Histone deacetylase inhibition by valproic acid down-regulates c-FLIP/CASH and sensitizes hepatoma cells towards CD95- and TRAIL receptor-mediated apoptosis and chemotherapy.

abstract：:Hepatocellular carcinoma (HCC) is different from other solid tumors because it is commonly associated with the occurrence of intrahepatic metastasis. Additionally, the liver, unlike other organs, is the main site of coagulation and fibrinolytic factor production. Therefore, it was speculated that coagulation and fibri...

journal_title：Oncology reports

authors： Li X,Gu B,Wang B,Feng Z,Ma Y,Li H,Lucas A,Chen H

更新日期：2020-12-01 00:00:00

abstract：:Sarcosine is currently one of the most discussed markers of prostate cancer. It is involved in amino acid metabolism and methylation processes that occur during the progression of prostate cancer. In this study, we monitored the effect of the addition of sarcosine (0; 10; 250; 500; 1,000 and 1,500 µM) in a time-depend...

journal_title：Oncology reports

authors： Cernei N,Zitka O,Skalickova S,Gumulec J,Sztalmachova M,Rodrigo MA,Sochor J,Masarik M,Adam V,Hubalek J,Trnkova L,Kruseova J,Eckschlager T,Kizek R

更新日期：2013-06-01 00:00:00

abstract：:The Chinese medicinal herb Sorbaria sorbifolia, native to Changbai Mountain, can induce apoptosis in HepG-2 cells. We studied the mechanism by which 5, 2', 4'-trihydroxy-6,7, 5'-trimethoxyflavone (TTF1) isolated from acetic ether extracts of Sorbaria sorbifolia induces apoptosis in HepG-2 cells. The results showed tha...

journal_title：Oncology reports

authors： Li Y,Bian L,Cui F,Li L,Zhang X

更新日期：2011-09-01 00:00:00

abstract：:The pathogenic mechanisms responsible for inflammatory bowel disease (IBD) are poorly understood. In an IBD animal model, the oral administration of polysaccharides such as dextran sulfate sodium (DSS) induced colitis, which exhibited several clinical and histological features similar to IBD. However, pathogenic facto...

journal_title：Oncology reports

authors： Araki Y,Mukaisyo K,Sugihara H,Hattori T

更新日期：2008-07-01 00:00:00

abstract：:Cancer represents a significant challenge for humankind, as early diagnosis and treatment are difficult to achieve. To systemically investigate the effect of sex, body mass index (BMI) and age on cancer incidence and prognosis, the data from 14,504 cases of cancer were downloaded from The Cancer Genome Atlas (TCGA). B...

journal_title：Oncology reports

authors： Huang X,Shu C,Chen L,Yao B

更新日期：2018-09-01 00:00:00

abstract：:The ING1 gene is involved in the regulation of the cell cycle, senescence, and apoptosis and is a novel candidate tumor suppressor gene. ING2, another gene in the ING family, was identified and cloned. The functions of ING1 and ING2 largely depend on the activity of p53. To determine whether an alteration in these gen...

journal_title：Oncology reports

authors： Okano T,Gemma A,Hosoya Y,Hosomi Y,Nara M,Kokubo Y,Yoshimura A,Shibuya M,Nagashima M,Harris CC,Kudoh S

更新日期：2006-03-01 00:00:00

abstract：:Highly malignant gliomas are characterized by pronounced intra‑ and intertumoral heterogeneity. On the genetic level, this heterogeneity may be caused by spontaneous mutation events, but recent studies have reported distinct mutational signatures that may be caused by an enzyme family with cytidine desaminase activity...

journal_title：Oncology reports

authors： Schmitt C,Lucius R,Synowitz M,Held-Feindt J,Hattermann K

更新日期：2018-11-01 00:00:00

abstract：:Zinc finger protein 307 (ZNF307) is a new Krüppel-associated box zinc-finger protein gene and a member of the zinc-finger family of transcriptional factors. Notably, the role of ZNF307 and its underlying mechanisms involved in hepatocarcinogenesis are poorly investigated. In the present study, we found that the expres...

journal_title：Oncology reports

authors： Liang Y,Li Q,Chen K,Ni W,Zhan Z,Ye F,Li Y,Fang Y,Zhang F,Chen L,Ding Y

更新日期：2017-10-01 00:00:00

abstract：:This study investigated the prognostic significance of thymidine phosphorylase (TP) and p53 expression in 96 surgically resected primary esophageal squamous cell carcinomas. Expression was assessed using immunohistochemical staining methods. Prognostic values were determined by multivariate analysis using Cox's propor...

journal_title：Oncology reports

authors： Makoto O,Takeda A,Ting-Leig L,Shinnichi O,Hisahiro M,Yutaka F,Yoshihiro N,Kobayashi S,Gunji Y,Suzuki T,Takenori O,Hideaki S

更新日期：2002-01-01 00:00:00

abstract：:E1A binding protein P300 (EP300), tumor protein P53 (TP53) and BCL2 associated X, apoptosis regulator (BAX) genes encode proteins which cooperate to regulate important cellular processes. The present study aimed to determine the expression levels of EP300, TP53 and BAX in colorectal cancer (CRC) and to investigate the...

journal_title：Oncology reports

authors： Kowalczyk AE,Krazinski BE,Godlewski J,Kiewisz J,Kwiatkowski P,Sliwinska-Jewsiewicka A,Kiezun J,Sulik M,Kmiec Z

更新日期：2017-07-01 00:00:00

abstract：:Semaphorin 3A (SEMA3A), a secretory protein, is a founding member of the semaphorin family and functions in both the biological behavior of tumor cells and the modulation of tumor-associated macrophages. However, the role of SEMA3A in hepatocellular carcinoma (HCC) is still not well established. In the present study, ...

journal_title：Oncology reports

authors： Li X,Chen Q,Yin D,Shi S,Yu L,Zhou S,Chen E,Zhou Z,Shi Y,Fan J,Zhou J,Dai Z

更新日期：2017-06-01 00:00:00

abstract：:Inhibitor of DNA-binding protein 1 (ID1) is commonly abnormally overexpressed in colorectal cancer (CRC); yet, the functional significance of ID1 in the growth and invasive properties of CRC cells remains largely unclear. The present study investigated the effects of ID1 downregulation on the cell growth and metastati...

journal_title：Oncology reports

authors： Lai X,Liao J,Lin W,Huang C,Li J,Lin J,Chen Q,Ye Y

更新日期：2014-07-01 00:00:00

abstract：:Solid tumors are abnormal tissues containing tumor and non-tumor cells, also known as tumor stromal cells. However, the malignant potential of tumor stromal cells remains largely unknown. The aim of the present study was to investigate the malignant potential of host bone marrow‑derived stroma cells in transplanted su...

journal_title：Oncology reports

authors： Dai X,Chen H,Chen Y,Wu J,Wang H,Shi J,Fei X,Wang Z,Wang A,Dong J,Lan Q,Huang Q

更新日期：2015-12-01 00:00:00

abstract：:Thrombospondin-1 (TSP1) is known to possess tumor suppressor functions. In contradiction, TSP1 enhances the stromal vascularization and growth of certain cancers. A cell adhesion receptor, CD36, has been shown to interact with a ligand TSP1. We studied how CD36 affects the growth of the osteosarcoma cell line (HOS) ex...

journal_title：Oncology reports

authors： Yamazaki H,Handa A,Nishi M,Tokunaga T,Tomisawa M,Hatanaka H,Abe Y,Kijima H,Ueyama Y,Nakamura M

更新日期：2004-02-01 00:00:00

abstract：:Cyclin Y (CCNY) is a newly identified PFTK1 interacting protein and has been found to be associated with the proliferation and tumorigenesis of human non-small cell lung cancer. In the present study, we analyzed the expression levels of CCNY in 65 cases of breast cancer (BC) tissues and in four BC cell lines, BT-474, ...

journal_title：Oncology reports

authors： Yan F,Wang X,Zhu M,Hu X

更新日期：2016-11-01 00:00:00

abstract：:Urokinase plasminogen activator (uPA) and metalloproteinases (MMP) play key roles in invasion and metastasis, degrading extracellular matrix compounds and modulating tumor cell motility. Their regulation is an attractive therapeutic target for controlling tumor metastasis. Previously we have demonstrated that urokinas...

journal_title：Oncology reports

authors： Todaro LB,Ladeda V,Bal de Kier Joffé E,Farías EF

更新日期：2003-05-01 00:00:00

abstract：:Osteosarcoma (OS) is the most common type of bone cancer. Even with early diagnosis and aggressive treatment, the prognosis for OS is poor. In the present study, we investigated the proliferation and invasion inhibitory effect of apigenin on human OS cells and the possible molecular mechanisms involved. The cell viabi...

journal_title：Oncology reports

authors： Liu X,Li L,Lv L,Chen D,Shen L,Xie Z

更新日期：2015-08-01 00:00:00

abstract：:Cisplatin (CDDP)‑based combination chemotherapy is the standard for muscle‑invasive bladder cancer (MIBC). However, nearly all patients undergoing CDDP chemotherapy become refractory due to the development of CDDP resistance. Therefore, clarification of the mechanisms of CDDP resistance is urgently needed. The transcr...

journal_title：Oncology reports

authors： Sekino Y,Sakamoto N,Ishikawa A,Honma R,Shigematsu Y,Hayashi T,Sentani K,Oue N,Teishima J,Matsubara A,Yasui W

更新日期：2019-05-01 00:00:00

abstract：:In recent years, several antioxidant substances have been found to have an antiproliferative effect on various types of carcinomas. α-lipoic acid (ALA) induces apoptosis in several types of cancer cell lines, but it is difficult to apply α-lipoic acid in clinical use as it is easily oxidized and unstable. Recently, we...

journal_title：Oncology reports

authors： Hiratsuka T,Inomata M,Kono Y,Yokoyama S,Shiraishi N,Kitano S

更新日期：2013-06-01 00:00:00

abstract：:B-cell-specific Moloney murine leukemia virus insertion site 1 (Bmi1) is directly involved in cell growth, proliferation and self-renewal of cancer stem cells (CSCs). The aim of the present study was to assess the role of Bmi1 in the maintenance of stemness properties and tumorigenicity of human bladder CSC-like side ...

journal_title：Oncology reports

authors： Zhu D,Wan X,Huang H,Chen X,Liang W,Zhao F,Lin T,Han J,Xie W

更新日期：2014-02-01 00:00:00

abstract：:Abnormal lymphangiogenesis is associated with several diseases such as tumor metastasis and lymphangioma. Human lymphangioma originated from the transformation of lymphatic endothelium is a benign malformation of lymphatic vessels and its pathogenesis has up to date not been illuminated and its cell model has also not...

journal_title：Oncology reports

authors： You L,Wu M,Chen Y,Xu G,Wei J,Li Q,Song A,Zhao L,Li S,Han Z,Zhou J,Lu Y,Wang S,Ma D,Meng L

更新日期：2010-01-01 00:00:00

abstract：:The aim of this study was to investigate the status of the c‑Myc‑related molecule Mina53 and the clinical impact of Mina53 nuclear localization in patients with stage II and III colorectal cancer (CRC). Patients (n=250) who underwent complete resection of CRC at our department were enrolled in this study, and tissue m...

journal_title：Oncology reports

authors： Fujino S,Kinugasa T,Sudo T,Mizobe T,Yoshida T,Yoshida N,Ohchi T,Tajiri K,Yuge K,Nagasu S,Katagiri M,Akagi Y

更新日期：2018-07-01 00:00:00

abstract：:Malnutrition affects 40-50% of patients with ear, nose and throat (ENT) cancer. The aim of this study was to assess changes induced by a specific nutritional supplement enriched with n-3 polyunsaturated fatty acids, fiber and greater amounts of proteins and electrolytes, as compared with a standard nutritional supplem...

journal_title：Oncology reports

authors： Roca-Rodríguez MM,García-Almeida JM,Lupiañez-Pérez Y,Rico JM,Toledo M,Alcaide-Torres J,Cardona F,Medina JA,Tinahones FJ

更新日期：2014-01-01 00:00:00

abstract：:Dendropanax morbifera Leveille is found throughout southwestern Korea, and has been used in traditional medicine for various diseases, such as migraine headache, infectious diseases, skin diseases and dysmenorrhea. However, the molecular mechanisms of D. morbifera concerning its biochemical actions in cancer have not ...

journal_title：Oncology reports

authors： Lee JW,Park C,Han MH,Hong SH,Lee TK,Lee SH,Kim GY,Choi YH

更新日期：2013-09-01 00:00:00

abstract：:Dendritic cells (DCs) as 'professional' antigen-presenting cells (APCs) initiate and regulate immune responses to various antigens. DC-based vaccines have become a promising modality in cancer immunotherapy. Cytokeratin 19 (CK19) protein is expressed at high levels in lung cancer and many other tumor cells, suggesting...

journal_title：Oncology reports

authors： Sun QF,Zhao XN,Peng CL,Hao YT,Zhao YP,Jiang N,Xue H,Guo JZ,Yun CH,Cong B,Zhao XG

更新日期：2015-11-01 00:00:00

abstract：:An arsenical compound, As2O3 has been reported to be effective for treating acute leukemia and induce apoptosis in many different tumor cell types. In this study we designed a novel arsenical compound, As4O6, and compared its ability to induce cell growth inhibition as well as gene expression profiles along with As2O3...

journal_title：Oncology reports

authors： Ahn WS,Bae SM,Lee KH,Kim YW,Lee JM,Namkoong SE,Lee IP,Kim CK,Seo JS,Sin JI,Kim YW

更新日期：2004-09-01 00:00:00

abstract：:The progress of the application of adenovirus in cancer gene therapy is hindered by the lack of expression of native adenovirus receptor on a variety of cancer types. Hence, strategies are needed to retarget the adenoviral vector to non-native cellular surface receptors. In the present study, a new peptide SWDIAWPPLKV...

journal_title：Oncology reports

authors： Wang D,Li W,Zhang H,Mao Q,Xia H

更新日期：2014-05-01 00:00:00

abstract：:The development and progression of epithelial cancers are the result of an imbalance in signals promoting and inhibiting cellular proliferation and apoptosis. The aim of this study is to evaluate the expression of cell-cycle and apoptosis regulators and correlate them with clinical outcome in the most frequent carcino...

journal_title：Oncology reports

authors： Abdulkader I,Sánchez L,Cameselle-Teijeiro J,Gude F,Chávez JE,López-López R,Forteza J,Fraga M

更新日期：2005-12-01 00:00:00

abstract：:Given such differences as relative tumor burden, the optimal dose and schedule for postoperative adjuvant chemotherapy of microscopic disease might be expected to differ significantly from therapy of advanced higher volume disease. We investigated this hypothesis by determining the optimal dose and schedule of the 5-F...

journal_title：Oncology reports

authors： Uchida J,Okabe H,Nakano K,Fujioka A,Saito H,Sugimoto Y,Oka T,Fukushima M

更新日期：2007-08-01 00:00:00

abstract：:This study aimed to investigate the effect of RNA interference (RNAi)-mediated downregulation of the expression of the c-jun gene (a proto-oncogene) on the radiosensitivity of a radioresistant human nasopharyngeal carcinoma cell line (CNE-2R) and to validate its potential as an anticancer target. A lentiviral vector w...

journal_title：Oncology reports

authors： Guo SY,Zhu XD,Ge LY,Qu S,Li L,Su F,Guo Y

更新日期：2015-03-01 00:00:00