Vasohibin-1 inhibits angiogenesis and suppresses tumor growth in renal cell carcinoma.

abstract：:Several investigators have demonstrated that TGF-beta stimulated clone-22 (TSC-22) regulates cell growth and differentiation, and cell death. TSC-22 is a putative transcriptional regulator containing a leucine zipper-like structure and a nuclear export signal. We previously showed the cytoplasmic localization of TSC-2...

journal_title：Oncology reports

authors： Hino S,Kawamata H,Omotehara F,Uchida D,Begum NM,Yoshida H,Sato M,Fujimori T

更新日期：2002-03-01 00:00:00

abstract：:ONECUT1 (HNF-6) is the prototype of a new class of homeodomain transcription factors, that controls the development of pancreatic ducts during mouse development. In the present study, the role of ONECUT1 and its targeted genes TCF2, PKHD1 and CYS1 was analyzed in human pancreatic ductal adenocarcinoma (PDAC). mRNA lev...

journal_title：Oncology reports

authors： Jiang X,Zhang W,Kayed H,Zheng P,Giese NA,Friess H,Kleeff J

更新日期：2008-01-01 00:00:00

abstract：:Tobacco smoke is one of the serious risk factors of gastric cancer. Epithelial‑mesenchymal transition (EMT) has been shown to be associated with the initiation and carcinogenesis of gastric cancer. The role of Notch pathway in regulating tobacco smoke-induced EMT has not been investigated. β‑carotene, a carotenoid pre...

journal_title：Oncology reports

authors： Lu L,Chen J,Li M,Tang L,Wu R,Jin L,Liang Z

更新日期：2018-04-01 00:00:00

abstract：:PSMB4, proteasome subunit β4, is a member of the ubiquitin-proteasome family, and is elevated in a variety of malignancies. However, the expression level and related mechanism of PSMB4 in breast cancer remains unclear. Therefore, the present study investigated the expression level of PSMB4 in eight pairs of breast can...

journal_title：Oncology reports

authors： Wang H,He Z,Xia L,Zhang W,Xu L,Yue X,Ru X,Xu Y

更新日期：2018-10-01 00:00:00

abstract：:This study was designed to investigate the effect of pseudo-G-Rh2, a novel metabolite of ginsenoside Rh2, on the apoptosis of SGC-7901 human gastric cancer cells. Pseudo-G-Rh2 demonstrated antitumor activity and significantly inhibited the proliferation of SGC-7901 cells in a concen...

journal_title：Oncology reports

authors： Qu X,Qu S,Yu X,Xu H,Chen Y,Ma X,Sui D

更新日期：2011-12-01 00:00:00

abstract：:Multidrug resistance (MDR) to chemotherapeutic drugs is the main cause of chemotherapy failure in cancer treatment, and it generally results from expression of ATP-dependent efflux pump P-glycoprotein (P-gp). MDR reversal agents typically act by inhibiting the drug efflux activity of P-gp, thereby increasing intracell...

journal_title：Oncology reports

authors： Cao Z,Wright M,Cheng J,Huang X,Liu L,Wu L,Yang P

更新日期：2014-09-01 00:00:00

abstract：:Quercetin, a naturally occurring flavonoid abundant in fruits and vegetables, has been demonstrated as a multipotent bioflavonoid with great potential for the prevention and treatment of cancer. Apoptosis is thought to be an important response to most chemotherapeutic agents in leukemia cells. However, the underlying ...

journal_title：Oncology reports

authors： Lee WJ,Chen YR,Tseng TH

更新日期：2011-02-01 00:00:00

abstract：:Bmi-1, a member of the polycomb family, it is involved in self renewal of stem cells and functions as an oncogene in many malignant human cancer types. Recent studies have demonstrated that Bmi-1 is a predictive factor for poor patient prognosis. However, the underlying mechanisms o...

journal_title：Oncology reports

authors： Liu ZG,Liu L,Xu LH,Yi W,Tao YL,Tu ZW,Li MZ,Zeng MS,Xia YF

更新日期：2012-04-01 00:00:00

abstract：:Post-transcriptional modification of p53 by phosphorylation has been proposed as an important mechanism of p53 stabilization and functional regulation. However, little is known about the phosphorylation state of mutant p53 protein overexpressed in human tumors. We evaluated immunohistochemically the p53 phosphorylatio...

journal_title：Oncology reports

authors： Matsumoto M,Furihata M,Kurabayashi A,Ohtsuki Y

更新日期：2004-11-01 00:00:00

abstract：:Epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase and mutations in this gene are major drivers of lung cancer development. EGFR tyrosine kinase inhibitors (TKIs) are standard first‑line therapies for patients with advanced non‑small cell lung cancer (NSCLC) with activating EGFR mutations, but are n...

journal_title：Oncology reports

authors： Ota K,Okuma T,Lorenzo A,Yokota A,Hino H,Kazama H,Moriya S,Takano N,Hiramoto M,Miyazawa K

更新日期：2019-07-01 00:00:00

abstract：:We investigated the prevalence of human papillomavirus (HPV) in a clinical series of 72 patients with head and neck squamous cell carcinoma (HNSCC) using a retrospective and prospective study design. The majority of patients were smokers and/or drinkers and were treated with concomitant chemoradiotherapy (CCR). Furthe...

journal_title：Oncology reports

authors： Duray A,Descamps G,Decaestecker C,Sirtaine N,Gilles A,Khalifé M,Chantrain G,Depuydt CE,Delvenne P,Saussez S

更新日期：2013-07-01 00:00:00

abstract：:We evaluated the efficacy of anti-human VEGF antibody (bevacizumab) with or without irinotecan (CPT-11) against lung metastases in which neovascularization was already induced, as a postoperative adjuvant therapy using orthotopically implanted colon cancer in rat. The high VEGF productive KM12SM human colon cancer cel...

journal_title：Oncology reports

authors： Mizobe T,Ogata Y,Murakami H,Akagi Y,Ishibashi N,Mori S,Sasatomi T,Shirouzu K

更新日期：2008-09-01 00:00:00

abstract：:To investigate the antitumor action of arsenic trioxide (As2O3) by intratumoral injection into solid tumors, tumor growth inhibition (TGI) and angiogenesis of heterotransplanted esophageal carcinoma in mice was carried out. The cultured human esophageal carcinoma cells were inoculated into both laterals of the abdomin...

journal_title：Oncology reports

authors： Shen ZY,Shen J,Chen MH,Wu XY,Wu MH,Zeng Y

更新日期：2003-11-01 00:00:00

abstract：:It has been reported that cimetidine, a histamine type-2 receptor (H2R) antagonist, inhibits the growth of glandular tumors such as colorectal cancer. However, its effects against salivary gland tumors are still unknown. We demonstrated previously that human salivary gland tumor (HSG) cells spontaneously express the n...

journal_title：Oncology reports

authors： Fukuda M,Tanaka S,Suzuki S,Kusama K,Kaneko T,Sakashita H

更新日期：2007-03-01 00:00:00

abstract：:Colorectal cancer (CRC) is the third most common cancer and the fourth leading cause of cancer-related mortality worldwide. Aberrant expression of miRNAs play important roles in the development and progression of various types of cancers by modulating oncogenic and tumour-suppressor pathways. Therefore, exploring the ...

journal_title：Oncology reports

authors： Zhao J,Xu J,Zhang R

更新日期：2018-02-01 00:00:00

abstract：:The advent of pathotropic (disease-seeking) targeting has transported genetic medicine across the threshold of history with the progressive clinical validation of Rexin-G, a tumor-targeted nanosized anti-cancer agent. Achieving noteworthy single-agent efficacy and survival benefits in otherwise intractable cancers, th...

journal_title：Oncology reports

authors： Hall FL,Levy JP,Reed RA,Petchpud WN,Chua VS,Chawla SP,Gordon EM

更新日期：2010-10-01 00:00:00

abstract：:Apoptosis has to be drastically controlled in organs with important cell turnover such as the colon. Deregulation of this process is often present in tumor progression. Tissues of 82 patients treated for colorectal cancer (CRC) were analyzed using antibodies against AIF, p53, DR4, DR5, cleaved caspase-3 and the TUNEL ...

journal_title：Oncology reports

authors： Perraud A,Akil H,Nouaille M,Petit D,Labrousse F,Jauberteau MO,Mathonnet M

更新日期：2011-11-01 00:00:00

abstract：:Correlation between inhibition of cell motility and anti-invasive activity by the water extract of HangAmDan-B (HAD-B), a crude extract of eight Korean medicinal animals and plants, in NCI-H460 human non-small cell lung cancer (NSCLC) cells was investigated. Within the concentration...

journal_title：Oncology reports

authors： Choi YJ,Shin DY,Lee YW,Cho CK,Kim GY,Kim WJ,Yoo HS,Choi YH

更新日期：2011-12-01 00:00:00

abstract：:Cancer cells in ascites are usually exposed to a hypoxia tumor microenvironment and utilize enhanced glycolysis which produces energy and metabolizes nutrients to support proliferation. Vesicular stomatitis virus (VSV) is an oncolytic virus that relies on the host cellular metabolism for replication. We tested the eff...

journal_title：Oncology reports

authors： Zhou Y,Wen F,Zhang P,Tang R,Li Q

更新日期：2016-03-01 00:00:00

abstract：:Modified actin dynamics are a unique feature of transformed cancer cells and thereby promising targets for cancer chemotherapy. While latrunculin B (LB) and pectenotoxin-2 (PTX-2), both derived from natural sources, inhibit actin polymerization, jasplakinolide (JSP) prevents actin depolymerization. The purpose of this...

journal_title：Oncology reports

authors： Shin IJ,Ahn YT,Kim Y,Kim JM,An WG

更新日期：2011-05-01 00:00:00

abstract：:WNT5B is a member of the WNT family that has been reported to be overexpressed in a variety of cancer cell lines and tissues, including colorectal cancer (CRC). However, the potential roles of WNT5B in tumorigenesis have not been reported. In the present study, the WNT5B gene was transfected into CRC cells and generat...

journal_title：Oncology reports

authors： Zhang Y,Lin L,Jin Y,Lin Y,Cao Y,Zheng C

更新日期：2016-07-01 00:00:00

abstract：:Secreted frizzled-related protein 1 (SFRP1) is a candidate tumor suppressor gene located at 8p11.2 and antagonizes the Wnt signaling pathway. Epigenetic inactivation of SFRP1 by methylation of its promoter CpG island has recently been reported in several types of cancers. In the present study, we examined the expressi...

journal_title：Oncology reports

authors： Awakura Y,Nakamura E,Ito N,Kamoto T,Ogawa O

更新日期：2008-11-01 00:00:00

abstract：:The p16 protein is a cyclin-dependent kinase (CDK) inhibitor, which plays an important role in the regulation of the cell cycle by inactivating the cyclin-dependent kinase (CDK) that phosphorylates the retinoblastoma (Rb) protein. Overexpression of p16 protein has been found in many types of human malignancy. Autoanti...

journal_title：Oncology reports

authors： Looi K,Megliorino R,Shi FD,Peng XX,Chen Y,Zhang JY

更新日期：2006-11-01 00:00:00

abstract：:Synovial sarcomas (SS) consistently show a characteristic chromosomal translocation, t(X;18)(p11;q11), which usually leads to the formation of 2 chimeric fusion transcripts, SYT-SSX1 and -SSX2. A recent multi-institutional retrospective study revealed that the SYT-SSX fusion type emerged as the only independent signif...

journal_title：Oncology reports

authors： Saito T,Oda Y,Kawaguchi K,Takahira T,Yamamoto H,Tanaka K,Matsuda S,Sakamoto A,Iwamoto Y,Tsuneyoshi M

更新日期：2004-05-01 00:00:00

abstract：:To elucidate the molecular mechanisms underlying the pathogenesis and treatment of human primary hepatocellular carcinoma (HCC), it is important to explore novel HCC-associated genes. In the present study, we examined the expression of ubiquitin-specific peptidase 14 (USP14) in patients with HCC using quantitative PCR...

journal_title：Oncology reports

authors： Huang G,Li L,Zhou W

更新日期：2015-12-01 00:00:00

abstract：:TRIM58 (tripartite motif containing 58) has been reported as a novel methylated gene in hepatocellular carcinoma (HCC) by methylation microarrays. However, its associations with mRNA expression and clinicopathological characteristics have not been evaluated. In this study, we explored the potential clinical implicatio...

journal_title：Oncology reports

authors： Qiu X,Huang Y,Zhou Y,Zheng F

更新日期：2016-08-01 00:00:00

abstract：:Several studies have shown that curcumin can induce apoptosis and inhibit growth in human A549 lung adenocarcinoma cells. However, the mechanism is not completely understood yet. The present study was designed to investigate the effects of curcumin on A549 cells to better understand its apoptosis and apoptosis-related...

journal_title：Oncology reports

authors： Chen Q,Wang Y,Xu K,Lu G,Ying Z,Wu L,Zhan J,Fang R,Wu Y,Zhou J

更新日期：2010-02-01 00:00:00

abstract：:The epidermal growth factor receptor (EGFR) network has rich targets for prostate cancer killing. Herein we evaluated the effects of combining the EGFR inhibition and radiation on DU145 prostate cancer. We treated DU145 prostate cancer cells with various doses of anti-EGFR antibody (C225) and gamma-irradiation (RAD). ...

journal_title：Oncology reports

authors： Wagener M,Zhang X,Villarreal HG,Levy L,Allen P,Shentu S,Fang B,Krishnan S,Chang JY,Cheung MR

更新日期：2008-05-01 00:00:00

abstract：:Breast cancer is one of the most common malignancies diagnosed in women and it is increasing in incidence. Siegesbeckia glabrescens (SG) has been used in traditional oriental medicine to treat cardiovascular diseases such as hypertension and angina pectoris. This study examined whether or not SG could induce apoptosis...

journal_title：Oncology reports

authors： Jun SY,Choi YH,Shin HM

更新日期：2006-06-01 00:00:00

abstract：:The Chinese medicinal herb Sorbaria sorbifolia, native to Changbai Mountain, can induce apoptosis in HepG-2 cells. We studied the mechanism by which 5, 2', 4'-trihydroxy-6,7, 5'-trimethoxyflavone (TTF1) isolated from acetic ether extracts of Sorbaria sorbifolia induces apoptosis in HepG-2 cells. The results showed tha...

journal_title：Oncology reports

authors： Li Y,Bian L,Cui F,Li L,Zhang X

更新日期：2011-09-01 00:00:00