Overexpression of the LKB1 gene inhibits lung carcinoma cell proliferation partly through degradation of c-myc protein.

abstract：:Epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase and mutations in this gene are major drivers of lung cancer development. EGFR tyrosine kinase inhibitors (TKIs) are standard first‑line therapies for patients with advanced non‑small cell lung cancer (NSCLC) with activating EGFR mutations, but are n...

journal_title：Oncology reports

authors： Ota K,Okuma T,Lorenzo A,Yokota A,Hino H,Kazama H,Moriya S,Takano N,Hiramoto M,Miyazawa K

更新日期：2019-07-01 00:00:00

abstract：:The aim of the present study was to evaluate the antitumor effects of the curcumin analogue GL63 on radioresistant nasopharyngeal carcinoma (NPC) CNE2R cells and parental CNE2 cells. The cell viability and proliferation of NPC cells were detected by MTT assay and colony formation assay. The suppressive effect on tumor...

journal_title：Oncology reports

authors： Pan Y,Xiao J,Liang G,Wang M,Wang D,Wang S,Yang H

更新日期：2013-07-01 00:00:00

abstract：:Circulating microRNAs (miRNAs) exist stably in body fluids and are potential biomarkers for hepatocellular carcinoma (HCC). Twenty-five patients with cirrhosis that evolved into HCC, who were treated at The Third Hospital of Zhenjiang Affiliated to Jiangsu University between January 2005 and December 2012, were enroll...

journal_title：Oncology reports

authors： Tan Y,Lin B,Ye Y,Wen D,Chen L,Zhou X

更新日期：2015-06-01 00:00:00

abstract：:The phosphatase and tensin homolog (PTEN) gene, an important tumor-suppressor gene, has been demonstrated to have the potential for inhibiting proliferation, migration and invasion in various types of cancer cells. The aim of the present study was to investigate the effect of PTEN expression on osteosarcoma (OS) cells...

journal_title：Oncology reports

authors： Hu Y,Xu S,Jin W,Yi Q,Wei W

更新日期：2014-10-01 00:00:00

abstract：:Although improvements in the chemotherapy modalities for pancreatic cancer have been realized, pancreatic cancer remains one of the most lethal malignancies. New-generation cancer immunotherapy methods, such as blocking of the PD-1/PD-L1 pathway, are consistently being investigated to improve the survival of pancreati...

journal_title：Oncology reports

authors： Doi T,Ishikawa T,Okayama T,Oka K,Mizushima K,Yasuda T,Sakamoto N,Katada K,Kamada K,Uchiyama K,Handa O,Takagi T,Naito Y,Itoh Y

更新日期：2017-03-01 00:00:00

abstract：:Inhibitor of DNA-binding protein 1 (ID1) is commonly abnormally overexpressed in colorectal cancer (CRC); yet, the functional significance of ID1 in the growth and invasive properties of CRC cells remains largely unclear. The present study investigated the effects of ID1 downregulation on the cell growth and metastati...

journal_title：Oncology reports

authors： Lai X,Liao J,Lin W,Huang C,Li J,Lin J,Chen Q,Ye Y

更新日期：2014-07-01 00:00:00

abstract：:Orotate phosphoribosyl transferase (OPRT) is the initial enzyme of 5-fluorouracil (5-FU) activation, in which 5-FU is converted to 5-fluorouridinemonophosphate. Dihydropyrimidine dehydrogenase (DPD) is a degrading enzyme that catabolizes 5-FU. In this study, we investigated the expression of these enzymes in normal pr...

journal_title：Oncology reports

authors： Tanaka T,Kawashima H,Matsumura K,Yamashita-Hosono T,Yoshimura R,Kuratsukuri K,Harimoto K,Nakatani T

更新日期：2009-01-01 00:00:00

abstract：:Neuroblastoma is an aggressive childhood disease. Even with intensive conventional treatments, the long term survival rate for children with neuroblastoma remains less than 40%, highlighting the importance of finding new therapies. Bcl-2 family proteins play crucial roles in survival, proliferation and chemotherapeuti...

journal_title：Oncology reports

authors： Wang X,Gu Z,Li G,Zhang S,Cao Z,Yang Z,Liu G

更新日期：2014-08-01 00:00:00

abstract：:Autophagy is an intracellular multi-step catabolic degradation process that involves the degradation and recycling of cellular proteins and cytoplasmic damaged organelles to maintain cellular homeostasis and reduction of metabolic stress. Numerous studies have indicated the importance of autophagy in cancer, but the r...

journal_title：Oncology reports

authors： Zhang L,Zhang J,Chen L,Wang J

更新日期：2015-12-01 00:00:00

abstract：:Tetraarsenic oxide (As4O6, TAO) is a new arsenic compound that inhibits cell growth and induces apoptosis in human cervical cancer cell lines. In the present study, we report that the growth of tumor cells (CaSki) was inhibited by treatment with TAO alone or in combination with cisp...

journal_title：Oncology reports

authors： Byun JM,Jeong DH,Lee DS,Kim JR,Park SG,Kang MS,Kim YN,Lee KB,Sung MS,Kim KT

更新日期：2013-04-01 00:00:00

abstract：:BTG1, which belongs to the BTG/Tob family, regulates cell cycle progression in a variety of cell types and appears to play roles in inhibiting proliferation, promoting apoptosis and stimulating cellular differentiation in multiple cell types. However, it remains unclear whether BTG1 is a breast cancer suppressor gene,...

journal_title：Oncology reports

authors： Zhu R,Zou ST,Wan JM,Li W,Li XL,Zhu W

更新日期：2013-11-01 00:00:00

abstract：:PTEN and the PI3K/Akt pathway are involved in the development and/or progression of endometrial carcinoma. To clarify the impact of the pathway-related molecules on prognosis, we analyzed PTEN, phosphorylated-Akt (p-Akt), and Ki-67 expression by immunohistochemistry in 99 patients with advanced endometrial carcinoma. ...

journal_title：Oncology reports

authors： Uegaki K,Kanamori Y,Kigawa J,Kawaguchi W,Kaneko R,Naniwa J,Takahashi M,Shimada M,Oishi T,Itamochi H,Terakawa N

更新日期：2005-08-01 00:00:00

abstract：:Sarcosine is currently one of the most discussed markers of prostate cancer. It is involved in amino acid metabolism and methylation processes that occur during the progression of prostate cancer. In this study, we monitored the effect of the addition of sarcosine (0; 10; 250; 500; 1,000 and 1,500 µM) in a time-depend...

journal_title：Oncology reports

authors： Cernei N,Zitka O,Skalickova S,Gumulec J,Sztalmachova M,Rodrigo MA,Sochor J,Masarik M,Adam V,Hubalek J,Trnkova L,Kruseova J,Eckschlager T,Kizek R

更新日期：2013-06-01 00:00:00

abstract：:A small subset of cells within a malignant neoplasm, named cancer stem cells (CSCs) or tumour initiating cells, are thought to be capable of initiating the neoplasm itself, and of driving its growth and recurrence after treatment. It is unclear whether CSCs can be identified and experimentally induced within oral squa...

journal_title：Oncology reports

authors： Qiao B,Johnson NW,Chen X,Li R,Tao Q,Gao J

更新日期：2011-08-01 00:00:00

abstract：:Cholangiocarcinoma (CCA) is the second most common hepatic cancer with high resistance to current chemotherapies and extremely poor prognosis. The present study aimed to examine the effects of schisandrin B (Sch B) on CCA cells both in vitro and in vivo and to examine its underlying mechanism. We found that Sch B inhi...

journal_title：Oncology reports

authors： Yang X,Wang S,Mu Y,Zheng Y

更新日期：2016-10-01 00:00:00

abstract：:Ubiquitin specific protease 22 (USP22) is an oncogene that is upregulated in many cancer types, and aberrant expression of USP22 correlates with clinical outcome. However, its potential functional impact in epithelial ovarian cancer (EOC) has not been determined. Here, we report that USP22 was upregulated in EOC speci...

journal_title：Oncology reports

authors： Ji M,Shi H,Xie Y,Zhao Z,Li S,Chang C,Cheng X,Li Y

更新日期：2015-01-01 00:00:00

abstract：:Pentoxifylline is commonly used in the treatment of peripheral vascular diseases. It improves microcirculatory flow and tissue perfusion. Moreover, pentoxifylline displays some immunomodulatory properties that presumably might affect the anticancer response. Therefore, the aim of the present study was to evaluate the ...

journal_title：Oncology reports

authors： Grzela T,Lazarczyk M,Niderla J,Golab J,Lazarczyk MA,Skopinski P

更新日期：2003-11-01 00:00:00

abstract：:In this study, we demonstrate an important role of activation of the hypoxia-inducible factor-1 (HIF-1) pathway in endometrial carcinogenesis and tumor phenotype development of endometrial carcinoma, and suggest a unique role of the HIF-1-target gene, differentiated embryo chondrocyte 2 (DEC2), in carcinogenesis. Hypo...

journal_title：Oncology reports

authors： Yunokawa M,Tanimoto K,Nakamura H,Nagai N,Kudo Y,Kawamoto T,Kato Y,Hiyama E,Hiyama K,Nishiyama M

更新日期：2007-04-01 00:00:00

abstract：:Studies of tumor-infiltrating immune cells have revealed that immune escape plays an important role in tumor growth. The aim of the present study was to investigate the impact of metastasis affecting CD4+ T cell subsets in human clinical samples. Single-cell suspensions derived from tumor-draining lymph node (TDLN) an...

journal_title：Oncology reports

authors： Okita Y,Ohira M,Tanaka H,Tokumoto M,Go Y,Sakurai K,Toyokawa T,Kubo N,Muguruma K,Sawada T,Maeda K,Hirakawa K

更新日期：2015-08-01 00:00:00

abstract：:Subsequently to the publication of the above paper, the authors have drawn to our attention that, owing to errors made in the compilation of the images in Fig. 6, the images shown in Fig. 6A‑C in the article were selected incorrectly (essentially, the images shown in Fig. 6A and B were alterative presentations of the ...

journal_title：Oncology reports

authors： Chen YH,Zhou BY,Wu XJ,Xu JF,Zhang JA,Chen YH,Liang SS

更新日期：2020-12-16 00:00:00

abstract：:Modulation of the activity of tumor suppressor p53 is a key event in the replication of many viruses. They could manipulate p53 function through modification of phosphorylation for their own purpose. However, there are scarce data on the relationship between high risk human papillomavirus (HPV) E6 protein and p53 phos...

journal_title：Oncology reports

authors： Zhang G,Sun L,Li Z,Si L,Song T,Huang C,Zhang W

更新日期：2009-02-01 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) is an important mediator of tumor angiogenesis. A high serum VEGF level has been shown to predict poor response to chemotherapy and poor survival in several cancers, but its prognostic value in hepatocellular carcinoma (HCC) remains unknown. We conducted a prospective study to...

journal_title：Oncology reports

authors： Poon RT,Lau C,Yu WC,Fan ST,Wong J

更新日期：2004-05-01 00:00:00

abstract：:Latent infection of the Epstein-Barr virus (EBV) is strongly associated with the pathogenesis of several human tumor types. The restricted expression of the latent EBV antigens is critical for EBV-associated tumors to escape from immune surveillance. EBV lytic replication can be triggered by various treatments and the...

journal_title：Oncology reports

authors： Seo JS,Cho NY,Kim HR,Tsurumi T,Jang YS,Lee WK,Lee SK

更新日期：2008-01-01 00:00:00

abstract：:Temozolomide (TMZ), as a kind of alkylating agent, is widely utilized for the treatment of glioblastoma (GBM). However, temozolomide resistance (TR) often develops quickly and results in tumor recurrence and poor outcome. Recent advances have demonstrated that miRNAs exert critical roles in chemoresistance. Downregula...

journal_title：Oncology reports

authors： Qian Z,Zhou S,Zhou Z,Yang X,Que S,Lan J,Qiu Y,Lin Y

更新日期：2017-11-01 00:00:00

abstract：:Dysregulation of microRNAs (miRNAs) occurs frequently in cervical carcinogenesis. miRNAs function as tumor-suppressors or oncogenes and are involved in tumor behavior. However, the expression and function of miR-27b in cervical carcinogenesis remain unknown. In the present study, we observed that miR-27b was significa...

journal_title：Oncology reports

authors： Yao J,Deng B,Zheng L,Dou L,Guo Y,Guo K

更新日期：2016-03-01 00:00:00

abstract：:Colorectal cancer (CRC) is the third most common cancer and the fourth leading cause of cancer-related mortality worldwide. Aberrant expression of miRNAs play important roles in the development and progression of various types of cancers by modulating oncogenic and tumour-suppressor pathways. Therefore, exploring the ...

journal_title：Oncology reports

authors： Zhao J,Xu J,Zhang R

更新日期：2018-02-01 00:00:00

abstract：:Licochalcone A (LicA) is a chalcone extracted from liquorice which has been used as a traditional Chinese medicine for many generations. Increased glucose consumption and glycolytic activity are important hallmarks of cancer cells, and hexokinase 2 (HK2) upregulation is a major contributor to the elevation of glycolys...

journal_title：Oncology reports

authors： Wu J,Zhang X,Wang Y,Sun Q,Chen M,Liu S,Zou X

更新日期：2018-03-01 00:00:00

abstract：:Gastroenteropancreatic neuroendocrine tumors (GEP‑NETs) are relatively uncommon. Unfortunately, epidemiological studies on the incidence of GEP‑NETs worldwide have reported a marked increase in the detection of these tumors. Although they often exhibit relatively indolent clinical courses, GEP‑NETs have the potential ...

journal_title：Oncology reports

authors： Tang C,Gong L,Zou W,Zhang J,Zhou Y,Wu X,Lu F,Ouyang C,Liu X

更新日期：2016-12-01 00:00:00

abstract：:B7-H1 is a co-inhibitory molecule belonging to the B7 family. The B7-H1 protein is only expressed on macrophage lineage of cells in normal tissues, but is overexpressed in most types of tumor. The aberrant expression of cell surface B7-H1 on cancer cells is generally associated with high-risk prognostic factors. The t...

journal_title：Oncology reports

authors： Zhang C,Wang W,Qin X,Xu Y,Huang T,Hao Q,Li W,Wu S,Zhang Y

更新日期：2013-11-01 00:00:00

abstract：:Pancreatic cancer (PC) is one of the leading causes of cancer-related deaths worldwide. Frequent metastasis and recurrence are the main reasons for the poor prognosis of PC patients. Thus, the discovery of new biomarkers and wider insights into the mechanisms involved in pancreatic tumorigenesis and metastasis is cruc...

journal_title：Oncology reports

authors： Ma D,Jing X,Shen B,Liu X,Cheng X,Wang B,Fu Z,Peng C,Qiu W

更新日期：2016-08-01 00:00:00