Vesicular stomatitis virus is a potent agent for the treatment of malignant ascites.

abstract：:Mammary stem cells (MSCs) are the progenitor population for human breast epithelia. MSCs give rise during mammary gland development to estrogen receptor (ER)-negative basal cells and the ER- luminal progenitor (LP) population which maintains ER+ and ER- luminal cells. The MSC population is expanded and tumorigenic in ...

journal_title：Oncology reports

authors： Wu J,Crowe DL

更新日期：2015-07-01 00:00:00

abstract：:Fecal microRNAs (miRNAs) are increasingly explored as non-invasive markers of colorectal cancer (CRC). However, its holistic profile in Asian CRC patients remains elusive. In the present study, the global human fecal miRNAs in Asian Chinese CRC patients was assayed to elucidate novel diagnostic fecal markers. Addition...

journal_title：Oncology reports

authors： Phua LC,Chue XP,Koh PK,Cheah PY,Chan EC,Ho HK

更新日期：2014-07-01 00:00:00

abstract：:Epithelial to mesenchymal transition (EMT) is a process implicated in cancer progression in which the underlying cellular changes have been identified mainly using in vitro models. We determined the expression of some putative EMT biomarkers including E-cadherin, beta-catenin, zinc finger factor Snail (Snail), transfo...

journal_title：Oncology reports

authors： Logullo AF,Nonogaki S,Pasini FS,Osório CA,Soares FA,Brentani MM

更新日期：2010-02-01 00:00:00

abstract：:Breast cancer mortality is strongly related to the invasive and metastatic potential of tumor cells. We previously showed that an active mutant of H-Ras induced invasive phenotype of MCF10A human breast epithelial cells. Membrane anchoring of Ras requires isoprenylation which involves the activity of 3-hydroxy 3-methy...

journal_title：Oncology reports

authors： Kang S,Kim ES,Moon A

更新日期：2009-05-01 00:00:00

abstract：:lncRNA metastasis-associated lung adencarcinoma transcript 1 (MALAT1) plays an important role in the metastasis of lung cancer. Yet, its role in bone metastasis and the related mechanism remain unknown. The present study aimed to investigate the role of lncRNA MALAT1 in the bone metastasis of non-small cell lung cance...

journal_title：Oncology reports

authors： Liu M,Sun W,Liu Y,Dong X

更新日期：2016-09-01 00:00:00

abstract：:Mice are particularly susceptible to carcinogens when exposure starts early in life. We evaluated the expression of stem cell antigen-1 (Sca-1) gene in the lung of variously aged CD-1 mice, either untreated or exposed to environmental cigarette smoke (ECS) and/or to a light source. Sca-1 expression progressively decre...

journal_title：Oncology reports

authors： Izzotti A,D'Agostini F,Larghero P,Cartiglia C,Travaini G,Balansky R,Steele VE,De Flora S

更新日期：2009-09-01 00:00:00

abstract：:LKB1 encodes a serine/threonine kinase generally inactivated in human lung cancers, which mediates cancer cell proliferation, migration and differentiation, but its biological function has not been completely elucidated. In this study, we demonstrated that LKB1 was associated with a substantial reduction of c-myc expr...

journal_title：Oncology reports

authors： Liang X,Nan KJ,Li ZL,Xu QZ

更新日期：2009-04-01 00:00:00

abstract：:A crucial step in the path to the malignant transformation of cells and tumor formation is immortalization, which essentially depends on telomere maintenance. The aim of this study was to investigate the role of telomerase in the progression of Barrett's esophagus. Telomerase activi...

journal_title：Oncology reports

authors： Qin X,Qi B,Zhao B

更新日期：2013-04-01 00:00:00

abstract：:Malignant peripheral nerve tumours (MPNT), e.g. malignant schwannoma, represent a relatively rare tumour entity which is usually regarded as a member of the group of soft-tissue sarcomas and treated accordingly. For chemotherapeutic approaches in metastasised disease, ifosfamide and doxorubicin have been identified as...

journal_title：Oncology reports

authors： Steins MB,Serve H,Zühlsdorf M,Senninger N,Semik M,Berdel WE

更新日期：2002-05-01 00:00:00

abstract：:Cancer stimulates macrophage infiltration and encourages angiogenesis, which is necessary for tumor growth and invasion. It seems, that the influence of photodynamic therapy (PDT) on immune cells and immune regulators plays a crucial role in this process. In order to study this effect, the influence of δ-aminolevulini...

journal_title：Oncology reports

authors： Kawczyk-Krupka A,Czuba Z,Szliszka E,Król W,Sieroń A

更新日期：2011-07-01 00:00:00

abstract：:The role of vascular endothelial growth factor (VEGF) during peritoneal dissemination of ovarian carcinoma and the association with tumor microvessel density (MVD) and matrix metalloproteinase (MMP) activity was investigated. To this end, MVD, tumor tissue and ascitic fluid levels of VEGF, and MMP activity of ascitic ...

journal_title：Oncology reports

authors： Yabushita H,Shimazu M,Noguchi M,Kishida T,Narumiya H,Sawaguchi K,Noguchi M

更新日期：2003-01-01 00:00:00

abstract：:We investigated the prevalence of human papillomavirus (HPV) in a clinical series of 72 patients with head and neck squamous cell carcinoma (HNSCC) using a retrospective and prospective study design. The majority of patients were smokers and/or drinkers and were treated with concomitant chemoradiotherapy (CCR). Furthe...

journal_title：Oncology reports

authors： Duray A,Descamps G,Decaestecker C,Sirtaine N,Gilles A,Khalifé M,Chantrain G,Depuydt CE,Delvenne P,Saussez S

更新日期：2013-07-01 00:00:00

abstract：:Curcumin, a phenolic compound extracted from Zingiberaceae turmeric, has strong anti-inflammatory, antioxidant and antitumor properties. However, the anticarcinogenic mechanism of curcumin has yet to be fully elucidated. Epithelial-mesenchymal transition (EMT) induced by transforming growth factor-β1 (TGF-β1) is invol...

journal_title：Oncology reports

authors： Sun XD,Liu XE,Huang DS

更新日期：2013-06-01 00:00:00

abstract：:Graft-versus-host disease (GVHD) is a devastating complication of hematopoietic stem cell transplantation (HSCT), and is characterized by systemic inflammation and tissue damage in multiple organs, such as the liver and small intestine. Interleukin-18 (IL-18), an important pro-inflammatory cytokine, is elevated during...

journal_title：Oncology reports

authors： Li X,Zhang C,Chen W,Pan B,Kong F,Zheng K,Tang R,Zeng L

更新日期：2015-10-01 00:00:00

abstract：:Breast cancer which is the most common type of diagnosed cancer among women worldwide possesses metastatic potential, multi‑drug resistance, and high mortality. The NF‑κB signaling pathway has been revealed to be abnormally activated in breast cancer cells and closely associated with high metastasis and poor prognosis...

journal_title：Oncology reports

authors： Zeng A,Liang X,Zhu S,Liu C,Wang S,Zhang Q,Zhao J,Song L

更新日期：2020-12-09 00:00:00

abstract：:It is well known that low-dose metronomic chemotherapy has antiangiogenic activity. The aim of the present trial was to investigate the antiangiogenic properties of weekly docetaxel in patients with metastatic breast cancer. In total, 157 metastatic breast cancer patients received 3...

journal_title：Oncology reports

authors： Pectasides D,Papaxoinis G,Kotoula V,Fountzilas H,Korantzis I,Koutras A,Dimopoulos AM,Papakostas P,Aravantinos G,Varthalitis I,Kosmidis P,Skarlos D,Bournakis E,Bafaloukos D,Kalofonos HP,Kalogeras KT,Fountzilas G

更新日期：2012-01-01 00:00:00

abstract：:This study evaluates and compares the accuracy of positron emission tomography with 18F-fluoro-2-deoxyglucose (FDG-PET) and gallium-67 citrate (Ga-67) scintigraphy in identifying disease sites in patients with malignant lymphoma at initial diagnosis or relapse. Histology subgroups included low (n=5), intermediate (n=6...

journal_title：Oncology reports

authors： Shen YY,Kao A,Yen RF

更新日期：2002-03-01 00:00:00

abstract：:Glucose‑6‑phosphate dehydrogenase (G6PD) is a cytoplasmic enzyme found in human erythrocytes that provides reduced NADPH for cell metabolism. Glutathione produced by the G6PD pathway can reduce the degree of harm caused by reactive oxygen species such as oxygen‑containing free radicals, peroxides and lipid peroxides. ...

journal_title：Oncology reports

authors： Li R,Wang W,Yang Y,Gu C

更新日期：2020-12-01 00:00:00

abstract：:The roles and mechanisms of mini-chromosome maintenance complex component 7 (MCM7) amplification and overexpression in esophageal carcinogenesis were investigated. By analyzing the TCGA datasets, we found that MCM7 was amplified in approximately 12% of esophageal squamous cell carcinomas (ESCCs), and in more than 4% o...

journal_title：Oncology reports

authors： Qiu YT,Wang WJ,Zhang B,Mei LL,Shi ZZ

更新日期：2017-06-01 00:00:00

abstract：:Bone marrow-derived endothelial progenitor cells (EPC) play an important role in neovascularisation and tumor growth. However, the clinical relevance of EPCs on blood vessel formation in non-small cell lung cancer (NSCLC) is unclear. EPC numbers in circulation are very low and therefore their detection is technically ...

journal_title：Oncology reports

authors： Pircher A,Kähler CM,Skvortsov S,Dlaska M,Kawaguchi G,Schmid T,Gunsilius E,Hilbe W

更新日期：2008-02-01 00:00:00

abstract：:Tumour cell proliferation is an important biological prognostic parameter to be considered alongside clinical and histopathological parameters. It has been evaluated by immunohistochemistry using proliferative markers (PCNA, Ki67, etc.) and by flow cytometry considering DNA content, growth fraction (S + G2M) and S-pha...

journal_title：Oncology reports

authors： Tirelli G,Sidari L,Giacomarra V,Papanikolla L,Sasso F,Russolo M,Melato M

更新日期：2002-05-01 00:00:00

abstract：:Pancreatic cancer is usually diagnosed in the advanced stages and is sensitive to only few therapies. The forkhead box L1 (FOXL1) and protein phosphatase 2A (PP2A) have been recognized to be tumor suppressive in human pancreatic cancers. In the present study, we co-expressed the two tumor suppressive molecules with a ...

journal_title：Oncology reports

authors： Li Y,Yu D,Sheng W,Song H,Li Y,Dong M

更新日期：2016-04-01 00:00:00

abstract：:Galla Rhois is a commonly used medicine in East Asia for the treatment of several diseases. However, the effects of Galla Rhois on the metastasis of colorectal cancer (CRC) and the underlying molecular mechanisms have not been studied. We investigated the anti‑metastatic properties of Galla Rhois water extract (GRWE) ...

journal_title：Oncology reports

authors： Mun JG,Kee JY,Han YH,Lee S,Park SH,Jeon HD,Hong SH

更新日期：2019-01-01 00:00:00

abstract：:Research has confirmed that abnormally expressed miRNAs are involved in the occurrence and development of hepatocellular carcinoma (HCC). In the present study, we confirmed that miR‑577 expression both in HCC tissues and cell lines was markedly downregulated. Clinically, downregulated expression of miR‑577 is notably ...

journal_title：Oncology reports

authors： Han S,Liu Z,Wang Y,Wang L,Yao B,Guo C,Song T,Tu K,Liu Q

更新日期：2018-06-01 00:00:00

abstract：:Thyroid cancer is the most commonly diagnosed malignancy of the endocrine system, the incidence of which has increased rapidly in the last 30 years. Genetic alterations in pathways, including the mitogen‑activated protein kinase (MAPK)/extracellular signal‑regulated kinase (Erk) and phosphatidylinositol‑3‑kinase (PI3K...

journal_title：Oncology reports

authors： Chen H,Chen W,Zhang X,Hu L,Tang G,Kong J,Wang Z

更新日期：2019-01-01 00:00:00

abstract：:Increasing evidence suggests that tumor necrosis factor receptor-associated factor 4 (TRAF4) is an oncogene which is frequently overexpressed in many human carcinomas. Although TRAF4 was originally identified in breast cancer, the underlying mechanism of TRAF4 in tumorigenesis remains largely unknown. In the present s...

journal_title：Oncology reports

authors： Zhang J,Li X,Yang W,Jiang X,Li N

更新日期：2014-09-01 00:00:00

abstract：:The expression of the DNA mismatch repair proteins hMSH2 and hMLH1 and p21(waf1) the cyclin G1 inhibitor, may determine response of adult cancers to anti-cancer drugs, that include alkylating agents and platinum-based drugs. The role of DNA mismatch repair proteins (hMSH2 and hMLH1) and p21(waf1) in pediatric tumor re...

journal_title：Oncology reports

authors： Idikio HA

更新日期：2001-09-01 00:00:00

abstract：:Histone deacetylase inhibitors are currently being evaluated for their therapeutic potential and have shown considerable promise as adjuvant therapies for a number of cancers. This study compared the effects of 2 hydroxamic acid based inhibitors, CG-1521 and SAHA, on gene expression...

journal_title：Oncology reports

authors： Knutson AK,Welsh J,Taylor T,Roy S,Wang WL,Tenniswood M

更新日期：2012-03-01 00:00:00

abstract：:Normal breast development is controlled by a balance between cell proliferation and apoptosis. The balance between the two parameters is crucial for determining the growth or regression of breast tumours in response to therapies and treatments. Therefore, it is necessary to understand the role of apoptosis in tumour p...

journal_title：Oncology reports

authors： Puertollano MA,Carrera MP,Puertollano E,Alvarez de Cienfuegos G,Ramirez-Expósito MJ,De Pablo MA,Martinez-Martos JM

更新日期：2008-09-01 00:00:00

abstract：:The aim of this study was to verify whether histopathological features of extratumoral and of primary tumor breast tissue could play a role in identifying patients with familial characteristics. We examined the clinicopathological features of 504 patients with sporadic or familial breast cancer stratified for risk of ...

journal_title：Oncology reports

authors： Mangia A,Tommasi S,Bruno M,Malfettone A,D'Amico C,Zito FA,Paradiso A,Simone G

更新日期：2010-06-01 00:00:00