Abstract:
:Retinoblastoma, a well-vascularized tumor that is dependent on a very robust angiogenic response, is the most common intraocular malignancy in children. Tissue factor (TF) is known to regulate tumor progression and in the present study we demonstrated that TF regulates tumor angiogenesis of retinoblastoma. In an orthotopic transplantation model of retinoblastoma, TF was selectively expressed in the proliferative area of retinoblastoma including tumor vessels as well as tumor cells, where TF expression was co-localized with endothelial cells of tumor vessels. TF expression progressively increased with fibroblast growth factor-2 (FGF-2)-induced proliferation of human umbilical vein endothelial cells (HUVECs), which was effectively inhibited by blockade of the TF pathway by TF pathway inhibitor (TFPI). In addition, FGF-2-induced angiogenic processes of migration and tube formation of vascular endothelial cells were also effectively suppressed by TFPI, which would be mediated by inhibition of extracellular signal-regulated kinase activation. Therefore, further to our previous report that TF is involved in tumor cell proliferation of retinoblastoma, our current data suggest that blockade of the TF pathway by TFPI could effectively inhibit tumor growth by suppressing tumor cell proliferation and tumor angiogenesis at the same time.
journal_name
Oncol Repjournal_title
Oncology reportsauthors
Song HB,Park KD,Kim JH,Kim DH,Yu YS,Kim JHdoi
10.3892/or.2012.2048subject
Has Abstractpub_date
2012-12-01 00:00:00pages
2057-62issue
6eissn
1021-335Xissn
1791-2431journal_volume
28pub_type
杂志文章相关文献
ONCOLOGY REPORTS文献大全abstract::For deveplopment and function of the lung, progesterone (Prog) fulfils important roles. In a recent report, immunolocalization of Prog and estrogen receptors in non-small cell lung carcinomas were examined and it was shown that the Prog receptor might be a potent prognostic factor. In the present study, a cell line wi...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2007-09-01 00:00:00
abstract::The incidence of malignant melanoma has increased greatly in recent decades presenting a high mortality rate despite intensive efforts in this area of research. Recent studies indicate that the chemokine receptor 4 (CXCR4) plays a critical role in cancer. Thus, it has been reported that CXCL12 binding to CXCR4 initiat...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2016.4620
更新日期:2016-04-01 00:00:00
abstract::Esophageal squamous cell carcinoma (ESCC) is a common cancer with a very poor prognosis. New methods are needed to screen high-risk populations and identify curable tumors and precursor lesions early. Molecular markers may be useful in such screening efforts. This study was designed to determine the prevalence of p16,...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2006-06-01 00:00:00
abstract::We previously reported that chromosome arm 10q is one of the target regions of allelic loss in human endometrial cancer. To identify the gene in this region responsible for endometrial cancer, we further characterized this region and localized the hBRAG gene. The function of hBRAG has not yet been fully studied, and t...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.7.6.1339
更新日期:2000-11-01 00:00:00
abstract::Loss of proliferative control and failure to undergo cellular differentiation are key events during carcinogenesis. We recently identified a new potential tumor suppressor gene named MTUS1 (mitochondrial tumor suppressor 1), down-regulated in undifferentiated tumor cell lines, inhibiting tumor cell proliferation after...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2010-01-01 00:00:00
abstract::Taxanes, a new class of antitumor drugs, are effective against a large number of human tumors, although there are problems with drug resistance. The novel taxane, IDN5109, is characterized by its high tolerability, antitumor efficacy, ability to overcome multidrug resistance, and oral bioavailabilty. We investigated t...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2006-02-01 00:00:00
abstract::Non‑small cell lung cancer (NSCLC) is the most common type of lung cancer, and numerous oncogenes are associated with this disease. Oxysterol‑binding protein‑related protein 8 (ORP8) is essential for cell growth, migration and the modulation of mitochondrial respiration and morphology. However, the underlying role of ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2020.7517
更新日期:2020-05-01 00:00:00
abstract::Colon cancer is the main cause of cancer mortality worldwide. Its poor prognosis is mainly ascribed to high recurrence rates. Identifying novel prognostic biomarkers and therapeutic key points for management is crucial and important. Long non-coding RNAs (lncRNAs) are a class of RNAs, which have various roles in carci...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2018.6412
更新日期:2018-07-01 00:00:00
abstract::Cyclin Y (CCNY) is a newly identified PFTK1 interacting protein and has been found to be associated with the proliferation and tumorigenesis of human non-small cell lung cancer. In the present study, we analyzed the expression levels of CCNY in 65 cases of breast cancer (BC) tissues and in four BC cell lines, BT-474, ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2016.5126
更新日期:2016-11-01 00:00:00
abstract::MicroRNAs (miRNAs) have been shown to play an important role in diverse biological processes and cancer progression. The objective of the present study was to investigate the role of miR-497 in ovarian cancer angiogenesis. We found that miR-497 expression was downregulated in human ovarian cancer tissues, and the low ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2014.3439
更新日期:2014-11-01 00:00:00
abstract::Breast cancer metastasizes to the bone in a majority of patients with advanced disease resulting in bone destruction. The underlying mechanisms are complex, and both processes are controlled by an interaction between locally and systemically derived signals. Clinically, breast cancer patients with depression have a hi...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2015.4430
更新日期:2016-02-01 00:00:00
abstract::To elucidate the molecular mechanisms underlying the pathogenesis and treatment of human primary hepatocellular carcinoma (HCC), it is important to explore novel HCC-associated genes. In the present study, we examined the expression of ubiquitin-specific peptidase 14 (USP14) in patients with HCC using quantitative PCR...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2015.4296
更新日期:2015-12-01 00:00:00
abstract::Acquisition of resistance to paclitaxel is a major obstacle to successful treatment of breast cancer patients, but the molecular mechanisms underlying the development of drug resistance remain largely unclear. The aim of the present study was to investigate the role and mechanism of action of miR‑200c‑3p in the resist...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2018.6735
更新日期:2018-12-01 00:00:00
abstract::The morbidity and mortality of prostate cancer have been increasing recently, and the comprehensive treatment for prostate cancer is unable to achieve satisfactory outcomes. Quercetin is a natural flavonoid compound that has attracted increased interest and attention due to its anticancer activity. In vitro and in viv...
journal_title:Oncology reports
pub_type: 杂志文章,评审
doi:10.3892/or.2015.3886
更新日期:2015-06-01 00:00:00
abstract::Apoptosis is a crucial event for anticancer drug efficacy. The signal pathways activated by anticancer drugs are classified as death receptor (DR) -dependent or -independent. The mechanisms by which anticancer drugs induce apoptosis via DR-dependent pathways are not fully understood. In the present study, we assessed ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2003-11-01 00:00:00
abstract::Angiogenesis is crucial for the development and metastasis of human brain glioma. Based on our previous successful construction of a lentivirus-mediated alphastatin (an endogenous angiogenesis inhibitor) gene transfer system and our findings that alphastatin exhibited potent inhibit...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2012.2187
更新日期:2013-03-01 00:00:00
abstract::Histone acetylation is one of the key chromatin modifications that control gene transcription during development and tumorigenesis. Recently, it was reported that the histone deacetylase inhibitor, Trichostatin A (TSA), induces growth arrest and apoptosis in tumors. However, the mol...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2011.1496
更新日期:2012-02-01 00:00:00
abstract::Eighteen primary human malignant mesotheliomas obtained from 18 patients were screened for point mutations and microdeletions/insertions in all exons of the tumour suppressor gene PTEN/MMAC1 by SSCP analysis. No mutation could be found. Our preliminary data indicate that disarrangements of PTEN/MMAC1 are at least not ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.8.6.1375
更新日期:2001-11-01 00:00:00
abstract::Analysis of HER-2/neu gene amplification by fluorescence in situ hybridization was performed in 40 patients with invasive bladder cancer in order to evaluate the potential for molecular targeted therapy of HER-2 as a tailor-made treatment for patients with invasive bladder cancer. This study included 40 patients seen ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2007-11-01 00:00:00
abstract::Thymidine phosphorylase (TP) and dihydropyrimidine dehydrogenase (DPD) are considered to be key enzymes affecting the prognosis for patients with various cancers. We tried to prove the correlation of TP and DPD expression in hepatocellular carcinoma (HCC) and liver metastasis. We quantified TP and DPD levels by an enz...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2004-08-01 00:00:00
abstract::Mathematical modeling and serial magnetic resonance imaging (MRI) used to calculate patient-specific rates of tumor diffusion, D, and proliferation, ρ, can be combined to simulate glioblastoma multiforme (GBM) growth. We showed that the proportion and distribution of tumor cells below the MRI threshold are determined ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2016.4878
更新日期:2016-08-01 00:00:00
abstract::Notch signaling plays a critical role in embryonic vascular development and tumor angiogenesis. The present study was conducted to investigate the prognostic role of the angiogenesis-related Notch ligand and the receptor in acute myeloid leukemia (AML) and assess whether their expre...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2012.1943
更新日期:2012-10-01 00:00:00
abstract::The androgen receptor (AR) plays an essential role in the development and progression of prostate cancer. Castration-resistant prostate cancer (CRPC) is a consequence of androgen deprivation therapy. Unchecked CRPC followed by metastasis is lethal. Some CRPCs show decreased AR gene expression due to epigenetic mechani...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2016.5000
更新日期:2016-10-01 00:00:00
abstract::The aim of the present study was to screen gastric cancer (GC) tissue and adjacent tissue for differences in mRNA and circular (circRNA) expression, to analyze the differences in circRNA and mRNA expression, and to investigate the circRNA expression in gastric carcinoma and its mechanism. circRNA and mRNA differential...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2017.5415
更新日期:2017-03-01 00:00:00
abstract::MicroRNA (miRNA) is a type of endogenous non‑coding RNA implicated in various cellular processes. Studies have shown that miR-124 is involved in the malignant progression of cancer, but little is known concerning its potential role in breast cancer. Therefore, the purpose of this study was to conduct a functional anal...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2016.5163
更新日期:2016-12-01 00:00:00
abstract::Butyrate was shown to have a preventive effect on colon cancer in vivo. Germinated barley foodstuff (GBF) was in a prebiotic stage and had the potency to attenuate mucosal inflammation and to increase fecal butyrate production in colitis. This study aimed to determine whether the GBF treatment in a colon cancer model ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2008-10-01 00:00:00
abstract::Mitogene-inducible gene-6 (Mig-6) is involved in the intracellular signaling pathway as an adaptor molecule. Mig-6 expression is rapidly induced upon various kinds of mitogenic and stressful stimulations. We previously demonstrated that Mig-6 expression is induced by activated Ki-ras in human colon cancer cells and th...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2005-03-01 00:00:00
abstract::We aimed to examine the relationship between the preoperative GSA index [uptake ratio of the liver to the liver plus heart at 15 min (LHL15) to uptake ratio of the heart at 15 min to that at 3 min (HH15) ratio] calculated from 99mTc‑labeled diethylene triamine pentaacetate-galactosyl human serum albumin (99mTc-GSA) sc...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2014.3691
更新日期:2015-03-01 00:00:00
abstract::The global rising incidence of hepatocellular carcinoma (HCC), which parallels the increase of hepatitis C virus (HCV) prevalence, has sparked a renewed interest in discovering additional HCC serum markers. In this study, we investigated the clinical use of serum E-cadherin, ICAM, MMP-2, VEGF, OPN and β-catenin as pot...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2011.1355
更新日期:2011-10-01 00:00:00
abstract::Mitogenic actions of estrogens are mediated by two distinct estrogen receptors (ERs), which are critical in the progression and therapeutic response of breast cancer. ER expression is a dynamic phenomenon that is regulated by numerous factors, including cytokines, in the tumor microenvironment. Recently, studies have ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2015.4294
更新日期:2015-12-01 00:00:00