% of all human cancers, and the best-established risk factor for TC is radiation exposure, particularly during childhood. Since the BER pathway seems to play an important role in the repair of DNA damage induced by IR and oth...

journal_title：Oncology reports

authors： Santos LS,Branco SC,Silva SN,Azevedo AP,Gil OM,Manita I,Ferreira TC,Limbert E,Rueff J,Gaspar JF

更新日期：2012-11-01 00:00:00

abstract：:Eighteen primary human malignant mesotheliomas obtained from 18 patients were screened for point mutations and microdeletions/insertions in all exons of the tumour suppressor gene PTEN/MMAC1 by SSCP analysis. No mutation could be found. Our preliminary data indicate that disarrangements of PTEN/MMAC1 are at least not ...

journal_title：Oncology reports

authors： Papp T,Schipper H,Pemsel H,Unverricht M,Muller KM,Wiethege T,Schiffmann D,Rahman Q

更新日期：2001-11-01 00:00:00

abstract：:Epigenetic mechanisms of histone acetylation/deacetylation play an important role in the regulation of gene expression associated with the cell cycle and apoptosis. Recently, sodium butyrate, a histone deacetylase (HDAC) inhibitor, has been shown to exhibit anticancer effects via di...

journal_title：Oncology reports

authors： Shin H,Lee YS,Lee YC

更新日期：2012-04-01 00:00:00

abstract：:The WHO clearly identifies tumors as a curable or a chronic disease. The use of natural agents in cancer prevention and therapy is currently playing an important role. Our laboratory has been investigating various natural phenolic compounds, including grifolin, neoalbaconol and epigallocatechin-3-gallate (EGCG). In th...

journal_title：Oncology reports

authors： Luo X,Yu X,Liu S,Deng Q,Liu X,Peng S,Li H,Liu J,Cao Y

更新日期：2015-08-01 00:00:00

abstract：:Despite significant advances in micro-metastasis detection methods, little is known about the relationship between micro-metastasis and primary tumors. The purpose of this study was to assess the ability of expression of the breast cancer-related markers, HER-2/neu, COX-2, VEGF and PDGF-B, as a predictor for micro-met...

journal_title：Oncology reports

authors： Zhu L,Loo WT,Cheng CW,Chow LW

更新日期：2006-05-01 00:00:00

abstract：:Minimal residual disease (MRD) is derived from tumor-initiating cells (TICs) and is responsible for tumor relapse. Neuroblastoma is characterized by extreme tumor heterogeneity, and more than half of high-risk patients experience tumor relapse. To overcome tumor heterogeneity and ac...

journal_title：Oncology reports

authors： Hartomo TB,Kozaki A,Hasegawa D,Van Huyen Pham T,Yamamoto N,Saitoh A,Ishida T,Kawasaki K,Kosaka Y,Ohashi H,Yamamoto T,Morikawa S,Hirase S,Kubokawa I,Mori T,Yanai T,Hayakawa A,Takeshima Y,Iijima K,Matsuo M,Nishio H

更新日期：2013-04-01 00:00:00

abstract：:The changes of the microtubular network induced by microtubule destabilizing (Vinblastine, VBL) and stabilizing (Taxol, TAX) agents were studied in NIH/3T3 fibroblastic cells in conventional culture conditions (NIHb) and in a subpopulation (NIHs), obtained after serum deprivation and expressing different morphofunctio...

journal_title：Oncology reports

authors： Spano A,Monaco G,Barni S,Sciola L

更新日期：2008-12-01 00:00:00

abstract：:Histone acetylation is one of the key chromatin modifications that control gene transcription during development and tumorigenesis. Recently, it was reported that the histone deacetylase inhibitor, Trichostatin A (TSA), induces growth arrest and apoptosis in tumors. However, the mol...

journal_title：Oncology reports

authors： Anh TD,Ahn MY,Kim SA,Yoon JH,Ahn SG

更新日期：2012-02-01 00:00:00

abstract：:Human gonadotropin-releasing hormone receptor (GnRHR) and its natural ligand human gonadotropin-releasing hormone (GnRH) were initially described as signaling complexes that play a key role in reproductive functions. By binding to specific receptors present on pituitary gonadotropes, GnRH regulates the sperm and ovum ...

journal_title：Oncology reports

authors： Aguilar-Rojas A,Huerta-Reyes M

更新日期：2009-11-01 00:00:00

abstract：:In the present study, we identified a gene termed Nbla10993 whose expression levels are higher in favorable neuroblastomas versus unfavorable ones. Structural analysis showed that Nbla10993 is a novel splicing variant of the ER-associated protein of 140 kDa (ERAP140), which lacks the central acidic as well as the COOH...

journal_title：Oncology reports

authors： Arai H,Ozaki T,Niizuma H,Nakamura Y,Ohira M,Takano K,Matsumoto M,Nakagawara A

更新日期：2008-06-01 00:00:00

abstract：:It is well known that low-dose metronomic chemotherapy has antiangiogenic activity. The aim of the present trial was to investigate the antiangiogenic properties of weekly docetaxel in patients with metastatic breast cancer. In total, 157 metastatic breast cancer patients received 3...

journal_title：Oncology reports

authors： Pectasides D,Papaxoinis G,Kotoula V,Fountzilas H,Korantzis I,Koutras A,Dimopoulos AM,Papakostas P,Aravantinos G,Varthalitis I,Kosmidis P,Skarlos D,Bournakis E,Bafaloukos D,Kalofonos HP,Kalogeras KT,Fountzilas G

更新日期：2012-01-01 00:00:00

abstract：:Ribonucleotide reductase M2 subunit (RRM2) is one of the two subunits of human ribonucleotide reductase which plays a critical role in tumor progression. The aim of the present study was to analyze its expression, clinical significance and biological functions in gastric adenocarcinoma. We observed the upregulation of...

journal_title：Oncology reports

authors： Kang W,Tong JH,Chan AW,Zhao J,Wang S,Dong Y,Sin FM,Yeung S,Cheng AS,Yu J,To K

更新日期：2014-06-01 00:00:00

abstract：:microRNAs are an abundant class of short endogenous non-coding RNAs that function as important regulators of multiple target genes and participate in diverse biological roles in carcinogenesis. However, the role of miR-7 in lung cancer remains unclear and requires further elucidation. In the present study, we found a ...

journal_title：Oncology reports

authors： Li J,Zheng Y,Sun G,Xiong S

更新日期：2014-12-01 00:00:00

abstract：:As a common malignancy of the endocrine system, papillary thyroid carcinoma (PTC) seriously affects the quality of life of patients. lncRNA PAX8‑AS1:28, or lnc‑PSD4‑1:14 has been reported to be abnormally expressed in PTC. However, the function of PAX8‑AS1:28 in PTC is still unknown. Therefore, the present study aimed...

journal_title：Oncology reports

authors： Zhang Y,Li F,Chen J

更新日期：2019-04-01 00:00:00

abstract：:Peroxisome proliferator-activated receptor-gamma (PPAR-gamma), a member of the nuclear hormone receptor superfamily, is involved in suppressing the growth of several tumors. We showed that PPAR-gamma is expressed in Barrett's adenocarcinoma cell lines and inhibited the growth of these lines through the induction of G1...

journal_title：Oncology reports

authors： Takashima T,Fujiwara Y,Hamaguchi M,Sasaki E,Tominaga K,Watanabe T,Oshitani N,Higuchi K,Arakawa T

更新日期：2005-04-01 00:00:00

abstract：:The NAD(P)H:quinone oxidoreductase 1 (NQO1) enzyme is implicated in protection against oxidative stress and carcinogenesis. NQO1 C609T genetic polymorphism was reported to be associated with an increased risk for cancers, including breast cancer. However, there is still lack of evidence whether higher oxidative stress...

journal_title：Oncology reports

authors： Tseng LM,Yin PH,Tsai YF,Chi CW,Wu CW,Lee LM,Lee HC

更新日期：2009-05-01 00:00:00

abstract：:Glioma is the most frequent and aggressive primary tumor of the brain in humans. Over the last few decades, significant progress has been made in early detection and multi-mode treatments, but the prognosis of gliomas is still extremely poor. MicroRNAs are endogenously expressed non-coding, single strand and short RNA...

journal_title：Oncology reports

authors： Ma J,Yu J,Liu J,Yang X,Lou M,Liu J,Feng F,Ji P,Wang L

更新日期：2017-02-01 00:00:00

abstract：:Epidemiologic studies indicate the use of either statins or aspirin have beneficial effects in prostate cancer patients. The present study was undertaken to evaluate the effects and mechanisms of atorvastatin and aspirin alone or in combination in human prostate cancer cells cultured in vitro and grown as xenograft tu...

journal_title：Oncology reports

authors： He Y,Huang H,Farischon C,Li D,Du Z,Zhang K,Zheng X,Goodin S

更新日期：2017-02-01 00:00:00

abstract：:Immunotherapy of cancer offers great promise, however translation into human studies has yielded relatively poor results to date. The concept of combining cancer vaccination with angiogenesis inhibition is appealing, due to favorable safety profile of both approaches, as well as possible biological synergies. Here we ...

journal_title：Oncology reports

authors： Chan RC,Gutierrez B,Ichim TE,Lin F

更新日期：2009-11-01 00:00:00

abstract：:The expression levels of tissue factor (TF), the clotting initiator protein, have been correlated with angiogenesis and the histological grade of malignancy in glioma patients. The pro-tumor function of TF is linked to a family of G protein-coupled receptors known as protease-activated receptors (PARs), which may be a...

journal_title：Oncology reports

authors： Carneiro-Lobo TC,Lima MT,Mariano-Oliveira A,Dutra-Oliveira A,Oba-Shinjo SM,Marie SK,Sogayar MC,Monteiro RQ

更新日期：2014-02-01 00:00:00

abstract：:Enhancer of zeste homolog 2 (EZH2) is involved in malignant transformation and the biological aggressiveness of several human malignancies. Growing evidence indicates that EZH2 may be an appropriate therapeutic target for malignancies, including cholangiocarcinoma. Recently, an S-adenosyl-L-homocysteine hydrolase inhi...

journal_title：Oncology reports

authors： Nakagawa S,Sakamoto Y,Okabe H,Hayashi H,Hashimoto D,Yokoyama N,Tokunaga R,Sakamoto K,Kuroki H,Mima K,Beppu T,Baba H

更新日期：2014-02-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is sexually disparate in humans, with a significantly increased prevalence in males. The molecular mechanisms by which the inhibition or development of liver cancer are facilitated require further investigation with regard to sex factors affecting disease progression. In the present stud...

journal_title：Oncology reports

authors： Wu Y,Yao N,Feng Y,Tian Z,Yang Y,Zhao Y

更新日期：2019-09-01 00:00:00

abstract：:CD147, a multifunction glycoprotein of the immuno-globulin family, is associated with many types of tumors, and the overexpression of CD147 can enhance malignancy. However, the role of CD147 in cervical cancer remains unclear. In the present study, cervical cancer cells were found to express much more CD147 protein an...

journal_title：Oncology reports

authors： Wu Y,Zhou X,Zheng PS

更新日期：2011-09-01 00:00:00

abstract：:Thymidine phosphorylase (TP) and dihydropyrimidine dehydrogenase (DPD) are considered to be key enzymes affecting the prognosis for patients with various cancers. We tried to prove the correlation of TP and DPD expression in hepatocellular carcinoma (HCC) and liver metastasis. We quantified TP and DPD levels by an enz...

journal_title：Oncology reports

authors： Hotta T,Kobayashi Y,Taniguchi K,Johata K,Sahara M,Watanabe T,Ochiai M,Tanimura H,Tsubota YT

更新日期：2004-08-01 00:00:00

abstract：:We radiographically evaluated the response of primary lesions to chemotherapy in 101 patients with inoperable advanced gastric cancer. The median survival time in the 50 responders (49.5%) was 379 days, as compared with only 210 days in the 51 non-responders (50.1%) (p<0. 001). Morphologic changes of the gastric mucos...

journal_title：Oncology reports

authors： Yamazaki I,Koizumi W,Kondo I,Saigenji K

更新日期：2000-11-01 00:00:00

abstract：:Previous studies have demonstrated that the α5β1 integrin-mediated interaction with fibronectin (FN) occurs through the Arg-Gly-Asp (RGD) cell-binding sequence in repeat III10. Indocyanine green (ICG) is a near-infrared (NIR) optical dye that has been approved by the US Food and Drug Administration. In the present stu...

journal_title：Oncology reports

authors： Ding J,Feng M,Wang F,Wang H,Guan W

更新日期：2015-10-01 00:00:00

abstract：:The esophageal squamous cell carcinoma (ESCC) subtype with STMN1 overexpression has a high likelihood of lymphatic metastatic recurrence. However, the underlying mechanism remains to be further elucidated. We assessed the expression level of STMN1 and PTEN in 96 pN0 ESCC patient tissues using immunohistochemistry and ...

journal_title：Oncology reports

authors： Jiang W,Huang S,Song L,Wang Z

更新日期：2018-02-01 00:00:00