Abstract:
:Platinum compounds and vinorelbine (VNB) are active in the treatment of non-small cell lung cancer (NSCLC), but moderate toxicity has been reported. The aims of the present study were to assess activity and tolerability of low dose carboplatin (CBDCA): 4.5 AUC according to Calvert formula on day 1, combined with vinorelbine: 25 mg/m2 on days 1 and 8, administered every 4 weeks. Eighty-five advanced NSCLC patients entered the study; all of them were evaluable for toxicity and 83 were evaluable for activity. According to an intent to treat analysis, 26 patients attained a partial response (30.5%; 95% CI 20.5-40.5), 27 (31.7%) obtained a disease stabilization and 30 (35%) progressed. This regimen appeared to be modestly toxic, grade 3-4 leukopenia and thrombocytopenia were observed in less than 5% of cases and grade 2 neuropathy in 10% of cases. Median time to progression and overall survival were 7 and 9 months, respectively. In conclusion, low dose CBDCA (administered following Calvert's formula) and VNB combination is an active and very well tolerated cytotoxic regimen in the treatment of advanced NSCLC. The application of the Calvert formula may have contributed to limit the side effects related to CBDCA.
journal_name
Oncol Repjournal_title
Oncology reportsauthors
Bretti S,Manzin E,Celano A,Ritorto G,Loddo C,Berruti Adoi
10.3892/or.8.2.381keywords:
subject
Has Abstractpub_date
2001-03-01 00:00:00pages
381-5issue
2eissn
1021-335Xissn
1791-2431journal_volume
8pub_type
临床试验,杂志文章相关文献
ONCOLOGY REPORTS文献大全abstract::Nuclear factor (NF)-κB is the key transcription factor involved in the inflammatory responses, and its activation aggravates tumors. Peptidoglycan (PGN), a main cell wall component of Gram-positive bacteria, stimulates Toll-like receptor 2 (TLR-2) and activates a number of inflammat...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2012.1937
更新日期:2012-10-01 00:00:00
abstract::MicroRNAs (miRNAs) are a class of highly conserved, small endogenous single-strand non-coding RNAs. They are aberrantly expressed in the circulation and tissue of patients with cancer. Therefore, it has been suggested that they may act as key regulators of carcinogenesis. The aim of the present study was to examine th...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2014.2971
更新日期:2014-03-01 00:00:00
abstract::Owing to aggressiveness and chemoresistance, pancreatic ductal adenocarcinoma (PDAC) is characterised by a poor prognosis. To address this disease-spe-cific dilemma we aimed to establish animal models, which can be used for identifying new specific tumor markers, as well as serving ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2012.2049
更新日期:2012-12-01 00:00:00
abstract::The aim of the present study was to evaluate human epididymis protein 4 (HE4) as a marker of epithelial ovarian cancer (EOC) relapse and the combination of this biomarker with contrast-enhanced high-resolution multidetector row computed tomography CE CT imaging to impove the monitoring of EOC patients. Twenty-one pati...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2013.2682
更新日期:2013-11-01 00:00:00
abstract::EGFR, p27kip1 and Skp2, have been implicated in human cancer development. We have studied these molecules in a search for molecular markers that may have prognostic value in head and neck squamous cell carcinomas (HNSCC). Tissue samples of 62 patients were collected and immunohistochemical analysis was carried out for...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2008-09-01 00:00:00
abstract::Oncolytic viruses are genetically engineered viruses designed for the treatment of solid tumors, and are often coupled with the antitumor immunity of the host. The challenge of using oncolytic herpes simplex virus (oHSV) as an efficacious oncolytic agent is the potential host tissue damage caused by the production of ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2018.6935
更新日期:2019-03-01 00:00:00
abstract::In the present study, we investigated the antitumor activity of caudatin in the human hepatoma cell line SMMC‑7721 by analysis of cell viability, cell cycle distribution, apoptosis and metastasis. The results showed that caudatin impaired the cell viability and inhibited the growth of SMMC-7721 cells in a time- and do...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2013.2749
更新日期:2013-12-01 00:00:00
abstract::The activation of receptor tyrosine kinases (RTKs) results in cellular effects including cell proliferation, survival, migration and invasion; RTKs also play an important role in tumourigenesis. It has been reported that EGFR signalling controls the migration of oral squamous cell carcinoma (OSCC) SAS and HSC3 cells b...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2017.5587
更新日期:2017-06-01 00:00:00
abstract::Prostate specific antigen (PSA) is still the best available tumour marker in prostate cancer (PCa), but presents some limits. Therefore, there is a need for novel markers in the detection and management of PCa. The 80-kDa soluble form of E-cadherin (sE-cad) and the cytokine IL-6 are being discussed as supplemental ser...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2012.1785
更新日期:2012-07-01 00:00:00
abstract::Numerous studies have demonstrated that triptolide induces cell cycle arrest and apoptosis in human cancer cell lines. However, triptolide-induced DNA damage and inhibition of DNA repair gene expression in human skin cancer cells has not previously been reported. We sought the effects of triptolide on DNA damage and a...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2012.2170
更新日期:2013-02-01 00:00:00
abstract::This study was aimed to obtain additional information on the activity of a cyclized 9-amino acid peptide (cP) containing the active site of alpha fetoprotein, which inhibits the estrogen-stimulated proliferation of tumor cells in culture and of xenografts in immunodeficient mice. Breast cancer cells cultured in the pr...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2008-01-01 00:00:00
abstract::The immune suppression of sentinel lymph node (SN) is directly influenced by primary tumors. It has been reported that the T-helper type 1 (Th1) to T-helper type 2 (Th2) ratio or T-cytotoxic type 1 (Tc1) to T-cytotoxic type 2 (Tc2) ratio of lymph node lymphocytes could be used to evaluate direct immunological circumst...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2008-03-01 00:00:00
abstract::microRNAs (miRNAs), a class of small non-coding RNA molecules, can regulate gene expression by interacting with the 3'-untranslated regions (3'UTR) of target genes and influence various biological processes. We investigated the potential role of miR-24-3p in the development of bladder cancer by regulating DEDD, a memb...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2016.5326
更新日期:2017-02-01 00:00:00
abstract::The clinical applications of Rhizoma paridis in traditional Chinese medicine are well known. However, the therapeutic potential of Rhizoma paridis and its active component such as Paris saponin I (polyphyllin D) and Paris saponin II (PSII) (formosanin C) in cancer treatments have not yet been fully explored. Recent st...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2015.3836
更新日期:2015-05-01 00:00:00
abstract::Oral lichen planus (OLP) is a chronic inflammatory disease that may transform to oral squamous cell carcinoma (OSCC), while its carcinogenesis mechanisms are not entirely clear. This study was designed to identify the important genes involved in the malignant transformation of OLP to OSCC. After RNA-sequencing, the di...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2017.5487
更新日期:2017-04-01 00:00:00
abstract::Cyclooxygenase-2 (COX-2) and its metabolite prostaglandin E2 (PGE2) can potentially affect most of the events in cancer development, including promotion of proliferation, resistance to apoptosis, angiogenesis, immune suppression and invasion. However, worldwide attention has predominantly centered on the cardiovascula...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2014.3543
更新日期:2014-12-01 00:00:00
abstract::The activity of NADPH oxidase is increased in malignant skin keratinocytes. We demonstrated that inhibition of NADPH oxidase activity by diphenyleneiodonium (DPI) suppressed free radical production, inhibited cell growth and promoted cell differentiation of B16 melanoma cells, as indicated by cell morphology, increase...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2008-05-01 00:00:00
abstract::Tobacco smoke is one of the serious risk factors of gastric cancer. Epithelial‑mesenchymal transition (EMT) has been shown to be associated with the initiation and carcinogenesis of gastric cancer. The role of Notch pathway in regulating tobacco smoke-induced EMT has not been investigated. β‑carotene, a carotenoid pre...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2018.6246
更新日期:2018-04-01 00:00:00
abstract::Pancreatic cancer is one of the most fatal types of cancer and is associated with a dismal prognosis. Gemcitabine-based chemotherapy is clinically used for the treatment of advanced pancreatic cancer. However, many forms of pancreatic cancer have acquired resistance to gemcitabine. In order to prevent patients from su...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2017.6026
更新日期:2017-12-01 00:00:00
abstract::The growth inhibitory effects of bufadienolide compounds were investigated in two intractable cancer cells, a human glioblastoma cell line U-87 and a pancreatic cancer cell line SW1990. Among four bufadienolide compounds, a dose-dependent cytotoxicity was observed in these cancer cells after treatment with gamabufotal...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2016.4946
更新日期:2016-09-01 00:00:00
abstract::microRNAs (miRNAs) are known to be involved in the pathogenesis of hepatocellular carcinoma (HCC). miR-128-3p was recently reported to be deregulated in several types of cancer. However, the biological function and potential mechanisms of miR-128-3p in HCC remain unknown. In the present study, we found that miR-128-3p...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2015.3936
更新日期:2015-06-01 00:00:00
abstract::Extranodal natural killer (NK)/T cell lymphoma, nasal type (ENKL) is a rare type of non‑Hodgkin's lymphoma that is associated with limited effective treatment options and unfavorable survival rate, which is partly the result of multidrug resistance (MDR). The presence of side population (SP) cells‑SNK‑6/ADM‑SP (SSP) c...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2020.7722
更新日期:2020-10-01 00:00:00
abstract::Cisplatin-paclitaxel and cisplatin-etoposide combination therapies were compared in limited and extensive disease in patients with small-cell lung cancer. The primary objectives were to determine median and overall survival, time to tumor progression and tolerance and the secondary objective, the response rate. From J...
journal_title:Oncology reports
pub_type: 杂志文章,多中心研究,随机对照试验
doi:
更新日期:2008-10-01 00:00:00
abstract::We have recently noticed an accidental error in part of a figure which appeared in the above‑mentioned article. In Fig. 3A, the image for the HGC27‑pEF, 15 h panel was mistakenly replicated as the HGC27‑KD, 0 h panel in the same figure, and the AGS‑pEF, 15 h and AGS KD, 0 h panels were mistakenly switched with each ot...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2018.6269
更新日期:2018-04-01 00:00:00
abstract::Cyclin Y (CCNY) is a newly identified PFTK1 interacting protein and has been found to be associated with the proliferation and tumorigenesis of human non-small cell lung cancer. In the present study, we analyzed the expression levels of CCNY in 65 cases of breast cancer (BC) tissues and in four BC cell lines, BT-474, ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2016.5126
更新日期:2016-11-01 00:00:00
abstract::Hepatocellular carcinoma (HCC) is sexually disparate in humans, with a significantly increased prevalence in males. The molecular mechanisms by which the inhibition or development of liver cancer are facilitated require further investigation with regard to sex factors affecting disease progression. In the present stud...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2019.7217
更新日期:2019-09-01 00:00:00
abstract::Dendritic cell-mediated cancer immunotherapy employs several ways to engage tumor antigens. We have demonstrated in both pre-clinical animal studies and early clinical trials that dendritomas, highly purified hybrids between dendritic cells (DC) and tumor cells, are superior activators of anti-tumor immunity. It has b...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2010-02-01 00:00:00
abstract::We evaluated the efficacy of anti-human VEGF antibody (bevacizumab) with or without irinotecan (CPT-11) against lung metastases in which neovascularization was already induced, as a postoperative adjuvant therapy using orthotopically implanted colon cancer in rat. The high VEGF productive KM12SM human colon cancer cel...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2008-09-01 00:00:00
abstract::Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) holds promise for cancer therapy due to its unique capacity to selectively trigger apoptosis in cancer cells. However, TRAIL therapy is greatly hampered by its resistance. A preclinical successful strategy is to identify combination treatments that sensit...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2016.4666
更新日期:2016-05-01 00:00:00
abstract::Although surgery and high‑dose radiotherapy have been the standard treatments for glioblastoma multiforme (GBM), these therapies are palliative, due to the high risk of local relapse. Emerging evidence has demonstrated that DNA double‑strand break (DSB) repair serves a critical role in resistance to radiotherapy. Prev...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2018.6756
更新日期:2018-12-01 00:00:00