Restoration of miR-7 expression suppresses the growth of Lewis lung cancer cells by modulating epidermal growth factor receptor signaling.

abstract：:Accumulating evidence has shown that aberrantly expressed microRNAs (miRNAs) are associated with tumor development and progression. Our previous study found that microRNA-375 (miR-375) was downregulated in colorectal cancer (CRC), but little is known concerning the role of miR-375 and the related mechanism in CRC deve...

journal_title：Oncology reports

authors： Cui F,Wang S,Lao I,Zhou C,Kong H,Bayaxi N,Li J,Chen Q,Zhu T,Zhu H

更新日期：2016-07-01 00:00:00

abstract：:Gallbladder cancer (GBC) is a rare disease associated with an extremely poor patient prognosis, and occasionally, aberrant expression of p53 is present. Considering that p53 is one of the most widely studied tumor‑suppressor genes, we used a cell-penetrating peptide, 11R, to enhance the transferring efficiency of the ...

journal_title：Oncology reports

authors： Wang J,Yu Y,Yan Z,Hu Z,Li L,Li J,Jiang X,Qian Q

更新日期：2013-08-01 00:00:00

abstract：:Subsequently to the publication of the above paper, the authors have drawn to our attention that, owing to errors made in the compilation of the images in Fig. 6, the images shown in Fig. 6A‑C in the article were selected incorrectly (essentially, the images shown in Fig. 6A and B were alterative presentations of the ...

journal_title：Oncology reports

authors： Chen YH,Zhou BY,Wu XJ,Xu JF,Zhang JA,Chen YH,Liang SS

更新日期：2020-12-16 00:00:00

abstract：:Retinoblastoma, a well-vascularized tumor that is dependent on a very robust angiogenic response, is the most common intraocular malignancy in children. Tissue factor (TF) is known to regulate tumor progression and in the present study we demonstrated that TF regulates tumor angioge...

journal_title：Oncology reports

authors： Song HB,Park KD,Kim JH,Kim DH,Yu YS,Kim JH

更新日期：2012-12-01 00:00:00

abstract：:Chronic stress and a high-fat diet are well-documented risk factors associated with the renin-angiotensin system in the development of breast cancer. The angiotensin II type 1 receptor (AT1R) is a novel component of the renin-angiotensin system. Several recent studies have focused on the function of AT1R in cell proli...

journal_title：Oncology reports

authors： Du N,Feng J,Hu LJ,Sun X,Sun HB,Zhao Y,Yang YP,Ren H

更新日期：2012-06-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is the most common form of adult liver cancer and accounts for approximately 90% of all cases of primary liver cancer annually. Rhotekin (RTKN), which functions as a cancer promoter, can be frequently detected in many human cancers, including gastric cancer, colorectal carcinoma and blad...

journal_title：Oncology reports

authors： Zhou J,Zhang Y,Qi Y,Yu D,Shao Q,Liang J

更新日期：2017-02-01 00:00:00

abstract：:Human papillomavirus (HPV) L1 capsid protein is only produced during a productive HPV infection at the end of the natural viral life cycle and is a major target of the immune response in women with HPV-related squamous intraepithelial lesions. We evaluated the usefulness of L1 detection by immunocytochemistry in high-...

journal_title：Oncology reports

authors： Norman I,Hjerpe A,Andersson S

更新日期：2013-08-01 00:00:00

abstract：:Few studies on sarcomas have examined the relationships between microsatellite alterations in particular loci, tumor prognosis and tumorigenesis, because sarcomas are uncommon and those prognoses can be confounded by coexisting factors, such as tumor site. We studied the relationship between microsatellite alterations...

journal_title：Oncology reports

authors： Iyoda A,Hiroshima K,Toyozaki T,Baba M,Fujisawa T,Yusa T,Ohwada H

更新日期：2001-07-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is highly resistant to chemotherapy, leading to a poor prognosis of advanced disease. Inhibitors of histone deacetylase (HDACi) induce re-differentiation in tumor cells and thereby re-establish sensitivity towards apoptotic stimuli. HDACi are entering the clinical stage of tumor treatmen...

journal_title：Oncology reports

authors： Schuchmann M,Schulze-Bergkamen H,Fleischer B,Schattenberg JM,Siebler J,Weinmann A,Teufel A,Wörns M,Fischer T,Strand S,Lohse AW,Galle PR

更新日期：2006-01-01 00:00:00

abstract：:Different members of the Ets-family of transcription factors are involved in TMPRSS-2-Ets translocations frequently found in human prostate cancers. We previously reported that Ets-1, which is the prototype of Ets-family members, promotes both migration and invasion of melanoma, Hela and glioma cells. Here, we examine...

journal_title：Oncology reports

authors： Shaikhibrahim Z,Langer B,Lindstrot A,Florin A,Bosserhoff A,Buettner R,Wernert N

更新日期：2011-04-01 00:00:00

abstract：:The incidence and associated mortality of melanoma continues to increase worldwide. At present, there is no curative therapy for advanced stage of melanoma. It is necessary to find new indicators of prognosis and therapeutic targets. Increasing evidence shows that miRNA can provide potential candidate biomarkers for m...

journal_title：Oncology reports

authors： Guo B,Hui Q,Zhang Y,Chang P,Tao K

更新日期：2016-10-01 00:00:00

abstract：:Autophagy is an intracellular multi-step catabolic degradation process that involves the degradation and recycling of cellular proteins and cytoplasmic damaged organelles to maintain cellular homeostasis and reduction of metabolic stress. Numerous studies have indicated the importance of autophagy in cancer, but the r...

journal_title：Oncology reports

authors： Zhang L,Zhang J,Chen L,Wang J

更新日期：2015-12-01 00:00:00

abstract：:To estimate the incidence of Epstein-Barr virus-associated gastric carcinoma (EBV-GC) in Colombia and to clarify its clinicopathological features, we examined 178 consecutive gastric carcinoma cases, diagnosed during the period from 1996 to 1998, at Hospital Universitario del Valle in Cali, Colombia. The mean age of t...

journal_title：Oncology reports

authors： Carrascal E,Koriyama C,Akiba S,Tamayo O,Itoh T,Eizuru Y,Garcia F,Sera M,Carrasquilla G,Piazuelo MB,Florez L,Bravo JC

更新日期：2003-07-01 00:00:00

abstract：:Glioblastoma is a highly angiogenic tumor with a dismal prognosis. Temozolomide (TMZ), a methylating agent is one of the most effective chemotherapeutic agents against glioblastoma. To overcome the problem that most of these tumors become resistant to chemotherapeutic regimens within a year, we investigated the antitu...

journal_title：Oncology reports

authors： Kim JT,Kim JS,Ko KW,Kong DS,Kang CM,Kim MH,Son MJ,Song HS,Shin HJ,Lee DS,Eoh W,Nam DH

更新日期：2006-07-01 00:00:00

abstract：:Vasohibin-1 (VASH1) has recently been isolated as a novel inhibitor of angiogenesis. Several studies have demonstrated that VASH1 plays important roles in tumor angiogenesis but the role of this angiogenic inhibitor in renal cell carcinoma (RCC) has not been elucidated. We previously reported that VASH1 expression is ...

journal_title：Oncology reports

authors： Zhao G,Na R,Li L,Xiao H,Ding N,Sun Y,Han R

更新日期：2017-08-01 00:00:00

abstract：:We studied the role of chemotherapy in cancer cachexia, which is well known to lower QOL and responsiveness to chemotherapy. In BALB/c mice we used two clones derived from the murine colon 26 adenocarcinoma cell line; clone 5, a non-cachexigenic tumor and clone 20, a cachexigenic tumor, in which IL-6 mRNA was selectiv...

journal_title：Oncology reports

authors： Takahashi Y,Yasumoto K,Mai M

更新日期：2005-07-01 00:00:00

abstract：:Pancreatic cancer is the fourth most common cause of cancer-related mortality. In the present study, we employed 2 types of therapeutic stem cells expressing cytosine deaminase (CD) with or without human interferon-β (IFN‑β), HB1.F3.CD and HB1.F3.CD.IFN-β cells, respectively, to selectively treat pancreatic cancer. Th...

journal_title：Oncology reports

authors： Kim DJ,Yi BR,Lee HR,Kim SU,Choi KC

更新日期：2013-09-01 00:00:00

abstract：:Tumor growth is accelerated by induction of angiogenesis regulated by many cytokines and growth factors. In a tumor mass, various angiogenic factors and their receptors are simultaneously expressed and the overlapped expressions of various factors may contribute to the aggressive growth of tumor. However, the possible...

journal_title：Oncology reports

authors： Lee YM,Bae MH,Lee OH,Moon EJ,Moon CK,Kim WH,Kim KW

更新日期：2004-10-01 00:00:00

abstract：:Aberrant expression of microRNAs has been identified as regulators of biological processes of hepatocellular carcinoma (HCC) by negatively regulating protein-coding mRNAs. Several studies have demonstrated that miR-638 expression was dysregulated in various human cancers. However, the clinical significance and underly...

journal_title：Oncology reports

authors： Zhang Y,Zhang D,Jiang J,Dong L

更新日期：2017-01-01 00:00:00

abstract：:Platinum compounds and vinorelbine (VNB) are active in the treatment of non-small cell lung cancer (NSCLC), but moderate toxicity has been reported. The aims of the present study were to assess activity and tolerability of low dose carboplatin (CBDCA): 4.5 AUC according to Calvert formula on day 1, combined with vinor...

journal_title：Oncology reports

authors： Bretti S,Manzin E,Celano A,Ritorto G,Loddo C,Berruti A

更新日期：2001-03-01 00:00:00

abstract：:Elucidating the effects of genes involved in tumors may improve therapeutic strategies for human cancer. Recently, several studies discovered that Akt1 plays a dual role in mediating cell proliferation, migration and invasion, depending on the cell type. However, the pathophysiological role of Akt1 in hepatocellular c...

journal_title：Oncology reports

authors： Chen L,Kang QH,Chen Y,Zhang YH,Li Q,Xie SQ,Wang CJ

更新日期：2014-02-01 00:00:00

abstract：:Prostate cancer is the second most commonly diagnosed cancer in men in Poland after lung cancer and the third leading cause of cancer-related mortality after lung and colon cancer. The etiology of most cases of prostate cancer are not fully known, and therefore it is essential to search for the molecular basis of pros...

journal_title：Oncology reports

authors： Nowacka-Zawisza M,Wiśnik E

更新日期：2017-11-01 00:00:00

abstract：:The peroxisome proliferator-activated receptor-γ (PPAR-γ) coactivator-1β (PGC-1β) is a well-established regulator of mitochondrial biogenesis. However, the underlying mechanism of PGC-1β action remains elusive. This study reveals that knockdown of endogenous PGC-1β by short-hairpin RNA (shRNA) leads to a decrease in t...

journal_title：Oncology reports

authors： Wang L,Liu Q,Li F,Qiu J,Fan H,Ma H,Zhu Y,Wu L,Han X,Yang Z,Jiang H,Wei J,Xia H

更新日期：2013-10-01 00:00:00

abstract：:MicroRNAs (miRNAs) that negatively regulate gene expression play a key role in the development and progression of cancer. Aberrant expression of hsa-miR-187 (miR-187) has been reported in various malignancies. However, the function of miR-187 in tumor progression remains controversial and its role in non-small cell lu...

journal_title：Oncology reports

authors： Cai Y,Ruan J,Yao X,Zhao L,Wang B

更新日期：2017-05-01 00:00:00

abstract：:Splenic metastasis from a lung cancer is infrequently noted, however, the pattern of the metastasis has not been studied, thus we conducted a retrospective study. Twelve of the consecutive 997 patients with lung cancer, who were admitted to our division, developed splenic metastasis. The pattern of splenic metastasis ...

journal_title：Oncology reports

authors： Satoh H,Watanabe K,Ishikawa H,Yamashita YT,Ohtsuka M,Sekizawa K

更新日期：2001-11-01 00:00:00

abstract：:In a human cancer cell line, we previously found a mutation in codon 322 of the extracellular signal-regulated kinase (ERK2E322K), the protein showed a faster migration when compared to wild-type in SDS-PAGE and constitutive phosphorylation. However, the reason for the faster migration, and the biochemical and biologi...

journal_title：Oncology reports

authors： Mahalingam M,Arvind R,Ida H,Murugan AK,Yamaguchi M,Tsuchida N

更新日期：2008-10-01 00:00:00

abstract：:Currently, various types of keratins have been reported to be highly expressed in cancer cells and to be associated with a malignant phenotype. In the present study, it was found that expression levels of keratin 6 (K6), keratin 16 (K16), and keratin 17 (K17) were highly elevated in SNU601 cells resistant to cisplatin...

journal_title：Oncology reports

authors： Lim SC,Parajuli KR,Han SI

更新日期：2019-08-01 00:00:00

abstract：:High mobility group N (HMGNs) are members of the high mobility group protein family, and are involved in the development and progression of several tumors. HMGN1 and HMGN5 were previously shown to be associated with the bioactivities of osteosarcoma. However, the effects and molecular mechanisms of HMGN2 on osteosarco...

journal_title：Oncology reports

authors： Liang G,Xu E,Yang C,Zhang C,Sheng X,Zhou X

更新日期：2015-03-01 00:00:00

abstract：:Nuclear factor (NF)-κB is the key transcription factor involved in the inflammatory responses, and its activation aggravates tumors. Peptidoglycan (PGN), a main cell wall component of Gram-positive bacteria, stimulates Toll-like receptor 2 (TLR-2) and activates a number of inflammat...

journal_title：Oncology reports

authors： Echigo R,Sugimoto N,Yachie A,Ohno-Shosaku T

更新日期：2012-10-01 00:00:00

abstract：:In the development and progression of cancer, tumor suppressor genes may be silenced by mechanisms such as methylation. Thus the discovery of new genes silenced by methylation may uncover new tumor suppressor genes, and improve our understanding of cancer biology. In this study we investigated the methylation of 19 ge...

journal_title：Oncology reports

authors： Tsunoda S,Smith E,De Young NJ,Wang X,Tian ZQ,Liu JF,Jamieson GG,Drew PA

更新日期：2009-04-01 00:00:00