Splenic metastasis of lung cancer.

abstract：:Telomerase activation is prevalent in most epithelial tumors, and may be a critical step in cellular immortalization and carcinogenesis. However, telomerase activity in tumors of mesenchymal origin is not well understood. In the present study, we examined telomerase activity in clinical samples from osteosarcoma and s...

journal_title：Oncology reports

authors： Terasaki T,Kyo S,Takakura M,Maida Y,Tsuchiya H,Tomita K,Inoue M

更新日期：2004-06-01 00:00:00

abstract：:High activity 125I brachytherapy has efficacy in selected recurrent malignant brain tumors, but limited efficacy and risk of radiation necrosis have prompted investigation of additional adjunctive therapies. This study aims to assess the toxicity of interstitial conductive hyperthermia used concurrently with 125I brac...

journal_title：Oncology reports

authors： Narayan P,Crocker I,Elder E,Olson JJ

更新日期：2004-01-01 00:00:00

abstract：:Esophageal carcinosarcoma (ECS) is a rare malignant neoplasm associated with a poor patient prognosis. It is characterized by the presence of both malignant epithelial and mesenchymal components. Molecular-targeted therapy of several receptor tyrosine kinases (RTKs) has been reported to be effective in the treatment o...

journal_title：Oncology reports

authors： Sano A,Sakurai S,Kato H,Suzuki S,Yokobori T,Sakai M,Tanaka N,Inose T,Sohda M,Nakajima M,Fukai Y,Miyazaki T,Ojima H,Hosoya Y,Enomoto T,Kanda T,Ajioka Y,Kuwano H

更新日期：2013-06-01 00:00:00

abstract：:Interleukin-15 (IL-15) has important anabolic effects on muscle protein metabolism through a decrease in the ATP-ubiquitin-dependent proteolytic pathway. The role of IL-15 in human cancer cachexia is unknown. The aim of this study was to assess the relationship between interleukin-1...

journal_title：Oncology reports

authors： Martínez-Hernández PL,Hernanz-Macías Á,Gómez-Candela C,Grande-Aragón C,Feliu-Batlle J,Castro-Carpeño J,Martínez-Muñoz I,Zurita-Rosa L,Villarino-Sanz M,Prados-Sánchez C,Sánchez García-Girón J

更新日期：2012-10-01 00:00:00

abstract：:Recent studies have shown that miRNAs have potent abilities to activate gene expression by targeting promoter elements, a phenomenon known as RNA activation (RNAa). In the present study, we identified a new endogenous miR-3619-5p which was decreased in prostate cancer tissues and cells compared to corresponding normal...

journal_title：Oncology reports

authors： Li S,Wang C,Yu X,Wu H,Hu J,Wang S,Ye Z

更新日期：2017-01-01 00:00:00

abstract：:We previously found that oleanolic acid (OA), a naturally pentacyclic triterpenoid, enhances the radiosensitizing effect on tumor cells. However, it is unclear whether or not OA enhances the radiosensitivity of hypoxic cells. Therefore, the aim of the present study was to further observe the influence of OA on hypoxic...

journal_title：Oncology reports

authors： Qi R,Jin W,Wang J,Yi Q,Yu M,Xu S,Jin W

更新日期：2014-05-01 00:00:00

abstract：:Chronic pancreatitis/pancreatic cancer (CP/PC) is characterized by fibrous connective tissue proliferation induced by activated pancreatic stellate cells (PSCs). Galectin-1 is upregulated in activated PSCs and is important for the continuing activation of PSCs. The aim of this study was to evaluate the effect of galec...

journal_title：Oncology reports

authors： Tang D,Wu Q,Zhang J,Zhang H,Yuan Z,Xu J,Chong Y,Huang Y,Xiong Q,Wang S,Tian Y,Lu Y,Ge X,Shen W,Wang D

更新日期：2018-03-01 00:00:00

abstract：:Lymph node metastasis is one of the most important prognostic factors in malignant tumors. In this study, we investigated vascular endothelial growth factor (VEGF)-C expression in human gastric cancer using immunohistochemical techniques and determined the number of microvessels in peritumoral tissue. VEGF-C expressio...

journal_title：Oncology reports

authors： Hachisuka T,Narikiyo M,Yamada Y,Ishikawa H,Ueno M,Uchida H,Yoriki R,Ohigashi Y,Miki K,Tamaki H,Mizuno T,Nakajima Y

更新日期：2005-04-01 00:00:00

abstract：:Emerging evidence suggests that cancer cells present profound epigenetic alterations in addition to featuring classic genetic mutations. Valproic acid (VPA), a histone deacetylase inhibitor, can potently inhibit tumor growth and induce differentiation. However, the effect and underlying mechanism of VPA on head and ne...

journal_title：Oncology reports

authors： Lee SH,Nam HJ,Kang HJ,Samuels TL,Johnston N,Lim YC

更新日期：2015-10-01 00:00:00

abstract：:Although surgery and high‑dose radiotherapy have been the standard treatments for glioblastoma multiforme (GBM), these therapies are palliative, due to the high risk of local relapse. Emerging evidence has demonstrated that DNA double‑strand break (DSB) repair serves a critical role in resistance to radiotherapy. Prev...

journal_title：Oncology reports

authors： Mu F,Liu T,Zheng H,Xie X,Lei T,He X,Du S,Tong R,Wang Y

更新日期：2018-12-01 00:00:00

abstract：:miR-367 is one of the most abundant miRNAs in human embryonic stem cells (hESCs) and is mainly involved in maintaining the pluripotency of stem cells. However, its role in cancer development remains poorly understood. In the present study, we explored the function and mechanism of the endogenous miR-367 in non-small c...

journal_title：Oncology reports

authors： Xiao G,Gao X,Sun X,Yang C,Zhang B,Sun R,Huang G,Li X,Liu J,Du N,Liu D,Liang R,Ren H,Qin S

更新日期：2017-08-01 00:00:00

abstract：:To estimate the incidence of Epstein-Barr virus-associated gastric carcinoma (EBV-GC) in Colombia and to clarify its clinicopathological features, we examined 178 consecutive gastric carcinoma cases, diagnosed during the period from 1996 to 1998, at Hospital Universitario del Valle in Cali, Colombia. The mean age of t...

journal_title：Oncology reports

authors： Carrascal E,Koriyama C,Akiba S,Tamayo O,Itoh T,Eizuru Y,Garcia F,Sera M,Carrasquilla G,Piazuelo MB,Florez L,Bravo JC

更新日期：2003-07-01 00:00:00

abstract：:X-ray-based radiotherapy is one of the most effective therapeutic strategies for breast cancer patients. However, radioresistance and side-effects continue to be the most challenging issues. B-cell translocation gene 1 (BTG1) is a member of the BTG/Tob family, which inhibits cancer growth and promotes apoptosis. We, t...

journal_title：Oncology reports

authors： Zhu R,Li W,Xu Y,Wan J,Zhang Z

更新日期：2015-12-01 00:00:00

abstract：:Circulating microRNAs (miRNAs) exist stably in body fluids and are potential biomarkers for hepatocellular carcinoma (HCC). Twenty-five patients with cirrhosis that evolved into HCC, who were treated at The Third Hospital of Zhenjiang Affiliated to Jiangsu University between January 2005 and December 2012, were enroll...

journal_title：Oncology reports

authors： Tan Y,Lin B,Ye Y,Wen D,Chen L,Zhou X

更新日期：2015-06-01 00:00:00

abstract：:The present study aimed to evaluate a previously reported predictive formula of output-limiting symptoms induced by radiofrequency (RF) to determine the efficacy of this neoadjuvant chemoradiation (NACR) and concurrent RF thermal therapy. The present study included 81 consecutive patients with confirmed diagnoses of r...

journal_title：Oncology reports

authors： Shoji H,Motegi M,Takakusagi Y,Asao T,Kuwano H,Takahashi T,Ogoshi K

更新日期：2017-02-01 00:00:00

abstract：:microRNAs (miRNAs), small non-coding RNAs, have emerged as key regulators of a large number of genes. The present study aimed to explore novel biological functions of miR-330 in the human prostate cancer cell lines DU145 and PC3. We confirmed that miR-330 was downregulated and inversely correlated with specificity pro...

journal_title：Oncology reports

authors： Mao Y,Chen H,Lin Y,Xu X,Hu Z,Zhu Y,Wu J,Xu X,Zheng X,Xie L

更新日期：2013-07-01 00:00:00

abstract：:The nitrostyrene scaffold was previously identified as a lead target structure for the development of effective compounds targeting Burkitt's lymphoma. The present study aimed to develop these compounds further in haematological malignancies, including chronic lymphocytic leukaemia (CLL). Cellular viability, flow cyto...

journal_title：Oncology reports

authors： Bright SA,Byrne AJ,Vandenberghe E,Browne PV,Mcelligott AM,Meegan MJ,Williams DC

更新日期：2019-05-01 00:00:00

abstract：:Colorectal cancer (CRC) is one of the most common cancers worldwide. Long non-coding RNAs (lncRNAs) have been confirmed to play a critical regulatory role in various biological processes including carcinogenesis, which indicates that lncRNAs are valuable biomarkers and therapeutic targets. The novel lncRNA prostate ca...

journal_title：Oncology reports

authors： Yang L,Qiu M,Xu Y,Wang J,Zheng Y,Li M,Xu L,Yin R

更新日期：2016-01-01 00:00:00

abstract：:Non-small cell lung cancer (NSCLC) is the leading cause of cancer-related death worldwide, and only 15% of lung cancer patients live more than 5 years. microRNAs (miRNAs) are endogenously expressed non-coding RNAs, and dysregulation of miRNAs is a common feature in human cancers including lung cancer. In this study, w...

journal_title：Oncology reports

authors： Chen Y,Min L,Zhang X,Hu S,Wang B,Liu W,Wang R,Gu X,Shen W,Lv H,Zou J,Chen Y,Xu X,Chen L

更新日期：2013-10-01 00:00:00

abstract：:Increasing evidence suggests that microRNAs are involved in human carcinogenesis as tumor suppressors or oncogenes. A growing number of reports has shown that an interest has been sparked in aberrant microRNA expression and how they can be used to treat human diseases, including cancer. However, their precise biologic...

journal_title：Oncology reports

authors： Pan J,Hu H,Zhou Z,Sun L,Peng L,Yu L,Sun L,Liu J,Yang Z,Ran Y

更新日期：2010-07-01 00:00:00

abstract：:Statins are the most effective drugs used in the reduction of intracellular synthesis of cholesterol. Numerous studies have confirmed that statins reduce the risk of multiple types of cancers. Statin use in cancer patients is associated with reduced cancer-related mortality. Epithelial-to-mesenchymal transition (EMT),...

journal_title：Oncology reports

authors： Fan Z,Jiang H,Wang Z,Qu J

更新日期：2016-08-01 00:00:00

abstract：:Cancer cachexia is a life‑threatening syndrome associated with myofiber damage. Tumor factors impair muscle regeneration by promoting myoblast apoptosis. Ghrelin is a multifunctional hormone with an anti‑apoptotic effect, but its mechanism of action is not fully understood. In the present study, we investigated whethe...

journal_title：Oncology reports

authors： Zeng X,Chen S,Lin Y,Ke Z

更新日期：2018-03-01 00:00:00

abstract：:Berbamine is an herbal compound derived from Berberis amurensis, which is used in Chinese traditional medicine. However, few studies have investigated this anti-tumor effect or the underlying mechanisms of berbamine on lymphoma cells. We investigate the effect, as well as the mechanism of action, of 4-chlorobenzoyl be...

journal_title：Oncology reports

authors： Du HP,Shen JK,Yang M,Wang YQ,Yuan XQ,Ma QL,Jin J

更新日期：2010-03-01 00:00:00

abstract：:MA128, a novel herbal medicine, was previously identified and its effectiveness in the treatment of asthma and atopic dermatitis (AD) was demonstrated. In particular, post-inflammatory hyperpigmentation (PIH) in AD mice was improved by treatment with MA128. In addition, MA128 exhibited anti-melanogenic activity by inh...

journal_title：Oncology reports

authors： Kim A,Im M,Yim NH,Hwang YH,Yang HJ,Ma JY

更新日期：2015-08-01 00:00:00

abstract：:Tumor growth is accelerated by induction of angiogenesis regulated by many cytokines and growth factors. In a tumor mass, various angiogenic factors and their receptors are simultaneously expressed and the overlapped expressions of various factors may contribute to the aggressive growth of tumor. However, the possible...

journal_title：Oncology reports

authors： Lee YM,Bae MH,Lee OH,Moon EJ,Moon CK,Kim WH,Kim KW

更新日期：2004-10-01 00:00:00

abstract：:We have studied the effects of Saiboku-to, a traditional Chinese medicine having suppressive activities for leukotriene production and release, on the proliferation of the estrogen-responsive mouse Leydig tumor cell line B-1F. In our previous reports, it is shown that Saiboku-to promotes, but Scutellaria baicalensis, ...

journal_title：Oncology reports

authors： Murashima T,Katayama H,Shojiro K,Nishizawa Y

更新日期：2011-05-01 00:00:00

abstract：:Sedum sarmentosum Bunge, a traditional Chinese herbal medicine, has a wide range of clinical applications including antibiosis, anti-inflammation and anti-oxidation. In the present study, we identified that its extract (SSBE) exerts pancreatic anticancer activity in vitro and in vivo. In the cultured pancreatic cancer...

journal_title：Oncology reports

authors： Bai Y,Chen B,Hong W,Liang Y,Zhou M,Zhou L

更新日期：2016-05-01 00:00:00

abstract：:Chronic stress and a high-fat diet are well-documented risk factors associated with the renin-angiotensin system in the development of breast cancer. The angiotensin II type 1 receptor (AT1R) is a novel component of the renin-angiotensin system. Several recent studies have focused on the function of AT1R in cell proli...

journal_title：Oncology reports

authors： Du N,Feng J,Hu LJ,Sun X,Sun HB,Zhao Y,Yang YP,Ren H

更新日期：2012-06-01 00:00:00

abstract：:Eighteen primary human malignant mesotheliomas obtained from 18 patients were screened for point mutations and microdeletions/insertions in all exons of the tumour suppressor gene PTEN/MMAC1 by SSCP analysis. No mutation could be found. Our preliminary data indicate that disarrangements of PTEN/MMAC1 are at least not ...

journal_title：Oncology reports

authors： Papp T,Schipper H,Pemsel H,Unverricht M,Muller KM,Wiethege T,Schiffmann D,Rahman Q

更新日期：2001-11-01 00:00:00

abstract：:To elucidate the molecular mechanisms underlying the pathogenesis and treatment of human primary hepatocellular carcinoma (HCC), it is important to explore novel HCC-associated genes. In the present study, we examined the expression of ubiquitin-specific peptidase 14 (USP14) in patients with HCC using quantitative PCR...

journal_title：Oncology reports

authors： Huang G,Li L,Zhou W

更新日期：2015-12-01 00:00:00