Downregulation of miR‑200c‑3p contributes to the resistance of breast cancer cells to paclitaxel by targeting SOX2.

abstract：:Enhanced cell migration and invasion play key roles in cancer metastasis. However, the molecules involved in this process are not fully understood. In this study, a full-length human BNIPL-2 (Bcl-2/adenovirus E1B 19 kDa interacting protein 2 like-2) cDNA was transfected into human hepatocellular carcinoma cells with l...

journal_title：Oncology reports

authors： Xie L,Qin W,Li J,He X,Zhang H,Yao G,Shu H,Yao M,Wan D,Gu J

更新日期：2007-03-01 00:00:00

abstract：:The number of new lung cancer cases diagnosed yearly is high, and the mortality rate has not substantially declined. Non-small cell lung cancer (NSCLC) is the most common type of lung cancer, and adenocarcinoma accounts for the largest proportion of NSCLC. Currently, platinum-based combined chemotherapy, particularly ...

journal_title：Oncology reports

authors： Cheng R,Lu C,Zhang G,Zhang G,Zhao G

更新日期：2017-04-01 00:00:00

abstract：:Subsequently to the publication of this paper, the authors have realized that the affilitation address omitted the name of the university at which this research was conducted (Capital Medical University). Therefore, the author affiliations for this paper should have appeared as follows (changes are highlighted in bold...

journal_title：Oncology reports

authors： Dong J,Xu M

更新日期：2019-12-01 00:00:00

abstract：:The modifying effect of dietary tuna (Thunnus thynnus orientalis) orbital oil rich in docosahexaenoic acid (DHA) and vitamin D3 (VD3) on the development of azoxymethane (AOM)-induced colonic aberrant crypt foci (ACF) was investigated in male F344 rats. Animals were given three weekly subcutaneous injections of AOM (15...

journal_title：Oncology reports

authors： Kohno H,Yamaguchi N,Ohdoi C,Nakajima S,Odashima S,Tanaka T

更新日期：2000-09-01 00:00:00

abstract：:HIF-1 is a heterodimer consisting of the HIF-1alpha and HIF-1beta subunits, and HIF-1alpha is the unique oxygen regulated subunit that determines HIF-1 activity. HIF-1alpha upgrades many gene products which include the glucose transporter protein 1 (Glut-1). Immunohistochemical studies using a monoclonal antibody spec...

journal_title：Oncology reports

authors： Palit V,Phillips RM,Puri R,Shah T,Bibby MC

更新日期：2005-10-01 00:00:00

abstract：:MA128, a novel herbal medicine, was previously identified and its effectiveness in the treatment of asthma and atopic dermatitis (AD) was demonstrated. In particular, post-inflammatory hyperpigmentation (PIH) in AD mice was improved by treatment with MA128. In addition, MA128 exhibited anti-melanogenic activity by inh...

journal_title：Oncology reports

authors： Kim A,Im M,Yim NH,Hwang YH,Yang HJ,Ma JY

更新日期：2015-08-01 00:00:00

abstract：:Homeobox containing 1 (HMBOX1) is a novel transcription repressor that is significantly downregulated in human liver cancer tissues and cell lines, but the exact biological function of HMBOX1 in liver cancer is still unknown. We observed a negative association between HMBOX1 expression level and the clinical stages of...

journal_title：Oncology reports

authors： Zhao H,Jia H,Han Q,Zhang J

更新日期：2018-09-01 00:00:00

abstract：:Sanguinarine (SAN), an alkaloid isolated from plants of the Papaveraceae family, is a compound with multiple biological activities. In the present study, we explored the anticancer properties of SAN in lung cancer using the human lung adenocarcinoma cell line SPC-A1. Our results revealed that SAN inhibited SPC-A1 cell...

journal_title：Oncology reports

authors： Gu S,Yang XC,Xiang XY,Wu Y,Zhang Y,Yan XY,Xue YN,Sun LK,Shao GG

更新日期：2015-08-01 00:00:00

abstract：:Annexin A2 (ANXA2) is a well-known calcium-dependent phospholipid binding protein widely distributed in the nucleus, cytoplasm and extracellular surface of various eukaryotic cells. It has been recognized as a pleiotropic protein affecting a wide range of molecular and cellular processes. Dysregulation and abnormal ex...

journal_title：Oncology reports

authors： Xu XH,Pan W,Kang LH,Feng H,Song YQ

更新日期：2015-05-01 00:00:00

abstract：:Apoptosis is a process associated with development and progression of breast cancer. The association between connexins and programmed cell death has only been demonstrated in a few studies. The aim of the present study was the evaluation of Cx26 and Cx43 expression in breast cancer in correlation with Bcl-2 and Bak pr...

journal_title：Oncology reports

authors： Kanczuga-Koda L,Sulkowski S,Tomaszewski J,Koda M,Sulkowska M,Przystupa W,Golaszewska J,Baltaziak M

更新日期：2005-08-01 00:00:00

abstract：:As tumor-associated antigens are not well characterized for the majority of human tumors, polyvalent vaccines prepared with whole-tumor antigens are an attractive approach for tumor vaccination. Vascular endothelial growth factor receptor-2 (VEGFR2), as a model antigen with which to...

journal_title：Oncology reports

authors： Yan HX,Cheng P,Wei HY,Shen GB,Fu LX,Ni J,Wu Y,Wei YQ

更新日期：2013-04-01 00:00:00

abstract：:Cigarette smoke has been implicated as a major risk factor for esophageal squamous cell carcinoma (ESCC). Several lines of evidence have suggested that the promoting effect of cigarette smoking extract (CSE) on ESCC is mediated by upregulation of cyclooxygenase-2 (COX-2) expression. Yet, the underlying molecular and c...

journal_title：Oncology reports

authors： Gong J,Chu Y,Xu M,Huo J,Lv L

更新日期：2016-01-01 00:00:00

abstract：:Resolvins, an endogenous lipid mediator derived from eicosapentaenoic acid (EPA) or docosahexaenoic acid (DHA) of fish oil, has been reported to have anti-inflammatory and antitumor effect in various pathogenic processes. However, there are no studies about the effects of resolvin D1 and E1 on concanavalin A-induced h...

journal_title：Oncology reports

authors： Kuang H,Hua X,Zhou J,Yang R

更新日期：2016-01-01 00:00:00

abstract：:The incidence of malignant melanoma has increased greatly in recent decades presenting a high mortality rate despite intensive efforts in this area of research. Recent studies indicate that the chemokine receptor 4 (CXCR4) plays a critical role in cancer. Thus, it has been reported that CXCL12 binding to CXCR4 initiat...

journal_title：Oncology reports

authors： André ND,Silva VA,Watanabe MA,De Lucca FL

更新日期：2016-04-01 00:00:00

abstract：:Colorectal cancer (CRC) is a common gastrointestinal malignancy worldwide and is a lethal and aggressive malignancy with a dismal prognosis. EphrinB2 is a membrane-bound ligand and has an intracellular domain that also possesses an intrinsic signaling capacity called 'reverse signaling'. In the present study, CRC cell...

journal_title：Oncology reports

authors： Li P,Chen W,Wang Y,Fu X,Wen K,Qian J,Huang C,Fu Z

更新日期：2015-02-01 00:00:00

abstract：:CYP1A1 expression in various tissues of 43 gastric cancer cases was analyzed with frozen tissue array-based immunohistochemical staining (IHC), RT-PCR, Western blot analysis and EROD (7-ethoxyresourfin-O-deethylase) assay. CYP1A1 was detected immunohistochemically in 86% (37/43) of gastric cancers, in both 57% (4/7) o...

journal_title：Oncology reports

authors： Zhang KL,Ma JX,Chen XY,Sun Y,Kong QY,Liu J,Li H

更新日期：2004-12-01 00:00:00

abstract：:Emodin (EMO) has been shown to possess pleiotropic anticancer capabilities in many types of cancer, including epithelial ovarian cancer (EOC). Inhibitory efficacy of EMO on EOC invasion and migration was previously observed, however, the underlying mechanisms have not been completely elucidated. The present study is a...

journal_title：Oncology reports

authors： Hu C,Dong T,Li R,Lu J,Wei X,Liu P

更新日期：2016-04-01 00:00:00

abstract：:The authors of the above article drew to our attention that they had identified three instances of data overlapping between data panels, suggesting that data purportedly showing results obtained under different experimental conditions had been derived from the same original source. Comparing between the two figures, t...

journal_title：Oncology reports

authors： Ji CX,Fan YH,Xu F,Lv SG,Ye MH,Wu MJ,Zh XG,Wu L

更新日期：2020-11-01 00:00:00

abstract：:Signal transducer and activator of transcription 3 (STAT3) is an oncogene that promotes cell survival, proliferation, and motility. In the present study, we explored the mechanism involved in the inhibition by epigallocatechin-3-gallate (EGCG) of STAT3 signaling as detected by surface plasmon resonance (SPR)-binding a...

journal_title：Oncology reports

authors： Wang Y,Ren X,Deng C,Yang L,Yan E,Guo T,Li Y,Xu MX

更新日期：2013-12-01 00:00:00

abstract：:We previously reported that chromosome arm 10q is one of the target regions of allelic loss in human endometrial cancer. To identify the gene in this region responsible for endometrial cancer, we further characterized this region and localized the hBRAG gene. The function of hBRAG has not yet been fully studied, and t...

journal_title：Oncology reports

authors： Yuki M,Yoshinaga K,Yamakawa H,Sakurada K,Sato S,Yajima A,Horii A

更新日期：2000-11-01 00:00:00

abstract：:Breast cancer which is the most common type of diagnosed cancer among women worldwide possesses metastatic potential, multi‑drug resistance, and high mortality. The NF‑κB signaling pathway has been revealed to be abnormally activated in breast cancer cells and closely associated with high metastasis and poor prognosis...

journal_title：Oncology reports

authors： Zeng A,Liang X,Zhu S,Liu C,Wang S,Zhang Q,Zhao J,Song L

更新日期：2020-12-09 00:00:00

abstract：:Our aim was to carry out mutational analysis of Smad7 exon 4 that codes for the Smad7 MH2 domain in human cervical cancer tissues. This study is warranted since genetic abnormalities of components of the transforming growth factor-beta (TGF-beta)/Smad signaling system have been implicated in a variety of human cancers...

journal_title：Oncology reports

authors： Hariharan R,Babu JM,P R,Pillai MR

更新日期：2009-04-01 00:00:00

abstract：:This study was mainly focused on the development of a dual-ligand liposomal delivery system for targeting the delivery of paclitaxel (PTX) to lung cancer. The specific ligand peptide HAIYPRH (T7) and the cationic cell-penetrating peptide TAT were connected with phospholipid via a polyethylene glycol (PEG) spacer to pr...

journal_title：Oncology reports

authors： Wang RH,Cao HM,Tian ZJ,Jin B,Wang Q,Ma H,Wu J

更新日期：2015-02-01 00:00:00

abstract：:Breast cancer mortality is strongly related to the invasive and metastatic potential of tumor cells. We previously showed that an active mutant of H-Ras induced invasive phenotype of MCF10A human breast epithelial cells. Membrane anchoring of Ras requires isoprenylation which involves the activity of 3-hydroxy 3-methy...

journal_title：Oncology reports

authors： Kang S,Kim ES,Moon A

更新日期：2009-05-01 00:00:00

abstract：:Progestin and adipoQ receptor family member III (PAQR3) is a regulator that negatively modulates the Ras/Raf/MEK/ERK signaling cascade and the GPCR Gβγ subunit signaling pathway. The role of PAQR3 in hepatocellular carcinoma (HCC) has not been elucidated. The present study investigated the expression of PAQR3 and its ...

journal_title：Oncology reports

authors： Wu HG,Zhang WJ,Ding Q,Peng G,Zou ZW,Liu T,Cao RB,Fei SJ,Li PC,Yang KY,Hu JL,Dai XF,Wu G,Li PD

更新日期：2014-12-01 00:00:00

abstract：:Mice are particularly susceptible to carcinogens when exposure starts early in life. We evaluated the expression of stem cell antigen-1 (Sca-1) gene in the lung of variously aged CD-1 mice, either untreated or exposed to environmental cigarette smoke (ECS) and/or to a light source. Sca-1 expression progressively decre...

journal_title：Oncology reports

authors： Izzotti A,D'Agostini F,Larghero P,Cartiglia C,Travaini G,Balansky R,Steele VE,De Flora S

更新日期：2009-09-01 00:00:00

abstract：:The multi-target kinase inhibitor sorafenib has been approved for the treatment of patients with advanced differentiated thyroid cancer. However, different sensitivities to sorafenib have been observed, and few patients have benefited from sorafenib treatment in the long term. In the event of acquired resistance to so...

journal_title：Oncology reports

authors： Yi H,Ye T,Ge M,Yang M,Zhang L,Jin S,Ye X,Long B,Li L

更新日期：2018-02-01 00:00:00

abstract：:Mesenchymal stem cells (MSCs) hold great promise as potential therapies for tumors through the delivery of various anticancer agents. However, exogenous tissue‑derived MSCs, such as those of bone marrow, have exhibited a tendency for malignant transformation in the tumor microenvironment. This issue remains controvers...

journal_title：Oncology reports

authors： Cui X,Jing X,Yi Q,Xiang Z,Tian J,Tan B,Zhu J

更新日期：2019-04-01 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) is known to play a central role in tumour angiogenesis. Up to now inconclusive data have been published on the clinical-biological significance of circulating VEGF and on the most suitable blood fraction for measuring it. The aims of this pilot study were to assess VEGF in blo...

journal_title：Oncology reports

authors： Ranieri G,Coviello M,Chiriatti A,Stea B,Montemurro S,Quaranta M,Dittadi R,Paradiso A

更新日期：2004-02-01 00:00:00

abstract：:Gastric cancer (GC) is one of the most common causes of cancer‑related mortality worldwide. Despite remarkable progress in the diagnosis and treatment of GC, a large number of cases are diagnosed as advanced GC, and treatment failure occurs. Emerging evidence has shown that non‑coding RNAs (ncRNAs), especially microRN...

journal_title：Oncology reports

authors： Shao Z,Gao D,Chen L,Ding W,Yu Q

更新日期：2020-10-01 00:00:00