Histological features of extratumoral breast lesions as a predictive factor of familial breast cancer.

Abstract:

:The aim of this study was to verify whether histopathological features of extratumoral and of primary tumor breast tissue could play a role in identifying patients with familial characteristics. We examined the clinicopathological features of 504 patients with sporadic or familial breast cancer stratified for risk of BRCA mutation. Patients with a higher risk of being carrier of BRCA gene mutations were significantly associated with tumor poor differentiation (p=0.003), positive lymph node invasion (p=0.02) and presence of vascular peritumoral invasion (p=0.008). Among the extra-tumoral lesions, only the epithelial proliferative lesions were related to higher mutation risk both in the overall series and familial patients (p<0.0001 and p=0.003, respectively). Interestingly, a significant difference in terms of high mutation risk was observed in usual ductal hyperplasia lesions (UDH), (p=0.002). We suggest that vascular peritumoral invasion and UDH lesions could predict a higher mutation risk of BRCA1 and BRCA2 genes and help in individuating patient candidates to further molecular analysis.

journal_name

Oncol Rep

journal_title

Oncology reports

authors

Mangia A,Tommasi S,Bruno M,Malfettone A,D'Amico C,Zito FA,Paradiso A,Simone G

doi

10.3892/or_00000806

subject

Has Abstract

pub_date

2010-06-01 00:00:00

pages

1641-5

issue

6

eissn

1021-335X

issn

1791-2431

journal_volume

23

pub_type

杂志文章
  • Upregulation of UHRF1 promotes the progression of melanoma by inducing cell proliferation.

    abstract::Melanoma is the most aggressive cutaneous cancer due to its propensity to metastasise and proliferate. Melanoma accounts for 80‑90% of skin‑cancer related deaths worldwide. Alhough numerous published studies have attempted to define the markers of diagnosis and prognosis of melanoma, a sensitive and specific biomarker...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or.2018.6356

    authors: Wei C,Lu N,Wang L,Zhang Y,Feng Z,Yang Y,Qi F,Gu J

    更新日期:2018-06-01 00:00:00

  • Regulation of apoptosis by p53-inducible transmembrane protein containing sushi domain.

    abstract::The tumor suppressor p53 is a transcription factor that induces the transcription of various target genes in response to DNA damage and it protects the cells from malignant transformation. In this study, we performed cDNA microarray analysis and found that the transmembrane protein containing sushi domain (TMPS) gene,...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or_00000972

    authors: Cui H,Kamino H,Nakamura Y,Kitamura N,Miyamoto T,Shinogi D,Goda O,Arakara H,Futamura M

    更新日期:2010-11-01 00:00:00

  • A phase II study of insulin-like growth factor receptor inhibition with nordihydroguaiaretic acid in men with non-metastatic hormone-sensitive prostate cancer.

    abstract::Insulin-like growth factor (IGF)-mediated signaling is a newly recognized clinical target in prostate cancer, and it is hypothesized that blockade of the IGF receptor (IGF1R) will impair downstream signaling and slow tumor growth. In this study the efficacy of nordihydroguaiaretic a...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or.2011.1487

    authors: Friedlander TW,Weinberg VK,Huang Y,Mi JT,Formaker CG,Small EJ,Harzstark AL,Lin AM,Fong L,Ryan CJ

    更新日期:2012-01-01 00:00:00

  • Analysis of the clinicopathological prognosis of stage IVb cervical carcinoma.

    abstract::The aim of this study was to evaluate the clinicopathological prognostic factors in patients with stage IVb cervical carcinoma (CC). All patients with stage IVb CC included in the study were diagnosed from 1997 to 2006 at the National Cancer Center Hospital. We retrospectively examined clinicopathological parameters i...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:

    authors: Nishio S,Katsumata N,Matsumoto K,Tanabe H,Yonemori K,Kohno T,Shimizu C,Ando M,Kasamatsu T,Fujiwara Y

    更新日期:2008-02-01 00:00:00

  • Resveratrol induces MMP-9 and cell migration via the p38 kinase and PI-3K pathways in HT1080 human fibrosarcoma cells.

    abstract::Trans-3,4',5-trihydroxystilbene (resveratrol) is a grape polyphenol present in various plants, food products, red wine and grapes. Resveratrol has anti-inflammatory, anticarcinogenic, anti-oxidant and anti-aging properties. Matrix metalloproteinases (MMPs) are key enzymes involved i...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or.2012.2151

    authors: Gweon EJ,Kim SJ

    更新日期:2013-02-01 00:00:00

  • Carboplatin/etoposide induces remission of metastasised malignant peripheral nerve tumours (malignant schwannoma) refractory to first-line therapy.

    abstract::Malignant peripheral nerve tumours (MPNT), e.g. malignant schwannoma, represent a relatively rare tumour entity which is usually regarded as a member of the group of soft-tissue sarcomas and treated accordingly. For chemotherapeutic approaches in metastasised disease, ifosfamide and doxorubicin have been identified as...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:

    authors: Steins MB,Serve H,Zühlsdorf M,Senninger N,Semik M,Berdel WE

    更新日期:2002-05-01 00:00:00

  • Fatty acid metabolic enzyme acyl-CoA thioesterase 8 promotes the development of hepatocellular carcinoma.

    abstract::Dysregulated metabolism is an emerging hallmark of cancer development, and upregulated lipid synthesis is one of the important tumor metabolic features. However, lipolysis may also contribute to cancer pathogenesis by altering free fatty acid (FFA) metabolism. In the present study, we investigated the importance of th...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or.2014.3155

    authors: Hung YH,Chan YS,Chang YS,Lee KT,Hsu HP,Yen MC,Chen WC,Wang CY,Lai MD

    更新日期:2014-06-01 00:00:00

  • Selective enhancement of hypoxic cell killing by tempol-regulated suicide gene expression.

    abstract::The presence of hypoxic regions within solid tumors is caused by an imbalance between cell proliferation and angiogenesis. Such regions may facilitate the onset of recurrence after radiation therapy and chemotherapy, as hypoxic cells show resistance to these treatments. We found that tempol, a nitroxide, strongly indu...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or.2015.4020

    authors: Kagiya G,Ogawa R,Choudhuri R,Cook JA,Hatashita M,Tanaka Y,Koda K,Yamashita K,Kubo M,Kawakami F,Mitchell JB

    更新日期:2015-08-01 00:00:00

  • Clear cell carcinoma of the ovary: potential pathogenic mechanisms (Review).

    abstract::Epithelial ovarian cancer (EOC) is the most common cause of gynecological cancer-related mortality. Clear cell EOC (cEOC) has a number of clinical features distinguishing it from other EOC because of frequent concurrence of endometriosis and highly chemoresistant nature resulting in a poor prognosis. Recent biochemica...

    journal_title:Oncology reports

    pub_type: 杂志文章,评审

    doi:10.3892/or_00000750

    authors: Kajihara H,Yamada Y,Kanayama S,Furukawa N,Noguchi T,Haruta S,Yoshida S,Sado T,Oi H,Kobayashi H

    更新日期:2010-05-01 00:00:00

  • Chemokines mediate mesenchymal stem cell migration toward gliomas in vitro.

    abstract::Previous studies have demonstrated the tremendous tropism of mesenchymal stem cells (MSCs) for malignant gliomas, making these cells a potential vehicle for delivery of therapeutic genes to disseminated glioma cells. However, the mechanisms underlying the tropism of MSCs for gliomas remain poorly defined. It has been ...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or_00000796

    authors: Xu F,Shi J,Yu B,Ni W,Wu X,Gu Z

    更新日期:2010-06-01 00:00:00

  • Does dexamethasone inhibit anticancer activity of cetuximab in squamous cell carcinoma cell lines of the head and neck?

    abstract::Glucocorticoids such as dexamethasone are widely used as comedication in the treatment of head and neck cancer, e.g., to improve appetite and decrease weight loss and fatigue in patients with advanced disease or as antiallergic and antiemetic prophylaxis during anti-EGFR therapy. However, the literature suggests that ...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or_00000421

    authors: Wagenblast J,Baghi M,Mörtel S,Hirth D,Thron L,Arnoldner C,Gstöttner W,May A,Hambek M

    更新日期:2009-07-01 00:00:00

  • miR-27b is upregulated in cervical carcinogenesis and promotes cell growth and invasion by regulating CDH11 and epithelial-mesenchymal transition.

    abstract::Dysregulation of microRNAs (miRNAs) occurs frequently in cervical carcinogenesis. miRNAs function as tumor-suppressors or oncogenes and are involved in tumor behavior. However, the expression and function of miR-27b in cervical carcinogenesis remain unknown. In the present study, we observed that miR-27b was significa...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or.2015.4500

    authors: Yao J,Deng B,Zheng L,Dou L,Guo Y,Guo K

    更新日期:2016-03-01 00:00:00

  • Differential regulation of DEC2 among hypoxia-inducible genes in endometrial carcinomas.

    abstract::In this study, we demonstrate an important role of activation of the hypoxia-inducible factor-1 (HIF-1) pathway in endometrial carcinogenesis and tumor phenotype development of endometrial carcinoma, and suggest a unique role of the HIF-1-target gene, differentiated embryo chondrocyte 2 (DEC2), in carcinogenesis. Hypo...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:

    authors: Yunokawa M,Tanimoto K,Nakamura H,Nagai N,Kudo Y,Kawamoto T,Kato Y,Hiyama E,Hiyama K,Nishiyama M

    更新日期:2007-04-01 00:00:00

  • Synthetic lethal interaction of CDK inhibition and autophagy inhibition in human solid cancer cell lines.

    abstract::Cell cycle control is a promising target in cancer treatments, and some small-molecule cyclin-dependent kinase (CDK) inhibitors have exhibited clinical effectiveness. However, no biomarkers predictive of efficacy have been developed. Recent studies have revealed that CDK inhibitor (CKI) proteins, such as p27 and p16, ...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or.2017.5684

    authors: Okada Y,Kato S,Sakamoto Y,Oishi T,Ishioka C

    更新日期:2017-07-01 00:00:00

  • Loss of mitochondrial DNA enhances angiogenic and invasive potential of hepatoma cells.

    abstract::Mitochondrial DNA (mtDNA) mutations are frequently found in a variety of tumors. However, the role of mtDNA mutations in tumor behavior is poorly understood. We explored the effects of mtDNA mutations on tumor phenotype employing mtDNA-depleted SK-Hep1 rho0 hepatoma cells. Expression of hypoxia inducible factor (HIF)-...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:

    authors: Cheon H,Moon HE,Lee MS,Kim SS

    更新日期:2010-03-01 00:00:00

  • Proteasome inhibitor sensitizes oral squamous cell carcinoma cells to TRAIL-mediated apoptosis.

    abstract::Oral squamous cell carcinoma (OSCC) cells are relatively resistant to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis during culture. We investigated the role of a proteaosome inhibitor in the survival and apoptosis of these cells. We found that the proteasome inhibitor MG132 markedl...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or.2010.1127

    authors: Yoshiba S,Iwase M,Kurihara S,Uchida M,Kurihara Y,Watanabe H,Shintani S

    更新日期:2011-03-01 00:00:00

  • Expression of the lysyl oxidase propeptide in hepatocellular carcinoma and its clinical relevance.

    abstract::Lysyl oxidase is an important extracellular matrix remodeling enzyme and plays critical roles in tumor progression and development. Its tumor-suppressor activity has been shown to depend on the propeptide region. Previous studies have reported that the expression levels of lysyl oxidase propeptide (LOX-PP) are associa...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or.2014.3044

    authors: Zheng Y,Wang X,Wang H,Yan W,Zhang Q,Chang X

    更新日期:2014-04-01 00:00:00

  • Factors influencing the detection of the BRAF T1799A mutation in papillary thyroid carcinoma.

    abstract::The BRAF T1799A mutation is a heterozygous point mutation and its reported prevalence in papillary thyroid carcinoma (PTC) has varied from 29 to 83%, with an overall mean of 44%. In Korea, the reported mutation rate reached 83% in PTC and 52% in micropapillary carcinoma. We hypothesized that the differences in prevale...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or.2011.1225

    authors: Kim HS,Kim JO,Lee DH,Lee HC,Kim HJ,Kim JH,Jang YS,Lee JM,Kim SY,Kim YS

    更新日期:2011-06-01 00:00:00

  • Overexpression of miR-203 increases the sensitivity of NSCLC A549/H460 cell lines to cisplatin by targeting Dickkopf-1.

    abstract::The number of new lung cancer cases diagnosed yearly is high, and the mortality rate has not substantially declined. Non-small cell lung cancer (NSCLC) is the most common type of lung cancer, and adenocarcinoma accounts for the largest proportion of NSCLC. Currently, platinum-based combined chemotherapy, particularly ...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or.2017.5505

    authors: Cheng R,Lu C,Zhang G,Zhang G,Zhao G

    更新日期:2017-04-01 00:00:00

  • Overexpression of IL-9 induced by STAT3 phosphorylation is mediated by miR-155 and miR-21 in chronic lymphocytic leukemia.

    abstract::Interleukin‑9 (IL‑9) can function as both a positive and negative regulator of immune response, however the role of IL‑9 in tumor immunity is poorly understood. Chronic lymphocytic leukemia (CLL) is the most common chronic lympho‑proliferative disorder. Twenty CLL patients from 2010 to 2011 were recruited in the study...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or.2018.6367

    authors: Chen N,Feng L,Qu H,Lu K,Li P,Lv X,Wang X

    更新日期:2018-06-01 00:00:00

  • S100A8 facilitates the migration of colorectal cancer cells through regulating macrophages in the inflammatory microenvironment.

    abstract::Previous studies have shown that S100 calcium-binding protein A8 (S100A8) contributes to the survival and migration of colorectal cancer (CRC) cells. However, whether S100A8 participates in the progression and metastasis of CRC via the regulation of macrophages in the tumor inflammatory microenvironment remains unknow...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or.2016.4790

    authors: Zha H,Sun H,Li X,Duan L,Li A,Gu Y,Zeng Z,Zhao J,Xie J,Yuan S,Li H,Zhou L

    更新日期:2016-07-01 00:00:00

  • Programmed cell death 2 protein induces gastric cancer cell growth arrest at the early S phase of the cell cycle and apoptosis in a p53-dependent manner.

    abstract::Programmed cell death 2 (PDCD2) is a highly conserved nuclear protein, and aberrant PDCD2 expression alters cell apoptosis. The present study aimed to investigate PDCD2 expression in gastric cancer. Tissue specimens from 34 gastric cancer patients were collected for analysis of PDCD2 expression using immunohistochemis...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or.2014.3551

    authors: Zhang J,Wei W,Jin HC,Ying RC,Zhu AK,Zhang FJ

    更新日期:2015-01-01 00:00:00

  • Downregulation of survivin expression and elevation of caspase-3 activity involved in pitavastatin-induced HepG 2 cell apoptosis.

    abstract::The aim of the present study was to research the apoptosis of human hepatocellular carcinoma cell line HepG 2 induced by pitavastatin. HepG 2 cells were treated with increasing doses of pitavastatin or with mevalonic acid for 48 h. The proliferation of cells was detected with WST-8. The morphology of the nucleus was o...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:

    authors: Wang J,Xu Z,Zhang M

    更新日期:2007-08-01 00:00:00

  • DNA damage sensor protein hRad9, a novel molecular target for lung cancer treatment.

    abstract::DNA damage sensor proteins are recognized as upstream components of the DNA damage checkpoint signaling pathway and are required for cell cycle control and the induction of apoptosis. hRad9 plays an important role as an upstream regulator of checkpoint signaling. In our previous studies, we confirmed the significant a...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:

    authors: Yuki T,Maniwa Y,Doi T,Okada K,Nishio W,Hayashi Y,Okita Y

    更新日期:2008-11-01 00:00:00

  • Combined use of PI3K and MEK inhibitors synergistically inhibits lung cancer with EGFR and KRAS mutations.

    abstract::EGFR and KRAS mutations are the two most common driver mutations in non-small cell lung cancer (NSCLC). Molecular target-based therapy using small molecules such as gefitinib has been used for inhibiting EGFR with good initial responses; however, drug resistance is common when using a mono-targeting strategy. At prese...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or.2016.4770

    authors: Jiang ZB,Huang J,Xie C,Li X,Liu L,He J,Pan H,Huang L,Fan XX,Yao XJ,Xie Y,Li N,Liu L,He JX,Leung EL

    更新日期:2016-07-01 00:00:00

  • Silencing DEK downregulates cervical cancer tumorigenesis and metastasis via the DEK/p-Ser9-GSK-3β/p-Tyr216-GSK-3β/β-catenin axis.

    abstract::Cervical cancer is the second most common gynecological malignancy. The mechanisms of the genesis and progression of cervical cancer are complicated and not thoroughly understood. DEK is reported as an oncogene in various cancers, such as acute myeloid leukemia, bladder cancer, breast cancer and hepatocellular cancer....

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or.2017.5721

    authors: Xu X,Zou L,Yao Q,Zhang Y,Gan L,Tang L

    更新日期:2017-08-01 00:00:00

  • Matrix metalloproteinase-2 and -9 in the sera and in the urine of human oncocytoma and renal cell carcinoma.

    abstract::Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases, capable of degrading all the molecular components of extracellular matrix. MMPs have been shown to play critical roles in tumor cell invasion and metastasis. We verified the activity of MMPs in the sera ...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or.2012.1864

    authors: Di Carlo A

    更新日期:2012-09-01 00:00:00

  • Effect of sarcosine on antioxidant parameters and metallothionein content in the PC-3 prostate cancer cell line.

    abstract::Sarcosine is currently one of the most discussed markers of prostate cancer. It is involved in amino acid metabolism and methylation processes that occur during the progression of prostate cancer. In this study, we monitored the effect of the addition of sarcosine (0; 10; 250; 500; 1,000 and 1,500 µM) in a time-depend...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or.2013.2389

    authors: Cernei N,Zitka O,Skalickova S,Gumulec J,Sztalmachova M,Rodrigo MA,Sochor J,Masarik M,Adam V,Hubalek J,Trnkova L,Kruseova J,Eckschlager T,Kizek R

    更新日期:2013-06-01 00:00:00

  • Effect of brachytherapy on NF-κB and VEGF in gastric carcinoma xenografts.

    abstract::Iodine-125 (125I) seed irradiation can be used as an important supplementary treatment for unresectable advanced gastric cancer. However, the radiobiological mechanism underlying brachytherapy remains unclear. Therefore, we investigated the influence of continuous and low-energy 125I irradiation on the cell cycle dist...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or.2014.3255

    authors: Zhang WF,Jin WD,Li B,Wang MC,Li XG,Mao WY,Luo KY

    更新日期:2014-08-01 00:00:00

  • A study on the mechanism of 5-aminolevulinic acid photodynamic therapy in vitro and in vivo in cervical cancer.

    abstract::5-Aminolevulinic acid-mediated photodynamic therapy (ALA-PDT) is a new ablation treatment for tumors, while its function mechanism in cervical cancer has not been elucidated. In this study, we investigated the effects of ALA-PDT on the cervical cancer cell line Me180, to search for optimal parameters of PDT. ALA-PDT o...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or_00000295

    authors: He GF,Bian ML,Zhao YW,Xiang Q,Li HY,Xiao C

    更新日期:2009-04-01 00:00:00